FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\toy
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General Information
Symbol
Dmel\toy
Species
D. melanogaster
Name
twin of eyeless
Annotation Symbol
CG11186
Feature Type
protein_coding_gene
FlyBase ID
FBgn0019650
Gene Model Status
Current
Stock Availability
46 publicly available
Gene Summary
twin of eyeless (toy) encodes a transcription factor that is involved in eye development as part of the retinal determination gene network, and contributes to formation of the central nervous system. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(4)8, l(4)102CDg

Key Links
Genomic Location
Cytogenetic map
102F4-102F5
Sequence location
Recombination map
4-0
RefSeq locus
NC_004353 REGION:989725..1007922
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from direct assay
(Blanco et al., 2005)
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from mutant phenotype
(Weasner et al., 2009)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA binding
(InterPro Project Members, 2004-)
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN002552508
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR017970
(InterPro Project Members, 2004-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN002552508
(GO Reference Genome Project, 2011-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in brain morphogenesis
inferred from mutant phenotype
(Furukubo-Tokunaga et al., 2009)
involved_in eye-antennal disc development
inferred from mutant phenotype
(Kronhamn et al., 2002)
involved_in mushroom body development
inferred from mutant phenotype
(Furukubo-Tokunaga et al., 2009)
involved_in ocellus development
inferred from mutant phenotype
(Blanco et al., 2010)
inferred from genetic interaction with FLYBASE:oc; FB:FBgn0004102
(Blanco et al., 2010)
involved_in positive regulation of gene expression
inferred from mutant phenotype
(Blanco et al., 2010)
involved_in positive regulation of transcription by RNA polymerase II
inferred from direct assay
(Blanco et al., 2005)
involved_in regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Weasner et al., 2009)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in brain development
inferred from biological aspect of ancestor with PANTHER:PTN008693041
(GO Reference Genome Project, 2011-)
involved_in compound eye development
traceable author statement
(Curtiss et al., 2002)
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR001523, InterPro:IPR017970, InterPro:IPR043565
(InterPro Project Members, 2004-)
inferred from electronic annotation with InterPro:IPR001523, InterPro:IPR043565
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN002552508
(GO Reference Genome Project, 2011-)
involved_in sensory organ development
inferred from biological aspect of ancestor with PANTHER:PTN008693041
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002552508
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
twin of eyeless (toy) encodes a transcription factor that is involved in eye development as part of the retinal determination gene network, and contributes to formation of the central nervous system. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
PAIRED HOMEOBOX TRANSCRIPTION FACTORS -
Paired homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. They have a characteristic paired domain in association with the homeodomain. (Adapted from FBrf0135231 and PMID:1672661).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\toy for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A6H2EG63)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Gene model reviewed during 5.49

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Stop-codon suppression (UGA) postulated; FBrf0243886.

Gene model reviewed during 6.32

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
toy-RA
FBtr0089185
NM_079899
2287
543
toy-RC
FBtr0339509
NM_001272151
3870
526
toy-RD
FBtr0479793
NM_001382011
3921
655
Additional Transcript Data and Comments
Reported size (kB)

3.8, 2.7, 2.4 (northern blot)

(Kronhamn et al., 2002)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
toy-PA
FBpp0088249
59.2
543
8.80
Q9V490
NP_524638
AAF59395
toy-PC
FBpp0308592
57.5
526
8.80
L0MPR7
NP_001259080
AGB96570
toy-PD
FBpp0428126
71.3
655
9.45
QJC18381
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\toy using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.83

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 5
visual anlage
(Czerny et al., 1999)
procephalic neurogenic region
(Czerny et al., 1999)
embryonic stage 6 -- 10
protocerebrum primordium
(Czerny et al., 1999)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
embryonic stage 9 -- 11
protocerebral neuroblast | subset
(Urbach and Technau, 2003)
procephalic neurogenic region & embryonic ocular segment | restricted
(Urbach and Technau, 2003)
deutocerebral neuroblast | subset
(Urbach and Technau, 2003)
procephalic neurogenic region & embryonic antennal segment | restricted
(Urbach and Technau, 2003)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
larval lateral VNC surface glial cell
(Fisher et al., 2012)
embryonic stage 13 -- 16
larval ventral nerve cord | segmentally repeated
(Czerny et al., 1999)
embryonic brain
(Fisher et al., 2012, Czerny et al., 1999)
embryonic central brain
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
embryonic lateral cord
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
embryonic stage 15
embryonic protocerebrum | restricted
(Takaesu et al., 2012)
wandering third instar larval stage
eye disc anterior to the morphogenetic furrow
(Czerny et al., 1999)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Kronhamn et al., 2002)
larval stage -- adult stage
(Kronhamn et al., 2002)
Additional Descriptive Data

toy transcript is detected in the embryonic protocerebrum, in the cells which will form the mushroom bodies.

(Takaesu et al., 2012)

Expression in procephalic neuroblasts stage 9-11: deuterocerebrum - d3, d6, d8; protocerebrum - ad15, av1, cd1-7, cd9, cd11-14, cd17-21, cv6-9, pd1-20, pv2, pv3

(Urbach and Technau, 2003)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
neuroblast NB2-1
(Lacin and Truman, 2016)
neuroblast NB2-4
(Lacin and Truman, 2016)
neuroblast NB3-2
(Lacin and Truman, 2016)
neuroblast NB3-4
(Lacin and Truman, 2016)
neuroblast NB4-4
(Lacin and Truman, 2016)
neuroblast NB5-2
(Lacin and Truman, 2016)
neuroblast NB5-3
(Lacin and Truman, 2016)
neuroblast NB5-6
(Lacin and Truman, 2016)
neuroblast NB6-4
(Lacin and Truman, 2016)
embryonic stage 8
procephalic neurogenic region | posterior
(Jacobsson et al., 2009)
organism | 20-30% egg length
(Skottheim Honn et al., 2016)
embryonic stage 9 -- 10
ventral posterior protocerebral neuroblast
(Jacobsson et al., 2009)
embryonic stage 9 -- 11
procephalic neurogenic region & embryonic antennal segment | restricted
(Urbach and Technau, 2003)
procephalic neurogenic region & embryonic ocular segment | restricted
(Urbach and Technau, 2003)
protocerebral neuroblast | subset
(Urbach and Technau, 2003)
deutocerebral neuroblast | subset
(Urbach and Technau, 2003)
embryonic stage 11 -- 17
embryonic deutocerebrum | restricted
(Kammermeier et al., 2001)
embryonic protocerebrum | restricted
(Kammermeier et al., 2001)
embryonic tritocerebrum | restricted
(Kammermeier et al., 2001)
embryonic stage 12 -- 17
embryonic VNC neuromere | segmentally repeated
(Kammermeier et al., 2001)
embryonic stage 13
Bolwig organ primordium
(Jacobsson et al., 2009)
embryonic optic lobe primordium
(Jacobsson et al., 2009)
embryonic stage 14
larval ventral nerve cord
(Skottheim Honn et al., 2016)
embryonic stage 14 -- 16
larval ventral nerve cord
(Jacobsson et al., 2009)
embryonic stage 15
eye-antennal disc primordium
(Jacobsson et al., 2009)
embryonic primordium of adult eye
(Blanco et al., 2010)
embryonic stage 16
visual primordium
(Skottheim Honn et al., 2016)
embryonic brain
(Skottheim Honn et al., 2016)
larval stage
neuron | subset of medulla anlage
(Li et al., 2013)
neuroblast NB3-4
(Lacin and Truman, 2016)
neuroblast NB4-4
(Lacin and Truman, 2016)
neuroblast NB5-2
(Lacin and Truman, 2016)
neuroblast NB5-3
(Lacin and Truman, 2016)
first instar larval stage
eye-antennal disc
(Wang and Sun, 2012)
second instar larval stage
eye disc | restricted
(Wang and Sun, 2012)
third instar larval stage
larval optic anlage | restricted
(Apitz and Salecker, 2015)
eye disc anterior to the morphogenetic furrow
(Jacobsson et al., 2009)
eye disc posterior to the morphogenetic furrow
(Jacobsson et al., 2009)
presumptive ocellus
(Jacobsson et al., 2009)
eye-antennal disc
(Skottheim Honn et al., 2016)
adult stage
transmedullary neuron Tm5
(Li et al., 2013)
transmedullary Y neuron TmY10
(Li et al., 2013)
transmedullary neuron Tm20
(Li et al., 2013)
Additional Descriptive Data

toy-protein is expressed in distal cells of the larval optic anlage.

(Apitz and Salecker, 2015)

toy and oc colocalize in the embryonic eye primordium.

