FlyBase Allele Report: Dmel\Tm1[eg9]

General Information

Symbol

Dmel\Tm1^eg9

Species

D. melanogaster

Name

FlyBase ID

FBal0049223

Feature type

allele

Associated gene

Dmel\Tm1

Associated Insertion(s)

Carried in Construct

Also Known As

TmII^eg9

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Erdelyi et al., 1995)

Progenitor genotype

Tm1^gs1

(Jankovics et al., 2001, Erdelyi et al., 1995)

Cytology

Description

Imprecise excision of P{lacW}Tm1^gs1, resulting in a greatly reduced expression of Tm1 isoforms C, H and I in homozygous ovaries.

(Gáspár et al., 2017)

Excision of the P{lacW} element.

(Jankovics et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

grandchildless

(Wong et al., 2011)

grandchildless (with Tm1^eg1)

(Gáspár et al., 2017)

Phenotype Manifest In

germline cell

(Jankovics et al., 2001)

germline cell | maternal effect

(Szuperak et al., 2005)

oocyte

(Gáspár et al., 2017)

oocyte (with Tm1^eg1)

(Gáspár et al., 2017)

Detailed Description

Statement

Reference

Tm1^eg9/Tm1^eg1 mutant oocytes show impaired plus-end-directed motility of osk messenger ribonucleoprotein particles as they fail to show the dominance of plus-end-directed runs over the minus-end-directed runs normally observed in wild-type oocytes) and delocalization of the osk mRNA (also observed in Tm1^eg9 homozygotes), the females display the grandchildless phenotype.

(Gáspár et al., 2017)

96.3% of the progeny of homozygous females are germ cell-less.

(Szuperak et al., 2005)

Strong germ cell-less phenotype.

(Jankovics et al., 2001)

Embryos fail to form pole cells. Transplantation of wild type pole cells into homozygous embryos results in wild type egg chambers and wild type embryos.

(Erdelyi et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | maternal effect | recessive phenotype, enhanceable by E(To)1¹

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | maternal effect | recessive phenotype, enhanceable by E(To)4⁴

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | maternal effect | recessive phenotype, enhanceable by E(To)5⁵

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | maternal effect | recessive phenotype, enhanceable by E(To)6⁶

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | maternal effect | recessive phenotype, enhanceable by E(To)8⁸

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | maternal effect | recessive phenotype, enhanceable by E(To)9⁹

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | maternal effect | recessive phenotype, enhanceable by Rab11^ETo11

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | maternal effect | recessive phenotype, enhanceable by Rab11^ETo3

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | maternal effect | recessive phenotype, enhanceable by mago^ETo2

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | maternal effect | recessive phenotype, enhanceable by vas^ETo14

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | maternal effect | recessive phenotype, enhanceable by E(To)10¹⁰

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | maternal effect | recessive phenotype, enhanceable by E(To)12¹²

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | maternal effect | recessive phenotype, enhanceable by E(To)13¹³

(Jankovics et al., 2001)

Suppressed by

Statement

Reference

Tm1^eg9 has grandchildless phenotype, suppressible by Scer\GAL4^{VP16.nanos.UTR}/Mmus\Synpo^UAS.cWa

(Wong et al., 2011)

Enhancer of

Statement

Reference

Tm1[+]/Tm1^eg9 is an enhancer of visible phenotype of br¹

(Ward et al., 2003)

Other

Statement

Reference

Tm1^eg9, osk^ETo7, vas^ETo14 has female sterile phenotype

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has some die during embryonic stage | recessive | recessive | maternal effect phenotype

(Jankovics et al., 2001)

E(To)1¹, Tm1^eg9, vas^ETo14 has female fertile phenotype

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk^ETo7/osk¹ has some die during embryonic stage | maternal effect phenotype

(Jankovics et al., 2001)

E(To)1¹, Tm1^eg9, osk^ETo7 has female sterile phenotype

(Jankovics et al., 2001)

Tm1[+]/Tm1^eg9, zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Tm1^eg9, zip[+]/zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

Tm1^eg20/Tm1^eg9 has germline cell phenotype, enhanceable by E(To)10¹⁰/E(To)10[+]

(Jankovics et al., 2001)

Tm1^eg20/Tm1^eg9 has germline cell phenotype, enhanceable by E(To)4[+]/E(To)4⁴

(Jankovics et al., 2001)

Tm1^eg20/Tm1^eg9 has germline cell phenotype, enhanceable by E(To)6⁶/E(To)6[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)10¹⁰/E(To)10[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)12¹²/E(To)12[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic/first instar larval cuticle phenotype, enhanceable by E(To)12¹²/E(To)12[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)13[+]/E(To)13¹³

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)1¹/E(To)1[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)4[+]/E(To)4⁴

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)5⁵/E(To)5[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic/first instar larval cuticle phenotype, enhanceable by E(To)5⁵/E(To)5[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)6⁶/E(To)6[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)8[+]/E(To)8⁸

(Jankovics et al., 2001)

Tm1^eg20/Tm1^eg9 has germline cell phenotype, enhanceable by Rab11^ETo11/Rab11[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)9[+]/E(To)9⁹

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype, enhanceable by Rab11^ETo11/Rab11[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype, enhanceable by Rab11[+]/Rab11^ETo3

