FlyBase Gene Report: Dmel\pdm2

General Information

Symbol

Dmel\pdm2

Species

D. melanogaster

Name

POU domain protein 2

Annotation Symbol

CG12287

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004394

Gene Model Status

Current

Stock Availability

100 publicly available

Gene Summary

POU domain protein 2 (pdm2) encodes a transcription factor that plays multiple roles in neurogenesis, including acting as a temporal identity gene and a timing gene required for the termination of the Kr temporal identity window. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

pdm-2, pdm, miti, dPOU28, dPOU-28

Key Links

Genomic Location

Cytogenetic map

33F2-33F3

Sequence location

2L:12,657,165..12,686,306 [+]

Recombination map

2-47

RefSeq locus

NT_033779 REGION:12657165..12686306

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables DNA binding

inferred from mutant phenotype

(Prakash et al., 1992)

enables DNA-binding transcription activator activity, RNA polymerase II-specific

inferred from direct assay

(Junell et al., 2007)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables DNA binding

inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR010982, InterPro:IPR013847

(InterPro Project Members, 2004-)

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from electronic annotation with InterPro:IPR017970

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000180816

(GO Reference Genome Project, 2011-)

enables DNA-binding transcription factor activity

inferred from electronic annotation with InterPro:IPR000327

(InterPro Project Members, 2004-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000180816

(GO Reference Genome Project, 2011-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in central nervous system development

inferred from mutant phenotype

(Prakash et al., 1992)

involved_in ectoderm development

inferred from mutant phenotype

(Prakash et al., 1992)

involved_in generation of neurons

inferred from mutant phenotype

(Tran et al., 2010)

involved_in neuroblast development

inferred from mutant phenotype

(Tsuji et al., 2008)

involved_in regulation of DNA-templated transcription

inferred from mutant phenotype

(Prakash et al., 1992)

involved_in regulation of neural precursor cell proliferation

inferred from genetic interaction with FLYBASE:nub; FB:FBgn0085424

(Bahrampour et al., 2017)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in regulation of DNA-templated transcription

inferred from electronic annotation with InterPro:IPR000327, InterPro:IPR017970

(InterPro Project Members, 2004-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000180816

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from mutant phenotype

(Prakash et al., 1992)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in nucleus

inferred by curator from GO:0006355

(Prakash et al., 1992)

part_of RNA polymerase II transcription regulator complex

inferred from biological aspect of ancestor with PANTHER:PTN000180816

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

POU HOMEOBOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Belongs to the POU transcription factor family. Class-2 subfamily. (Q9VK71 P31369)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

POU HOMEOBOX TRANSCRIPTION FACTORS -: POU homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by a POU-specific domain N-terminal to a homeodomain. POU proteins can bind as homodimers or heterodimers to DNA. (Adapted from FBrf0232555 and PMID:18797923).

Protein Function (UniProtKB)

DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.

(UniProt, Q9VK71 P31369)

Summary (Interactive Fly)

transcription factor - homeodomain and pou domain - along with pdm-1 involved in cell fate determination of a subset of temporally determined neural subtypes - morphology of sensory neurons is diversified through a series of suppressive transcriptional interactions involving Pdm1 (Nubbin) and Pdm2, the homeodomain transcription factor Cut, and the transcriptional regulators Scalloped and Vestigial

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\pdm2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VK71)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

pdm2-RA

FBtr0080393

NM_078834

2171

498

pdm2-RB

FBtr0080392

NM_165017

3627

893

pdm2-RC

FBtr0340539

NM_001298948

3729

893

pdm2-RD

FBtr0340540

NM_001298949

4286

893

Additional Transcript Data and Comments

Reported size (kB)

2.3 (northern blot)

(Prakash et al., 1992)

2.5 (northern blot)

(Billin et al., 1991)

2.2 (northern blot)

(Dick et al., 1991, Lloyd and Sakonju, 1991)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

pdm2-PA

FBpp0079974

55.5

498

6.52

FBpp0079973

98.5

893

6.90

FBpp0309438

98.5

893

6.90

FBpp0309439

98.5

893

6.90

Q9VK71

NP_001285878

AHN54392

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

893 aa isoforms: pdm2-PB, pdm2-PC, pdm2-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

498 (aa); 54 (kD)

(Prakash et al., 1992)

413 (aa); 45.8 (kD)

