FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Tm1
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General Information
Symbol
Dmel\Tm1
Species
D. melanogaster
Name
Tropomyosin 1
Annotation Symbol
CG4898
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003721
Gene Model Status
Current
Stock Availability
36 publicly available
Gene Summary
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. (UniProt, P06754P49455)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

TmII, tropomyosin, tropomyosin II, cTm, Tm

Key Links
Genomic Location
Cytogenetic map
88E11-88E13
Sequence location
Recombination map
3-56
RefSeq locus
NT_033777 REGION:15278220..15308779
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables actin filament binding
inferred from direct assay
(Kim et al., 2011)
enables kinesin binding
inferred from physical interaction with FLYBASE:Khc; FB:FBgn0001308
(Veeranan-Karmegam et al., 2016)
enables protein kinase binding
inferred from physical interaction with UniProtKB:A8DYP0
(Katzemich et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables actin binding
traceable author statement
(Johnstone and Lasko, 2001)
enables actin filament binding
inferred from biological aspect of ancestor with PANTHER:PTN000443979
(GO Reference Genome Project, 2011-)
Biological Process (9 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in dendrite morphogenesis
inferred from mutant phenotype
(Li and Gao, 2003)
involved_in pole plasm oskar mRNA localization
inferred from mutant phenotype
(Veeranan-Karmegam et al., 2016, Erdelyi et al., 1995)
involved_in regulation of lamellipodium assembly
inferred from mutant phenotype
(Iwasa and Mullins, 2007)
involved_in response to hyperoxia
inferred from mutant phenotype
(Zhao et al., 2010)
involved_in stress fiber assembly
inferred from mutant phenotype
(Cho et al., 2016)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
involved_in actin filament organization
inferred from biological aspect of ancestor with PANTHER:PTN000443979
(GO Reference Genome Project, 2011-)
involved_in dendrite morphogenesis
traceable author statement
(Grueber and Jan, 2004)
involved_in muscle contraction
non-traceable author statement
(Tekotte and Davis, 2002)
inferred from biological aspect of ancestor with PANTHER:PTN001059856
(GO Reference Genome Project, 2011-)
involved_in oogenesis
traceable author statement
(Wylie, 1999)
involved_in pole plasm assembly
non-traceable author statement
(Williamson and Lehmann, 1996)
involved_in pole plasm oskar mRNA localization
traceable author statement
(Tekotte and Davis, 2002, Johnstone and Lasko, 2001)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
colocalizes_with cortical actin cytoskeleton
inferred from mutant phenotype
(Cho et al., 2016)
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
located_in investment cone
inferred from direct assay
(Texada et al., 2011)
located_in P granule
inferred from direct assay
(Veeranan-Karmegam et al., 2016)
located_in sarcomere
inferred from direct assay
(Hudson et al., 2008)
colocalizes_with stress fiber
inferred from mutant phenotype
(Cho et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in actin filament
inferred from biological aspect of ancestor with PANTHER:PTN000443979
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the tropomyosin family. (P06754P49455)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
(UniProt, P06754P49455)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Tm1: Tropomyosin 1 (J.C. Hall)
Structural gene for tropomyosin, a 34,000-dalton protein that acts as a regulator of motility in muscle and nonmuscle cells. At least five tropomyosin isoforms are encoded by Tm1, some in embryos (during myogenesis) and myogenic cell culture and others in the myofibrils of adult indirect flight muscles and leg muscles.
Gene Model and Products
Number of Transcripts
18
Number of Unique Polypeptides
14

Please see the JBrowse view of Dmel\Tm1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P49455)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Gene model reviewed during 6.32

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Tm1-RA
FBtr0089960
NM_079636
2003
252
Tm1-RC
FBtr0089962
NM_169640
2651
441
Tm1-RE
FBtr0089965
NM_169638
2531
711
Tm1-RF
FBtr0089959
NM_169637
1684
501
Tm1-RG
FBtr0089964
NM_169635
2485
285
Tm1-RH
FBtr0089963
NM_169639
3054
678
Tm1-RI
FBtr0089961
NM_169641
2501
441
Tm1-RJ
FBtr0089967
NM_169636
1248
285
Tm1-RK
FBtr0089957
NM_206495
1665
518
Tm1-RL
FBtr0089968
NM_206494
2194
284
Tm1-RM
FBtr0301959
NM_169634
1253
285
Tm1-RN
FBtr0301960
NM_001170148
1253
285
Tm1-RO
FBtr0305654
NM_169633
1503
285
Tm1-RP
FBtr0305655
NM_001260190
752
161
Tm1-RQ
FBtr0305656
NM_001260191
1318
250
Tm1-RR
FBtr0333917
NM_001275661
1861
250
Tm1-RS
FBtr0333918
NM_001275662
1253
285
Tm1-RT
FBtr0479735
NM_001382175
1898
282
Additional Transcript Data and Comments
Reported size (kB)

1.253 (longest cDNA)

