TmI, Ifm(3)3, Tropomyosin, Tm, tropomyosin I
Gene model reviewed during 5.49
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.55
1.9, 1.7, 1.6, 1.3 (northern blot)
The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tm2 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Tm2 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Tm2 CG4843
Haploinsufficient locus (not associated with strong haplolethality or haplosterility).
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Mutation analysis and protein binding studies of the muscle activator (MA) region identifies cis-acting elements and protein binding sites that may regulate MA function.
Tm2 is a target gene for Mef2 regulation, proximal and distal muscle enhancers within the first intron of Tm2 contain a Mef2 binding site. Mef2 is a positive regulator of Tm2 gene transcription that is necessary but not sufficient for high level expression in somatic muscle of the embryo, larva and adult.
Regulation of Tm1 expression during myogenesis is under the control of at least two muscle enhancer regions within the Tm1 first intron. The distribution of muscle enhancer elements and their control is similar to those regulating the expression of Tm2.
Comparative studies with other insects, and with synchronous and asynchronous flight muscles, suggest that troponin-H is not sufficient for stretch activation of flight muscles but it may enhance stretch activation.
Two forms of troponin-H are present in aynchronous flight muscle.
The flightless phenotype can be rescued by P-element mediated transformation with two copies of the wild-type allele of Tm2.
Troponin-H is a fusion protein of tropomyosin and a highly proline-rich sequence. In direction of increasing cytology: Tm1+ Tm2+ Act88F+