(Billin et al., 1991)

475 (aa); 53 (kD)

(Dick et al., 1991)

498 (aa); 55 (kD)

(Lloyd and Sakonju, 1991)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pdm2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.77

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

ectoderm | striped

(Dick et al., 1991)

adult optic lobe

(Dick et al., 1991)

labral segment

(Dick et al., 1991)

central nervous system | restricted

(Dick et al., 1991)

embryonic/larval labral segment sense organ

(Dick et al., 1991)

embryonic stage 5

parasegment 7

(Lloyd and Sakonju, 1991)

organism | 20-40% egg length

(Prakash et al., 1992)

gastrula stage

ectoderm | striped

(Billin et al., 1991)

organism | segment polarity expression pattern

(Prakash et al., 1992)

embryonic stage 6

organism | odd pair rule expression pattern

(Lloyd and Sakonju, 1991)

embryonic stage 10

tracheal primordium

(Lloyd and Sakonju, 1991)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic brain

(Dick et al., 1991)

presumptive embryonic/larval peripheral nervous system | restricted

(Dick et al., 1991)

ventral pharyngeal sense organ

(Dick et al., 1991)

neurogenic region

(Dick et al., 1991)

presumptive embryonic/larval central nervous system | restricted

(Prakash et al., 1992)

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

organism | gap expression pattern

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 5

organism | 90-100% egg length

Comment: 95-100% egg length

(Prakash et al., 1992)

labral segment

(Lloyd and Sakonju, 1991)

parasegment 7

(Lloyd and Sakonju, 1991)

organism | 30-50% egg length

(Dick et al., 1991)

organism | 20-50% egg length

(Billin et al., 1991)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

mesectoderm anlage | subset

(Kearney et al., 2004)

embryonic stage 9

organism | segment polarity expression pattern

(Lloyd and Sakonju, 1991)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

anterior endoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

labial sensory complex primordium

Comment: reported as labial complex specific anlage

(Fisher et al., 2012)

maxillary sensory complex primordium

Comment: reported as maxillary organ specific anlage

(Fisher et al., 2012)

embryonic stage 10

presumptive embryonic/larval central nervous system

(Billin et al., 1991)

neuroblast | subset

(Billin et al., 1991)

embryonic primordium of adult hindgut precursor

(Billin et al., 1991)

embryonic brain | restricted

(Billin et al., 1991)

embryonic stage 10 -- 12

embryonic ganglion mother cell | segmentally repeated | subset

(Berman et al., 2004)

embryonic neuroblast | segmentally repeated | subset

(Berman et al., 2004)

embryonic stage 11

MP3 precursor

(Wheeler et al., 2006)

larval MP1 neuron

(Wheeler et al., 2006)

embryonic stage 11 -- 12

antennal primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

dorsal sensory complex primordium

(Fisher et al., 2012)

embryonic optic lobe primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

ventral sensory complex anlage

(Fisher et al., 2012)

embryonic ganglion mother cell

(Fisher et al., 2012)

embryonic neuroblast of ventral nerve cord primordium

(Fisher et al., 2012)

labial sensory complex primordium

(Fisher et al., 2012)

maxillary sensory complex primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

embryonic stage 12

ventral pharyngeal sense organ

(Lloyd and Sakonju, 1991)

embryonic stage 12 -- 13

embryonic thoracic lateral sensory organ precursor cluster of prothoracic segment

(Lloyd and Sakonju, 1991)

embryonic abdominal lateral sensory organ precursor cluster of abdominal segment 1

(Lloyd and Sakonju, 1991)

embryonic abdominal lateral sensory organ precursor cluster of abdominal segment 2

(Lloyd and Sakonju, 1991)

embryonic abdominal lateral sensory organ precursor cluster of abdominal segment 3

(Lloyd and Sakonju, 1991)

embryonic abdominal lateral sensory organ precursor cluster of abdominal segment 4

(Lloyd and Sakonju, 1991)

embryonic abdominal lateral sensory organ precursor cluster of abdominal segment 5

(Lloyd and Sakonju, 1991)

embryonic abdominal lateral sensory organ precursor cluster of abdominal segment 6

(Lloyd and Sakonju, 1991)

embryonic abdominal lateral sensory organ precursor cluster of abdominal segment 7