(Hanke and Storti, 1986)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Tm1-PA
FBpp0088899
29.3
252
4.47
NP_524360
AAF55164
Tm1-PC
FBpp0088901
48.0
441
5.15
Q95TA3
NP_732008
AAN13650
Tm1-PE
FBpp0088904
80.1
711
5.09
Q8IGY1
NP_732006
AAN13648
Tm1-PF
FBpp0088898
53.4
501
4.05
H1UUP7
NP_732005
AAN13647
Tm1-PG
FBpp0088903
32.7
285
4.38
NP_732003
AAN13645
Tm1-PH
FBpp0088902
74.7
678
9.49
Q8IG84
NP_732007
AAN13649
Tm1-PI
FBpp0088900
48.0
441
5.15
Q95TA3
NP_732009
AAN13651
Tm1-PJ
FBpp0088906
32.7
285
4.38
NP_732004
AAN13646
Tm1-PK
FBpp0088896
54.6
518
4.08
P49455
NP_996217
AAS65155
Tm1-PL
FBpp0089024
32.5
284
4.43
NP_996216
AAS65156
Tm1-PM
FBpp0291171
32.7
285
4.38
NP_732002
AAN13644
Tm1-PN
FBpp0291172
32.8
285
4.40
Q6NN28
NP_001163619
ACZ94915
Tm1-PO
FBpp0296934
32.7
285
4.38
NP_732001
AAF55163
Tm1-PP
FBpp0296935
18.4
161
5.02
A0A0B4K6Y8
NP_001247119
AFH06437
Tm1-PQ
FBpp0296936
29.2
250
4.54
A0A0B4K661
NP_001247120
AFH06438
Tm1-PR
FBpp0306045
29.1
250
4.54
A0A0B4KG68
NP_001262590
AGB95971
Tm1-PS
FBpp0306046
32.7
285
4.40
A0A0B4KG06
NP_001262591
AGB95972
Tm1-PT
FBpp0428078
32.3
282
4.43
QJC18464
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

285 aa isoforms: Tm1-PG, Tm1-PJ, Tm1-PM, Tm1-PO
441 aa isoforms: Tm1-PC, Tm1-PI
Additional Polypeptide Data and Comments
Reported size (kDa)

518, 504, 285, 252 (aa)

(Hanke and Storti, 1988)
Comments
External Data
Subunit Structure (UniProtKB)

Homodimer (Probable). May interact with Unc-89 (via protein kinase domain 2) (PubMed:26251439).

(UniProt, P06754)

Homodimer.

(UniProt, P49455)
Domain

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

(UniProt, P06754, P49455)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tm1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.98

Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
seminal receptacle
(Prokupek et al., 2009)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 1 -- 4
pole plasm | posterior
(Lecuyer et al., 2007)
embryonic stage 4
embryo | posterior
(Hales et al., 1994)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 5
primordial germ cell
(Lecuyer et al., 2007)
embryonic cortex
(Hales et al., 1994)
embryonic stage 6 -- 11
ventral furrow
(Hales et al., 1994)
germ band
(Hales et al., 1994)
cephalic furrow
(Hales et al., 1994)
embryonic stage 6 -- 15
posterior midgut primordium
(Hales et al., 1994)
anterior midgut primordium
(Hales et al., 1994)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11
ectoderm | segmentally repeated
(Hales et al., 1994)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
trunk visceral muscle primordium
(Fisher et al., 2012)
embryonic stage 13
dorsal ectoderm
(Hales et al., 1994)
embryonic stage 13 -- 16
embryonic primordium of adult muscle precursor
(Fisher et al., 2012)
dorsal pharyngeal muscle cell
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval muscle system
(Fisher et al., 2012)
larval somatic muscle cell
(Fisher et al., 2012)
larval visceral muscle cell
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 17
presumptive embryonic/larval central nervous system
(Hales et al., 1994)
embryonic brain
(Hales et al., 1994)
embryonic midgut constriction
(Hales et al., 1994)
embryonic stage 16
larval somatic muscle cell
(Lord et al., 1995)
adult stageoogenesis stage S10 -- S12
nurse cell
(Hales et al., 1994)
follicle cell
(Hales et al., 1994)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 11

Comment: reference states 0-6 hr AEL

(Hales et al., 1994)
embryonic stage 8 -- 17

Comment: reference states >3-6 hr AEL

(Hales et al., 1994)
Additional Descriptive Data

Tm1 expression at embryonic stages 1-4 is localized to the posterior pole of the embryo.

(Lecuyer et al., 2007)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
embryonic dorsal vessel
(Trujillo et al., 2016)
adult stage | female & oogenesis
follicle cell
(Cho et al., 2016)
germarium cap cell
(Cho et al., 2016)
oogenesis & adult stage | female
border follicle cell
(Cho et al., 2016)
nurse cell

Comment: not seen using C-terminal specific antibody

(Cho et al., 2016)
oocyte

Comment: not seen using C-terminal specific antibody

(Cho et al., 2016)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
indirect flight muscle cell
(Clayton et al., 1998)
Additional Descriptive Data

An antibody that recognizes a C-terminal epitope of Tm1 stained follicle cells and the germline stem cell niche (cap cells). An antibody that recognizes all Tm1 isoforms showed both germ-line and somatic staining.

(Cho et al., 2016)
Marker for
 
larval somatic muscle cell
(Rudolf et al., 2012)
larval visceral muscle cell
(Rudolf et al., 2012)
Subcellular Localization
CV Term
Evidence
References
colocalizes_with cortical actin cytoskeleton
inferred from mutant phenotype
(Cho et al., 2016)
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
located_in investment cone
inferred from direct assay
(Texada et al., 2011)
located_in P granule
inferred from direct assay
(Veeranan-Karmegam et al., 2016)
located_in sarcomere
inferred from direct assay
(Hudson et al., 2008)
colocalizes_with stress fiber
inferred from mutant phenotype
(Cho et al., 2016)
Expression Deduced from Reporters
Reporter:
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
embryonic dorsal vessel
(Trujillo et al., 2016)
adult stage | female & oogenesis
follicle cell
(Cho et al., 2016)
germarium cap cell
(Cho et al., 2016)
oogenesis & adult stage | female
border follicle cell
(Cho et al., 2016)
nurse cell