(Blanco et al., 2010)

Expression in procephalic neuroblasts stage 9-11: deuterocerebrum - d3, d6, d8; protocerebrum - ad15, av1, cd1-7, cd9, cd11-14, cd17-21, cv6-9, pd1-20, pv2, pv3

(Urbach and Technau, 2003)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{toy-lacZ.EEP}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15
embryonic primordium of adult eye
(Blanco et al., 2010)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\toy in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 29 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of toy
Transgenic constructs containing regulatory region of toy
Aberrations (Deficiencies and Duplications) ( 11 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Bx-MS1096
lethal (with Df(4)8-M91)
lethal (with Df(4)8-M318)
lethal (with Df(4)O2)
lethal | cold sensitive, with Scer\GAL4Bx-MS1096
lethal | recessive
lethal - all die before end of larval stage, with Scer\GAL4ey-OK107
lethal - all die before end of P-stage
partially lethal (with Df(4)O2)
partially lethal - majority die
partially lethal - majority die | embryonic stage
partially lethal - majority die | pharate adult stage
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4ey-OK107
abnormal neuroanatomy, with Scer\GAL4ey-OK107, toyhdl
abnormal neuroanatomy, with Scer\GAL4ey-OK107, toyUAS.cCa
increased cell death | embryonic stage
increased cell death | larval stage
some die during larval stage, with Scer\GAL4ey-OK107
some die during larval stage | recessive
some die during pharate adult stage
some die during P-stage | recessive | heat sensitive
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4dpp.PU
visible (with Df(4)O2)
wild-type
Phenotype manifest in
Allele
adult head
adult head capsule (with Df(4)O2)
adult mushroom body
adult mushroom body, with Scer\GAL4ey-OK107
antenna, with Scer\GAL4dpp.blk1
antenna, with Scer\GAL4dpp.PU
embryonic brain
eye | ectopic, with Scer\GAL4ap-md544
eye | ectopic, with Scer\GAL4dpp.blk1
eye | ectopic, with Scer\GAL4dpp.PU
eye | ectopic | heat sensitive, with Scer\GAL4dpp.blk1
eye-antennal disc
eye disc
haltere, with Scer\GAL4ap-md544
head
larval brain
larval brain, with Scer\GAL4ey-OK107
larval brain, with Scer\GAL4ey-OK107, toyhdl
larval brain, with Scer\GAL4ey-OK107, toyUAS.cCa
leg, with Scer\GAL4dpp.blk1
leg, with Scer\GAL4dpp.PU
leg & eye | ectopic, with Scer\GAL4dpp.blk1
ocellar bristle (with Df(4)O2)
ocellus
ocellus (with Df(4)O2)
ocellus | pharate adult stage
symmetrical commissure
symmetrical commissure, with Scer\GAL4ey-OK107, toyhdl
symmetrical commissure, with Scer\GAL4ey-OK107, toyUAS.cCa
vertical lobe of adult mushroom body, with Scer\GAL4ey-OK107
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4dpp.PU
wing & eye | ectopic, with Scer\GAL4dpp.blk1
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (185)
Hsap\PAX6
12 of 14
Yes
Yes
2  
Hsap\PAX4
4 of 14
No
Yes
Hsap\PAX2
3 of 14
No
No
Hsap\PAX5
3 of 14
No
No
Hsap\DUX4
2 of 14
No
Yes
2  
Hsap\MIXL1
2 of 14
No
No
Hsap\PAX3
2 of 14
No
No
1  
Hsap\PAX7
2 of 14
No
No
0  
Hsap\PAX8
2 of 14
No
No
Hsap\ALX1
1 of 14
No
No
Hsap\ALX3
1 of 14
No
No
Hsap\ALX4
1 of 14
No
No
Hsap\ARGFX
1 of 14
No
Yes
Hsap\ARX
1 of 14
No
No
Hsap\BARHL1
1 of 14
No
No
Hsap\BARHL2
1 of 14
No
No
Hsap\BARX1
1 of 14
No
No
Hsap\BARX2
1 of 14
No
No
Hsap\BSX
1 of 14
No
No
Hsap\CDX1
1 of 14
No
No
Hsap\CDX2
1 of 14
No
No
Hsap\CDX4
1 of 14
No
No
Hsap\CPHXL
1 of 14
No
No
Hsap\CRX
1 of 14
No
No
5  
Hsap\CUX1
1 of 14
No
No
1  
Hsap\DBX1
1 of 14
No
No
Hsap\DBX2
1 of 14
No
No
Hsap\DLX1
1 of 14
No
No
Hsap\DLX2
1 of 14
No
No
Hsap\DLX3
1 of 14
No
No
1  
Hsap\DLX4
1 of 14
No
No
1  
Hsap\DLX5
1 of 14
No
No
Hsap\DLX6
1 of 14
No
No
Hsap\DMBX1
1 of 14
No
No
Hsap\DPRX
1 of 14
No
Yes
Hsap\DRGX
1 of 14
No
No
Hsap\DUX1
1 of 14
No
Yes
Hsap\DUX3
1 of 14
No
Yes
Hsap\DUX4L4
1 of 14
No
Yes
Hsap\DUX4L7
1 of 14
No
Yes
Hsap\DUX4L9
1 of 14
No
Yes
Hsap\DUX5
1 of 14
No
Yes
Hsap\DUXA
1 of 14
No
Yes
Hsap\DUXB
1 of 14
No
Yes
Hsap\EMX1
1 of 14
No
No
Hsap\EMX2
1 of 14
No
No
Hsap\EN1
1 of 14
No
No
1  
Hsap\EN2
1 of 14
No
No
Hsap\ESX1
1 of 14
No
No
Hsap\EVX1
1 of 14
No
No
Hsap\EVX2
1 of 14
No
No
Hsap\GBX1
1 of 14
No
No
Hsap\GBX2
1 of 14
No
No
1  
Hsap\GSC2
1 of 14
No
No
Hsap\GSC
1 of 14
No
No
Hsap\GSX1
1 of 14
No
No
Hsap\GSX2
1 of 14
No
No
Hsap\HESX1
1 of 14
No
Yes
Hsap\HHEX
1 of 14
No
No
Hsap\HLX
1 of 14
No
No
Hsap\HMX2
1 of 14
No
No
Hsap\HMX3
1 of 14
No
No
Hsap\HNF1B
1 of 14
No
Yes
Hsap\HOPX
1 of 14
No
Yes
Hsap\HOXA1
1 of 14
No
No
Hsap\HOXA2
1 of 14
No
No
1  
Hsap\HOXA3
1 of 14
No
No
Hsap\HOXA4
1 of 14
No
No
Hsap\HOXA5
1 of 14
No
No
1  
Hsap\HOXA6
1 of 14
No
No
Hsap\HOXA7
1 of 14
No
No
Hsap\HOXA9
1 of 14
No
No
1  
Hsap\HOXA10
1 of 14
No
No
1  
Hsap\HOXA13
1 of 14
No
No
Hsap\HOXB1
1 of 14
No
No
Hsap\HOXB2
1 of 14
No
No
1  
Hsap\HOXB3
1 of 14
No
No
Hsap\HOXB4
1 of 14
No
No
Hsap\HOXB5
1 of 14
No
No
1  
Hsap\HOXB6
1 of 14
No
No
1  
Hsap\HOXB7
1 of 14
No
No
Hsap\HOXB8
1 of 14
No
No
Hsap\HOXB9
1 of 14
No
No
1  
Hsap\HOXB13
1 of 14
No
No
1  
Hsap\HOXC4
1 of 14
No
No
Hsap\HOXC5
1 of 14
No
No
Hsap\HOXC6
1 of 14
No
No
Hsap\HOXC8
1 of 14
No
No
1  
Hsap\HOXC9
1 of 14
No
No
Hsap\HOXC10
1 of 14
No
No
1  
Hsap\HOXC11
1 of 14
No
No
Hsap\HOXC12
1 of 14
No
No
Hsap\HOXC13
1 of 14
No
Yes
Hsap\HOXD1
1 of 14
No
No
Hsap\HOXD3
1 of 14
No
No
Hsap\HOXD4
1 of 14
No
No
2  
Hsap\HOXD8
1 of 14
No
No
Hsap\HOXD9
1 of 14
No
No
Hsap\HOXD10
1 of 14
No
No
1  
Hsap\HOXD11
1 of 14
No
No
Hsap\HOXD13
1 of 14
No
No
Hsap\ISL1
1 of 14
No
No
Hsap\ISL2
1 of 14
No
No
1  
Hsap\ISX
1 of 14
No
No
Hsap\LBX1
1 of 14
No
No
Hsap\LBX2
1 of 14
No
No
2  
Hsap\LEUTX
1 of 14
No
No
Hsap\LHX1
1 of 14
No
No
1  
Hsap\LHX2
1 of 14
No
No
1  
Hsap\LHX3
1 of 14
No
No
Hsap\LHX4
1 of 14
No
No
Hsap\LHX5
1 of 14
No
No
Hsap\LHX6
1 of 14
No
No
1  
Hsap\LHX8
1 of 14
No
No
Hsap\LHX9
1 of 14
No
No
1  
Hsap\LMX1A
1 of 14
No
No
Hsap\LMX1B
1 of 14
No
No
Hsap\LOC112268164
1 of 14
No
Yes
Hsap\MEOX1
1 of 14
No
No
1  
Hsap\MEOX2
1 of 14
No
No
Hsap\MKX
1 of 14
No
No
Hsap\MNX1
1 of 14
No
No
Hsap\MSX1
1 of 14
No
No
Hsap\MSX2
1 of 14
No
No
Hsap\NANOG
1 of 14
No
No
Hsap\NANOGP1
1 of 14
No
Yes
Hsap\NANOGP8
1 of 14
No
No
Hsap\NKX1-2
1 of 14
No
No
Hsap\NKX2-1
1 of 14
No
No
Hsap\NKX2-2
1 of 14
No
No
Hsap\NKX2-3
1 of 14
No
No
Hsap\NKX2-4
1 of 14
No
No
Hsap\NKX2-5
1 of 14
No
No
Hsap\NKX2-6
1 of 14
No
No
Hsap\NKX2-8
1 of 14
No
No
Hsap\NKX3-1
1 of 14
No
No
Hsap\NKX3-2
1 of 14
No
No
Hsap\NKX6-1
1 of 14
No
No
1  
Hsap\NKX6-2
1 of 14
No
No
Hsap\NKX6-3
1 of 14
No
No
Hsap\NOBOX
1 of 14
No
No
Hsap\NOTO
1 of 14
No
No
Hsap\OTP
1 of 14
No
No
Hsap\OTX1
1 of 14
