FlyBase Gene Report: Dmel\al

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\al

General Information

Symbol

Dmel\al

Species

D. melanogaster

Name

aristaless

Annotation Symbol

CG3935

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000061

Gene Model Status

Stock Availability

178 publicly available

Gene Summary

Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development. (UniProt, Q06453)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

L13-4

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:378,112..387,439 [+]

Recombination map

2-0.7

RefSeq locus

NT_033779 REGION:378112..387439

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

contributes_to sequence-specific DNA binding

inferred from direct assay

(Kojima et al., 2005)

inferred from physical interaction with FLYBASE:C15; FB:FBgn0004863

(Kojima et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA binding

inferred from electronic annotation with InterPro:IPR000047, InterPro:IPR001356

(InterPro Project Members, 2004-)

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from electronic annotation with InterPro:IPR017970

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN004692309

(GO Reference Genome Project, 2011-)

enables RNA polymerase II transcription regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN004692309

(GO Reference Genome Project, 2011-)

Biological Process (9 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in antennal morphogenesis

inferred from mutant phenotype

(Kojima et al., 2005, He and Adler, 2002)

involved_in chaeta development

inferred from mutant phenotype

(Kojima et al., 2005)

involved_in elongation of arista core

inferred from mutant phenotype

(Campbell, 2005)

involved_in imaginal disc-derived leg morphogenesis

inferred from mutant phenotype

(Kojima et al., 2005)

involved_in leg disc development

inferred from mutant phenotype

(Campbell, 2005)

involved_in negative regulation of DNA-templated transcription

inferred from mutant phenotype

(Kojima et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in neuron development

inferred from biological aspect of ancestor with PANTHER:PTN001216073

(GO Reference Genome Project, 2011-)

involved_in regulation of DNA-templated transcription

inferred from electronic annotation with InterPro:IPR017970

(InterPro Project Members, 2004-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN004692309

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of protein-containing complex

inferred from physical interaction with FLYBASE:C15; FB:FBgn0004863

(Kojima et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN004692309

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PAIRED-LIKE HOMEOBOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Belongs to the paired homeobox family. (Q06453)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

PAIRED-LIKE HOMEOBOX TRANSCRIPTION FACTORS -: Paired-like (PRD-like) homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. PRD-like transcription factors lack a paired domain but possess a homeodomain characteristic of the paired homeobox transcription factors. Some members also possess an Engrailed Homology 1 (EH1) and/or an OAR motif near the C-terminus. (Adapted from FBrf0232555 and FBrf0106517).

Protein Function (UniProtKB)

Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development.

(UniProt, Q06453)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

al: aristaless

Aristae strongly reduced. Postscutellars widely separated and erect but strongly divergent. Scutellum shortened; sternopleurals irregular in size, position, and number; wings slightly bowed downward, narrowed, and pointed; first longitudinal vein raised and thickened. Tarsal claws transformed into bristle-like structures or absent; effect enhanced by presence of th or ssa40a or both [Mglinetz and Ivanova, 1975, Genetika (Moscow) 11, 4: 88-96]. Enhances transformations of AntpNS [Mikuta and Mglinetz, 1978, Genetika (Moscow) 14: 1578-85] and ssa40a; al ssa40a flies exhibit partial transformation of third antennal segment to basitarsus; anomalous outgrowths of distal basitarsus and foreshortening of second and third tarsal joints of thoracic legs; spineless phenotype also enhanced. al females exhibit reduced mating success (Burnet, Connolly, and Dennis, 1971, Anim. Behav. 19: 409-15). RK1.

al8

Homozygous lethal; 1% survival in combination with Df(2L)al = Df(2L)21B8-C1;21C8-D1; survivors have reduced aristae, broad thorax, arched wings with incomplete veins, enlarged eyes.