Comment: not seen using C-terminal specific antibody

(Cho et al., 2016)
oocyte

Comment: not seen using C-terminal specific antibody

(Cho et al., 2016)
adult stage
adult head
• membrane
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
indirect flight muscle cell
(Clayton et al., 1998)
Reporter: P{-22-1367HSP}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & larval stage & adult stage
muscle system
(Meredith and Storti, 1993)
Reporter: P{-22PI}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & larval stage & adult stage
muscle system
(Meredith and Storti, 1993)
Reporter: P{-243PI}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & larval stage & adult stage
muscle system
(Meredith and Storti, 1993)
Reporter: P{-1200LACcTm-3'}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4
embryo | posterior
(Hales et al., 1994)
embryonic stage 5
embryonic cortex
(Hales et al., 1994)
embryonic stage 6 -- 11
germ band
(Hales et al., 1994)
cephalic furrow
(Hales et al., 1994)
ventral furrow
(Hales et al., 1994)
embryonic stage 6 -- 15
posterior midgut primordium
(Hales et al., 1994)
anterior midgut primordium
(Hales et al., 1994)
embryonic stage 11
ectoderm | segmentally repeated
(Hales et al., 1994)
embryonic stage 13
dorsal ectoderm
(Hales et al., 1994)
embryonic stage 13 -- 17
embryonic midgut constriction
(Hales et al., 1994)
presumptive embryonic/larval central nervous system
(Hales et al., 1994)
embryonic brain
(Hales et al., 1994)
adult stage & oogenesis
oocyte
(Hales et al., 1994)
nurse cell
(Hales et al., 1994)
Reporter: P{-1400PI}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & larval stage & adult stage
muscle system
(Meredith and Storti, 1993)
Reporter: P{-1400PIΔ1.2}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & larval stage & adult stage
muscle system | restricted
(Meredith and Storti, 1993)
Reporter: P{-1400PIΔBglII}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & larval stage & adult stage
muscle system
(Meredith and Storti, 1993)
Reporter: P{+167-621-1400PIΔ1.2}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & larval stage & adult stage
muscle system
(Meredith and Storti, 1993)
Reporter: P{+167-621HSP}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & larval stage & adult stage
muscle system
(Meredith and Storti, 1993)
Reporter: P{+167-1367HSP}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & larval stage & adult stage
muscle system
(Meredith and Storti, 1993)
Reporter: P{GAL4}2-35
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
neuron | subset of adult ventral nerve cord
(Yu et al., 2010)
Reporter: P{GawB}Tm1C817
Stage
Tissue/Position (including subcellular localization)
Reference
pupal stage
photoreceptor neuron | subset
(Wernet et al., 2003)
photoreceptor neuron of eye disc posterior to the morphogenetic furrow
(Wernet et al., 2003)
eye disc posterior to the morphogenetic furrow
(Wernet et al., 2003)
adult stage
central nervous system | restricted
(Sarpal et al., 2003)
neuron of central nervous system | subset
(Sarpal et al., 2003)
neuron | subset
(Sarpal et al., 2003)
chordotonal organ
(Sarpal et al., 2003)
Reporter: P{GawB}Tm1NP3018
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
neuron | subset of adult ventral nerve cord
(Yu et al., 2010)
Reporter: P{PTT-GC}Tm1G5
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
muscle cell
• sarcomere
(Morin et al., 2001)
Reporter: P{PTT-un}Tm1ZCL0722
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
follicle cell
(Cash and Andrews, 2012)
Reporter: P{ST.lexA::HG}Tm1SE230
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
larval central nervous system
(Bloomington Drosophila Stock Center, 2019)
larval ventral nerve cord
(Bloomington Drosophila Stock Center, 2019)
embryonic/larval fat body
(Bloomington Drosophila Stock Center, 2019)
embryonic/larval anterior midgut
(Bloomington Drosophila Stock Center, 2019)
eye disc
(Bloomington Drosophila Stock Center, 2019)
photoreceptor neuron
(Bloomington Drosophila Stock Center, 2019)
Reporter: PBac{602.P.SVS-1}Tm1CPTI000760
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
fan-shaped body

Comment: expression in many parts of the central brain, including the fan-shaped body

(Knowles-Barley, 2011.8.24)
adult mushroom body
(Knowles-Barley, 2011.8.24)
adult gnathal ganglion
(Knowles-Barley, 2011.8.24)
Reporter: PBac{754.P.FSVS-0}Tm1CPTI002243
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult gnathal ganglion
(Knowles-Barley, 2011.8.24)
adult brain