No
No
3  
Hsap\OTX2
1 of 14
No
No
3  
Hsap\PAX1
1 of 14
No
No
Hsap\PAX9
1 of 14
No
No
1  
Hsap\PBX1
1 of 14
No
No
Hsap\PBX2
1 of 14
No
No
Hsap\PBX3
1 of 14
No
No
Hsap\PBX4
1 of 14
No
No
1  
Hsap\PDX1
1 of 14
No
No
Hsap\PHOX2A
1 of 14
No
No
Hsap\PHOX2B
1 of 14
No
No
Hsap\PITX1
1 of 14
No
No
3  
Hsap\PITX2
1 of 14
No
No
1  
Hsap\PITX3
1 of 14
No
No
1  
Hsap\POU3F3
1 of 14
No
No
Hsap\POU3F4
1 of 14
No
No
Hsap\POU5F1
1 of 14
No
No
Hsap\POU6F2
1 of 14
No
No
Hsap\PROP1
1 of 14
No
No
Hsap\PRRX1
1 of 14
No
No
Hsap\PRRX2
1 of 14
No
No
Hsap\RAX2
1 of 14
No
No
Hsap\RAX
1 of 14
No
No
1  
Hsap\RHOXF1
1 of 14
No
No
Hsap\RHOXF2B
1 of 14
No
No
Hsap\RHOXF2
1 of 14
No
No
Hsap\SDCBP
1 of 14
No
No
Hsap\SEBOX
1 of 14
No
Yes
Hsap\SHOX2
1 of 14
No
No
Hsap\SHOX
1 of 14
No
No
1  
Hsap\TLX1
1 of 14
No
No
Hsap\TLX2
1 of 14
No
No
Hsap\TLX3
1 of 14
No
No
Hsap\TRIO
1 of 14
No
No
1  
Hsap\UNCX
1 of 14
No
No
Hsap\VAX1
1 of 14
No
No
Hsap\VAX2
1 of 14
No
No
Hsap\VENTX
1 of 14
No
No
Hsap\VSX1
1 of 14
No
No
1  
Hsap\VSX2
1 of 14
No
No
1  
Hsap\ZFHX3
1 of 14
No
No
1  
Hsap\ZFHX4
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (152)
Rnor\Pax6
11 of 14
Yes
Yes
Rnor\Pax4
5 of 14
No
Yes
Rnor\Pax2
3 of 14
No
No
Rnor\Pax8
3 of 14
No
No
Rnor\Dux4
2 of 14
No
Yes
Rnor\Mixl1
2 of 14
No
No
Rnor\Pax3
2 of 14
No
No
Rnor\Pax5
2 of 14
No
No
Rnor\Pax7
2 of 14
No
No
Rnor\Alx1
1 of 14
No
No
Rnor\Alx3
1 of 14
No
No
Rnor\Alx4
1 of 14
No
No
Rnor\Arx
1 of 14
No
No
Rnor\Barhl1
1 of 14
No
No
Rnor\Barhl2
1 of 14
No
No
Rnor\Barx1
1 of 14
No
No
Rnor\Barx2
1 of 14
No
No
Rnor\Bsx
1 of 14
No
No
Rnor\Cdx4
1 of 14
No
No
Rnor\Cers4
1 of 14
No
No
Rnor\Cphx1
1 of 14
No
Yes
Rnor\Crx
1 of 14
No
No
Rnor\Cux1
1 of 14
No
No
Rnor\Dbx1
1 of 14
No
No
Rnor\Dbx2
1 of 14
No
No
Rnor\Dlx3
1 of 14
No
No
Rnor\Dlx4
1 of 14
No
No
Rnor\Dlx5
1 of 14
No
No
Rnor\Dlx6
1 of 14
No
No
Rnor\Dmbx1
1 of 14
No
No
Rnor\Drgx
1 of 14
No
No
Rnor\Emx1
1 of 14
No
No
Rnor\Emx2
1 of 14
No
No
Rnor\En1
1 of 14
No
No
Rnor\Gbx1
1 of 14
No
No
Rnor\Gbx2
1 of 14
No
No
Rnor\Gsc2
1 of 14
No
No
Rnor\Gsc
1 of 14
No
No
Rnor\Gsx1
1 of 14
No
No
Rnor\Gsx2
1 of 14
No
No
Rnor\Hesx1
1 of 14
No
Yes
Rnor\Hhex
1 of 14
No
No
Rnor\Hlx
1 of 14
No
No
Rnor\Hmx2
1 of 14
No
No
Rnor\Hmx3
1 of 14
No
No
Rnor\Hopx
1 of 14
No
Yes
Rnor\Hoxa1
1 of 14
No
No
Rnor\Hoxa2
1 of 14
No
No
Rnor\Hoxa3
1 of 14
No
Yes
Rnor\Hoxa6
1 of 14
No
No
Rnor\Hoxa9
1 of 14
No
No
Rnor\Hoxa10
1 of 14
No
No
Rnor\Hoxa13
1 of 14
No
Yes
Rnor\Hoxb1
1 of 14
No
No
Rnor\Hoxb2
1 of 14
No
No
Rnor\Hoxb3
1 of 14
No
No
Rnor\Hoxb4
1 of 14
No
No
Rnor\Hoxb5
1 of 14
No
No
Rnor\Hoxb7
1 of 14
No
No
Rnor\Hoxb9
1 of 14
No
No
Rnor\Hoxc5
1 of 14
No
No
Rnor\Hoxc6
1 of 14
No
No
Rnor\Hoxc10
1 of 14
No
No
Rnor\Hoxd1
1 of 14
No
No
Rnor\Hoxd3
1 of 14
No
No
Rnor\Hoxd4
1 of 14
No
No
Rnor\Hoxd10
1 of 14
No
No
Rnor\Hoxd12
1 of 14
No
Yes
Rnor\Isl1
1 of 14
No
No
Rnor\Isl2
1 of 14
No
No
Rnor\Isx
1 of 14
No
No
Rnor\Lbx1
1 of 14
No
No
Rnor\Lbx2
1 of 14
No
No
Rnor\Lhx1
1 of 14
No
No
Rnor\Lhx2
1 of 14
No
No
Rnor\Lhx3
1 of 14
No
No
Rnor\Lhx4
1 of 14
No
No
Rnor\Lhx5
1 of 14
No
No
Rnor\Lhx6
1 of 14
No
No
Rnor\Lhx8
1 of 14
No
No
Rnor\Lhx9
1 of 14
No
No
Rnor\Lmx1a
1 of 14
No
No
Rnor\Lmx1b
1 of 14
No
No
Rnor\LOC691272
1 of 14
No
Yes
Rnor\LOC691325
1 of 14
No
No
Rnor\LOC100361016
1 of 14
No
Yes
Rnor\LOC100364002
1 of 14
No
No
Rnor\LOC100911668
1 of 14
No
No
Rnor\LOC102553890
1 of 14
No
Yes
Rnor\Meox1
1 of 14
No
No
Rnor\Meox2
1 of 14
No
No
Rnor\Mkx
1 of 14
No
No
Rnor\Mnx1
1 of 14
No
No
Rnor\Msx1
1 of 14
No
No
Rnor\Msx2
1 of 14
No
No
Rnor\Msx3
1 of 14
No
No
Rnor\Nanog
1 of 14
No
No
Rnor\Nkx1-1
1 of 14
No
No
Rnor\Nkx2-1
1 of 14
No
No
Rnor\Nkx2-2
1 of 14
No
No
Rnor\Nkx2-3
1 of 14
No
No
Rnor\Nkx2-4
1 of 14
No
No
Rnor\Nkx2-5
1 of 14
No
No
Rnor\Nkx2-6
1 of 14
No
No
Rnor\Nkx2-8
1 of 14
No
No
Rnor\Nkx3-1
1 of 14
No
No
Rnor\Nkx3-2
1 of 14
No
No
Rnor\Nkx6-1
1 of 14
No
No
Rnor\Nkx6-2
1 of 14
No
No
Rnor\Nkx6-3
1 of 14
No
No
Rnor\Nobox
1 of 14
No
No
Rnor\Noto
1 of 14
No
No
Rnor\Obox2
1 of 14
No
Yes
Rnor\Otp
1 of 14
No
No
Rnor\Otx1
1 of 14
No
No
Rnor\Pax1
1 of 14
No
No
Rnor\Pax9
1 of 14
No
No
Rnor\Pbx1
1 of 14
No
No
Rnor\Pbx2
1 of 14
No
No
Rnor\Pbx3
1 of 14
No
No
Rnor\Pbx4
1 of 14
No
No
Rnor\Pdx1
1 of 14
No
No
Rnor\Phox2a
1 of 14
No
No
Rnor\Phox2b
1 of 14
No
No
Rnor\Pitx1
1 of 14
No
No
Rnor\Pitx2
1 of 14
No
No
Rnor\Pitx3
1 of 14
No
No
Rnor\Prop1
1 of 14
No
No
Rnor\Prrx1
1 of 14
No
No
Rnor\Prrx2
1 of 14
No
No
Rnor\Rax
1 of 14
No
No
Rnor\Rhox3
1 of 14
No
Yes
Rnor\Rhox4g
1 of 14
No
Yes
Rnor\Rhox8
1 of 14
No
No
Rnor\Rhox9
1 of 14
No
Yes
Rnor\Rhox10
1 of 14
No
No
Rnor\Rhox11
1 of 14
No
No
Rnor\Rhox12
1 of 14
No
No
Rnor\Rhox13
1 of 14
No
No
Rnor\Sdcbp
1 of 14
No
No
Rnor\Sebox
1 of 14
No
Yes
Rnor\Shox2
1 of 14
No
No
Rnor\Tlx1
1 of 14
No
No
Rnor\Tlx2
1 of 14
No
No
Rnor\Tlx3
1 of 14
No
No
Rnor\Uncx
1 of 14
No
No
Rnor\Vax1
1 of 14
No
No
Rnor\Vax2
1 of 14
No
No
Rnor\Vsx1
1 of 14
No
No
Rnor\Vsx2
1 of 14
No
No
Rnor\Zfhx3
1 of 14
No
No
Rnor\Zfhx4
1 of 14
No
No
Mus musculus (laboratory mouse) (190)
Mmus\Pax6
11 of 14
Yes
Yes
3  
Mmus\Pax4
5 of 14
No
Yes
Mmus\Pax2
3 of 14
No
No
Mmus\Pax5
3 of 14
No
No
Mmus\Pax8
3 of 14
No
No
0  
Mmus\Cphx1
2 of 14
No
Yes
Mmus\Duxbl1
2 of 14
No
Yes
Mmus\Mixl1
2 of 14
No
No
Mmus\Pax3
2 of 14
No
No
1  
Mmus\Pax7
2 of 14
No
No
Mmus\Alx1
1 of 14
No
No
Mmus\Alx3
1 of 14
No
No
Mmus\Alx4
1 of 14
No
No
Mmus\Arx
1 of 14
No
No
Mmus\Barhl1
1 of 14
No
No
Mmus\Barhl2
1 of 14
No
No
Mmus\Barx1
1 of 14
No
No
Mmus\Barx2
1 of 14
No
No
Mmus\Bsx
1 of 14
No
No
Mmus\Cdx1
1 of 14
No
No
Mmus\Cdx4
1 of 14
No
No
Mmus\Cers4
1 of 14
No
No
Mmus\Crx
1 of 14
No
No
Mmus\Crxos
1 of 14
No
Yes
Mmus\Cux1
1 of 14
No
No
Mmus\Dbx1
1 of 14
No
No
Mmus\Dbx2
1 of 14
No
No
Mmus\Dlx1
1 of 14
No
No
Mmus\Dlx2
1 of 14
No
No
Mmus\Dlx3
1 of 14
No
No
Mmus\Dlx4
1 of 14
No
No
Mmus\Dlx5
1 of 14
No
No
Mmus\Dlx6
1 of 14
No
No
Mmus\Dmbx1
1 of 14
No
No
Mmus\Duxf3
1 of 14
No
Yes
Mmus\Emx1
1 of 14
No
No
Mmus\Emx2
1 of 14
No
No
1  
Mmus\En1
1 of 14
No
No
0  
Mmus\Esx1
1 of 14
No
Yes
Mmus\Evx1
1 of 14
No
No
2  
Mmus\Gbx1
1 of 14
No
No
Mmus\Gbx2
1 of 14
No
No
Mmus\Gm4981
1 of 14
No
Yes
Mmus\Gsc2
1 of 14
No
No
Mmus\Gsc
1 of 14
No
No
Mmus\Gsx1
1 of 14
No
No
Mmus\Gsx2
1 of 14
No
No
Mmus\Hesx1
1 of 14
No
Yes
Mmus\Hhex
1 of 14
No
No
Mmus\Hlx
1 of 14
No
No
Mmus\Hmx2
1 of 14
No
No
Mmus\Hmx3
1 of 14
No
No
Mmus\Hopx
1 of 14
No
Yes
Mmus\Hoxa1
1 of 14
No
No
Mmus\Hoxa2
1 of 14
No
No
3  
Mmus\Hoxa3
1 of 14
No
No
Mmus\Hoxa4
1 of 14
No
No
Mmus\Hoxa6
1 of 14
No
No
Mmus\Hoxa7
1 of 14
No
No
1  
Mmus\Hoxa9
1 of 14
No
No
Mmus\Hoxa10
1 of 14
No
No
Mmus\Hoxa13
1 of 14
No
Yes
Mmus\Hoxb1