Summary (Interactive Fly)

transcription factor - homeodomain - paired-like - involved in the ontogeny of specific head segments and the initiation of appendage development - required for the development of specific leg segments

Interactive Fly

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\al for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q06453)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Gene model reviewed during 5.44

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0078053

1806

408

Additional Transcript Data and Comments

Reported size (kB)

4.5, 3, 2.2, 1.9 (northern blot); 2.1 (compiled cDNA); 1.1 (longest cDNA)

(Schneitz et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0077713

43.7

408

9.96

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

408 (aa)

(Schneitz et al., 1993)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q06453

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\al using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

al_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.31

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 9 -- 10

dorsal ectoderm

(Fisher et al., 2012)

labial sensory complex primordium

Comment: reported as labial complex specific anlage

(Fisher et al., 2012)

maxillary sensory complex primordium

Comment: reported as maxillary organ specific anlage

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 10 -- 17

embryonic maxillary segment | restricted

(Schneitz et al., 1993)

embryonic labial segment | restricted

(Schneitz et al., 1993)

embryonic stage 11 -- 12

antennal primordium

(Fisher et al., 2012)

embryonic leading edge cell primordium

Comment: reported as embryonic leading edge cell specific anlage

(Fisher et al., 2012)

labial sensory complex primordium

(Fisher et al., 2012)

maxillary sensory complex primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 11 -- 17

embryonic antennal segment | restricted

(Schneitz et al., 1993)

embryonic mandibular segment | restricted

(Schneitz et al., 1993)

embryonic stage 13

embryonic metathoracic segment | restricted

(Schneitz et al., 1993)

embryonic abdominal segment 1 -- embryonic abdominal segment 8

(Schneitz et al., 1993)

mesothoracic segment | restricted

(Schneitz et al., 1993)

embryonic prothoracic segment | restricted

(Schneitz et al., 1993)

third instar larval stage

leg disc | restricted

(Schneitz et al., 1993)

wing disc | restricted

(Schneitz et al., 1993)

eye-antennal disc | restricted

(Schneitz et al., 1993)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

male genital disc

(Chatterjee et al., 2011)

female genital disc

(Chatterjee et al., 2011)

prothoracic leg disc

(Tsubota et al., 2008)

mesothoracic leg disc

(Tsubota et al., 2008)

metathoracic leg disc

(Tsubota et al., 2008)

Additional Descriptive Data

al protein is expressed in both male and female genital discs of third instar larvae. Expression is more extensive and at a higher level in female than in male discs.

(Chatterjee et al., 2011)

al is expressed in the dorsal-proximal region of all leg discs. al expression gradually decreases at the proximal edges. The distal region of the ss domain overlaps with the most proximal region of the al domain. Expression is observed from third instar at least until early pupal stages.

(Bennett et al., 2008)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of protein-containing complex

inferred from physical interaction with FLYBASE:C15; FB:FBgn0004863

(Kojima et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\al in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\al

View exonic expression by tissue for Dmel\al

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000061

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33208/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000061

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000061

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000061

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3935

Flygut - An atlas of the Drosophila adult midgut

FBgn0000061

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\al

Stages(s) 1-3
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 21 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 20 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of al

Transgenic constructs containing regulatory region of al

Aberrations (Deficiencies and Duplications) ( 25 )

Inferred from experimentation ( 25 )

Gene disrupted in

(Franc et al., 1999, Schneitz and Noll, 1990, Korochkina and Golubovsky, 1978, Lewis, 1945)

(Miller et al., 2020, Deal and Cook, 2005.3.10)

(Meyer, 1963)

Ts(1Lt;2Rt)Hw^bap

Gene not duplicated in

Dp(1;Y)su(f)⁺

(Gethmann, 1967)

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(2L)al)

al⁸

lethal | recessive

lethal - all die before end of P-stage | recessive

al^ice

lethal - all die during embryonic stage | recessive

al^ex

partially lethal

partially lethal - majority die | recessive

al³

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

al^GD1371

viable, with Scer\GAL4^Mef2.PR

al^GD1371

viable, with Scer\GAL4^pnr-MD237

al^GD1371

viable, with Scer\GAL4^tin.CΔ4

al^GD1371

Sterility

Allele

al³

al^f04261

Other Phenotypes

Allele

abnormal mating | female

al¹

some die during embryonic stage | recessive

al^ex

some die during pharate adult stage | recessive

al^ice

visible, with Scer\GAL4^Bx-MS1096

visible (with al¹)

al^ex

visible (with al¹³⁰)

al^ush

visible (with al^ex)

visible (with al^ice)

al^ex

visible (with al^ush)

al¹³⁰

visible (with Df(2L)al)

visible | cold sensitive, with Scer\GAL4^Bx-MS1096

al^{UAS.ORF.GW.Tag:HA}

visible | recessive

visible | somatic clone

al^ex

al^B38

Phenotype manifest in

Allele

adult thorax (with Df(2L)al)

