paired-like homeobox transcription factor -defines enteroendocrine cells (EEs) in the intestinal epithelium - functions in the midgut in global and regional interstitial stem cell regulation - regulates development of early mesoderm< - differentiates posterior from anterior lateral mesoderm
Gene model reviewed during 5.47
Gene model reviewed during 5.44
Stop-codon suppression (UGA) postulated; FBrf0216884.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).
3.5 (sequence analysis)
None of the polypeptides share 100% sequence identity.
513 (aa); 62 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptx1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Ptx1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Ptx1 CG1447
dsRNA has been made from templates generated with primers directed against this gene. RNAi of Ptx1 disrupts the dendritic routing patterns of the ddaD and ddaE neurons, resulting in aberrantly oriented primary dendrites. RNAi also causes defects in dendrite morphogenesis.