FlyBase Gene Report: Dmel\hb

central brain anlage in statu nascendi

(Zhao et al., 2002)

embryonic stage 4 -- 6

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

foregut anlage in statu nascendi

(Fisher et al., 2012)

hindgut anlage in statu nascendi

(Fisher et al., 2012)

mesectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic cycle 11 -- embryonic cycle 13

Comment: 55-100% egg length

(Tautz et al., 1987)

embryonic cycle 13

organism | 0-30% egg length

Comment: 0-25% egg length

(Tautz et al., 1987)

embryonic stage 5

dorsal head epidermis anlage

(Margolis et al., 1995)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic cycle 14

organism | 50-90% egg length

Comment: 55-90% egg length

(Tautz et al., 1987)

organism | 10-30% egg length

Comment: 10-25% egg length

(Tautz et al., 1987)

dorsal head epidermis primordium

(Hirono et al., 2012)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 9 -- 17

presumptive embryonic/larval central nervous system

(Tautz et al., 1987)

(Hirono et al., 2012)

(Hirono et al., 2012)

(Niessing et al., 1999)

embryonic central brain glial cell

(Niessing et al., 1999)

organism | 0-20% egg length

(Niessing et al., 1999)

organism | posterior

(Niessing et al., 1999)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic neuroblast of ventral nerve cord primordium

(Fisher et al., 2012)

larval lateral VNC glial cell

(Fisher et al., 2012)

procephalic neuroblast

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 14

(Wolf and Schuh, 2000)

embryonic stage 12

larval ventral nerve cord

(Wolf et al., 2002)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

(Fisher et al., 2012)

(Hirono et al., 2012)

adult stage oogenesis stage S7 -- S11

nurse cell

(Margolis et al., 1994)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 12

Comment: reference states 0-8 hr AEL

(Tautz et al., 1987)

embryonic stage 5 -- 11

Comment: reference states 2-6 hr AEL

(Tautz et al., 1987)

adult stage | female

(Tautz et al., 1987)

Additional Descriptive Data

hb RNA and protein levels are time course were compared for the formation of the parasegment 4 stripe. The stripe is formed very quickly at the RNA level and is delayed and takes 5 times longer at the protein level. hb RNA and protein accumulation do not follow the same time course in the anterior and posterior domains.

(Surkova et al., 2019)

hb-RNA is detected in neuroblasts at embryonic stages 9 and 10. At embryonic stage 11 labeling is seen in ganglion mother cells. At embryonic stage 16 hb-RNA labels early-born neurons in the deepest layers of the embryonic CNS.

(Hirono et al., 2012)

hb-RB transcript is not expressed until late in embryonic cycle 14, when the hb expression pattern has been refined to two stripes.

(Margolis et al., 1995)

hb transcripts are produced only by the germline-derived nurse cells. Transcripts are first detected at stage 7, increase dramatically in stages 8 and 9 and are no longer detectable by stage 12.

(Margolis et al., 1994)

The hb transcript is expressed in the early embryo in two domains, an anterior domain which spans from the anterior tip to %50 egg length and posterior domain which spans from 90% egg length to the posterior tip.

(Boring et al., 1993)

The hb transcript is expressed in two broad regions in the cellular blastoderm, one which covers up to 50% egg length from the anterior and one which covers up to 20% egg length from the posterior.

(Ronchi et al., 1993)

The 3.0kb and 3.2kb hb transcripts accumulate to their highest levels over the first 8 hours of embryogenesis. They are also present in adult females and males with higher levels in females. In situ hybridization shows that the hb gene is first expressed uniformly over the embryo. In syncytial blastoderm embryos, expression is seen in a broad anterior stripe (50-100% EL) and a narrower posterior signal (0-15% EL). In late stage 4 embryos the anterior hb stripe weakens and narrows to two broad stripes. These are gone by the extended germ band stage when ventral hypoderm expression is seen.

(Bender et al., 1988)

The 2.8kb and 2.6kb hb transcripts are expressed only during first 6 hours of embryogenesis with a peak at 2-4 hrs. In situ hybridization shows that the hb gene is first expressed uniformly over the embryo. In syncytial blastoderm embryos, expression is seen in a broad anterior stripe (50-100% EL) and a narrower posterior signal (0-15% EL). In late stage 4 embryos the anterior hb stripe weakens and narrows to two broad stripes. These are gone by the extended germ band stage when ventral hypoderm expression is seen.

(Bender et al., 1988)

2.9kb hb transcripts are first detected at nuclear cycle 11-12 in the anterior half of the embryos and in the yolk nuclei in that region. Transcripts disappear at the beginning of gastrulation.