1 of 14
No
No
0  
Mmus\Hoxb2
1 of 14
No
No
Mmus\Hoxb3
1 of 14
No
No
0  
Mmus\Hoxb5
1 of 14
No
No
Mmus\Hoxb7
1 of 14
No
No
Mmus\Hoxb9
1 of 14
No
No
1  
Mmus\Hoxc4
1 of 14
No
No
Mmus\Hoxc5
1 of 14
No
No
Mmus\Hoxc6
1 of 14
No
No
Mmus\Hoxc10
1 of 14
No
No
Mmus\Hoxd1
1 of 14
No
No
Mmus\Hoxd3
1 of 14
No
No
Mmus\Hoxd4
1 of 14
No
No
Mmus\Hoxd8
1 of 14
No
No
Mmus\Hoxd9
1 of 14
No
No
Mmus\Hoxd10
1 of 14
No
No
1  
Mmus\Hoxd12
1 of 14
No
Yes
Mmus\Irx1
1 of 14
No
No
Mmus\Isl1
1 of 14
No
No
Mmus\Isl2
1 of 14
No
No
Mmus\Isx
1 of 14
No
No
Mmus\Lbx1
1 of 14
No
No
Mmus\Lbx2
1 of 14
No
No
Mmus\Lhx1
1 of 14
No
No
Mmus\Lhx2
1 of 14
No
No
Mmus\Lhx3
1 of 14
No
No
Mmus\Lhx4
1 of 14
No
No
Mmus\Lhx5
1 of 14
No
No
Mmus\Lhx6
1 of 14
No
No
Mmus\Lhx8
1 of 14
No
No
Mmus\Lhx9
1 of 14
No
No
Mmus\Lmx1a
1 of 14
No
No
Mmus\Lmx1b
1 of 14
No
No
Mmus\LOC100504180
1 of 14
No
Yes
Mmus\Meox1
1 of 14
No
No
Mmus\Mkx
1 of 14
No
No
Mmus\Mnx1
1 of 14
No
No
Mmus\Msx1
1 of 14
No
No
Mmus\Msx2
1 of 14
No
No
0  
Mmus\Msx3
1 of 14
No
No
Mmus\Nanog
1 of 14
No
No
Mmus\Nkx1-1
1 of 14
No
No
Mmus\Nkx2-1
1 of 14
No
No
Mmus\Nkx2-2
1 of 14
No
No
Mmus\Nkx2-3
1 of 14
No
No
Mmus\Nkx2-4
1 of 14
No
No
Mmus\Nkx2-5
1 of 14
No
No
5  
Mmus\Nkx2-6
1 of 14
No
No
Mmus\Nkx2-9
1 of 14
No
No
Mmus\Nkx3-1
1 of 14
No
No
Mmus\Nkx3-2
1 of 14
No
No
Mmus\Nkx6-1
1 of 14
No
No
Mmus\Nkx6-2
1 of 14
No
No
Mmus\Nkx6-3
1 of 14
No
No
Mmus\Nobox
1 of 14
No
No
Mmus\Noto
1 of 14
No
No
Mmus\Obox1
1 of 14
No
No
Mmus\Obox2
1 of 14
No
Yes
Mmus\Obox3
1 of 14
No
Yes
Mmus\Obox5
1 of 14
No
No
Mmus\Obox6
1 of 14
No
No
Mmus\Obox7
1 of 14
No
No
Mmus\Obox8
1 of 14
No
No
Mmus\Otp
1 of 14
No
No
Mmus\Otx1
1 of 14
No
No
Mmus\Otx2
1 of 14
No
No
Mmus\Pax1
1 of 14
No
No
Mmus\Pax9
1 of 14
No
No
Mmus\Pbx1
1 of 14
No
No
Mmus\Pbx2
1 of 14
No
No
Mmus\Pbx3
1 of 14
No
No
Mmus\Pbx4
1 of 14
No
No
Mmus\Pdx1
1 of 14
No
No
Mmus\Phox2a
1 of 14
No
No
Mmus\Phox2b
1 of 14
No
No
Mmus\Pitx1
1 of 14
No
No
Mmus\Pitx2
1 of 14
No
No
Mmus\Pitx3
1 of 14
No
No
Mmus\Prop1
1 of 14
No
No
Mmus\Prrx1
1 of 14
No
No
Mmus\Prrx2
1 of 14
No
No
Mmus\Prrxl1
1 of 14
No
No
Mmus\Rax
1 of 14
No
No
Mmus\Rhox2a
1 of 14
No
Yes
Mmus\Rhox2b
1 of 14
No
Yes
Mmus\Rhox2c
1 of 14
No
Yes
Mmus\Rhox2d
1 of 14
No
Yes
Mmus\Rhox2e
1 of 14
No
Yes
Mmus\Rhox2f
1 of 14
No
Yes
Mmus\Rhox2g
1 of 14
No
Yes
Mmus\Rhox2h
1 of 14
No
Yes
Mmus\Rhox3a2
1 of 14
No
Yes
Mmus\Rhox3a
1 of 14
No
Yes
Mmus\Rhox3c
1 of 14
No
Yes
Mmus\Rhox3e
1 of 14
No
Yes
Mmus\Rhox3f
1 of 14
No
Yes
Mmus\Rhox3g
1 of 14
No
Yes
Mmus\Rhox3h
1 of 14
No
Yes
Mmus\Rhox4a2
1 of 14
No
Yes
Mmus\Rhox4a
1 of 14
No
Yes
Mmus\Rhox4b
1 of 14
No
Yes
Mmus\Rhox4c
1 of 14
No
Yes
Mmus\Rhox4d
1 of 14
No
Yes
Mmus\Rhox4e
1 of 14
No
Yes
Mmus\Rhox4f
1 of 14
No
Yes
Mmus\Rhox4g
1 of 14
No
Yes
Mmus\Rhox6
1 of 14
No
Yes
Mmus\Rhox7a
1 of 14
No
Yes
Mmus\Rhox7b
1 of 14
No
Yes
Mmus\Rhox8
1 of 14
No
Yes
Mmus\Rhox9
1 of 14
No
Yes
Mmus\Rhox10
1 of 14
No
No
Mmus\Rhox11
1 of 14
No
No
Mmus\Rhox12
1 of 14
No
Yes
Mmus\Rhox13
1 of 14
No
No
Mmus\Sdcbp
1 of 14
No
No
Mmus\Sebox
1 of 14
No
Yes
Mmus\Shox2
1 of 14
No
No
Mmus\Tlx1
1 of 14
No
No
Mmus\Tlx2
1 of 14
No
No
Mmus\Tlx3
1 of 14
No
No
Mmus\Uncx
1 of 14
No
No
Mmus\Vax1
1 of 14
No
No
1  
Mmus\Vax2
1 of 14
No
No
Mmus\Vsx1
1 of 14
No
No
Mmus\Vsx2
1 of 14
No
No
Mmus\Zfhx3
1 of 14
No
No
Mmus\Zfhx4
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (143)
Xtro\pax6
8 of 13
Yes
Yes
Xtro\LOC100485335
3 of 13
No
Yes
Xtro\pax8
2 of 13
No
No
Xtro\alx4
1 of 13
No
No
Xtro\arx
1 of 13
No
No
Xtro\barhl1
1 of 13
No
No
Xtro\barhl2
1 of 13
No
No
Xtro\barx1
1 of 13
No
No
Xtro\barx2
1 of 13
No
No
Xtro\bsx
1 of 13
No
No
Xtro\cdx1
1 of 13
No
No
Xtro\cdx4
1 of 13
No
No
Xtro\crx
1 of 13
No
No
Xtro\crybb2
1 of 13
No
No
Xtro\cux2
1 of 13
No
No
Xtro\dbx1
1 of 13
No
No
Xtro\dbx2
1 of 13
No
No
Xtro\dlx2
1 of 13
No
No
Xtro\dlx5
1 of 13
No
No
Xtro\dlx6
1 of 13
No
No
Xtro\dmbx1
1 of 13
No
No
Xtro\drgx
1 of 13
No
No
Xtro\emx1l
1 of 13
No
No
Xtro\emx1
1 of 13
No
No
Xtro\en2
1 of 13
No
No
Xtro\evx1
1 of 13
No
No
Xtro\evx2
1 of 13
No
No
Xtro\gbx2.1
1 of 13
No
No
Xtro\gsc2
1 of 13
No
No
Xtro\gsx1
1 of 13
No
No
Xtro\hesx1
1 of 13
No
Yes
Xtro\hhex
1 of 13
No
No
Xtro\higd1a
1 of 13
No
No
Xtro\hlx
1 of 13
No
No
Xtro\hmx1
1 of 13
No
No
Xtro\hmx2
1 of 13
No
No
Xtro\hmx3
1 of 13
No
No
Xtro\homeobox100496651-provisional
1 of 13
No
No
Xtro\hopx
1 of 13
No
Yes
Xtro\hoxa1
1 of 13
No
No
Xtro\hoxa2
1 of 13
No
No
Xtro\hoxa3
1 of 13
No
No
Xtro\hoxa4
1 of 13
No
No
Xtro\hoxa5
1 of 13
No
No
Xtro\hoxa7
1 of 13
No
No
Xtro\hoxa9
1 of 13
No
No
Xtro\hoxb2
1 of 13
No
No
Xtro\hoxb3
1 of 13
No
No
Xtro\hoxb5
1 of 13
No
No
Xtro\hoxb8
1 of 13
No
No
Xtro\hoxc3
1 of 13
No
No
Xtro\hoxc5
1 of 13
No
No
Xtro\hoxc8
1 of 13
No
No
Xtro\hoxc10
1 of 13
No
No
Xtro\hoxc12
1 of 13
No
Yes
Xtro\hoxc13
1 of 13
No
Yes
Xtro\hoxd1
1 of 13
No
No
Xtro\hoxd3
1 of 13
No
No
Xtro\hoxd8
1 of 13
No
No
Xtro\hoxd13
1 of 13
No
Yes
Xtro\isl2
1 of 13
No
No
Xtro\lbx1
1 of 13
No
No
Xtro\lhx1
1 of 13
No
No
Xtro\lhx5
1 of 13
No
No
Xtro\lhx6
1 of 13
No
No
Xtro\lhx8
1 of 13
No
No
Xtro\lhx9
1 of 13
No
No
Xtro\lmx1a
1 of 13
No
No
Xtro\lmx1b.1
1 of 13
No
No
Xtro\lmx1b.2
1 of 13
No
No
Xtro\LOC100485081
1 of 13
No
No
Xtro\LOC100485697
1 of 13
No
No
Xtro\LOC100486032
1 of 13
No
No
Xtro\LOC100487588
1 of 13
No
No
Xtro\LOC100490929
1 of 13
No
No
Xtro\LOC100492873
1 of 13
No
No
Xtro\LOC100493706
1 of 13
No
No
Xtro\LOC100496089
1 of 13
No
No
Xtro\LOC100497614
1 of 13
No
No
Xtro\LOC101731251
1 of 13
No
No
Xtro\LOC101731897
1 of 13
No
No
Xtro\LOC101732809
1 of 13
No
No
Xtro\LOC101734831
1 of 13
No
Yes
Xtro\LOC116406456
1 of 13
No
Yes
Xtro\med9
1 of 13
No
No
Xtro\meox2
1 of 13
No
No
Xtro\mnx1
1 of 13
No
No
Xtro\msx1
1 of 13
No
No
Xtro\msx2
1 of 13
No
No
Xtro\nkx1-1
1 of 13
No
No
Xtro\nkx2-1
1 of 13
No
No
Xtro\nkx2-3
1 of 13
No
No
Xtro\nkx2-5
1 of 13
No
No
Xtro\nkx2-6
1 of 13
No
No
Xtro\nkx3-2
1 of 13
No
No
Xtro\nkx3-3
1 of 13
No
No
Xtro\nkx6-2
1 of 13
No
No
Xtro\nkx6-3
1 of 13
No
No
Xtro\nobox
1 of 13
No
No
Xtro\not
1 of 13
No
No
Xtro\nyap2
1 of 13
No
No
Xtro\otp
1 of 13
No
No
Xtro\otx2
1 of 13
No
No
Xtro\pax2
1 of 13
No
No
Xtro\pax3
1 of 13
No
No
Xtro\pax4
1 of 13
No
Yes
Xtro\pax5
1 of 13
No
No
Xtro\pax9
1 of 13
No
No
Xtro\pbx1
1 of 13
No
No
Xtro\pbx2
1 of 13
No
No
Xtro\pbx3
1 of 13
No
No
Xtro\pdx1
1 of 13
No
No
Xtro\phox2b
1 of 13
No
No
Xtro\pitx2
1 of 13
No
No
Xtro\pitx3
1 of 13
No
No
Xtro\pou2f1
1 of 13
No
No
Xtro\pou2f2
1 of 13
No
No
Xtro\pou5f3.2
1 of 13
No
No
Xtro\prop1
1 of 13
No
No
Xtro\prrx1
1 of 13
No
No
Xtro\prrx2
1 of 13
No
No
Xtro\rax2
1 of 13
No
No
Xtro\rax
1 of 13
No
No
Xtro\scd
1 of 13
No