(Lloyd and Sakonju, 1991)

abdominal segment 9 of presumptive embryonic/larval peripheral nervous system

(Lloyd and Sakonju, 1991)

abdominal segment 8 of presumptive embryonic/larval peripheral nervous system

(Lloyd and Sakonju, 1991)

embryonic/larval labral segment sense organ | precursor

(Lloyd and Sakonju, 1991)

presumptive embryonic/larval central nervous system | restricted

(Lloyd and Sakonju, 1991)

abdominal dorsal multidendritic neuron

(Lloyd and Sakonju, 1991)

chordotonal organ of embryonic thoracic lateral sensory organ precursor cluster

(Lloyd and Sakonju, 1991)

abdominal dorsal bipolar neuron dbp

(Lloyd and Sakonju, 1991)

scolopidial ligament cell of embryonic abdominal lateral sensory organ precursor cluster

(Lloyd and Sakonju, 1991)

dorsal thoracic bipolar dendrite neuron precursor cell

(Lloyd and Sakonju, 1991)

dorsal pharyngeal sense organ

(Lloyd and Sakonju, 1991)

presumptive embryonic/larval peripheral nervous system | restricted

(Lloyd and Sakonju, 1991)

embryonic stage 13

larval MP1 neuron

(Wheeler et al., 2006)

larval H-cell

(Wheeler et al., 2006)

larval H-cell sib

(Wheeler et al., 2006)

embryonic stage 14

neuron

(Lloyd and Sakonju, 1991)

larval stage

wing disc

(Organista et al., 2015)

wandering third instar larval stage

wing pouch | restricted

(Klebes et al., 2005)

Additional Descriptive Data

Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.

(Wheeler et al., 2006)

pdm2 transcript is expressed in cells surrounding the wing pouch, with higher expression levels observed in the anterior compartment. Expression is undetectable in the leg discs.

(Klebes et al., 2005)

In cellular blastoderm stage embryos, pdm2 is expressed in a broad band from 20-40% egg length and at the dorsal tip of the embryo. This pattern is replace by a complicated pattern of stripes. After gastrulation, 14 stripes are observed, one per parasegment. In later embryos, expression is seen in a resticted set of cells in the CNS. Maximum levels of pdm2 RNA are observed between 4 and 12 hours of embryonic development on northern blots.

(Prakash et al., 1992)

pdm2 transcripts are detected predominantly in 3-6 hr embryo RNA. They are expressed in the blastoderm embryo in a band of staining from 25-50% egg length and in an anterior cap. During gastrulation, a striped pattern is observed. Later pdm2 expression is observed in discrete subsets of neuroblasts in the developing CNS, in the brain, and in the hindgut.

(Billin et al., 1991)

pdm2 transcripts are first expressed in the cellular blastoderm stage in two broad stripes in the posterior half of the embryo. These develop into a complicated pattern of stripes. Expression is later seen along the neurectoderm and in a restricted set of cells of the CNS and PNS. Expression in the head region occurs in the optic lobe primordium, brain primordia, clypeolabrum, epiphysis, labral sense organ, and in the ventral ectodermal regions of the labial, maxillary, and mandibullary buds. pdm2 transcripts are present at maximal levels in 0-12 hr embryos and at much reduced levels at later stages.

(Dick et al., 1991)

pdm2 transcripts are expressed at high levels during the first 12 hours of embryogenesis and in 2nd instar larvae and are detectable in other stages at reduced levels. pdm2 expression is initially seen at the cellular blastoderm stage in two bands in parasegments 7 and 11. During gastrulation, expression is seen in an odd pair-rule pattern which later becomes a segment polarity pattern with alternating wide and narrow stripes. At stage 10, expression is seen in the neurogenic region with the exception of the midline. In germband extended embryos, expression is seen in selected neurons and their support cells. Expression is also seen in some lateral and dorsal clusters of PNS cells, in the ligament cells of the chordotonal organs, and in two types of neurons (bipolar dendrite neurons and dendritic arbor cells).

(Lloyd and Sakonju, 1991)

Marker for

larval H-cell

(Stagg et al., 2011)

larval H-cell sib

(Stagg et al., 2011)

larval MP1 neuron

(Stagg et al., 2011)

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11

ganglion mother cell GMC4-2a

(Yeo et al., 1995)

neuroblast NB3-3

(Tsuji et al., 2008)

Additional Descriptive Data

pdm2 is expressed in early stages of the developing CNS in a highly dynamic pattern that includes roughly half of the neuroblasts and several ganglion mother cells. Here, nub and pdm2 are shown to be coexpressed in GMC4-2a but not in its progenitor neuroblast or its mature progeny.