(Schroder et al., 1988)

The 3.2kb hb transcripts are homogenously distributed in early embryos, then form an anterior-posterior gradient and are gone before the blastoderm stage. They appear again at nuclear cycle 13-14, where they form an anterior stripe at ~53% egg length and a posterior stripe. They are also expressed in the anterior yolk nuclei. The anterior stripe is in the region of the 2nd thoracic segment on the fate map and the posterior stripe is in the region of abdominal segments 7 and 8. The 3.2kb transcript persists throughout germ band extension.

(Schroder et al., 1988)

The 2.9kb hb transcript is detected between 2 and 6 hours of embryonic development.

(Tautz et al., 1987)

The 3.2kb hb transcript is present in maternal RNA and continues to be present for the first 8 hours of embryonic development. It is also detected in adult females.

(Tautz et al., 1987)

Marker for

organism | anterior posterior gradient

(Wolf and Schuh, 2000)

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

neuroblast

(Cabrera and Alonso, 1991)

oogenesis

(Lehmann and Nusslein-Volhard, 1987)

distribution deduced from reporter

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10 -- 11

neuroblast MP2

(Kim et al., 2007)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic cycle 8 -- embryonic cycle 9

(Barker et al., 1992)

blastoderm stage

organism | posterior

(Gavis and Lehmann, 1992)

(Struhl et al., 1989)

(Struhl et al., 1989)

embryonic stage 4 -- 5

• nucleus

(Small et al., 1991)

organism | 10-20% egg length

(Perkins et al., 1992)

embryonic stage 5

(Langeland et al., 1994, Stanojevic et al., 1989)

embryonic stage 5 -- 6

thoracic neuroblast NB5-6

(Schroder et al., 1988)

embryonic stage 8 -- 10

(Karlsson et al., 2010)

abdominal neuroblast NB5-6

(Karlsson et al., 2010)

embryonic cycle 14

organism | 0-50% egg length

(Janssens et al., 2013)

protocerebral neuroblast | subset

ganglion mother cell

(Karlsson et al., 2010)

embryonic stage 9 -- 11

(Urbach and Technau, 2003)

tritocerebral neuroblast | subset

(Urbach and Technau, 2003)

deutocerebral neuroblast | subset

(Urbach and Technau, 2003)

neuroblast of ventral nervous system

(Chang et al., 2000)

larval MP1 neuron

(Wheeler et al., 2006)

embryonic stage 11 -- 14

• nucleus

(Wolf and Schuh, 2000)

embryonic stage 13

larval MP1 neuron

(Wheeler et al., 2006)

embryonic stage 15 -- 17

EW1 neuron

(Lundell et al., 2003)

embryonic GW neuron

(Lundell et al., 2003)

larval ventral nerve cord

(Hirono et al., 2012)

larval DO1 motor neuron

(Touma et al., 2012)

larval DO2 motor neuron

(Touma et al., 2012)

embryonic stage 17

midline glial cell

(Wheeler et al., 2006)

embryonic GW neuron

(Karcavich and Doe, 2005)

EW1 neuron

(Karcavich and Doe, 2005)

pupal stage | male

brain

(Goto et al., 2011)

pupal stage P6 | male

(Goto et al., 2011)

immunoprecipitation

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 7 -- 9

• nucleus

(Stivers et al., 2000)

embryonic/larval plasmatocyte

• nucleus

(Stivers et al., 2000)

• nucleus

(Stivers et al., 2000)

Additional Descriptive Data

(Surkova et al., 2019)

At embryonic stage 16 both hb-protein is detected in early-born neurons in the deepest layers of the embryonic CNS.

(Hirono et al., 2012)

hb protein is detected in neurons of the male pupal brain and in the ventral nerve cord. A subset of neurons that express hb protein also express fru protein, and a subset of the latter are labelled by ScerGAL4^fru-NP0021.

(Goto et al., 2011)

Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.

(Wheeler et al., 2006)

Markers that uniquely identify the cells of the NB3-7 lineage were used to examine the serotonin expressing cell lineages.

(Lundell et al., 2003)

Expression in procephalic neuroblasts stage 9-11: tritocerebrum - d3-7, v2; deuterocerebrum - d1, d13, v3, v4,v6; protocerebrum - ad1, ad3, ad4, ad14-15, ad17, av1, cd2, cd6, cd 7, cd13, cd18, cd19, cd21, cv1, cv3, cv6-9, pd3, pd15, pv2

(Urbach and Technau, 2003)

In blastoderm embryos, the anterior domain of hb protein expression extends to the posterior border of eve stripe 3, while the posterior domain of hb expression overlaps eve stripe 7.

