FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tm25
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General Information
Symbol
Dmel\Tm25
Species
D. melanogaster
Name
FlyBase ID
FBal0016896
Feature type
allele
Associated gene
Dmel\Tm2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Insertion of 8.8kb DNA element into the transcribed region of Tm2.

(Karlik and Fyrberg, 1985)

8-kb copia-like insertion

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flightless mutant, having structurally and functionally abnormal flight muscles.

      (Karlik and Fyrberg, 1985)

      identical to Tm23 dominant flight-defective Heterozygotes frequently hold wings up. Homozygotes lack myofibrils and display characteristic departures from wild-type protein patterns in two-dimensional gels (Mogami and Hotta, 1981).

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The insertion is the same size and location as that in Tm23, however the flight muscle defects associated with Tm25 are more severe, probably due to one or more additional mutations in the Tm25 genome.

      (Karlik and Fyrberg, 1985)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ifm(3)5
      (Karlik and Fyrberg, 1985)
      Tm25
      Name Synonyms
      Indirect flight muscle
      Secondary FlyBase IDs
        References (3)