No
Xtro\sebox
1 of 13
No
No
Xtro\shox2
1 of 13
No
No
Xtro\shox
1 of 13
No
No
Xtro\sia1
1 of 13
No
No
Xtro\sia2
1 of 13
No
Yes
Xtro\sia3
1 of 13
No
Yes
Xtro\tgif2
1 of 13
No
No
Xtro\tmem143
1 of 13
No
No
Xtro\uncx
1 of 13
No
No
Xtro\ventx1.1
1 of 13
No
No
Xtro\ventx1.2
1 of 13
No
No
Xtro\ventx2.1
1 of 13
No
No
Xtro\ventx2.2
1 of 13
No
No
Xtro\ventx3.2
1 of 13
No
No
Xtro\vsx1
1 of 13
No
No
Xtro\vsx2
1 of 13
No
No
Xtro\vtn
1 of 13
No
No
Xtro\zfhx3
1 of 13
No
No
Xtro\zfhx4
1 of 13
No
No
Danio rerio (Zebrafish) (204)
Drer\pax6a
11 of 14
Yes
Yes
Drer\pax6b
11 of 14
Yes
Yes
Drer\pax4
5 of 14
No
Yes
Drer\pax2a
3 of 14
No
No
Drer\pax2b
3 of 14
No
No
Drer\pax8
3 of 14
No
No
Drer\pax10
3 of 14
No
Yes
Drer\mixl1
2 of 14
No
No
Drer\mxtx1
2 of 14
No
No
Drer\mxtx2
2 of 14
No
No
Drer\pax3a
2 of 14
No
No
Drer\pax3b
2 of 14
No
No
Drer\pax5
2 of 14
No
No
Drer\pax7b
2 of 14
No
No
Drer\sebox
2 of 14
No
Yes
Drer\alx1
1 of 14
No
No
Drer\alx3
1 of 14
No
No
Drer\alx4a
1 of 14
No
No
Drer\alx4b
1 of 14
No
No
Drer\arxa
1 of 14
No
No
Drer\arxb
1 of 14
No
No
Drer\barhl1a
1 of 14
No
No
Drer\barhl1b
1 of 14
No
No
Drer\barhl2
1 of 14
No
No
Drer\barx1
1 of 14
No
No
Drer\barx2
1 of 14
No
No
Drer\bsx
1 of 14
No
No
Drer\cdx1a
1 of 14
No
No
Drer\cdx1b
1 of 14
No
No
Drer\cdx4
1 of 14
No
No
Drer\crx
1 of 14
No
No
Drer\cux1a
1 of 14
No
No
Drer\cux2b
1 of 14
No
No
Drer\dbx1a
1 of 14
No
No
Drer\dbx1b
1 of 14
No
No
Drer\dbx2
1 of 14
No
No
Drer\dharma
1 of 14
No
No
Drer\dlx1a
1 of 14
No
No
Drer\dlx2a
1 of 14
No
No
Drer\dlx2b
1 of 14
No
No
Drer\dlx3b
1 of 14
No
No
Drer\dlx4a
1 of 14
No
No
Drer\dlx4b
1 of 14
No
No
Drer\dlx5a
1 of 14
No
No
Drer\dlx6a
1 of 14
No
No
Drer\dmbx1a
1 of 14
No
No
Drer\dmbx1b
1 of 14
No
No
Drer\drgx
1 of 14
No
No
Drer\emx1
1 of 14
No
No
Drer\emx2
1 of 14
No
No
Drer\en1a
1 of 14
No
No
Drer\en2a
1 of 14
No
No
Drer\eve1
1 of 14
No
No
Drer\evx1
1 of 14
No
No
Drer\gbx1
1 of 14
No
No
Drer\gbx2
1 of 14
No
No
Drer\gsc
1 of 14
No
No
Drer\gsx1
1 of 14
No
No
1  
Drer\gsx2
1 of 14
No
No
Drer\hhex
1 of 14
No
No
Drer\hlx1
1 of 14
No
No
Drer\hmx1
1 of 14
No
No
Drer\hmx2
1 of 14
No
No
Drer\hmx3a
1 of 14
No
No
Drer\hmx3b
1 of 14
No
No
Drer\hmx4
1 of 14
No
No
Drer\hopx
1 of 14
No
Yes
Drer\hoxa1a
1 of 14
No
No
Drer\hoxa2b
1 of 14
No
No
Drer\hoxa3a
1 of 14
No
No
Drer\hoxa4a
1 of 14
No
No
Drer\hoxa5a
1 of 14
No
No
Drer\hoxa9b
1 of 14
No
No
Drer\hoxa10b
1 of 14
No
No
Drer\hoxa11a
1 of 14
No
No
Drer\hoxa11b
1 of 14
No
No
Drer\hoxa13a
1 of 14
No
Yes
Drer\hoxa13b
1 of 14
No
Yes
Drer\hoxb1a
1 of 14
No
No
Drer\hoxb1b
1 of 14
No
No
Drer\hoxb2a
1 of 14
No
No
Drer\hoxb3a
1 of 14
No
No
Drer\hoxb4a
1 of 14
No
No
Drer\hoxb5b
1 of 14
No
No
Drer\hoxb6b
1 of 14
No
No
Drer\hoxb7a
1 of 14
No
No
Drer\hoxb8a
1 of 14
No
No
Drer\hoxb8b
1 of 14
No
No
Drer\hoxb10a
1 of 14
No
No
Drer\hoxb13a
1 of 14
No
Yes
Drer\hoxc1a
1 of 14
No
No
Drer\hoxc3a
1 of 14
No
No
Drer\hoxc4a
1 of 14
No
No
Drer\hoxc6a
1 of 14
No
No
Drer\hoxc6b
1 of 14
No
No
Drer\hoxc8a
1 of 14
No
No
Drer\hoxc9a
1 of 14
No
No
Drer\hoxc10a
1 of 14
No
No
Drer\hoxc11b
1 of 14
No
No
Drer\hoxc13a
1 of 14
No
Yes
Drer\hoxd3a
1 of 14
No
No
Drer\hoxd4a
1 of 14
No
No
Drer\hoxd9a
1 of 14
No
No
Drer\hoxd10a
1 of 14
No
No
Drer\hoxd11a
1 of 14
No
No
Drer\hoxd12a
1 of 14
No
No
Drer\hoxd13a
1 of 14
No
No
Drer\lbx1a
1 of 14
No
No
Drer\lbx1b
1 of 14
No
No
Drer\lbx2
1 of 14
No
No
Drer\lhx1a
1 of 14
No
No
Drer\lhx1b
1 of 14
No
No
Drer\lhx2a
1 of 14
No
No
Drer\lhx2b
1 of 14
No
No
Drer\lhx3
1 of 14
No
No
Drer\lhx4
1 of 14
No
No
Drer\lhx5
1 of 14
No
No
Drer\lhx6a
1 of 14
No
No
Drer\lhx6b
1 of 14
No
No
Drer\lhx9
1 of 14
No
No
Drer\lmx1bb
1 of 14
No
No
Drer\LOC100008066
1 of 14
No
No
Drer\meis1b
1 of 14
No
No
Drer\meox1
1 of 14
No
No
Drer\meox2a
1 of 14
No
No
Drer\meox2b
1 of 14
No
No
Drer\mnx1
1 of 14
No
No
Drer\mnx2b
1 of 14
No
No
Drer\msx1a
1 of 14
No
No
Drer\msx1b
1 of 14
No
No
Drer\msx2a
1 of 14
No
No
Drer\msx2b
1 of 14
No
No
Drer\msx3
1 of 14
No
No
Drer\nanog
1 of 14
No
No
Drer\nkx1.2la
1 of 14
No
No
Drer\nkx2.1
1 of 14
No
No
Drer\nkx2.2a
1 of 14
No
No
Drer\nkx2.2b
1 of 14
No
No
Drer\nkx2.3
1 of 14
No
No
Drer\nkx2.4a
1 of 14
No
No
Drer\nkx2.4b
1 of 14
No
No
Drer\nkx2.5
1 of 14
No
No
Drer\nkx2.7
1 of 14
No
No
Drer\nkx3-1
1 of 14
No
No
Drer\nkx3-2
1 of 14
No
No
Drer\nkx3.3
1 of 14
No
No
Drer\nkx6.1
1 of 14
No
No
1  
Drer\nkx6.2
1 of 14
No
No
Drer\nkx6.3
1 of 14
No
No
Drer\noto
1 of 14
No
No
Drer\otpa
1 of 14
No
No
Drer\otpb
1 of 14
No
No
Drer\otx1
1 of 14
No
No
Drer\otx2a
1 of 14
No
No
Drer\otx2b
1 of 14
No
No
Drer\otx5
1 of 14
No
No
Drer\pax1a
1 of 14
No
No
Drer\pax1b
1 of 14
No
No
Drer\pax7a
1 of 14
No
No
Drer\pax9
1 of 14
No
No
Drer\pbx1a
1 of 14
No
No
Drer\pbx1b
1 of 14
No
No
Drer\pbx2
1 of 14
No
No
Drer\pbx3a
1 of 14
No
No
Drer\pbx3b
1 of 14
No
No
Drer\pbx4
1 of 14
No
No
Drer\pdx1
1 of 14
No
No
Drer\phox2a
1 of 14
No
No
Drer\phox2ba
1 of 14
No
No
Drer\phox2bb
1 of 14
No
No
Drer\pitx1
1 of 14
No
No
Drer\pitx2
1 of 14
No
No
Drer\pitx3
1 of 14
No
No
Drer\pnx
1 of 14
No
No
Drer\pou2f2a
1 of 14
No
No
Drer\prop1
1 of 14
No
No
Drer\prrx1a
1 of 14
No
No
Drer\prrx1b
1 of 14
No
No
Drer\rx1
1 of 14
No
No
Drer\rx2
1 of 14
No
No
Drer\rx3
1 of 14
No
No
Drer\sdcbp2
1 of 14
No
No
Drer\shox2
1 of 14
No
No
Drer\shox
1 of 14
No
No
Drer\si:dkey-43p13.5
1 of 14
No
No
Drer\six1b
1 of 14
No
No
Drer\six2b
1 of 14
No
No
Drer\six4a
1 of 14
No
No
Drer\six7
1 of 14
No
No
Drer\tlx1
1 of 14
No
No
Drer\tlx2
1 of 14
No
No
Drer\tlx3b
1 of 14
No
No
Drer\uncx
1 of 14
No
No
Drer\vax1
1 of 14
No
No
Drer\vax2
1 of 14
No
No
Drer\ved
1 of 14
No
No
Drer\vent
1 of 14
No
No
Drer\vox
1 of 14
No
No
Drer\vsx1
1 of 14
No
No
Drer\vsx2
1 of 14
No
No
Drer\zfhx3a
1 of 14
No
No
Drer\zfhx3b
1 of 14
No
No
Drer\zfhx4
1 of 14
No
No
Drer\zgc:101100
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (69)
Cele\vab-3
9 of 14
Yes
Yes
Cele\ceh-53
3 of 14
No
No
Cele\egl-38
3 of 14
No
No
Cele\eyg-1
2 of 14
No
No
Cele\npax-1
2 of 14
No
No
Cele\npax-2
2 of 14
No
No
Cele\npax-3
2 of 14
No
No
Cele\pax-2
2 of 14
No
No
Cele\pax-3
2 of 14
No
No
Cele\alr-1
1 of 14
No
No
Cele\ceh-1
1 of 14
No
No
Cele\ceh-2
1 of 14
No
No
Cele\ceh-5
1 of 14
No
No
Cele\ceh-7
1 of 14
No
No
Cele\ceh-8
1 of 14
No
No
Cele\ceh-9
1 of 14
No
No
Cele\ceh-10
1 of 14
No
No
Cele\ceh-12
1 of 14
No
No
Cele\ceh-13
1 of 14
No
No
0  
Cele\ceh-14
1 of 14
No
No
Cele\ceh-16
1 of 14
No
No
Cele\ceh-17
1 of 14
No
No
Cele\ceh-19
1 of 14
No
No
Cele\ceh-20
1 of 14
No
No
Cele\ceh-21
1 of 14
No
No
Cele\ceh-23
1 of 14
No
No
Cele\ceh-24
1 of 14
No
No
Cele\ceh-27
1 of 14
No
No
Cele\ceh-28
1 of 14
No
No
Cele\ceh-30
1 of 14
No
No
Cele\ceh-31