(Small et al., 1991)

Marker for

(Wolf and Schuh, 2000)

larval DO1 motor neuron

(Touma et al., 2012)

larval DO2 motor neuron

(Touma et al., 2012)

neuroblast MP2

(Kim et al., 2007)

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from high throughput direct assay

(Sarov et al., 2016)

Expression Deduced from Reporters

Reporter: P{hb0.7-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5 -- 6

(Schroder et al., 1988)

Reporter: P{hb1.2-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5 -- 6

(Schroder et al., 1988)

mesoderm

(Schroder et al., 1988)

Reporter: P{HB123}

Stage

Tissue/Position (including subcellular localization)

Reference

(Struhl et al., 1989)

(Struhl et al., 1989)

Reporter: P{HB123x2}

Stage

Tissue/Position (including subcellular localization)

Reference

(Struhl et al., 1989)

(Struhl et al., 1989)

Reporter: P{HB263}

Stage

Tissue/Position (including subcellular localization)

Reference

(Struhl et al., 1989)

(Struhl et al., 1989)

Reporter: P{HB747}

Stage

Tissue/Position (including subcellular localization)

Reference

Comment: reference states 55-100% egg length

(Struhl et al., 1989)

(Struhl et al., 1989)

Reporter: P{hb-GFP.HG4-1}

Stage

Tissue/Position (including subcellular localization)

Reference

(Hirono et al., 2012)

(Hirono et al., 2012)

neuroblast of ventral nervous system | subset

(Hirono et al., 2012)

(Hirono et al., 2012)

(Hirono et al., 2012)

Reporter: P{hb-GFP.HG4-2}

Stage

Tissue/Position (including subcellular localization)

Reference

(Hirono et al., 2012)

(Hirono et al., 2012)

Reporter: P{hb-GFP.HG4-3}

Stage

Tissue/Position (including subcellular localization)

Reference

(Hirono et al., 2012)

(Hirono et al., 2012)

neuroblast of ventral nervous system | restricted

(Hirono et al., 2012)

(Hirono et al., 2012)

(Hirono et al., 2012)

Reporter: P{hb-GFP.HG4-7}

Stage

Tissue/Position (including subcellular localization)

Reference

(Hirono et al., 2012)

(Hirono et al., 2012)

neuroblast of ventral nervous system | subset

(Hirono et al., 2012)

(Hirono et al., 2012)

(Hirono et al., 2012)

Reporter: P{HB-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

blastoderm stage

(Struhl et al., 1989)

Reporter: P{HG4-5-GFP}

Stage

Tissue/Position (including subcellular localization)

Reference

(Hirono et al., 2012)

(Hirono et al., 2012)

Reporter: P{Thb1-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

(Driever et al., 1989)

Reporter: P{Thb2-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

(Driever et al., 1989)

Reporter: P{Thb3-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

(Driever et al., 1989)

Reporter: P{Thb5-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

(Driever et al., 1989)

Reporter: P{Thb6-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

(Driever et al., 1989)

Reporter: P{Thb7-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

(Driever et al., 1989)

Reporter: P{Thb8-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

(Driever et al., 1989)

(Driever et al., 1989)

Reporter: P{Thb9-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

(Driever et al., 1989)

Reporter: P{Thb10-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

(Driever et al., 1989)

Reporter: P{Thb11-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

(Driever et al., 1989)

Reporter: P{Thb15-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

(Driever et al., 1989)

Reporter: P{Thb16-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

View exonic expression by developmental stage for Dmel\hb

(Driever et al., 1989)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\hb in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by tissue for Dmel\hb

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0001180

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41032/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0001180

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0001180

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0001180

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9786

Flygut - An atlas of the Drosophila adult midgut

FBgn0001180

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\hb

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 62 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 96 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of hb

Transgenic constructs containing regulatory region of hb

Aberrations (Deficiencies and Duplications) ( 48 )

Inferred from experimentation ( 48 )

Gene disrupted in

Df(3R)Antp^Ctx

(Jurgens et al., 1984)

Df(3R)BSC197

(Gresens and Cook, 2006.8.29)

Df(3R)BSC466

(Christensen et al., 2008.4.15)

Df(3R)BSC477

(Christensen et al., 2008.4.15)

Df(3R)BSC478

(Christensen et al., 2008.4.15)

Df(3R)CA4B

(Jones and Rawls, 1988)

Df(3R)Exel6150

(Ryder, 2004.4.26)

Df(3R)Exel8143

(Ryder, 2004.4.26)

Df(3R)FA11

(Muller et al., 1999, Jurgens et al., 1984)

Df(3R)G63

(Muller et al., 1999)

Df(3R)p13

(Bender et al., 1988, Tautz et al., 1987)

Df(3R)p25

(Bender et al., 1988, Jones and Rawls, 1988, Bender et al., 1987, Riley et al., 1987, Carroll and Scott, 1986)

Df(3R)p712

(Harbecke and Lengyel, 1995)