Comment: low expression throughout adult brain

(Knowles-Barley, 2011.8.24)
Reporter: TI{TI}Tm1KI.mCherry
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis & adult stage | female
female germline cell
(Cho et al., 2016)
oocyte | posterior
(Cho et al., 2016)
somatic cell of ovariole
(Cho et al., 2016)
polar follicle cell
(Cho et al., 2016)
border follicle cell
(Cho et al., 2016)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Tm1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 63 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 33 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tm1
Transgenic constructs containing regulatory region of Tm1
Aberrations (Deficiencies and Duplications) ( 4 )
Inferred from experimentation ( 4 )
Gene not disrupted in
Df(3R)sbd105
(Spradling et al., 1999)
Gene disrupted in
Df(3R)ea-5022rx1
(Erdelyi et al., 1995)
Df(3R)ea
(Tetzlaff et al., 1996)
Df(3R)sbd26
(Deak et al., 1997)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Mef2.PR
lethal (with Df(3R)sbd26)
lethal | recessive
lethal - all die before end of larval stage | recessive
lethal - all die during embryonic stage | recessive
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority live | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
grandchildless
grandchildless (with Tm1eg1)
grandchildless (with Tm1eg9)
sterile | germline clone | maternal effect
Other Phenotypes
Allele
abnormal behavior | recessive
abnormal neuroanatomy
abnormal neuroanatomy (with Tm102299)
abnormal neuroanatomy (with Tm1el4)
abnormal neuroanatomy (with Tm1S130510)
abnormal neuroanatomy | third instar larval stage
abnormal oxidative stress response
some die during embryonic stage | recessive
some die during larval stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
border follicle cell
border follicle cell, with Scer\GAL4slbo.2.6
border follicle cell | somatic clone
chromosome | embryonic stage
dendritic arborising neuron & dendrite
dendritic arborising neuron & dendrite (with Tm1el4)
dendritic arborising neuron & dendrite (with Tm1S130510)
dorsal multidendritic neuron ddaC & dendrite | somatic clone
dorsal multidendritic neuron ddaE & dendrite
dorsal multidendritic neuron ddaE & dendrite (with Tm102299)
dorsal multidendritic neuron ddaE & dendrite (with Tm1el4)
dorsal multidendritic neuron ddaE & dendrite (with Tm1S130510)
egg | clone of cells
egg | clone of cells, with Scer\GAL4unspecified
egg | clone of cells, with Scer\GAL4unspecified, Tm1RNAi.UAS.A
egg | clone of cells, with Scer\GAL4unspecified, Tm1RNAi.UAS.L
egg chamber
egg chamber, with Scer\GAL4GR1
egg chamber, with Scer\GAL4VP16.mat.αTub67C
elongation stage spermatid, with Scer\GAL4ptc-559.1
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval pharynx | embryonic stage
follicle cell, with Scer\GAL4unspecified
follicle cell, with Scer\GAL4unspecified, Tm1RNAi.UAS.A
follicle cell, with Scer\GAL4unspecified, Tm1RNAi.UAS.L
follicle cell | somatic clone
germline cell
germline cell | maternal effect
mesonotum, with Scer\GAL4pnr-MD237
nucleus | embryonic stage 4
nurse cell, with Scer\GAL4GR1
oocyte
oocyte, with Scer\GAL4unspecified
oocyte, with Scer\GAL4unspecified, Tm1RNAi.UAS.A
oocyte, with Scer\GAL4unspecified, Tm1RNAi.UAS.L
oocyte (with Tm1eg1)
oocyte (with Tm1eg9)
oocyte | somatic clone
primordial germ cell
stress fiber, with Scer\GAL4unspecified
stress fiber, with Scer\GAL4unspecified, Tm1RNAi.UAS.A
stress fiber, with Scer\GAL4unspecified, Tm1RNAi.UAS.L
stress fiber | adult stage | female | somatic clone
type Ib terminal bouton | third instar larval stage
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (20)
Hsap\TPM1
13 of 14
Yes
Yes
1  
Hsap\TPM2
12 of 14
No
Yes
10  
Hsap\TPM3
12 of 14
No
Yes
1  
Hsap\TPM4
11 of 14
No
Yes
2  
Hsap\CDC42BPG
1 of 14
No
No
Hsap\CTTNBP2
1 of 14
No
No
Hsap\CUX1
1 of 14
No
No
1  
Hsap\EPS15L1
1 of 14
No
No
1  
Hsap\GOLIM4
1 of 14
No
Yes
Hsap\LAMA1
1 of 14
No
No
Hsap\LAMA2
1 of 14
No
No
1  
Hsap\LAMB1
1 of 14
No
No
9  
Hsap\LAMB2
1 of 14
No
No
Hsap\LAMB3
1 of 14
No
No
Hsap\LAMB4
1 of 14
No
No
Hsap\LAMC1
1 of 14
No
No
Hsap\LAMC3
1 of 14
No
No
Hsap\PLEKHH1
1 of 14
No
No
Hsap\TSC1
1 of 14
No
No
Hsap\TSPOAP1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (14)
Rnor\Tpm1
12 of 14
Yes
Yes
Rnor\Tpm2
12 of 14
Yes
Yes
Rnor\Tpm4
10 of 14
No
Yes
Rnor\Tpm3
9 of 14
No
No
Rnor\Cux1
1 of 14
No
No
Rnor\Golim4
1 of 14
No
Yes
Rnor\Lama1
1 of 14
No
No
Rnor\Lama2
1 of 14
No
No
Rnor\Lama4
1 of 14
No
No
Rnor\Lamb1
1 of 14
No
No
Rnor\Lamb2
1 of 14
No
No
Rnor\Lamc1
1 of 14
No
No
Rnor\Plekhh1
1 of 14
No
No
Rnor\Tspoap1
1 of 14
No
No
Mus musculus (laboratory mouse) (15)
Mmus\Tpm1
12 of 14
Yes
Yes
Mmus\Tpm2
12 of 14
Yes
Yes
Mmus\Tpm3
11 of 14
No
Yes
Mmus\Tpm4
10 of 14
No
Yes
Mmus\Tpm3-rs7
8 of 14
No
Yes
Mmus\Cux1
1 of 14
No
No
Mmus\Golim4
1 of 14
No
Yes
Mmus\Krt78
1 of 14
No
Yes
Mmus\Lama1
1 of 14
No
No
Mmus\Lama2
1 of 14
No
No
Mmus\Lamb1
1 of 14
No
No
Mmus\Lamb2
1 of 14
No
No
Mmus\Lamc1
1 of 14
No
No
Mmus\Plekhh1
1 of 14
No
No
Mmus\Tspoap1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\tpm4
8 of 13
Yes
Yes
Xtro\MGC76092
6 of 13
No
No
Xtro\tpm2
6 of 13
No
Yes
Xtro\tpm1
5 of 13
No
Yes
Xtro\ank3
1 of 13
No
No
Xtro\eps15l1
1 of 13
No
No
Xtro\golim4
1 of 13
No
Yes
Xtro\lamb2
1 of 13
No
No
Xtro\lamb3
1 of 13
No
No
Xtro\lamc1
1 of 13
No
No
Xtro\ndnf
1 of 13
No
No
Xtro\XB5969698
1 of 13
No
No
Danio rerio (Zebrafish) (13)
Drer\tpm1
12 of 14
Yes
Yes
Drer\tpm2
11 of 14
No
Yes
Drer\tpm3
11 of 14
No
Yes
Drer\tpm4a
11 of 14
No
Yes
Drer\tpma
11 of 14
No
Yes
Drer\tpm4b
9 of 14
No
Yes
Drer\ikbip
1 of 14
No
Yes
Drer\lama5
1 of 14
No
No
Drer\lamb1a
1 of 14
No
No
Drer\lamb2
1 of 14
No
No
Drer\lamb2l
1 of 14
No
No
Drer\lamb4
1 of 14
No
No
Drer\lamc1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\lev-11
12 of 14
Yes
Yes
Cele\epi-1
1 of 14
No
No
Cele\lam-2
1 of 14
No
No
Cele\lam-3
1 of 14
No
No
Cele\myo-3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (6)
Agam\AgaP_AGAP001797
5 of 12
Yes
Yes
Agam\AgaP_AGAP001799
4 of 12
No
No
Agam\AgaP_AGAP001381
1 of 12
No
No
Agam\AgaP_AGAP001633
1 of 12
No
No
Agam\AgaP_AGAP009189
1 of 12
No
No
Agam\LANB2
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\TPM1
2 of 13
Yes
Yes
Scer\EDE1
1 of 13
No
No
Scer\NNF2
1 of 13
No
Yes
Scer\TPM2
1 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\cdc8
2 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Tm1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
Tm2
10 of 13
Eps-15
1 of 13
LanA
1 of 13
LanB1
1 of 13
LanB2
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 6 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TPM1; tropomyosin 1
    13 of 14
    TROPOMYOSIN 1; TPM1
     
