FlyBase Allele Report: Dmel\Rab11[ETo11]

General Information

Symbol

Dmel\Rab11^ETo11

Species

D. melanogaster

Name

FlyBase ID

FBal0126496

Feature type

allele

Associated gene

Dmel\Rab11

Associated Insertion(s)

Carried in Construct

Also Known As

Rab11^E(To)11

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Jankovics et al., 2001)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cytokinesis | male (with Rab11^93Bi)

(Giansanti et al., 2007)

abnormal meiotic cell cycle | male (with Rab11^93Bi)

(Giansanti et al., 2007)

female sterile (with Rab11^93Bi)

(Jankovics et al., 2001)

lethal

(Giansanti et al., 2007)

lethal (with Df(3R)e-R1)

(Giansanti et al., 2007)

lethal (with Rab11^EP3017)

(Giansanti et al., 2007)

lethal (with Rab11^ETo3)

(Giansanti et al., 2007)

lethal | recessive

(Jankovics et al., 2001)

partially lethal - majority die (with Rab11^93Bi)

(Giansanti et al., 2007)

Phenotype Manifest In

acroblast (with Rab11^93Bi)

(Giansanti et al., 2007)

cleavage furrow (with Rab11^93Bi)

(Giansanti et al., 2007)

contractile ring (with Rab11^93Bi)

(Giansanti et al., 2007)

egg chamber | germline clone

(Jankovics et al., 2001)

Golgi-associated vesicle (with Rab11^93Bi)

(Giansanti et al., 2007)

macrochaeta (with Rab11^93Bi)

(Jankovics et al., 2001)

Nebenkern (with Rab11^93Bi)

(Giansanti et al., 2007)

spermatid (with Rab11^93Bi)

(Giansanti et al., 2007)

spindle (with Rab11^93Bi)

(Giansanti et al., 2007)

Detailed Description

Statement

Reference

Testes from Rab11^93Bi/Rab11^ETo11 larvae have spermatids composed of an abnormally large Nebenkern associated with multiple nuclei.

Mid and late telophases in Rab11^93Bi/Rab11^ETo11 spermatocytes display contractile rings that are not fully constricted or poorly constricted and broken into irregular pieces. Defective central spindles are seen in 80% of these cases. In those spermatocytes that failed to complete cytokinesis, the furrow ingresses to a limited extent and then regresses, coincident with disassembly of the central spindle.

48% of telophases in Rab11^93Bi/Rab11^ETo11 spermatocytes display abnormal localization of Golgi-derived vesicle-like structures.

Rab11^93Bi/Rab11^ETo11 testes show disorganized acroblasts in both early and (particularly) elongating spermatids.

Rab11^93Bi/Rab11^ETo11 brains do not exhibit polyploid mitoses.

(Giansanti et al., 2007)

Rab11^ETo11/+ flies show no eye phenotype.

(Khodosh et al., 2006)

Egg chambers older than stage 4 are never detected in females containing homozygous germ-line clones.

(Jankovics et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Rab11^ETo11 is an enhancer of some die during embryonic stage | maternal effect | recessive phenotype of Tm1^el4/Tm1^eg9, osk¹

(Jankovics et al., 2001)

NOT Enhancer of

Statement

Reference

Rab11^93Bi/Rab11^ETo11 is a non-enhancer of abnormal cytokinesis | male phenotype of fwd^Z0453/fwd³

(Giansanti et al., 2007)

Rab11^93Bi/Rab11^ETo11 is a non-enhancer of abnormal cytokinesis | male phenotype of vib^EP513

(Giansanti et al., 2007)

NOT Suppressor of

Statement

Reference

Rab11^93Bi/Rab11^ETo11 is a non-suppressor of abnormal cytokinesis | male phenotype of vib^EP513

(Giansanti et al., 2007)

Rab11^93Bi/Rab11^ETo11 is a non-suppressor of abnormal cytokinesis | male phenotype of fwd^Z0453/fwd³

(Giansanti et al., 2007)

Other

Statement

Reference

Rab11^93Bi/Rab11^ETo11, fwd^Z0453/fwd³ has abnormal cytokinesis | male phenotype

(Giansanti et al., 2007)