Df(3R)p819

(Harbecke and Lengyel, 1995)

Df(3R)p-XM66

(Tearle and Nusslein-Volhard, 1987, Jurgens et al., 1984)

Df(3R)p-XT9

(Lehmann and Nusslein-Volhard, 1987)

Df(3R)p-XT15

(Goto et al., 1989, Lehmann and Nusslein-Volhard, 1987)

Df(3R)p-XT26

(Lehmann and Nusslein-Volhard, 1987)

Df(3R)p-XT27

(Lehmann and Nusslein-Volhard, 1987)

Df(3R)p-XT103

(Lehmann and Nusslein-Volhard, 1987)

Df(3R)p-XT104

(Tremml and Bienz, 1989, Lehmann and Nusslein-Volhard, 1987, Tautz et al., 1987)

Df(3R)p-XT115

(Struhl et al., 1989)

Df(3R)p-XT118

(Tearle and Nusslein-Volhard, 1987, Jurgens et al., 1984)

Df(3R)V1

(Jones and Rawls, 1988)

Df(3R)V5

(Jones and Rawls, 1988)

In(3R)hb^bs23

(Bender et al., 1988)

In(3R)hb^D1

(Bender et al., 1987, Carroll and Scott, 1986)

Ts(2Rt;3Lt)p^XT126+Ts(YSt;3Rt)R36

(Lehmann and Nusslein-Volhard, 1987)

Gene not disrupted in

Df(3R)CA1

(Jones and Rawls, 1988)

Df(3R)CA3

(Jones and Rawls, 1988, Bender et al., 1987)

Df(3R)D6

(Bender et al., 1987)

Df(3R)D8

(Jones and Rawls, 1988)

Df(3R)Dhod15

(Bender et al., 1987)

Df(3R)dsx11

(Jones and Rawls, 1988)

Df(3R)G1

(Bender et al., 1988, Jones and Rawls, 1988, Bender et al., 1987)

Df(3R)p5

(Jones and Rawls, 1988)

Df(3R)p7

(Bender et al., 1987)

Df(3R)p16

(Jones and Rawls, 1988, Bender et al., 1987)

Df(3R)p17

(Bender et al., 1987)

Df(3R)p19

(Jones and Rawls, 1988, Bender et al., 1987)

Df(3R)p-XT118

(Lehmann and Nusslein-Volhard, 1987)

Df(3R)V2

(Jones and Rawls, 1988)

In(3R)hb^D1

(Bender et al., 1988)

T(1;3)FA62

(Lehmann and Nusslein-Volhard, 1987)

T(2;3)FC9

(Lehmann and Nusslein-Volhard, 1987)

T(2;3)FC10

(Lehmann and Nusslein-Volhard, 1987)

T(Y;3)MA9

(Lehmann and Nusslein-Volhard, 1987)

Tp(3;1)FA11

(Lehmann and Nusslein-Volhard, 1987)

Tp(3;1)FC8

(Lehmann and Nusslein-Volhard, 1987)

Gene not duplicated in

Dp(3;Y)P92

(Lehmann and Nusslein-Volhard, 1987)

Inferred from location ( 10 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | embryonic stage | homeotic | recessive

hb^D2

lethal | embryonic stage | recessive

hb^D2

lethal | female

hb^Sxl.Pe

lethal | maternal effect | heat sensitive

hb^ts1

lethal | recessive

hb^D1

lethal - all die before end of larval stage, with Scer\GAL4^eg-Mz360

hb^UAS.cWa

lethal - all die before end of larval stage | dominant | maternal effect

hb^G1-3U

lethal - all die before end of pupal stage, with Scer\GAL4^hkb.PU

hb^UAS.cWa

lethal - all die during embryonic stage | dominant | maternal effect

lethal - all die during embryonic stage | maternal effect

lethal - all die during embryonic stage | recessive, with Scer\GAL4^{GCN4.nanos.bcd3'UTR}