    TPM2; tropomyosin 2
    12 of 14
    TROPOMYOSIN 2; TPM2
     
    TPM3; tropomyosin 3
    12 of 14
    191030
     
    TPM4; tropomyosin 4
    11 of 14
    600317
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Tm1
      x-ray crystallography, isothermal titration calorimetry, predetermined participant, comigration in sds page, western blot, transmission electron microscopy
      (Dimitrova-Paternoga et al., 2021, Cho et al., 2016, Mateos et al., 2006)
      Tm1 - CG10681
      two hybrid
      (Hu et al., 2017.6.13)
      Tm1 - CG13476
      two hybrid
      (Hu et al., 2017.6.13)
      Tm1 - CG30349
      two hybrid
      (Hu et al., 2017.6.13)
      Tm1 - CG46281
      two hybrid
      (Hu et al., 2017.6.13)
      Tm1 - CG5376
      two hybrid
      (Hu et al., 2017.6.13)
      Tm1 - CG6654
      two hybrid
      (Hu et al., 2017.6.13)
      Tm1 - CG9040
      two hybrid
      (Hu et al., 2017.6.13)
      Tm1 - CtsL3
      experimental knowledge based
      (Guruharsha et al., 2011)
      Tm1 - Dlip1
      two hybrid
      (Hu et al., 2017.6.13)
      Tm1 - Fibp
      experimental knowledge based
      (Guruharsha et al., 2011)
      Tm1 - GstS1
      comigration in sds page, western blot, inferred by author, cosedimentation
      (Mateos et al., 2006, Clayton et al., 1998)
      Tm1 - Khc
      anti tag coimmunoprecipitation, Identification by mass spectrometry, surface plasmon resonance, predetermined participant, x-ray crystallography, anti tag western blot, western blot, molecular sieving, molecular weight estimation by staining, pull down, two hybrid
      (Dimitrova-Paternoga et al., 2021, Lu et al., 2018, Gáspár et al., 2017, Veeranan-Karmegam et al., 2016)
      Tm1 - Mlc-c
      experimental knowledge based
      (Guruharsha et al., 2011)
      Tm1 - Pnn
      two hybrid
      (Hu et al., 2017.6.13)
      Tm1 - Swip-1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Tm1 - Tm2
      comigration in sds page, western blot
      (Mateos et al., 2006)
      Tm1 - dgrn
      two hybrid
      (Hu et al., 2017.6.13)
      Tm1 - gdrd
      two hybrid
      (Hu et al., 2017.6.13)
      Tm1 - osk
      nucleic acid uv cross-linking assay, anti tag coimmunoprecipitation, quantitative reverse transcription pcr, Identification by mass spectrometry
      (Gáspár et al., 2017, Hurd et al., 2016)
      Tm1 - p53
      pull down, autoradiography
      (Lunardi et al., 2010)
      Tm1 - speck
      experimental knowledge based
      (Guruharsha et al., 2011)
      Tm1 - stau
      anti tag coimmunoprecipitation, western blot
      (Gáspár et al., 2017)
      Tm1 - yuri
      anti bait coimmunoprecipitation, western blot
      (Texada et al., 2011)
      Tm1 - zip
      experimental knowledge based
      (Guruharsha et al., 2011)
      RNA-protein
      Physical Interaction
      Assay
      References
      Tm1 - osk
      nucleic acid uv cross-linking assay, anti tag coimmunoprecipitation, quantitative reverse transcription pcr, Identification by mass spectrometry
      (Gáspár et al., 2017, Hurd et al., 2016)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Tm1|osk
      enhanceable
      E(To)1
      (Jankovics et al., 2001)
      Tm1
      enhanceable
      E(To)1
      (Jankovics et al., 2001)
      Tm1|osk
      enhanceable
      E(To)4
      (Jankovics et al., 2001)
      Tm1
      enhanceable
      E(To)4
      (Jankovics et al., 2001)
      Tm1|osk
      enhanceable
      E(To)5
      (Jankovics et al., 2001)
      Tm1|osk
      enhanceable
      E(To)6
      (Jankovics et al., 2001)
      Tm1
      enhanceable
      E(To)6
      (Jankovics et al., 2001)
      Tm1|osk
      enhanceable
      E(To)8
      (Jankovics et al., 2001)
      Tm1|osk
      enhanceable
      E(To)9
      (Jankovics et al., 2001)
      Tm1|osk
      enhanceable
      E(To)10
      (Jankovics et al., 2001)
      Tm1
      enhanceable
      E(To)10
      (Jankovics et al., 2001)
      Tm1|osk
      enhanceable
      E(To)12
      (Jankovics et al., 2001)
      Tm1
      suppressible
      E(To)12
      (Jankovics et al., 2001)
      Tm1|osk
      enhanceable
      E(To)13
      (Jankovics et al., 2001)
      Tm1
      suppressible
      E(To)13
      (Jankovics et al., 2001)
      Tm1
      suppressible
      Khc
      (Gáspár et al., 2017)
      Tm1|osk
      enhanceable
      mago
      (Jankovics et al., 2001)
      Tm1
      enhanceable
      osk
      (Jankovics et al., 2001)
      Tm1
      enhanceable
      osk|E(To)12
      (Jankovics et al., 2001)
      Tm1
      suppressible
      psidin
      (Kim et al., 2011)
      Tm1
      enhanceable
      Rab11
      (Jankovics et al., 2001)
      Tm1|osk
      enhanceable
      Rab11
      (Jankovics et al., 2001)
      Tm1
      enhanceable
      stan
      (Li and Gao, 2003)
      Tm1
      enhanceable
      vas
      (Jankovics et al., 2001)
      Tm1|osk
      enhanceable
      vas
      (Jankovics et al., 2001)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      br
      enhanceable
      Tm1
      (Ward et al., 2003)
      flw
      suppressible
      Tm1
      (Vereshchagina et al., 2004)
      MYPT-75D
      suppressible
      Tm1
      (Vereshchagina et al., 2004)
      MYPT-75D
      enhanceable
      Tm1
      (Vereshchagina et al., 2004)
      psidin
      suppressible
      Tm1
      (Stephan et al., 2012, Kim et al., 2011)
      Shrm
      suppressible
      Tm1
      (Hildebrand et al., 2021)
      External Data
      Subunit Structure (UniProtKB)
      Homodimer (Probable). May interact with Unc-89 (via protein kinase domain 2) (PubMed:26251439).
      (UniProt, P06754 )
      Homodimer.
      (UniProt, P49455 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-56
      Cytogenetic map
      88E11-88E13
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      88E11-88E13
      ; Limits computationally determined from genome sequence between P{lacW}MRG15j6A3 and P{PZ}l(3)0653606536
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      88E9-88E12
      (determined by in situ hybridisation)
      (Ranz et al., 2001)
      88F1-88F2
      (determined by in situ hybridisation)
      (Spradling et al., 1999)
      88F1-88F2
      (BDGP Project Members, 1994-1999)
      88F2-88F5
      (determined by in situ hybridisation)
      (Bautch et al., 1982)
      Experimentally Determined Recombination Data
      Location