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype, enhanceable by mago^ETo2/mago[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype, enhanceable by vas^ETo14/vas[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)10¹⁰/E(To)10[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)12¹²/E(To)12[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic/first instar larval cuticle phenotype, enhanceable by E(To)12¹²/E(To)12[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9 has embryonic/first instar larval cuticle phenotype, enhanceable by osk[+]/osk¹/E(To)12¹²/E(To)12[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)13[+]/E(To)13¹³

(Jankovics et al., 2001)

Tm1^eg20/Tm1^eg9 has germline cell phenotype, enhanceable by osk[+]/osk^ETo7

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)1¹/E(To)1[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)4[+]/E(To)4⁴

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)5⁵/E(To)5[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic/first instar larval cuticle phenotype, enhanceable by E(To)5⁵/E(To)5[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)6⁶/E(To)6[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)8[+]/E(To)8⁸

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype, enhanceable by E(To)9[+]/E(To)9⁹

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype, enhanceable by Rab11^ETo11/Rab11[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype, enhanceable by Rab11[+]/Rab11^ETo3

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype, enhanceable by mago^ETo2/mago[+]

(Jankovics et al., 2001)

Tm1^eg20/Tm1^eg9 has germline cell phenotype, enhanceable by vas^ETo14/vas[+]

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype, enhanceable by vas^ETo14/vas[+]

(Jankovics et al., 2001)

Tm1^eg20/Tm1^eg9 has germline cell phenotype, enhanceable by E(To)1¹/E(To)1[+]

(Jankovics et al., 2001)

Suppressed by

Statement

Reference

Tm1^eg9/Tm1^eg1 has oocyte phenotype, suppressible by Scer\GAL4^VP16.osk/Khc^{401.UASp.Tag:MCP}

(Gáspár et al., 2017)

Tm1^eg20/Tm1^eg9 has germline cell phenotype, suppressible by E(To)12¹²/E(To)12[+]

(Jankovics et al., 2001)

Tm1^eg20/Tm1^eg9 has germline cell phenotype, suppressible by E(To)13[+]/E(To)13¹³

(Jankovics et al., 2001)

Enhancer of

Statement

Reference

Tm1[+]/Tm1^eg9 is an enhancer of leg phenotype of br¹

(Ward et al., 2003)

Other

Statement

Reference

Tm1^eg9, osk^ETo7, vas^ETo14 has embryonic abdominal segment phenotype

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk^ETo7/osk¹ has embryonic abdominal segment phenotype

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic abdominal segment phenotype

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk[+]/osk¹ has embryonic/first instar larval cuticle phenotype

(Jankovics et al., 2001)

E(To)1¹, Tm1^eg9, osk^ETo7 has embryonic abdominal segment phenotype

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic abdominal segment phenotype

(Jankovics et al., 2001)

Tm1^el4/Tm1^eg9, osk¹ has embryonic/first instar larval cuticle phenotype

(Jankovics et al., 2001)

Tm1[+]/Tm1^eg9, zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Tm1[+]/Tm1^eg9, zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Tm1^eg9, zip[+]/zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Tm1^eg9, zip[+]/zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Khc^{401.Scer\UAS.P\T.T:MS2\MCP} under the control of Scer\GAL4^{osk.T:Hsim\VP16} rescues the impaired plus-end-directed motility of osk messenger ribonucleoprotein particles (restoring the dominance of plus-end-directed runs over the minus-end-directed runs) and the posterior pole localization of osk mRNA in the mutant oocytes.

(Gáspár et al., 2017)

Dominantly weakly enhances the frequency of br¹ mutant animals with malformed legs.

(Ward et al., 2003)

66% of eggs derived from Tm1^eg9 +/Tm1^el4 osk¹ females do not develop into viable larvae. In 44% of the dead eggs, embryogenesis does not commence, or is terminated before cuticle formation, while 56% of the dead eggs have a characteristic "posterior group" phenotype with missing abdominal segments.

(Jankovics et al., 2001)

Second site non-complementing phenotype with zip^Ebr but not zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

Xenogenetic Interactions

Statement

Reference

The expression of Mmus\Synpo^Scer\UAS.cWa via Scer\GAL4^{nos.UTR.T:Hsim\VP16} suppresses the grandchildless phenotype of Tm1^eg9 mutants.

(Wong et al., 2011)

Complementation and Rescue Data

Rescued by

Tm1^eg9/Tm1^eg1 is rescued by Scer\GAL4^VP16.osk/Tm1^{UASp.I.Emerald}

(Gáspár et al., 2017)

Comments

Expression of Tm1^{Scer\UAS.P\T.I.T:Avic\GFP-EMD} under the control of Scer\GAL4^{osk.T:Hsim\VP16} rescues the grandchildless phenotype of Tm1^eg9/Tm1^eg1 and restores the posterior pole localization of osk mRNA in the mutant oocytes.

(Gáspár et al., 2017)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Tm1^eg9

(Gaber et al., 2025, Gáspár et al., 2023, Cassella and Ephrussi, 2022, Dimitrova-Paternoga et al., 2021, Gáspár et al., 2017)

TmII^eg9

(Wong et al., 2011, Szuperak et al., 2005, Jankovics et al., 2001)

cTm^eg9

(Halsell and Kiehart, 1998)

Name Synonyms

Secondary FlyBase IDs

References (11)

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