hb^UAS.cWa

partially lethal - majority die, with Scer\GAL4^pnr-MD237

hb^GD1460

partially lethal - majority die | maternal effect

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

hb^GD1460

viable, with Scer\GAL4^Mef2.PR

hb^GD1460

viable, with Scer\GAL4^tin.CΔ4

hb^GD1460

Sterility

Allele

fertile

hb^f00586

Other Phenotypes

Allele

abnormal cell number | larval stage, with Scer\GAL4^eg-Mz360

hb^UAS.cWa

abnormal cell number | larval stage, with Scer\GAL4^elav-C155

hb^UAS.cWa

abnormal neuroanatomy

hb^UAS.cWa

abnormal neuroanatomy, with Scer\GAL4^en-e16E

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb¹⁵, hb^P1only

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb¹⁵, hb^UAS.cWa

hb^P1only

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb¹⁵, hb^UAS.VP16

hb^P1only

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb^P1only, hb^UAS.cWa

hb¹⁵

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb^P1only, hb^UAS.VP16

hb¹⁵

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb^{ΔAB.VP16.UAS}, hb¹⁵

hb^P1only

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb^{ΔAB.VP16.UAS}, hb^P1only

hb¹⁵

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb^ΔB.VP16.UAS, hb¹⁵

hb^P1only

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb^ΔB.VP16.UAS, hb^P1only

hb¹⁵

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb^ΔD.VP16.UAS, hb¹⁵

hb^P1only

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb^ΔD.VP16.UAS, hb^P1only

hb¹⁵

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb^{ΔDMZ.VP16.UAS}, hb¹⁵

hb^P1only

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb^{ΔDMZ.VP16.UAS}, hb^P1only

hb¹⁵

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb^ΔE.VP16.UAS, hb¹⁵

hb^P1only

abnormal neuroanatomy, with Scer\GAL4^en-e16E, hb^ΔE.VP16.UAS, hb^P1only

hb¹⁵

abnormal neuroanatomy, with Scer\GAL4^GMR75C02

hb^HMS01183

abnormal neuroanatomy, with Scer\GAL4^NP0021

hb^JF03309

abnormal neuroanatomy, with Scer\GAL4^pros.PMG

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^en-e16E

hb^UAS.cWa

abnormal neuroanatomy | first instar larval stage, with Hsim\VP16^AD.ac, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

hb^UAS.cWa

abnormal neuroanatomy | heat sensitive

hb^hs.PS

abnormal neuroanatomy | heat sensitive, with Scer\GAL4^pros.PMG

hb^UAS.cWa

decreased occurrence of cell division | embryonic stage 13, with hb¹⁵

hb^P1only

decreased occurrence of cell division | embryonic stage 13, with hb^P1only

hb¹⁵

decreased occurrence of cell division | embryonic stage 14, with hb¹⁵

hb^P1only

decreased occurrence of cell division | embryonic stage 14, with hb^P1only

hb¹⁵

embryonic/larval segmentation phenotype

gap phenotype | embryonic stage

hb^unspecified

gap phenotype | embryonic stage | recessive

increased cell death | embryonic stage

hb⁹

increased cell number | embryonic stage, with Scer\GAL4^ase.PZ

hb^UAS.cWa

increased cell number | embryonic stage, with Scer\GAL4^eg-Mz360

hb^UAS.cWa

increased cell number | embryonic stage, with Scer\GAL4^hkb.PU

hb^UAS.cWa

increased cell number | first instar larval stage, with Hsim\VP16^AD.ac, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

hb^UAS.cWa

increased cell number | larval stage, with Scer\GAL4^hkb.PU

hb^UAS.cWa

increased occurrence of cell division | embryonic stage 16, with Scer\GAL4^elav-C155

hb^UAS.Tag:MYC

pair rule phenotype

hb^D2

pair rule phenotype | embryonic stage | recessive

hb^D2

short lived, with Scer\GAL4^Mef2.PR

hb^GD1460

some die during embryonic stage | dominant | maternal effect | maternal effect

some die during embryonic stage | maternal effect

some die during embryonic stage | recessive

some die during embryonic stage | recessive, with Scer\GAL4^{GCN4.nanos.bcd3'UTR}

hb^UAS.cWa

some die during larval stage | maternal effect

hb^G1-3U

some die during pupal stage, with Scer\GAL4^pnr-MD237

hb^GD1460

visible

hb^D1

visible, with Scer\GAL4^Bx-MS1096

hb^{UAS.ORF.GW.Tag:HA}

visible | cold sensitive, with Scer\GAL4^Bx-MS1096

hb^{UAS.ORF.GW.Tag:HA}

visible | dominant

hb^D1

Phenotype manifest in

Allele

abdomen

abdominal 8 ventral denticle belt | embryonic stage

hb¹²

abdominal segment 1

hb¹²

abdominal segment 8

hb²

abdominal segment | maternal effect

adult metathoracic segment

hb^D1

antennal lobe neuroblast | somatic clone, with Scer\GAL4^GMR.PF

hb^JF03309

cephalopharyngeal skeleton

cephalopharyngeal skeleton, with Scer\GAL4^{GCN4.nanos.bcd3'UTR}

hb^UAS.cWa

dorsal arm of pharyngeal sclerite, with Scer\GAL4^{GCN4.nanos.bcd3'UTR}

hb^UAS.cWa

dorsal bridge, with Scer\GAL4^{GCN4.nanos.bcd3'UTR}

hb^UAS.cWa

embryonic/first instar larval cuticle

embryonic/larval esophagus | embryonic stage, with Scer\GAL4^{GCN4.nanos.bcd3'UTR}