(Yeo et al., 1995)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from mutant phenotype

(Prakash et al., 1992)

Expression Deduced from Reporters

Reporter: P{GMR11F02-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15 -- larval stage

larval EL neuron

(Marshall and Heckscher, 2022)

larval stage

dorsal organ cool cell

(Knecht et al., 2016, Ni et al., 2016)

larval brain | restricted

(Ni et al., 2016)

larval ventral nerve cord | restricted

(Ni et al., 2016)

terminal organ | restricted

(Ni et al., 2016)

sensory neuron | subset

(Ni et al., 2016)

third instar larval stage

wing pouch

(Obata et al., 2014)

haltere disc

(Obata et al., 2014)

P-stage

wing

(Obata et al., 2014)

haltere

(Obata et al., 2014)

leg | restricted

(Obata et al., 2014)

adult stage

vest | intense | restricted

(Jenett and Svirskas, 2012.9.24)

adult antennal lobe | intense | restricted

(Jenett and Svirskas, 2012.9.24)

neuron of aristal sensillum

(Li et al., 2022)

adult stage | male

testis

(Obata et al., 2014)

Reporter: P{GMR11G05-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 16

embryonic head

(Manning et al., 2012)

neuron

(Manning et al., 2012)

embryonic stage 16

embryonic/larval hypodermal muscle cell

(Manning et al., 2012)

embryonic midline of ventral nerve cord

(Manning et al., 2012)

larval brain

(Manning et al., 2012)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\pdm2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\pdm2

View exonic expression by tissue for Dmel\pdm2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004394

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34673/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004394

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004394

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004394

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12287

Flygut - An atlas of the Drosophila adult midgut

FBgn0004394

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\pdm2

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 16 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of pdm2

Transgenic constructs containing regulatory region of pdm2

Aberrations (Deficiencies and Duplications) ( 11 )

Inferred from experimentation ( 11 )

Gene disrupted in

Df(2L)Exel6034

(Ryder, 2004.4.26)

Df(2L)GR4

(Brewster et al., 2001, Yeo et al., 1995)

Df(2L)pdm2^GR19

(Yeo et al., 1995)

Df(2L)pdm-2^PR6

(Yeo et al., 1995)

Df(2L)prd1.7

(Yeo et al., 1995, Bhat and Schedl, 1994)

Gene duplicated in

Dp(2;2)GYL

(Bhat and Schedl, 1994)

Gene not disrupted in

Df(2L)Prl

(Yeo et al., 1995, Bhat and Schedl, 1994)

Gene partially disrupted in

Df(2L)CRIMIC-CR70869

(Gene Disruption Project members, 2018-)

Df(2L)nub¹

(Loker and Mann, 2022)

Df(2L)nub-NPW-large

(Loker and Mann, 2022)

Df(2L)nub-NPW-small

(Loker and Mann, 2022)

Inferred from location ( 12 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