al⁸

arista (with al¹)

al^ex

arista (with al¹³⁰)

al^ush

arista (with al^ex)

arista (with al^ice)

al^ex

arista (with al^ush)

al¹³⁰

arista (with Df(2L)al)

al⁸

al⁸

eye (with Df(2L)al)

al⁸

al^ice

leg | distal (with al^ex)

al^ice

leg | distal (with al^ice)

al^ex

macrochaeta & thorax

al³

mesothoracic bristle (with al^ex)

al^ice

mesothoracic bristle (with al^ice)

al^ex

microchaeta & thorax

al³

pleurum | somatic clone

al^ex

posterior scutellar bristle

pretarsus (with Df(2L)al)

al^ice

pretarsus | somatic clone

al^ex

scutellum | somatic clone

al^ex

sternopleural bristle

sternopleural bristle (with Df(2L)al)

al^ice

tarsal segment 4, with Scer\GAL4^ap-md544

al^UAS.cSa

tarsal segment 4 | somatic clone

al^ex

tarsal segment, with Scer\GAL4^30A

al^UAS.cSa

unguis (with al^ex)

al^ice

unguis (with al^ice)

al^ex

unguis (with Df(2L)al)

unguis | somatic clone

al^ex

wing, with Scer\GAL4^Bx-MS1096

wing (with Df(2L)al)

al⁸

wing | cold sensitive, with Scer\GAL4^Bx-MS1096

al^{UAS.ORF.GW.Tag:HA}

al^αTub84B.PC

al⁸

wing vein (with Df(2L)al)

al⁸

wing vein L2 | somatic clone

al^ex

al³

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (179)

8 of 14

Yes

Yes

5 of 14

No

Yes

4 of 14

No

No

4 of 14

No

No

3 of 14

No

No

3 of 14

No

Yes

3 of 14

No

No

3 of 14

No

No

1

2 of 14

No

No

5

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

2 of 14

No

No

3

2 of 14

No

No

3

2 of 14

No

No

1

2 of 14

No

No

0

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

2

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

Yes

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

3

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (136)

7 of 14

Yes

Yes

5 of 14

No

Yes

4 of 14

No

No

4 of 14

No

No

3 of 14

No

No

3 of 14

No

Yes

3 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

Rnor\LOC100361016

1 of 14

No

Yes

Rnor\LOC100364002

1 of 14

No

No

Rnor\LOC100911668

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Mus musculus (laboratory mouse) (177)

8 of 14

Yes

Yes

4 of 14

No

No

4 of 14

No

No

3 of 14

No

No

3 of 14

No

Yes

3 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

0

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Mmus\LOC100504180

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

0

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

5

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

3

1 of 14

No

No

0

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Xenopus tropicalis (Western clawed frog) (136)

6 of 13

Yes

Yes

4 of 13

No

Yes

4 of 13

No

No

3 of 13

No

Yes

3 of 13

No

No

2 of 13

No

No

2 of 13

No

Yes

2 of 13

No

Yes

Xtro\homeobox100496651-provisional

2 of 13

No

Yes

Xtro\LOC100485335

2 of 13

No

No

2 of 13

No

Yes

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Xtro\LOC100485081

1 of 13

No

No

Xtro\LOC100485697

1 of 13

No

No

Xtro\LOC100486032

1 of 13

No

No

Xtro\LOC100487588

1 of 13

No

No

Xtro\LOC100490929

1 of 13

No

No

Xtro\LOC100492873

1 of 13

No

No

Xtro\LOC100493706

1 of 13

No

No

Xtro\LOC100496089

1 of 13

No

No

Xtro\LOC100497614

1 of 13

No

No

Xtro\LOC101731251

1 of 13

No

No

Xtro\LOC101731897

1 of 13

No

No

Xtro\LOC101732809

1 of 13

No

No

Xtro\LOC101734831

1 of 13

No

Yes

Xtro\LOC116406456

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Danio rerio (Zebrafish) (191)

8 of 14

Yes

Yes

6 of 14

No

Yes

3 of 14

No

Yes

3 of 14

No

Yes

3 of 14

No

Yes

3 of 14

No

No

3 of 14

No

No

3 of 14

No

No

3 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

Drer\si:dkey-43p13.5

2 of 14

No

No

Drer\zgc:101100

2 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Drer\LOC100008066

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Caenorhabditis elegans (Nematode, roundworm) (67)