hb^UAS.cWa

embryonic/larval labial segment sensillum

hb¹²

embryonic/larval neuromuscular junction | first instar larval stage, with Hsim\VP16^AD.ac, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

hb^UAS.cWa

embryonic/larval pharynx | embryonic stage, with Scer\GAL4^{GCN4.nanos.bcd3'UTR}

hb^UAS.cWa

embryonic/larval proventriculus | embryonic stage, with Scer\GAL4^{GCN4.nanos.bcd3'UTR}

hb^UAS.cWa

embryonic/larval tracheal dorsal trunk

embryonic/larval tracheal dorsal trunk, with Scer\GAL4^12.1

hb^UAS.cWa

embryonic abdomen | anterior

hb¹²

embryonic abdominal segment

embryonic abdominal segment 1

hb⁶

embryonic abdominal segment 2

hb^D2

embryonic abdominal segment 4

hb^D2

embryonic abdominal segment 7

embryonic abdominal segment 7 (with hb¹²)

hb^D2

embryonic abdominal segment 7 (with hb^D2)

hb¹²

embryonic abdominal segment 8

embryonic abdominal segment 8 (with hb¹²)

hb^D2

embryonic abdominal segment 8 (with hb^D2)

hb¹²

embryonic abdominal segment | maternal effect

embryonic abdominal segment | posterior

embryonic epidermis

hb^bcd.3UTR

embryonic ganglion mother cell | embryonic stage 13, with hb¹⁵

hb^P1only

embryonic ganglion mother cell | embryonic stage 13, with hb^P1only

hb¹⁵

embryonic gnathal segment

embryonic GW neuron

hb¹²

embryonic GW neuron | embryonic stage

hb⁹

embryonic head

embryonic labial segment

embryonic mesothoracic segment

embryonic metathoracic segment

embryonic neuroblast

hb⁴

embryonic neuroblast | embryonic stage 13, with hb¹⁵

hb^P1only

embryonic neuroblast | embryonic stage 13, with hb^P1only

hb¹⁵

embryonic neuroblast | embryonic stage 14, with hb¹⁵

hb^P1only

embryonic neuroblast | embryonic stage 14, with hb^P1only

hb¹⁵

embryonic neuroblast | embryonic stage 16, with Scer\GAL4^elav-C155

hb^UAS.Tag:MYC

embryonic primordium of adult salivary gland

hb¹²

embryonic prothoracic segment

embryonic thoracic segment

hb^unspecified

embryonic ventral nerve cord, with Scer\GAL4^eg-Mz360

hb^UAS.cWa

embryonic ventral nerve cord, with Scer\GAL4^hkb.PU

hb^UAS.cWa

epipharyngeal sclerite, with Scer\GAL4^{GCN4.nanos.bcd3'UTR}

hb^UAS.cWa

EW1 neuron, with hb¹²

hb^KM

EW1 neuron, with hb^KM

hb¹²

EW1 neuron | ectopic, with Scer\GAL4^en-e16E

hb^UAS.cWa

EW2 neuron | ectopic, with hb¹²

hb^KM

EW2 neuron | ectopic, with hb^KM

hb¹²

eye, with Scer\GAL4^GMR.PF

hb^UAS.cWa

filzkorper

filzkorper (with hb¹²)

hb^D2

filzkorper (with hb^D2)

hb¹²

FMRFamide SE2 neuron | increased number, with Scer\GAL4^elav-C155

hb^UAS.cWa

ganglion mother cell GMC1-1a, with hb¹²

hb^KM

ganglion mother cell GMC1-1a, with hb^KM

hb¹²

ganglion mother cell GMC1-1a | ectopic, with Scer\GAL4^en-e16E

hb^UAS.cWa

gastric caecum, with Scer\GAL4^{GCN4.nanos.bcd3'UTR}

hb^UAS.cWa

gnathal segment

hb²

haltere

hb^D1

hypostomal sclerite

hb¹²

larval abdominal segment 7

hb⁸

larval abdominal segment 8

hb⁸

larval DA1 motor neuron

hb¹²

larval DA1 motor neuron, with hb¹²

hb^KM

larval DA1 motor neuron, with hb^KM

hb¹²

larval DA1 motor neuron | ectopic, with Scer\GAL4^en-e16E

hb^UAS.cWa

larval DA2 motor neuron, with Scer\GAL4^sca-109-68

hb^UAS.cWa

larval DA2 motor neuron | increased number, with Scer\GAL4^en-e16E

larval DA2 motor neuron | increased number, with Scer\GAL4^en-e16E, hb¹⁵, hb^P1only

larval DA2 motor neuron | increased number, with Scer\GAL4^en-e16E, hb^ΔD.VP16.UAS, hb¹⁵

