FlyBase Allele Report: Dmel\Rab11[ETo3]

General Information

Symbol

Dmel\Rab11^ETo3

Species

D. melanogaster

Name

FlyBase ID

FBal0126495

Feature type

allele

Associated gene

Dmel\Rab11

Associated Insertion(s)

Carried in Construct

Also Known As

Rab11^E(To)3

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Jankovics et al., 2001)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cytokinesis | male (with Rab11^93Bi)

(Giansanti et al., 2007)

abnormal meiotic cell cycle | male (with Rab11^93Bi)

(Giansanti et al., 2007)

female sterile (with Rab11^93Bi)

(Jankovics et al., 2001)

female sterile | germline clone

(Lighthouse et al., 2008)

lethal

(Giansanti et al., 2007)

lethal (with Df(3R)e-R1)

(Giansanti et al., 2007)

lethal (with Rab11^EP3017)

(Giansanti et al., 2007)

lethal (with Rab11^ETo11)

(Giansanti et al., 2007)

lethal | recessive

(Lighthouse et al., 2008, Jankovics et al., 2001)

partially lethal - majority die (with Rab11^93Bi)

(Giansanti et al., 2007)

Phenotype Manifest In

fusome | germline clone

(Lighthouse et al., 2008)

germline stem cell | germline clone

(Lighthouse et al., 2008)

macrochaeta (with Rab11^93Bi)

(Jankovics et al., 2001)

Nebenkern (with Rab11^93Bi)

(Giansanti et al., 2007)

spermatid (with Rab11^93Bi)

(Giansanti et al., 2007)

Detailed Description

Statement

Reference

Females carrying homozygous germline clones are sterile.

Homozygous clones in the adult germ cells result in defective fusomes. Germline stem cell clones show an approximately 4-fold reduction in half-life compared to control clones.

(Lighthouse et al., 2008)

Testes from Rab11^93Bi/Rab11^ETo3 larvae have spermatids composed of an abnormally large Nebenkern associated with multiple nuclei.

Rab11^93Bi/Rab11^ETo3 brains do not exhibit polyploid mitoses.

(Giansanti et al., 2007)

Rab11^ETo3/+ flies show no eye phenotype.

(Khodosh et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Rab11[+]/Rab11^ETo3 is an enhancer of abnormal meiotic cell cycle | male phenotype of brun^Z3358/Df(2L)pr2b

(Robinett et al., 2009)

Rab11[+]/Rab11^ETo3 is an enhancer of abnormal cytokinesis | male phenotype of brun^Z3358/Df(2L)pr2b

(Robinett et al., 2009)

Rab11^ETo3 is an enhancer of some die during embryonic stage | maternal effect | recessive phenotype of Tm1^el4/Tm1^eg9, osk¹

(Jankovics et al., 2001)

Other

Statement

Reference

Rab11^93Bi/Rab11^ETo3, brun^Z3358 has lethal | larval stage phenotype

(Robinett et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

Rab11[+]/Rab11^ETo3 is an enhancer of spermatid phenotype of brun^Z3358/Df(2L)pr2b

(Robinett et al., 2009)

Rab11[+]/Rab11^ETo3 is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, bchs^EP2299

(Khodosh et al., 2006)

Rab11[+]/Rab11^ETo3 is an enhancer of embryonic abdominal segment phenotype of Tm1^el4/Tm1^eg9, osk¹

(Jankovics et al., 2001)

Rab11[+]/Rab11^ETo3 is an enhancer of embryonic abdominal segment phenotype of Tm1^el4/Tm1^eg9, osk[+]/osk¹

(Jankovics et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Flies homozygous for bru^Z3358 and transheterozygous for Rab11^93Bi/Rab11^ETo3 die in early larval stages at 25[o]C.

Testes from bru^Z3358/Df(2L)pr2b;Rab11^ETo3 males raised at 25[o]C exhibit a 4.5-fold increase in the percentage of tetranucleate early spermatids relative to testes from bru^Z3358/Df(2L)pr2b males.

(Robinett et al., 2009)

Rab11^ETo3 heterozygotes act as dominant enhancers of the Scer\GAL4^GMR.PF>bchs^EP2299 eye phenotype, resulting in adults with severely reduced eyes.

(Khodosh et al., 2006)

Dominantly increases the penetrance of the "posterior group" phenotype of embryos derived from Tm1^eg9 +/Tm1^el4 osk¹ females to 98.0%.

(Jankovics et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Rab11^ETo11

(Jankovics et al., 2001)

Rab11^EP3017

(Jankovics et al., 2001)

Rab11^j2D1

(Jankovics et al., 2001)

Rab11^93Bi

(Jankovics et al., 2001)

Rescued by

Rab11^93Bi/Rab11^ETo3 is rescued by Rab11^GFP

(Giansanti et al., 2007)

Comments

Rab11^93Bi/Rab11^ETo3 flies carrying Rab11^T:Avic\GFP are fully viable and testes from larvae of these genotypes do not exhibit abnormal spermatids.

(Giansanti et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a dominant enhancer of the Tm1^eg9 +/Tm1^el4 osk¹ phenotype. Separable from: a mutation (lethal or female sterile) on the 2nd chromosome.

(Jankovics et al., 2001)

Comments

Order of alleles (based on transheterozygous sterile phenotype): Rab11^93Bi < Rab11^j2D1 < Rab11^EP3017 = Rab11^ETo11 = Rab11^ETo3 < Df(3R)e-N19.

(Jankovics et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Rab11^E(To)3

(Giansanti et al., 2015, Robinett et al., 2009, Khodosh et al., 2006, Jankovics et al., 2001)

Rab11^ETo3

Rab11^e(To)3

(Belloni et al., 2012)

rab11^E(To)3

(Giansanti et al., 2007)

rab11^E(to)3

(Lighthouse et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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