10 of 14

Yes

Yes

4 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

0

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Anopheles gambiae (African malaria mosquito) (72)

Agam\AgaP_AGAP007985

11 of 12

Yes

Yes

Agam\AgaP_AGAP005311

4 of 12

No

No

Agam\AgaP_AGAP000858

3 of 12

No

No

Agam\AgaP_AGAP001483

3 of 12

No

No

Agam\AgaP_AGAP000057

2 of 12

No

No

Agam\AgaP_AGAP000215

2 of 12

No

No

Agam\AgaP_AGAP001493

2 of 12

No

No

Agam\AgaP_AGAP001593

2 of 12

No

No

Agam\AgaP_AGAP002487

2 of 12

No

No

Agam\AgaP_AGAP005096

2 of 12

No

No

Agam\AgaP_AGAP008868

2 of 12

No

No

Agam\AgaP_AGAP009293

2 of 12

No

No

Agam\AgaP_AGAP009294

2 of 12

No

No

Agam\AgaP_AGAP010358

2 of 12

No

No

Agam\AgaP_AGAP010359

2 of 12

No

No

Agam\AgaP_AGAP011417

2 of 12

No

No

Agam\AgaP_AGAP012303

2 of 12

No

No

Agam\AgaP_AGAP012501

2 of 12

No

No

Agam\ABDA_ANOGA

1 of 12

No

No

Agam\AgaP_AGAP000063

1 of 12

No

No

Agam\AgaP_AGAP000067

1 of 12

No

No

Agam\AgaP_AGAP000190

1 of 12

No

No

Agam\AgaP_AGAP000484

1 of 12

No

No

Agam\AgaP_AGAP000488

1 of 12

No

No

Agam\AgaP_AGAP000779

1 of 12

No

No

Agam\AgaP_AGAP001187

1 of 12

No

No

Agam\AgaP_AGAP001389

1 of 12

No

No

Agam\AgaP_AGAP001495

1 of 12

No

No

Agam\AgaP_AGAP001560

1 of 12

No

No

Agam\AgaP_AGAP001618

1 of 12

No

No

Agam\AgaP_AGAP002372

1 of 12

No

No

Agam\AgaP_AGAP002431

1 of 12

No

No

Agam\AgaP_AGAP003406

1 of 12

No

No

Agam\AgaP_AGAP003669

1 of 12

No

No

Agam\AgaP_AGAP003670

1 of 12

No

No

Agam\AgaP_AGAP003671

1 of 12

No

No

Agam\AgaP_AGAP003672

1 of 12

No

No

Agam\AgaP_AGAP003674

1 of 12

No

No

Agam\AgaP_AGAP004646

1 of 12

No

No

Agam\AgaP_AGAP004647

1 of 12

No

No

Agam\AgaP_AGAP004648

1 of 12

No

No

Agam\AgaP_AGAP004649

1 of 12

No

No

Agam\AgaP_AGAP004659

1 of 12

No

No

Agam\AgaP_AGAP004661

1 of 12

No

No

Agam\AgaP_AGAP004664

1 of 12

No

No

Agam\AgaP_AGAP005041

1 of 12

No

No

Agam\AgaP_AGAP005099

1 of 12

No

No

Agam\AgaP_AGAP005346

1 of 12

No

No

Agam\AgaP_AGAP005425

1 of 12

No

No

Agam\AgaP_AGAP005727

1 of 12

No

No

Agam\AgaP_AGAP006536

1 of 12

No

No

Agam\AgaP_AGAP006537

1 of 12

No

No

Agam\AgaP_AGAP006540

1 of 12

No

No

Agam\AgaP_AGAP006923

1 of 12

No

No

Agam\AgaP_AGAP007058

1 of 12

No

No

Agam\AgaP_AGAP008818

1 of 12

No

No

Agam\AgaP_AGAP009088

1 of 12

No

No

Agam\AgaP_AGAP009302

1 of 12

No

No

Agam\AgaP_AGAP009500

1 of 12

No

No

Agam\AgaP_AGAP009646

1 of 12

No

No

Agam\AgaP_AGAP010209

1 of 12

No

No

Agam\AgaP_AGAP010279

1 of 12

No

No

Agam\AgaP_AGAP011134

1 of 12

No

No

Agam\AgaP_AGAP011143

1 of 12

No

No

Agam\AgaP_AGAP011253

1 of 12

No

No

Agam\AgaP_AGAP012001

1 of 12

No

No

Agam\AgaP_AGAP012428

1 of 12

No

No

Agam\AgaP_AGAP013075

1 of 12

No

No

Agam\AgaP_AGAP013157

1 of 12

No

No

Agam\AgaP_AGAP013373

1 of 12

No

No

1 of 12

No

No

Agam\HMEN_ANOGA

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (45)

2 of 13

Yes

Yes

2 of 13

Yes

Yes

2 of 13

Yes

No

2 of 13

Yes

No

2 of 13

Yes

No

2 of 13

Yes

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Saccharomyces cerevisiae (Brewer's yeast) (3)

2 of 13

Yes

No

2 of 13

Yes

No

2 of 13

Yes

No