hb^P1only

larval DA2 motor neuron | increased number, with Scer\GAL4^en-e16E, hb^ΔD.VP16.UAS, hb^P1only

hb¹⁵

larval DA2 motor neuron | increased number, with Scer\GAL4^en-e16E, hb^{ΔDMZ.VP16.UAS}, hb¹⁵

hb^P1only

larval DA2 motor neuron | increased number, with Scer\GAL4^en-e16E, hb^{ΔDMZ.VP16.UAS}, hb^P1only

hb¹⁵

larval DA3 motor neuron, with Scer\GAL4^sca-109-68

hb^UAS.cWa

larval DO1 motor neuron, with Scer\GAL4^en-e16E, hb¹⁵, hb^P1only

larval DO1 motor neuron, with Scer\GAL4^en-e16E, hb^ΔD.VP16.UAS, hb¹⁵

hb^P1only

larval DO1 motor neuron, with Scer\GAL4^en-e16E, hb^ΔD.VP16.UAS, hb^P1only

hb¹⁵

larval DO1 motor neuron, with Scer\GAL4^en-e16E, hb^{ΔDMZ.VP16.UAS}, hb¹⁵

hb^P1only

larval DO1 motor neuron, with Scer\GAL4^en-e16E, hb^{ΔDMZ.VP16.UAS}, hb^P1only

hb¹⁵

larval DO1 motor neuron | ectopic, with Scer\GAL4^en-e16E

hb^UAS.cWa

larval DO1 motor neuron | ectopic | embryonic stage, with Scer\GAL4^en-e16E

hb^UAS.cWa

larval DO1 motor neuron | ectopic | heat sensitive

hb^hs.PS

larval DO1 motor neuron | ectopic | heat sensitive, with Scer\GAL4^pros.PMG

hb^UAS.cWa

larval DO2 motor neuron

hb^UAS.cWa

larval DO2 motor neuron, with Scer\GAL4^en-e16E, hb¹⁵, hb^P1only

larval DO2 motor neuron, with Scer\GAL4^en-e16E, hb^ΔD.VP16.UAS, hb¹⁵

hb^P1only

larval DO2 motor neuron, with Scer\GAL4^en-e16E, hb^ΔD.VP16.UAS, hb^P1only

hb¹⁵

larval DO2 motor neuron, with Scer\GAL4^en-e16E, hb^{ΔDMZ.VP16.UAS}, hb¹⁵

hb^P1only

larval DO2 motor neuron, with Scer\GAL4^en-e16E, hb^{ΔDMZ.VP16.UAS}, hb^P1only

hb¹⁵

larval DO2 motor neuron | ectopic | embryonic stage, with Scer\GAL4^en-e16E

hb^UAS.cWa

larval DO2 motor neuron | ectopic | heat sensitive

hb^hs.PS

larval DO2 motor neuron | ectopic | heat sensitive, with Scer\GAL4^pros.PMG

hb^UAS.cWa

larval fpCC neuron

hb¹²

larval fpCC neuron | ectopic, with Scer\GAL4^en-e16E

hb^UAS.cWa

larval fpCC neuron | ectopic, with Scer\GAL4^sca.PC

hb^UAS.cWa

larval head

hb¹²

larval labial segment

larval LL1 motor neuron, with Scer\GAL4^sca-109-68

hb^UAS.cWa

larval LL1 motor neuron | increased number, with Scer\GAL4^en-e16E

hb^ΔD.VP16.UAS

larval longitudinal connective

hb⁴

larval mesothoracic segment

hb⁸

larval metathoracic segment

hb⁸

larval pair1 neuron, with Scer\GAL4^GMR75C02

hb^HMS01183

larval prothoracic segment

hb⁸

larval RP2 motor neuron

hb¹²

larval RP2 motor neuron, with hb¹²

hb^KM

larval RP2 motor neuron, with hb^KM

hb¹²

larval RP2 motor neuron | ectopic, with Scer\GAL4^en-e16E

hb^UAS.cWa

larval ventral nerve cord, with Scer\GAL4^eg-Mz360

hb^UAS.cWa

larval ventral nerve cord, with Scer\GAL4^elav-C155

hb^UAS.cWa

larval ventral nerve cord, with Scer\GAL4^hkb.PU

hb^UAS.cWa

lineage NB7-1 primary motor neuron | first instar larval stage, with Hsim\VP16^AD.ac, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

