FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tm1RNAi.UAS.A
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General Information
Symbol
Dmel\Tm1RNAi.UAS.A
Species
D. melanogaster
Name
FlyBase ID
FBal0325755
Feature type
allele
Associated gene
Dmel\Tm1
Associated Insertion(s)
Carried in Construct
P{UAS-Tm1.A.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Cho et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Cho et al., 2016)
Mutagen
in vitro construct
(Cho et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-Tm1.A.RNAi}
Cytology
Description

UAS regulatory sequences (from pVALIUM20) drive expression of a short hairpin repeat (sequence AAGAAGATGCGCCAGACCAAA) that targets the Tm1 A isoform.

(Cho et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Tm1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Tm1dsRNA.UAS.A - either alone or in combination with Tm1dsRNA.UAS.L - under the control of Scer\GAL4slbo.2.6 does not lead to significant border follicle cell migration defects in oocytes relative to controls nor does it affect formation of basal stress fibers in the follicle cells as detected by phalloidin staining. However, when Tm1dsRNA.UAS.L and Tm1dsRNA.UAS.A are expressed simultaneously (driven by Scer\GAL4unspecified) the stress fibre formation is decreased.

      Eggs from females expressing both Tm1dsRNA.UAS.A and Tm1dsRNA.UAS.L in random heat-shock clones under the control of Scer\GAL4unspecified are often round (not elongated as in wild-type).

      (Cho et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Tm1RNAi.UAS.A
      Tm1dsRNA.Scer\UAS.A
      Tm1dsRNA.UAS.A
      Name Synonyms
      Secondary FlyBase IDs
        References (2)