      3-56

      (FlyBase, 2016)

      3-56.1

      (Comeron et al., 2012)

      3-56.75 +/- 0.92

      (Cripps and Sparrow, 1992)
      Left of (cM)
      Right of (cM)
      Notes

      Closely linked to Tm2.

      Stocks and Reagents
      Stocks (36)
      Genomic Clones (28)
      cDNA Clones (412)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Cho et al., 2016)
      Commercially Available Antibodies
       
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          The 'heavy tropomyosins', TmH-33 and TmH-34, are encoded by the Tm1 gene, using exons 16 and 15, respectively. They are specifically expressed in the indirect flight muscles.

          (Mateos et al., 2006)

          ChEST reveals this is a target of Mef2.

          (Junion et al., 2005)

          dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

          (Rogers et al., 2003)

          Area matching Drosophila EST AI109898.

          (Davies, 2001.3.15)

          GstS1 interacts with the TnH-34 isoform of troponin-H in asynchronous indirect flight muscle.

          (Clayton et al., 1998)

          Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

          (Harvie et al., 1998)

          Tm1 is required for specific cell movements during head morphogenesis and for accumulating high levels of osk mRNA at the posterior pole necessary for germ cell formation but not for abdominal development.

          (Tetzlaff et al., 1996)

          Tm1 regulatory regions have high affinity binding sites for Cf2, gel mobility shift assays reveal that Cf2 recognises a target site in the Tm1 enhancer region located in the first intron.

          (Bagni and Kafatos, 1995)

          Mutations in Tm1 virtually abolish osk RNA localisation to the posterior pole suggesting an involvement of the actin network in osk RNA localisation.

          (Erdelyi et al., 1995)

          Tm1 cis-acting sequences contain a 90bp muscle activator site (MA), the region is sufficient to direct low level transcriptional regulation of an Hsp70/Ecol\lacZ reporter gene in all somatic and visceral muscles of the embryo and adult.

          (Lin and Storti, 1995)

          Gel mobility shift assays have revealed a Mef2 binding site in Tm1 gene proximal enhancer.

          (Lin et al., 1995)

          Tm1 mRNA synthesis and accumulation in the developing ovary and embryo has been studied. lac reporter gene constructs demonstrate 1.2kb of 5' sequence upstream of the Tm1 transcription start site is required to drive expression of both the maternal and zygotic transcripts in the nurse cells and embryo but not in the follicle cells of the ovariole.

          (Hales et al., 1994)

          The distribution of muscle enhancer elements and their control is similar to those regulating the expression of Tm1.

          (Gremke et al., 1993)

          Tm1 transcription is controlled by multiple muscle type-specific cis-acting control elements and upstream and downstream promoter control elements.

