Overexpression of bchsEP2299 in the eye under the control of Scer\GAL4GMR.PF results in a rough eye phenotype and age related neuronal degeneration.
Expression of bchsEP2299 in the developing nervous system, driven by Scer\GAL4elav-C155 results in a 14.6% increase in brain volume when compared to controls.
Flies expressing bchsEP2299 under the control of Scer\GAL4GMR.PF have a roughened eye surface and a slight decrease in overall eye size compared to controls.
Animals expressing bchsEP2299 under the control of Scer\GAL4GMR.PF show alterations in the neural projection patterns of photoreceptor cells compared to wild-type in mid-pupae; the number and basic array of R7 and R8 axonal projections remain relatively normal, but there is a loss of growth cone morphology, premature termination of developing synapses and axonal swellings or varicosities are seen.
Expression of bchsEP2299 in third instar eye discs, under the control of Scer\GAL4GMR.PF, does not affect the patterning of the disc. Expression in the developing retina results in photoreceptor growth cones with an unusually bulbous central region that are less expanded than wild-type growth cones. However, Scer\GAL4GMR.PF>bchsEP2299 growth cones appear to grow normally towards their targets. At the adult stage, flies of this genotype have small, glazed eyes that lack distinct ommatidia compared to those of wild-type flies.
Expression of bchsEP2299 under the control of Scer\GAL4GMR.PF results in smaller eyes than normal which have a glossy appearance.
bchsEP2299 homozygotes and bchsEP2299/Df(2L)cl7 flies have a reduced average lifespan compared to wild-type. These flies also have age-dependent ubiquitinated aggregates, that appear to be insoluble, throughout the CNS.
Mutant larvae expressing bchsEP2299 under the control of Scer\GAL4elav-C155 have altered ISN synapses with abnormal bulges at the junctions between the axons and the synaptic branches.
Expression of bchsEP2299 under the control of Scer\GAL4sca-537.4 results in severe loss of microchaetae on the abdomen and loss of scutellar and dorsocentral macrochaetae. Sensory organs with one socket, no shaft and one sheath cell are seen.