Schizosaccharomyces pombe (Fission yeast) (2)

3 of 12

Yes

No

1 of 12

No

No

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:al. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (88)

7 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 6 )

Human Ortholog

Disease

Evidence

References

ARX; aristaless related homeobox

model of Partington syndrome

IEA

(FlyBase, 2019-)

model of X-linked lissencephaly 2

IEA

(FlyBase, 2019-)

model of developmental and epileptic encephalopathy 1

IEA

(FlyBase, 2019-)

model of non-syndromic X-linked intellectual disability ARX-related

IEA

(FlyBase, 2019-)

model of corpus callosum agenesis-abnormal genitalia syndrome

IEA

(FlyBase, 2019-)

ALX1; ALX homeobox 1

model of frontonasal dysplasia 3

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ARX; aristaless related homeobox

8 of 14

ALX1; ALX homeobox 1

5 of 14

FRONTONASAL DYSPLASIA 3; FND3

frontonasal dysplasia 3

ALX3; ALX homeobox 3

4 of 14

FRONTONASAL DYSPLASIA 1; FND1

frontonasal dysplasia 1

ALX4; ALX homeobox 4

4 of 14

DRGX; dorsal root ganglia homeobox

3 of 14

ISX; intestine specific homeobox

3 of 14

RAX2; retina and anterior neural fold homeobox 2

3 of 14

RAX; retina and anterior neural fold homeobox

3 of 14

MICROPHTHALMIA, SYNDROMIC 16; MCOPS16

isolated microphthalmia 3

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

x-ray crystallography, pull down, autoradiography, western blot

(Mojica-Vázquez et al., 2017, Miyazono et al., 2010, Kojima et al., 2005)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting

(Rhee et al., 2014, Guruharsha et al., 2011)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

pull down, western blot

(Pueyo and Couso, 2004)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

two hybrid, bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018, Hsiao et al., 2014)

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Pueyo and Couso, 2004)

enhanceable

(Campbell, 2005)

enhanceable

(Mglinets and Ivanov, 1975)

enhanceable

(Wehn and Campbell, 2006)

enhanceable

(Wehn and Campbell, 2006)

enhanceable

(Pueyo et al., 2000)

enhanceable

(Wehn and Campbell, 2006)

enhanceable

(Mglinets and Ivanov, 1975)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Mikuta and Mglinets, 1978)

enhanceable

(Pueyo et al., 2000, Tsuji et al., 2000)

enhanceable

(Mikuta and Mglinets, 1978)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59464

DroID - A comprehensive database of gene and protein interactions.

FBgn0000061

MIST (genetic) - An integrated Molecular Interaction Database

33208

MIST (protein-protein) - An integrated Molecular Interaction Database

33208

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-0.7

Cytogenetic map

Sequence location

2L:378,112..387,439 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21C1-21C1

Limits computationally determined from genome sequence between P{lacW}U2af38^k14504 and P{lacW}RpI135^k16513&P{lacW}ebi^k16213

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

21C5-21C6

(determined by in situ hybridisation)

(BDGP Project Members, 1994-1999)

21C1-21C2

(determined by in situ hybridisation)

(Schneitz et al., 1993)

21C1-21D2

(Schneitz and Noll, 1990)

21B8-21C1

(Golubovsky et al., 1978)