1 of 14
No
No
Cele\ceh-34
1 of 14
No
No
Cele\ceh-36
1 of 14
No
No
Cele\ceh-37
1 of 14
No
No
Cele\ceh-40
1 of 14
No
No
Cele\ceh-43
1 of 14
No
No
Cele\ceh-44
1 of 14
No
No
Cele\ceh-45
1 of 14
No
No
Cele\ceh-51
1 of 14
No
No
Cele\ceh-54
1 of 14
No
No
Cele\ceh-58
1 of 14
No
Yes
Cele\ceh-60
1 of 14
No
No
Cele\ceh-87
1 of 14
No
Yes
Cele\cog-1
1 of 14
No
No
Cele\dsc-1
1 of 14
No
No
Cele\egl-5
1 of 14
No
No
Cele\hmbx-1
1 of 14
No
Yes
Cele\lim-4
1 of 14
No
No
Cele\lim-6
1 of 14
No
No
Cele\lin-11
1 of 14
No
No
Cele\lin-39
1 of 14
No
No
Cele\mab-5
1 of 14
No
No
Cele\mls-2
1 of 14
No
No
Cele\nob-1
1 of 14
No
No
Cele\npax-4
1 of 14
No
No
Cele\pax-1
1 of 14
No
No
Cele\pha-2
1 of 14
No
No
Cele\php-3
1 of 14
No
No
Cele\tab-1
1 of 14
No
No
Cele\ttx-1
1 of 14
No
No
Cele\ttx-3
1 of 14
No
No
Cele\unc-4
1 of 14
No
No
Cele\unc-30
1 of 14
No
No
Cele\unc-39
1 of 14
No
No
Cele\unc-42
1 of 14
No
No
Cele\vab-7
1 of 14
No
No
1  
Cele\vab-15
1 of 14
No
No
Cele\zag-1
1 of 14
No
No
Cele\zfh-2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (77)
Agam\AgaP_AGAP000067
9 of 12
Yes
Yes
Agam\AgaP_AGAP000063
8 of 12
No
Yes
Agam\AgaP_AGAP000057
4 of 12
No
No
Agam\AgaP_AGAP008818
2 of 12
No
No
Agam\AgaP_AGAP010358
2 of 12
No
No
Agam\AgaP_AGAP010359
2 of 12
No
No
Agam\AgaP_AGAP011417
2 of 12
No
No
Agam\ABDA_ANOGA
1 of 12
No
No
Agam\AgaP_AGAP000058
1 of 12
No
No
Agam\AgaP_AGAP000190
1 of 12
No
No
Agam\AgaP_AGAP000215
1 of 12
No
No
Agam\AgaP_AGAP000484
1 of 12
No
No
Agam\AgaP_AGAP000488
1 of 12
No
No
Agam\AgaP_AGAP000858
1 of 12
No
No
Agam\AgaP_AGAP001389
1 of 12
No
No
Agam\AgaP_AGAP001483
1 of 12
No
No
Agam\AgaP_AGAP001493
1 of 12
No
No
Agam\AgaP_AGAP001560
1 of 12
No
No
Agam\AgaP_AGAP001593
1 of 12
No
No
Agam\AgaP_AGAP001618
1 of 12
No
No
Agam\AgaP_AGAP001619
1 of 12
No
No
Agam\AgaP_AGAP002372
1 of 12
No
No
Agam\AgaP_AGAP002431
1 of 12
No
No
Agam\AgaP_AGAP002487
1 of 12
No
No
Agam\AgaP_AGAP003574
1 of 12
No
No
Agam\AgaP_AGAP003669
1 of 12
No
No
Agam\AgaP_AGAP003670
1 of 12
No
No
Agam\AgaP_AGAP003671
1 of 12
No
No
Agam\AgaP_AGAP003672
1 of 12
No
No
Agam\AgaP_AGAP003674
1 of 12
No
No
Agam\AgaP_AGAP004646
1 of 12
No
No
Agam\AgaP_AGAP004647
1 of 12
No
No
Agam\AgaP_AGAP004648
1 of 12
No
No
Agam\AgaP_AGAP004649
1 of 12
No
No
Agam\AgaP_AGAP004659
1 of 12
No
No
Agam\AgaP_AGAP004660
1 of 12
No
No
Agam\AgaP_AGAP004661
1 of 12
No
No
Agam\AgaP_AGAP004664
1 of 12
No
No
Agam\AgaP_AGAP005022
1 of 12
No
Yes
Agam\AgaP_AGAP005027
1 of 12
No
Yes
Agam\AgaP_AGAP005041
1 of 12
No
No
Agam\AgaP_AGAP005096
1 of 12
No
No
Agam\AgaP_AGAP005099
1 of 12
No
No
Agam\AgaP_AGAP005137
1 of 12
No
No
Agam\AgaP_AGAP005138
1 of 12
No
No
Agam\AgaP_AGAP005281
1 of 12
No
No
Agam\AgaP_AGAP005311
1 of 12
No
No
Agam\AgaP_AGAP005346
1 of 12
No
No
Agam\AgaP_AGAP005727
1 of 12
No
No
Agam\AgaP_AGAP006536
1 of 12
No
No
Agam\AgaP_AGAP006537
1 of 12
No
No
Agam\AgaP_AGAP006540
1 of 12
No
No
Agam\AgaP_AGAP006923
1 of 12
No
No
Agam\AgaP_AGAP007058
1 of 12
No
No
Agam\AgaP_AGAP007985
1 of 12
No
No
Agam\AgaP_AGAP008980
1 of 12
No
No
Agam\AgaP_AGAP009088
1 of 12
No
No
Agam\AgaP_AGAP009302
1 of 12
No
No
Agam\AgaP_AGAP009500
1 of 12
No
No
Agam\AgaP_AGAP009569
1 of 12
No
Yes
Agam\AgaP_AGAP009630
1 of 12
No
Yes
Agam\AgaP_AGAP009646
1 of 12
No
No
Agam\AgaP_AGAP010209
1 of 12
No
No
Agam\AgaP_AGAP010279
1 of 12
No
No
Agam\AgaP_AGAP011134
1 of 12
No
No
Agam\AgaP_AGAP011143
1 of 12
No
No
Agam\AgaP_AGAP011253
1 of 12
No
No
Agam\AgaP_AGAP011695
1 of 12
No
No
Agam\AgaP_AGAP012001
1 of 12
No
No
Agam\AgaP_AGAP012303
1 of 12
No
No
Agam\AgaP_AGAP012428
1 of 12
No
No
Agam\AgaP_AGAP012501
1 of 12
No
No
Agam\AgaP_AGAP013157
1 of 12
No
No
Agam\AgaP_AGAP013315
1 of 12
No
No
Agam\AgaP_AGAP013373
1 of 12
No
No
Agam\EXD_ANOGA
1 of 12
No
No
Agam\HMEN_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (51)
Atha\ANL2
2 of 13
Yes
Yes
Atha\HB-1
2 of 13
Yes
Yes
Atha\HB-3
2 of 13
Yes
No
Atha\HB20
2 of 13
Yes
No
Atha\HB21
2 of 13
Yes
No
Atha\HB40
2 of 13
Yes
No
Atha\HB53
2 of 13
Yes
No
Atha\HDG1
2 of 13
Yes
Yes
Atha\HDG7
2 of 13
Yes
Yes
Atha\RLT2
2 of 13
Yes
Yes
Atha\AT4G03090
1 of 13
No
Yes
Atha\ATHB13
1 of 13
No
No
Atha\ATHB-15
1 of 13
No
Yes
Atha\AtHB23
1 of 13
No
No
Atha\ATHB54
1 of 13
No
No
Atha\ATML1
1 of 13
No
No
Atha\FWA
1 of 13
No
No
Atha\GL2
1 of 13
No
No
Atha\HAT1
1 of 13
No
No
Atha\HAT2
1 of 13
No
No
Atha\HAT3
1 of 13
No
No
Atha\HAT9
1 of 13
No
No
Atha\HAT14
1 of 13
No
No
Atha\HAT22
1 of 13
No
No
Atha\HB-1
1 of 13
No
No
Atha\HB-2
1 of 13
No
No
Atha\HB4
1 of 13
No
No
Atha\HB5
1 of 13
No
No
Atha\HB6
1 of 13
No
No
Atha\HB-7
1 of 13
No
No
Atha\HB-7
1 of 13
No
No
Atha\HB-8
1 of 13
No
No
Atha\HB-12
1 of 13
No
No
Atha\HB16
1 of 13
No
No
Atha\HB17
1 of 13
No
No
Atha\HB18
1 of 13
No
No
Atha\HB22
1 of 13
No
No
Atha\HB51
1 of 13
No
No
Atha\HB52
1 of 13
No
No
Atha\HDG2
1 of 13
No
No
Atha\HDG3
1 of 13
No
No
Atha\HDG4
1 of 13
No
No
Atha\HDG9
1 of 13
No
No
Atha\HDG11
1 of 13
No
No
Atha\HDG12
1 of 13
No
No
Atha\PDF2
1 of 13
No
No
Atha\PHB
1 of 13
No
No
Atha\PHV
1 of 13
No
No
Atha\REV
1 of 13
No
No
Atha\WOX13
1 of 13
No
Yes
Atha\WOX14
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\PHO2
3 of 13
Yes
Yes
Scer\YOX1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\phx1
3 of 12
Yes
No
Spom\yox1
2 of 12
No
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:toy. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (84)
ey
5 of 13
eyg
4 of 13
gsb
4 of 13
gsb-n
4 of 13
prd
4 of 13
toe
4 of 13
Poxn
3 of 13
sv
3 of 13
al
2 of 13
ap
2 of 13
B-H1
2 of 13
B-H2
2 of 13
CG9876
2 of 13
CG11294
2 of 13
CG15696
2 of 13
CG32532
2 of 13
Drgx
2 of 13
E5
2 of 13
Gsc
2 of 13
hbn
2 of 13
HGTX
2 of 13
lms
2 of 13
oc
2 of 13
OdsH
2 of 13
otp
2 of 13
PHDP
2 of 13
Poxm
2 of 13
Pph13
2 of 13
Ptx1
2 of 13
repo
2 of 13
Rx
2 of 13
scro
2 of 13
tin
2 of 13
unc-4
2 of 13
Vsx1
2 of 13
Vsx2
2 of 13
abd-A
1 of 13
Abd-B
1 of 13
Antp
1 of 13
Awh
1 of 13
bap
1 of 13
bsh
1 of 13
btn
1 of 13
C15
1 of 13
cad
1 of 13
CG4328
1 of 13
CG11085
1 of 13
CG18599
1 of 13
CG34031
1 of 13
CG34367
1 of 13
ct
1 of 13
Dbx
1 of 13
Dfd
1 of 13
Dll
1 of 13
Dr
1 of 13
ems
1 of 13
en
1 of 13
eve
1 of 13
exd
1 of 13
exex
1 of 13
ftz
1 of 13
H2.0
1 of 13
HHEX
1 of 13
Hmx
1 of 13
ind
1 of 13
inv
1 of 13
lbe
1 of 13
Lim1
1 of 13
Lim3
1 of 13
Lmx1a
1 of 13
mirr
1 of 13
NK7.1
1 of 13
pb
1 of 13
Scr
1 of 13
slou
1 of 13
Tes
1 of 13
tup
1 of 13
Ubx
1 of 13
unpg
1 of 13
vnd
1 of 13
vvl
1 of 13
zen2
1 of 13
zen
1 of 13
zfh2
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 12 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PAX6; paired box 6
    12 of 14
    607108
     
