FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Hsap\CUX1
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General Information
Symbol
Hsap\CUX1
Species
H. sapiens
Name
cut-like homeobox 1
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0017601
Gene Model Status
Not Applicable
Stock Availability
None publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

CDP

Key Links
Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == CUX1; HGNC:2557.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hsap\CUX1
Transgenic constructs containing regulatory region of Hsap\CUX1
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (19)
ct
10 of 14
Yes
Yes
 
0  
onecut
2 of 14
No
No
0  
btn
1 of 14
No
No
0  
CG4328
1 of 14
No
No
0  
CG11294
1 of 14
No
No
0  
CG18599
1 of 14
No
No
0  
CG32532
1 of 14
No
No
0  
CG34031
1 of 14
No
No
0  
gsb
1 of 14
No
No
0  
gsb-n
1 of 14
No
No
0  
Gsc
1 of 14
No
No
0  
lbl
1 of 14
No
No
0  
PHDP
1 of 14
No
No
0  
Pph13
1 of 14
No
No
0  
ro
1 of 14
No
No
0  
so
1 of 14
No
No
0  
Tm1
1 of 14
No
No
0  
Tm2
1 of 14
No
No
0  
toy
1 of 14
No
No
0  
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
ct
Hsap\CUX1
(Ludlow et al., 1996)
Interactions
Summary of Physical Interactions
Interaction Browsers
Summary of Genetic Interactions
Interaction Browsers
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
Class of Gene
Stocks and Reagents
Stocks (0)
Other Comments

Ectopic expression of ct, Hsap\CUTL1, and Mmus\Cutl1 similarly affects embryonic sensory organ development and can rescue a wing scalloping mutant phenotype associated with loss of ct expression along the prospective wing margin. These results suggest the function of ct is evolutionarily conserved.

(Ludlow et al., 1996)
Relationship to Other Genes
Source for database merge of
Additional comments

FlyBase curator comment: Symbol and name changed to reflect current HGNC symbol and name (19th Nov. 2012).

(FlyBase Curators, 1992-)
Nomenclature History
Source for database identify of
Nomenclature comments
Etymology
Synonyms and Secondary IDs (23)
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
Study result (0)
Result
Result Type
Title
External Crossreferences and Linkouts ( 6 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
Other crossreferences
Ensembl_Homo_sapiens -
HUGO Gene Nomenclature Committee -
MARRVEL - MARRVEL (human gene)
OMIM_GENE - Online Mendelian Inheritance in Man (Genes)
OMIM_PHENOTYPE - Online Mendelian Inheritance in Man (Phenotypes)
References (7)