          (Meredith and Storti, 1993)

          Three variants of Tm1 have been determined, this variation does not affect flight ability.

          (Cripps and Sparrow, 1992)

          Three variants of Tm1 have been determined by their mobility on 1-D and 2-D SDS-PAGE.

          (Cripps and Sparrow, 1992)

          Tm1 acts as a regulator of motility in muscle and nonmuscle cells.

          (Lindsley and Zimm, 1992)

          Structural gene for tropomyosin, a 34,000-dalton protein. At least five tropomyosin isoforms are encoded by Tm1, some in embryos (during myogenesis) and myogenic cell culture and others in the myofibrils of adult indirect flight muscles and leg muscles.

          (Lindsley and Zimm, 1992)

          Tm1, muscle promoter of Tm2, Act57B and Mlc2 were not transcribed by embryonic extracts. The contractile protein genes may possess a common feature related to in vitro transcription that prevents their transcription.

          (Lichter and Storti, 1991)

          Tm1 has been cloned and sequenced.

          (Hanke and Storti, 1988)

          Tm1 has been sequenced, and its expression pattern analysed.

          (Basi et al., 1984)

          Defined during molecular analysis of the 88F region.

          (Karlik et al., 1984)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: Tm1 l(3)S130510

          (Li and Gao, 2003)

          Source for merge of: Tm1 BcDNA:SD21996

          (FlyBase, 1996-)

          Source for merge of: Tm1 BcDNA:LD37158

          (FlyBase, 1996-)

          Source for merge of: Tm1 BcDNA:GH09289

          (FlyBase, 1996-)
          Additional comments

          Relationship between "l(3)88EFi" and "Tm1" is unclear; a temperature-sensitive "l(3)88EFi" allele partially complements Tm102299 at 29oC.

          (Zraly et al., 2002)

          Source for merge of Tm1 BcDNA:SD21996 was a shared cDNA ( date:030728 ).

          (FlyBase, 1996-)

          Source for merge of Tm1 BcDNA:LD37158 was a shared cDNA ( date:020730 ).

          (FlyBase, 1996-)

          Source for merge of Tm1 BcDNA:GH09289 was a shared cDNA ( date:030728 ).

          (FlyBase, 1996-)
          Nomenclature History
          Source for database identify of