Experimentally Determined Recombination Data

Location

2-0.7

(FlyBase, 2016)

2-0.0

(Comeron et al., 2012, Meyer, 1963)

2-0.01

(Reuter and Szidonya, 1983)

2-0.4

(Golubovsky et al., 1978)

Left of (cM)

Fs(2)M

(Szabad et al., 1989)

Pgk

(Voelker et al., 1979)

Right of (cM)

Notes

Stocks and Reagents

Stocks (178)

Aberrations including deletions of this gene Aberrations including duplications of this gene

1125

al¹ Gpdh1ⁿ⁰/SM1

1123

al¹ Gpdh1^n1-5/SM1

1124

al¹ Gpdh1^n1-4/SM1

2402

al¹ Gpdh1^n5-4/SM1

F003240

M{UAS-al.ORF-CC}ZH-21F

F004750

M{UAS-al.ORF-VN}ZH-86Fb

F000057

M{UAS-al.ORF.3xHA.GW}ZH-86Fb

106213

al¹ Gpdh1^n1-5/SM1

3935R-1

3935R-3

v101981

P{KK110423}VIE-260B

v4542

w¹¹¹⁸; P{GD1371}v4542

More stocks available...

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (104)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE68460

Other clones

DPiM_RE68460

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000061

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000061

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

In the leg, al is only required for the growth and differentiation of the tip of the leg and not for the formation of the proximo-distal axis.

(Campbell and Tomlinson, 1998)

Genetic combinations with mutants of nub cause additive phenotypes.

(Cifuentes and Garcia-Bellido, 1997)

Ectopic expression of hh and dpp is able to induce expression of al, which is proposed to influence the proximal-distal specification of adult appendages.

(Capdevila and Guerrero, 1994)

The presumptive tips of both the leg and wing are characterized by the close association of cells expressing wg, dpp and al. Ectopic expression of wg can induce both ectopic al expression and a duplication of the proximodistal axis, but only in regions with high levels of dpp.

(Campbell et al., 1993)

al gene has been cloned, identified and characterised.

(Schneitz et al., 1993)

al is a prd-type homeobox gene.

(Schneitz and Noll, 1990)

Relationship to Other Genes

Source for database merge of

Additional comments

"al" mutant phenotype resembles that reported for "tg" mutants. Since "tg" is genetically closely linked to "al" it may be allelic to "al".

(Schneitz et al., 1993)

Nomenclature History

Source for database identify of

Source for identity of: al CG3935

(Guan, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

A1

(Emerald and Cohen, 2004)

AL

(Dey et al., 2009, Bassett et al., 1997)

Al

(Ruiz-Losada et al., 2018, Kachhap et al., 2017, Mojica-Vázquez et al., 2017, Hsiao et al., 2014)

CG3935

(National Institute of Genetics Fly Stocks, 2022-, Ibrahim et al., 2013, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Davis, 2000.10.25)

L13-4

(Noll, 1998.2.10, Schneitz and Noll, 1990)

lambda13-4

Name Synonyms

Aristaless

(Davis et al., 2005)

aristaless

(Gaspar et al., 2022, Ibrahim et al., 2013, Baker, 2011, Chatterjee et al., 2011, Singh et al., 2010, Dey et al., 2009, Tsubota et al., 2008, Emmons et al., 2007, Halachmi et al., 2007, Reig et al., 2007, Sakurai et al., 2007, Tajiri et al., 2007, Van Gelder, 2006, Yasunaga et al., 2006, Dimitri et al., 2003, Schneitz, 1994.4.14)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33208

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q06453

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q06453

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q06453

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000061

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33208/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000061

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000061

FlyMine - An integrated database for Drosophila genomics

FBgn0000061

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3935

MARRVEL_MODEL - MARRVEL (model organism gene)

33208

PDB - An information portal to biological macromolecular structures

Linkouts

BioGRID - A database of protein and genetic interactions.

59464

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000061

DroID - A comprehensive database of gene and protein interactions.

FBgn0000061

DRSC - Results frm RNAi screens

FBgn0000061

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

al_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000061

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000061

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3935

Flygut - An atlas of the Drosophila adult midgut

FBgn0000061

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033171

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

33208

MIST (protein-protein) - An integrated Molecular Interaction Database

33208

References (199)