pdm2^Δmiti.Hsp83

lethal | heat sensitive

pdm2^Δmiti.hs

lethal | male limited, with Scer\GAL4^Bx-MS1096

pdm2^{UAS.ORF.GW.Tag:HA}

lethal | male limited | cold sensitive, with Scer\GAL4^Bx-MS1096

pdm2^{UAS.ORF.GW.Tag:HA}

partially lethal | female limited, with Scer\GAL4^Bx-MS1096

pdm2^{UAS.ORF.GW.Tag:HA}

partially lethal | female limited | cold sensitive, with Scer\GAL4^Bx-MS1096

pdm2^{UAS.ORF.GW.Tag:HA}

viable

pdm2^d09994

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

pdm2^GD5046

viable, with Scer\GAL4^Mef2.PR

pdm2^GD5046

viable, with Scer\GAL4^pnr-MD237

pdm2^GD5046

viable, with Scer\GAL4^tin.CΔ4

pdm2^GD5046

Sterility

Allele

fertile

pdm2^d09994

Other Phenotypes

Allele

abnormal neuroanatomy | embryonic stage

pdm2^UAS.Tag:HA

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^pros.PMG

pdm2^UAS.Tag:HA

Phenotype manifest in

Allele

embryonic abdominal segment 2

pdm2^Δmiti.Hsp83

embryonic abdominal segment 2 | heat sensitive

pdm2^Δmiti.hs

embryonic abdominal segment 6 | heat sensitive

pdm2^Δmiti.hs

embryonic ganglion mother cell | ectopic

pdm2^hs.P

ganglion mother cell

pdm2^Δmiti.Hsp83

ganglion mother cell | heat sensitive

pdm2^Δmiti.hs

ganglion mother cell GMC4-2a

pdm2^E46

larval abdominal segment 1

pdm2^hs.PC

larval abdominal segment 2

pdm2^hs.PC

larval abdominal segment 3

pdm2^hs.PC

larval DA2 motor neuron, with Scer\GAL4^en-e16E

pdm2^UAS.Tag:HA

larval DA3 motor neuron, with Scer\GAL4^en-e16E

pdm2^UAS.Tag:HA

larval head

pdm2^hs.PC

larval LL1 motor neuron | increased number, with Scer\GAL4^en-e16E

pdm2^UAS.Tag:HA

larval LL1 motor neuron | increased number, with Scer\GAL4^pros.PMG

pdm2^UAS.Tag:HA

larval RP2 motor neuron

larval RP2 motor neuron | ectopic

pdm2^hs.P

larval RP2 motor neuron | heat sensitive

pdm2^Δmiti.hs

neuroblast NB3-3 | embryonic stage

pdm2^UAS.Tag:HA

neuroblast NB4-2

pdm2^hs.P

RP2sib neuron

pdm2^Δmiti.Hsp83

RP2sib neuron | heat sensitive

pdm2^Δmiti.hs

wing | female limited, with Scer\GAL4^Bx-MS1096

pdm2^{UAS.ORF.GW.Tag:HA}

wing | female limited | cold sensitive, with Scer\GAL4^Bx-MS1096

pdm2^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (61)

Hsap\POU2F2

6 of 14

Yes

Hsap\POU2F3

6 of 14

Yes

5 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\DBX2

1 of 14

Hsap\DLX3

1 of 14

Hsap\DUXA

1 of 14

Yes

Hsap\ESX1

1 of 14

Hsap\GBX2

1 of 14

Hsap\HDX

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (32)

Rnor\Pou2f3

6 of 14

Yes

4 of 14

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Gbx2

1 of 14

Rnor\Hdx

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (37)

Mmus\Pou2f3

6 of 14

Yes

5 of 14

4 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Hdx

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (53)

Xtro\pou2f2

5 of 13

Yes

Xtro\pou2f1

4 of 13

Xtro\pou2f3

4 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (42)

Drer\pou2f3

5 of 14

Yes

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\pou6f2

1 of 14

Drer\rx1

1 of 14

Drer\rx2

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\ceh-18

3 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (20)

Agam\AgaP_AGAP009500

5 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PHO2

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:pdm2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (22)

nub

7 of 13

acj6

4 of 13

vvl

4 of 13

pdm3

3 of 13

Antp

1 of 13

Awh

1 of 13

B-H1

1 of 13

C15

1 of 13

Drgx

1 of 13

ems

1 of 13

eve

1 of 13

exd

1 of 13

gsb

1 of 13

hbn

1 of 13

HHEX

1 of 13

Lim1

1 of 13

lms

1 of 13

Lmx1a

1 of 13

Ptx1

1 of 13

tin

1 of 13

toe

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

pdm2^KK110854

exacerbates atypical teratoid rhabdoid tumor

modeled by Snr1^KK101602

(Tegeder et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

POU2F2; POU class 2 homeobox 2

6 of 14

164176

POU2F3; POU class 2 homeobox 3

6 of 14

607394

POU2F1; POU class 2 homeobox 1

5 of 14

164175

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

pdm2 - CG1233

two hybrid array

(Shokri et al., 2019)

pdm2 - CG14441

two hybrid array

(Shokri et al., 2019)

pdm2 - CG8319

two hybrid array

(Shokri et al., 2019)

(Ma et al., 2000)

(Shokri et al., 2019)

pdm2 - Sox102F

two hybrid array

(Shokri et al., 2019)

pdm2 - ara

two hybrid array

(Shokri et al., 2019)

pdm2 - fd3F

two hybrid array

(Shokri et al., 2019)

pdm2 - nub

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

pdm2

enhanceable

insc

(Bhat and Apsel, 2004)

pdm2

suppressible

numb

(Bhat and Apsel, 2004)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

pdm2

(Tran et al., 2010)

Snr1

suppressible

pdm2

(Tegeder et al., 2019)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60717

DroID - A comprehensive database of gene and protein interactions.