    PAX4; paired box 4
    4 of 14
    167413
    PAX2; paired box 2
    3 of 14
    167409
    PAX5; paired box 5
    3 of 14
    167414
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      toy - Atf6
      two hybrid array
      (Shokri et al., 2019)
      toy - CG10431
      two hybrid array
      (Shokri et al., 2019)
      toy - CG15435
      two hybrid array
      (Shokri et al., 2019)
      toy - CG3847
      two hybrid array
      (Shokri et al., 2019)
      toy - CG9215
      two hybrid array
      (Shokri et al., 2019)
      toy - Chrac-14
      two hybrid array
      (Shokri et al., 2019)
      toy - D19B
      two hybrid array
      (Shokri et al., 2019)
      toy - Hipk
      enzymatic study, autoradiography, bimolecular fluorescence complementation, fluorescence microscopy
      (Steinmetz et al., 2018)
      toy - Lpt
      two hybrid array
      (Shokri et al., 2019)
      toy - Myc
      two hybrid array
      (Shokri et al., 2019)
      toy - REPTOR-BP
      two hybrid array
      (Shokri et al., 2019)
      toy - Sry-δ
      two hybrid array
      (Shokri et al., 2019)
      toy - ZIPIC
      two hybrid array
      (Shokri et al., 2019)
      toy - Zif
      two hybrid
      (Hu et al., 2017.6.13)
      toy - ara
      two hybrid array
      (Shokri et al., 2019)
      toy - ase
      two hybrid array
      (Shokri et al., 2019)
      toy - grh
      two hybrid array
      (Shokri et al., 2019)
      toy - lmd
      two hybrid array
      (Shokri et al., 2019)
      toy - lov
      two hybrid array
      (Shokri et al., 2019)
      toy - nom
      two hybrid array
      (Shokri et al., 2019)
      toy - p53
      pull down, autoradiography, two hybrid array
      (Shokri et al., 2019, Lunardi et al., 2010)
      toy - pzg
      two hybrid array
      (Shokri et al., 2019)
      toy - salm
      two hybrid array
      (Shokri et al., 2019)
      toy - slbo
      two hybrid array
      (Shokri et al., 2019)
      toy - sob
      two hybrid array
      (Shokri et al., 2019)
      toy - tgo
      two hybrid array
      (Shokri et al., 2019)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      toy
      suppressible
      ey
      (Jacobsson et al., 2009, Czerny et al., 1999)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      ey
      suppressible
      toy
      (Jacobsson et al., 2009, Punzo et al., 2002)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      4
      Recombination map
      4-0
      Cytogenetic map
      102F4-102F5
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      102F4-102F5
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      102E1-102E1
      (Czerny, 1999.3.11)
      102E1-102E1
      (determined by in situ hybridisation)
      (Czerny et al., 1999)
      102B6-102E10
      (Lindsley and Zimm, 1992)
      Maps close to ey.
      (Halder et al., 1998)
      Experimentally Determined Recombination Data
      Location