Rab11^93Bi/Rab11^ETo11, vib^EP513 has abnormal cytokinesis | male phenotype

(Giansanti et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

Rab11^ETo11/Rab11[+] is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, bchs^EP2299

(Khodosh et al., 2006)

Rab11^ETo11/Rab11[+] is an enhancer of germline cell phenotype of Tm1^eg20/Tm1^eg9

(Jankovics et al., 2001)

Rab11^ETo11/Rab11[+] is an enhancer of embryonic abdominal segment phenotype of Tm1^el4/Tm1^eg9, osk¹

(Jankovics et al., 2001)

Rab11^ETo11/Rab11[+] is an enhancer of embryonic abdominal segment phenotype of Tm1^el4/Tm1^eg9, osk[+]/osk¹

(Jankovics et al., 2001)

NOT Enhancer of

Statement

Reference

Rab11^93Bi/Rab11^ETo11 is a non-enhancer of spermatid phenotype of fwd^Z0453/fwd³

(Giansanti et al., 2007)

Rab11^93Bi/Rab11^ETo11 is a non-enhancer of spermatid phenotype of vib^EP513

(Giansanti et al., 2007)

NOT Suppressor of

Statement

Reference

Rab11^93Bi/Rab11^ETo11 is a non-suppressor of spermatid phenotype of vib^EP513

(Giansanti et al., 2007)

Rab11^93Bi/Rab11^ETo11 is a non-suppressor of spermatid phenotype of fwd^Z0453/fwd³

(Giansanti et al., 2007)

Other

Statement

Reference

Rab11^93Bi/Rab11^ETo11, fwd^Z0453/fwd³ has spermatid phenotype

(Giansanti et al., 2007)

Rab11^93Bi/Rab11^ETo11, vib^EP513 has spermatid phenotype

(Giansanti et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Rab11^93Bi/Rab11^ETo11, fwd³/fwd^Z0453 spermatids are multinucleated at a similar frequency to fwd³/fwd^Z0453 spermatids.

Rab11^93Bi/Rab11^ETo11, vib^EP513 spermatids are multinucleated at a similar frequency to vib^EP513 spermatids.

(Giansanti et al., 2007)

Rab11^ETo11 heterozygotes act as dominant enhancers of the Scer\GAL4^GMR.PF>bchs^EP2299 eye phenotype, resulting in adults with severely reduced eyes.

(Khodosh et al., 2006)

Dominantly increases the penetrance of the "posterior group" phenotype of embryos derived from Tm1^eg9 +/Tm1^el4 osk¹ females to 86.7%. Dominantly increases the penetrance of the germ cell-less phenotype of flies derived from Tm1^eg9/Tm1^eg20 females to 81.7%.

(Jankovics et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Rab11^ETo3

(Jankovics et al., 2001)

Rab11^EP3017

(Jankovics et al., 2001)

Rab11^j2D1

(Jankovics et al., 2001)

Rab11^93Bi

(Jankovics et al., 2001)

Rescued by

Rab11^93Bi/Rab11^ETo11 is rescued by Rab11^GFP

(Giansanti et al., 2007)

Comments

Rab11^93Bi/Rab11^ETo11 flies carrying Rab11^T:Avic\GFP are fully viable and testes from larvae of these genotypes do not exhibit abnormal spermatids.

(Giansanti et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a dominant enhancer of the Tm1^eg9 +/Tm1^el4 osk¹ phenotype. Separable from: a mutation (lethal or female sterile) on the 2nd chromosome.

(Jankovics et al., 2001)

Comments

Order of alleles (based on transheterozygous sterile phenotype): Rab11^93Bi < Rab11^j2D1 < Rab11^EP3017 = Rab11^ETo11 = Rab11^ETo3 < Df(3R)e-N19.

(Jankovics et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Rab11^E(To)11

(Giansanti et al., 2015, Sasikumar and Roy, 2009, Khodosh et al., 2006, Jankovics et al., 2001)

Rab11^ETo11

rab11^E(To)11

(Giansanti et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (5)

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