          Source for identity of: Tm1 CG4898

          (Zheng, 1999.11)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (54)
          Reported As
          Symbol Synonym
          1305/10
          (Deak et al., 1997)
          2299
          (Harvie et al., 1998)
          BcDNA:GH09289
          BcDNA:LD37158
          BcDNA:SD21996
          CG4898
          (Kolkhof et al., 2017, Neuert et al., 2017, Çiçek et al., 2016, Hurd et al., 2016, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Jensen et al., 2013, Jaspers et al., 2012, Cammarato et al., 2011, Lunardi et al., 2010, Ni et al., 2010.12.1, Perkins et al., 2009, Quinones-Coello, 2007, Quinones-Coello, 2007, Rogers et al., 2003, Goldstein and Gunawardena, 2000)
          Dm Tm1
          (Herranz et al., 2005)
          Dm TmH33
          (Mateos et al., 2006)
          Dm TmH34
          (Mateos et al., 2006)
          DmTm1
          (Mateos et al., 2006)
          PmI
          TM
          (Trujillo et al., 2016, Bai et al., 2009)
          TM1
          (Sysoev et al., 2020, Schaub et al., 2012, Prokupek et al., 2009)
          TMII
          (Bonin and Mann, 2004, Li and Gao, 2003, Mateos et al., 2002, Janzer and Steinmann-Zwicky, 2001)
          Tm
          (Bawa et al., 2020, Dequéant et al., 2015, Lindquist et al., 2011, Nongthomba et al., 2004, Clayton et al., 1998)
          Tm1
          (Bandyadka et al., 2025, Bischoff et al., 2025, Gaber et al., 2025, Rommelaere et al., 2025, Santos-Cruz et al., 2025, Xiao et al., 2025, Aziz et al., 2024, Beghelli et al., 2024, Isaacson et al., 2024, Peng and Wang, 2024, Trujillo et al., 2024, Gáspár et al., 2023, Pollington et al., 2023, Titlow et al., 2023, Cabrita et al., 2022, Cassella and Ephrussi, 2022, Jia et al., 2022, Rounds et al., 2022, Anqueira-González et al., 2021, Bordet et al., 2021, Bouska and Bai, 2021, DeAngelis et al., 2021, Dimitrova-Paternoga et al., 2021, Kao et al., 2021, Lindsey et al., 2021, Pang et al., 2021, Uçkun et al., 2021, Aboukilila et al., 2020, López-Gay et al., 2020, Poovathumkadavil and Jagla, 2020, Vásquez-Procopio et al., 2020, Walls et al., 2020, Kockel et al., 2019, Lu et al., 2018, Abruzzi et al., 2017, Bonneaud et al., 2017, Gáspár et al., 2017, Gonsalvez, 2017.2.21, Hu et al., 2017.6.13, Neuert et al., 2017, Cho et al., 2016, Clandinin and Owens, 2016-, Aradska et al., 2015, Goins and Mullins, 2015, Hsiao et al., 2015, Liu and Lasko, 2015, Williams et al., 2015, Ashwal-Fluss et al., 2014, Molnár et al., 2014, Spletter and Schnorrer, 2014, Kwon et al., 2013, Terriente-Felix et al., 2013, Cash and Andrews, 2012, Kaushik et al., 2012, Friedman et al., 2011, Kim et al., 2011, Rees et al., 2011, Texada et al., 2011, Knowles-Barley et al., 2010, Zhao et al., 2010, Sahota et al., 2009, Sharma and Singh, 2009, García-Zaragoza et al., 2008, Hudson et al., 2008, Adryan et al., 2007, Buszczak et al., 2007, Dietzl et al., 2007, Gabut et al., 2007, Lecuyer et al., 2007, Potthoff and Olson, 2007, Quinones-Coello, 2007, Quinones-Coello, 2007, Bandyopadhyay et al., 2006, Mateos et al., 2006, Montana and Littleton, 2006, Stark et al., 2005)
          TmH
          (Sevdali et al., 2013)
          TmH-33
          (Vikhorev et al., 2010, Mateos et al., 2006)
          TmH-34
          (Vikhorev et al., 2010, Mateos et al., 2006)
          TmH33
          (Mateos et al., 2006)
          TmH34
          (Mateos et al., 2006)
          TmII
          (Hurd et al., 2016, Gardiol and St Johnston, 2014, Wong et al., 2011, Zimyanin et al., 2008, Sandmann et al., 2006, Szuperak et al., 2005, Herranz et al., 2004, Palacios and St. Johnston, 2002, Jankovics et al., 2001, Johnstone and Lasko, 2001, Hazelrigg, 1998, Cooperstock and Lipshitz, 1997, Robinson and Cooley, 1997, Ephrussi, 1996, Grunert and St. Johnston, 1996, Kreuz et al., 1996, Kreuz et al., 1996, Erdelyi et al., 1995, Markussen et al., 1995, Gremke et al., 1993, Hanke, 1993.12.1, Meredith and Storti, 1993, Cripps and Sparrow, 1992, Hanke and Storti, 1988)
          Tmr33
          (Karlik et al., 1984)
          Tmr34
          (Karlik et al., 1984)
          TnH
          (Haigh et al., 2010, Vigoreaux, 2001, Razzaq et al., 1999, Clayton et al., 1998)
          TnH-33
          (Clayton et al., 1998)
          TnH-34
          (Clayton et al., 1998, Cripps and Sparrow, 1992)
          cTM
          (Gavis, 1997)
          cTm
          (Iwasa and Mullins, 2007, Ward et al., 2003, Strigini and Cohen, 2000, Halsell and Kiehart, 1998, Hales et al., 1994, Basi et al., 1984)
          cTmII
          (Bassell and Singer, 1997, Nasmyth and Jansen, 1997, Tetzlaff et al., 1996)
          chr3R:11122272..11122408
          (Will et al., 2013)
          l(3)02299
          l(3)S130510
          (Szeged Stock Center, 1998-)
          l(3)s2958
          mTmII
          (Boardman et al., 1985, Basi et al., 1984, Bautch and Storti, 1983)
          region 3
          (Bautch and Storti, 1983)
          tm1
          (Goldman and Gonsalvez, 2017, Stephan et al., 2012, Papatsenko et al., 2006)
          tmII
          (Tekotte and Davis, 2002)
          tropomyosin
          (Clayton et al., 1998)
          Name Synonyms
          Tropomyosin
          (Johnson, 2024, Bawa et al., 2020, Manhart et al., 2020, Ryuda et al., 2018, Ocorr et al., 2014, Sevdali et al., 2013, Schaub et al., 2012, Ismat et al., 2010, Garcia-Zaragoza et al., 2004, Mas et al., 2004, Ward et al., 2003, Taylor, 1998)
          Tropomyosin 1
          (Warecki et al., 2025, Wójtowicz et al., 2015, Spletter and Schnorrer, 2014, Johnson et al., 2013, Jaspers et al., 2012, Rudolf et al., 2012, Cammarato et al., 2011, Texada et al., 2011, Zhao and Haddad, 2011, Pedersen et al., 2010, Zhao et al., 2010, Lebo et al., 2009, García-Zaragoza et al., 2008, Hudson et al., 2008, Gabut et al., 2007, Kaplow et al., 2007, Potthoff and Olson, 2007, Mack et al., 2006, Rogers et al., 2003)
          Tropomyosin I
          (Cash and Andrews, 2012, D'Avino et al., 2008, Sandmann et al., 2006)
          Tropomyosin II
          (Texada et al., 2011, Zimyanin et al., 2008, Grueber and Jan, 2004, Sweeney et al., 1999)
          Tropomyosin-1
          (Katzemich et al., 2015, Fyrberg et al., 1988)
          Tropomyosin1
          (Goldman and Gonsalvez, 2017)
          Troponin H
          (Jacinto and Baum, 2003)
          cytoplasmic tropomyosin
          (Strigini and Cohen, 2000)
          cytoskeletal Tropomyosin
          (Ward et al., 2002)
          tropomyosin
          (Dequéant et al., 2015, Vikhorev et al., 2010, Bai et al., 2009, Texada et al., 2007, Nguyen and Frasch, 2006, Clyne et al., 2003, Mardahl-Dumesnil and Fowler, 2001, Paululat et al., 1999, van Straaten et al., 1999, Halsell and Kiehart, 1998, Fyrberg et al., 1991)
          tropomyosin II
          (Sen and Cox, 2016, Irion et al., 2006, Cervera et al., 2005, Fischer, 2000, Vieira et al., 2000, Saffman and Lasko, 1999, Williamson and Lehmann, 1996, Hanke, 1993.12.1)
          tropomyosinII
          (Morin et al., 2001)
          tropomysin II
          (Extavour and Akam, 2003, Rogers et al., 2003, Wylie, 1999)
          troponin H
          (Haigh et al., 2010)
          troponin-H
          (Clayton et al., 1998)
          troponin-H isoform 34
          (Clayton et al., 1998)
          Secondary FlyBase IDs
          • FBgn0010776
          • FBgn0011036
          • FBgn0015832
          • FBgn0015833
          • FBgn0046771
          • FBgn0046800
          • FBgn0060408
          • FBgn0064771
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 157 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          PDB - An information portal to biological macromolecular structures
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (318)