      4-0

      (FlyBase, 2016)

      4-

      (Halder et al., 1998)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (46)
      Genomic Clones (8)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (115)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Konstantinides et al., 2022, Özel et al., 2021, Jacobsson et al., 2009)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            The pupal lethality of toy mutants is caused by cell loss due to apoptosis.

            (Jacobsson et al., 2009)

            toy induces expression of dac.

            (Anderson et al., 2006)

            toy is crucial at the very beginning of eye-antennal development in the primordia of eye-antennal discs. toy also has parallel and partially redundant functions with ey.

            (Kronhamn et al., 2002)

            A single amino acid substitution in the ey protein is able to change the DNA-binding affinity of its paired domain to that of toy.

            (Czerny et al., 1999)

            toy acts upstream of ey in the control of eye development. Despite the similarity in structure and expression of toy and ey, normal expression of toy cannot compensate for the loss of ey function.

            (Czerny et al., 1999)

            In the embryonic head, so acts in parallel to ey and toy.

            (Halder et al., 1998)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: l(4)102CDg toy

            (Kronhamn et al., 2002)
            Additional comments
            Nomenclature History
            Source for database identify of
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (12)
            Reported As
            Symbol Synonym
            CG11186
            (Datta et al., 2011, Lunardi et al., 2010, Ni et al., 2010.12.1, Seinen et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009)
            Pax-6
            (Jacobsson et al., 2008)
            TOY
            (Percival-Smith, 2017, Blatti et al., 2015)
            Toy
            (El-Danaf et al., 2025, Avellino et al., 2023, Hildebrandt et al., 2022, Ray et al., 2022, Chen and Desplan, 2020, Luo et al., 2020, Naidu et al., 2020, Sato et al., 2019, Steinmetz et al., 2018, Davis and Rebay, 2017, Apitz and Salecker, 2016, Pinto-Teixeira et al., 2016, Yasugi and Nishimura, 2016, Apitz and Salecker, 2015, Eroglu et al., 2014, Ferrero et al., 2014, Ting et al., 2014, Ting et al., 2014, Li et al., 2013, Wang and Sun, 2012, Lynch and Wagner, 2011, Kim et al., 2005, Kozmik, 2005)
            l(4)102CDg
            (Noll and Frei, 2002.11.22, Hochman et al., 1964)
            l(4)8
            (Kronhamn et al., 2002, Noll and Frei, 2002.11.22, Hochman, 1976, Hochman, 1974, Hochman, 1971)
            toy
            (Dresch et al., 2025, Soffers et al., 2025, Bravo González-Blas et al., 2023, Voutyraki et al., 2023, Fourth Chromosome Resource Project and Newfeld, 2022-, Ma et al., 2021, Ordway et al., 2021, Cho et al., 2020, FlyBase Genome Annotators, 2020, Kurmangaliyev et al., 2020, Li and Hidalgo, 2020, Meyer-Nava et al., 2020, Curt et al., 2019, FlyBase Genome Annotators, 2019-, Gaspar et al., 2019, Hall et al., 2019, Meltzer et al., 2019, Shokri et al., 2019, Ariss et al., 2018, Baker et al., 2018, Bischof et al., 2018, Palliyil et al., 2018, Yeung et al., 2018, Zhu et al., 2018, Hu et al., 2017.6.13, Karaiskos et al., 2017, Transgenic RNAi Project members, 2017-, Zhu et al., 2017, Bürglin and Affolter, 2016, Skottheim Honn et al., 2016, Doggett et al., 2015, Enriquez et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Schertel et al., 2015, Ashwal-Fluss et al., 2014, Blaquiere et al., 2014, Glossop et al., 2014, Naval-Sánchez et al., 2013, Southall et al., 2013, Nfonsam et al., 2012, Riddle et al., 2012, Rodriguez et al., 2012, Takaesu et al., 2012, Wang and Sun, 2012, Brockmann et al., 2011, Datta et al., 2011, Friedrich and Caravas, 2011, Gehring, 2011, Gehring, 2011, Michaut et al., 2011, Papadopoulos et al., 2011, Aerts et al., 2010, Baig et al., 2010, Blanco et al., 2010, Frise et al., 2010, Lopes and Casares, 2010, Popov et al., 2010, Salzer and Kumar, 2010, Salzer et al., 2010, Furukubo-Tokunaga et al., 2009, Jacobsson et al., 2009, Schuettengruber et al., 2009, Weasner et al., 2009, Anderson and Kumar, 2008, Blanco and Gehring, 2008, Jacobsson et al., 2008, Pfeiffer et al., 2008, Weasner and Kumar, 2008, Yao et al., 2008, Aerts et al., 2007, Kumar and Datta, 2007, Kumar and Luhur, 2007, Kumar and Salzer, 2007, Kumar and Weanser, 2007, Sprecher et al., 2007, Weasner et al., 2007, Anderson et al., 2006, Choksi et al., 2006, Friedrich, 2006, Oakley et al., 2006, Zhang et al., 2006, Brown and Feder, 2005, Roederer et al., 2005, Podemski et al., 2004, Punzo et al., 2004, Stanyon et al., 2004, Onuma et al., 2002)
            twin of eyeless
            (Skottheim Honn et al., 2016, Enriquez et al., 2015, Gehring, 2011, Edwards et al., 2006)
            Name Synonyms
            Twin of Eyeless
            (Apitz and Salecker, 2015)
            eyeless
            (Su, 2015)
            lethal(4)102CDg
            twin of eyeless
            (Naval-Sánchez et al., 2013, Southall et al., 2013, Takaesu et al., 2012, Friedrich and Caravas, 2011, Gehring, 2011, Blanco et al., 2010, Lopes and Casares, 2010, Furukubo-Tokunaga et al., 2009, Schuettengruber et al., 2009, Weasner et al., 2009, Blanco and Gehring, 2008, Pfeiffer et al., 2008, Kumar and Datta, 2007, Kumar and Luhur, 2007, Kumar and Salzer, 2007, Kumar and Weanser, 2007, Choksi et al., 2006, Edwards et al., 2006, Fernald, 2006, Friedrich, 2006, Roederer et al., 2005, Roush, 1997)
            twin-of-eyeless
            (Jacobsson et al., 2009, Jacobsson et al., 2008)
            Secondary FlyBase IDs
            • FBgn0004523
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 99 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            References (247)