FBgn0004394

MIST (protein-protein) - An integrated Molecular Interaction Database

34673

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-47

Cytogenetic map

33F2-33F3

Sequence location

2L:12,657,165..12,686,306 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

33F2-33F3

Limits computationally determined from genome sequence between P{lacW}bun^k00612&P{EP}EP682^EP682 and P{lacW}l(2)k07015^k07015&P{PZ}l(2)rK639^rK639

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

33F-33F

(determined by in situ hybridisation)

(Prakash et al., 1992, Billin et al., 1991, Dick et al., 1991)

33F1-33F2

(determined by in situ hybridisation)

(Lloyd and Sakonju, 1991)

Experimentally Determined Recombination Data

Location

2-47

(FlyBase, 2016)

2-42.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (100)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

8855

pdm2^E46/CyO

Korea

12579

P{VT006477-GAL4}attP2

12845

P{VT006474-GAL4}attP2

13245

P{VT006486-GAL4}attP2

13368

P{VT006460-GAL4}attP2

14915

P{VT006480-GAL4}attP2

15002

P{VT006483-GAL4}attP2

16376

P{GMR11F02-lexA}JK66B

17613

P{GMR11F02-lexA}attP2

17614

P{GMR11F02-lexA}JK73A

16255

P{GMR11F05-lexA}attP40

VDRC

v102126

P{KK110854}VIE-260B

More stocks available...

Genomic Clones (29)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (15)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI17318

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004394

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RE51329

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004394

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

nub/pdm2 and cas regulate late-born motor neuron identity within the NB7-1 lineage; nub/pdm2 specifies fourth-born U4 motor neuron identity, while nub/pdm2/cas together specify fifth-born U5 motor neuron identity.

(Grosskortenhaus et al., 2006)

Virtually all aspects of pdm2 RNA expression are conserved between D.melanogaster and D.virilis.

(Poole, 1995)

nub and pdm2 both contribute toward the development of a full complement of mature RP2 neurons by being expressed in and acting on ganglion mother cell 2a (GMC-2a), the RP2 progenitor cell. nub plays a quantitatively less important role than pdm2. nub and pdm2 act to specify GMC-2a cell identity and not merely act to positively regulate GMC-2a cell division. Within the hierarchy of genes expressed in GMC4-2a nub and pdm2 lie downstream of pros and ftz and upstream of eve.

(Yeo et al., 1995)

pdm2 is required for segmentation and neurogenesis.

(Bhat and Schedl, 1994)

The genomic organisation and early embryonic expression pattern of pdm2 has been determined.

(Cockerill et al., 1993)

The pdm2 gene product specifies the cell fate of GMC-1 in the NB4-2 lineage. Its ectopic expression in the two progeny cells of GMC-1 is sufficient to cause both the cells to adopt a GMC-1 cell identity.

(Yang et al., 1993)

pdm2 is transcribed in elements of the developing nervous system suggesting a functional role in neurogenesis and neurospecification.

(Dick et al., 1992)

pdm2 has been cloned and its spatial expression patterns characterized. pdm2 belongs to the class II type of POU genes. The pdm2 gene product is an octamer-dependent transcription factor that is capable of activating transcription in yeast.

(Prakash et al., 1992)

pdm2 contains a POU domain, and is expressed at maximum levels during early development.

(Billin et al., 1991)

The cDNA sequences of pdm2 and nub and their developmental expression patterns have been determined.

(Dick et al., 1991)

The spatial expression pattern of pdm2 has been characterized.

