FB2026_02 , released June 18, 2026
Allele: Dmel\Tm1gs1
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General Information
Symbol
Dmel\Tm1gs1
Species
D. melanogaster
Name
FlyBase ID
FBal0049228
Feature type
allele
Associated gene
Dmel\Tm1
Associated Insertion(s)
P{lacW}Tm1gs1
Carried in Construct
Also Known As
TmIIgs1, TmIIgs
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Erdelyi et al., 1995)
Progenitor genotype
Associated Insertion(s)
P{lacW}Tm1gs1
Cytology
Description

Insertion of a P{lacW} element immediately downstream of the first exon at position 3753.

(Erdelyi et al., 1995)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Tm1gs1/Tm1gs1 larvae have a significantly reduced number of type Ib boutons compared to wild type.

      (Gardiol and St Johnston, 2014)

      98.4% of the progeny of homozygous females are germ cell-less.

      (Szuperak et al., 2005)

      When wild-type females previously mated to wild-type males are mated with Tm1gs1 males (which ejaculate seminal fluid but no sperm) the proportion of females with no stored sperm is significantly less than for females that have not undergone a second mating. However when the second mating is with prd4/Df(2L)Prl; prdwt males (which do not ejaculate at all) the proportion of females with stored sperm is no different to that seen when the second mating is with Tm1gs1 males, suggesting that seminal fluid is not necessary for the loss of stored sperm on mating.

      (Snook and Hosken, 2004)

      Ooplasmic streaming is normal at stage 9 and stage 10b in mutant oocytes.

      (Palacios and St. Johnston, 2002)

      Embryos fail to form pole cells.

      (Erdelyi et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (14)