(Lloyd and Sakonju, 1991)

Relationship to Other Genes

Source for database merge of

Source for merge of: pdm2 CG15486 CG15487

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG12287, CG15486 and CG15487 merged as CG12287 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (24)

Reported As

Symbol Synonym

CG12287

(National Institute of Genetics Fly Stocks, 2022-, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Macdonald and Long, 2006, Klebes et al., 2005, Kreiman, 2004)

CG15486

(Manning et al., 2012)

CG15487

Miti

(Tang and Engström, 2019)

Oct-2

(Malin et al., 2005)

Oct2

(Malin et al., 2005)

POU domain protein 2

(Edwards et al., 2006)

Pdm

(Ray et al., 2022, Lopes et al., 2020, Doe, 2017, Sousa-Nunes et al., 2010, Grosskortenhaus et al., 2006)

Pdm-2

(Ma et al., 2000, Brody and Odenwald, 1999, Brody and Odenwald, 1999, Brody and Odnewald, 1999, Odenwald et al., 1999, Nakagoshi et al., 1998)

dOct2

(Prakash et al., 1992)

dPOU-28

(Goodman and Doe, 1993, Cabrera, 1992, Dick et al., 1991)

dPOU28

(Yeo et al., 1995, Yang et al., 1993, Dick et al., 1992)

dPOU28/pdm-2

(Jimenez and Modolell, 1993, Yang et al., 1993, Yang et al., 1993)

dim

(Prakash et al., 1992)

dpou28

(Jan and Jan, 1994)

miti

(Bhat and Apsel, 2004, Mehta and Bhat, 2001, Bhat et al., 1995, Bhat and Schedl, 1994, Bhat and Schedl, 1993)

pdm

(Myasnikova and Spirov, 2020, Nakajima et al., 2010, Tsuji et al., 2008, Tran and Doe, 2007, Grosskortenhaus et al., 2005, Odenwald, 2005, Rougvie, 2005, Abbott, 2003, Kanai et al., 2003, Pearson and Doe, 2003, Bellaiche and Schweisguth, 2001, Harris, 2001)

pdm2

(Huang and Calvi, 2025, Corthals et al., 2023, Josserand et al., 2023, Deshpande et al., 2022, Fox et al., 2022, Loker and Mann, 2022, National Institute of Genetics Fly Stocks, 2022-, Velten et al., 2022, Ma et al., 2021, Díaz-de-la-Peña et al., 2020, Oberst et al., 2019, Sapar and Han, 2019, Shokri et al., 2019, Tegeder et al., 2019, Bischof et al., 2018, Tian et al., 2017, Transgenic RNAi Project members, 2017-, Bürglin and Affolter, 2016, Duque and Sinha, 2015, Organista et al., 2015, Schertel et al., 2015, Ghavi-Helm et al., 2014, Neville et al., 2014, Aleksic et al., 2013, Kao et al., 2012, Manning et al., 2012, Nikulova et al., 2012, Sorge et al., 2012, Yuan et al., 2012, Stagg et al., 2011, Turchyn et al., 2011, Kazemian et al., 2010, Tran et al., 2010, Gaziova and Bhat, 2009, Segal et al., 2008, Tran and Doe, 2008, Wheeler et al., 2008, Yu and Small, 2008, Hooper et al., 2007, Junell et al., 2007, Tomancak et al., 2007, Grosskortenhaus et al., 2006, Jacobsen et al., 2006, Macdonald and Long, 2006, Wheeler et al., 2006, Berman et al., 2004, Kreiman, 2004)

Name Synonyms

Miti-mere

(Bhat and Schedl, 1993)

POU domain prot 2

(Carpenter et al., 2009)

POU domain protein 2

(Homem and Knoblich, 2012, Yu and Small, 2008, Edwards et al., 2006, Macdonald and Long, 2006, Wheeler et al., 2006, Berman et al., 2004)

didymous

miti-mere

(Odenwald et al., 1996, Bhat and Schedl, 1994)

Secondary FlyBase IDs

FBgn0032441
FBgn0032443

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 63 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34673

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VK71

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2J9L4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VK71

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004394

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34673/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004394

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004394

FlyMine - An integrated database for Drosophila genomics

FBgn0004394

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG12287

MARRVEL_MODEL - MARRVEL (model organism gene)

34673

Linkouts

BioGRID - A database of protein and genetic interactions.

60717

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004394

DroID - A comprehensive database of gene and protein interactions.

FBgn0004394

DRSC - Results frm RNAi screens

FBgn0004394

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004394

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004394

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12287

Flygut - An atlas of the Drosophila adult midgut

FBgn0004394

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004394

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

34673

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (217)

The following external sites may use different assemblies or annotations than FlyBase.

-0.77

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