hb^UAS.cWa

medial-most cell body glial cell, with hb¹²

hb^KM

medial-most cell body glial cell, with hb^KM

hb¹²

medial-most cell body glial cell | ectopic, with Scer\GAL4^en-e16E

hb^UAS.cWa

median tooth, with Scer\GAL4^{GCN4.nanos.bcd3'UTR}

hb^UAS.cWa

mesothoracic segment

hb¹²

metathoracic segment

mitotic domain 1 | extended germ band stage

hb⁴

motor neuron, with hb¹²

hb^KM

motor neuron, with hb^KM

hb¹²

mouth hook

hb⁸

muscle cell of dorsal oblique muscle 1 | first instar larval stage, with Hsim\VP16^AD.ac, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

hb^UAS.cWa

muscle cell of dorsal oblique muscle 2 | first instar larval stage, with Hsim\VP16^AD.ac, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

hb^UAS.cWa

muscle cell of lateral longitudinal muscle 1 | first instar larval stage, with Hsim\VP16^AD.ac, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

hb^UAS.cWa

neuroblast NB7-1

hb¹²

neuroblast NB7-3

hb¹²

neuroblast NB7-3, with Scer\GAL4^eg-Mz360

hb^UAS.cWa

parasegment 6

hb^D2

parasegment 13

hb^D2

pCC neuron

hb¹²

pCC neuron | ectopic, with Scer\GAL4^en-e16E

hb^UAS.cWa

precursor cell of the stomatogastric nervous system, with Scer\GAL4^{GCN4.nanos.bcd3'UTR}

hb^UAS.cWa

primordial germ cell

hb^Δ

prothoracic segment

symmetrical commissure

hb⁴

synapse | increased number, with Scer\GAL4^GMR75C02

hb^HMS01183

thorax

U neuron

hb¹²

U neuron, with Scer\GAL4^en-e16E, hb¹⁵, hb^P1only

hb^UAS.VP16

U neuron, with Scer\GAL4^en-e16E, hb¹⁵, hb^UAS.VP16

hb^P1only

U neuron, with Scer\GAL4^en-e16E, hb^P1only, hb^UAS.VP16

hb¹⁵

U neuron | ectopic, with Scer\GAL4^en-e16E

hb^UAS.cWa

U neuron | ectopic, with Scer\GAL4^sca.PC

hb^UAS.cWa

U neuron | ectopic | heat sensitive

hb^hs.PS

U neuron | embryonic stage | increased number, with Scer\GAL4^ase.PZ

hb^UAS.cWa

U neuron | increased number, with Scer\GAL4^en-e16E

U neuron | increased number, with Scer\GAL4^en-e16E, hb¹⁵, hb^P1only

U neuron | increased number, with Scer\GAL4^en-e16E, hb¹⁵, hb^UAS.cWa

hb^P1only

U neuron | increased number, with Scer\GAL4^en-e16E, hb^P1only, hb^UAS.cWa

hb¹⁵

U neuron | increased number, with Scer\GAL4^en-e16E, hb^{ΔAB.VP16.UAS}, hb¹⁵

hb^P1only

U neuron | increased number, with Scer\GAL4^en-e16E, hb^{ΔAB.VP16.UAS}, hb^P1only

hb¹⁵

U neuron | increased number, with Scer\GAL4^en-e16E, hb^ΔB.VP16.UAS, hb¹⁵

hb^P1only

U neuron | increased number, with Scer\GAL4^en-e16E, hb^ΔB.VP16.UAS, hb^P1only

hb¹⁵

U neuron | increased number, with Scer\GAL4^en-e16E, hb^ΔE.VP16.UAS, hb¹⁵

hb^P1only

U neuron | increased number, with Scer\GAL4^en-e16E, hb^ΔE.VP16.UAS, hb^P1only

hb¹⁵

U neuron | increased number, with Scer\GAL4^pros.PMG

ventral arm of pharyngeal sclerite, with Scer\GAL4^{GCN4.nanos.bcd3'UTR}

hb^UAS.cWa

wing, with Scer\GAL4^Bx-MS1096

hb^{UAS.ORF.GW.Tag:HA}

wing | cold sensitive, with Scer\GAL4^Bx-MS1096

hb^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (49)

Hsap\IKZF5

4 of 14

Yes

Hsap\REST

3 of 14

Yes

Hsap\ZNF518A

2 of 14

Yes

Hsap\ZSCAN1

2 of 14

Yes

Hsap\IKZF1

1 of 14

Hsap\IKZF2

1 of 14

Hsap\LOC728743

1 of 14

Yes

Hsap\OVOL2

1 of 14

Hsap\OVOL3

1 of 14

Hsap\PEG3

1 of 14

Yes

Hsap\PLAG1

1 of 14

Hsap\PLAGL1

1 of 14

Yes

Hsap\PLAGL2

1 of 14

Yes

Hsap\PRDM15

1 of 14

Yes

Hsap\SCAND1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF180

1 of 14

Hsap\ZNF202

1 of 14

Hsap\ZNF236

1 of 14

Yes

Hsap\ZNF266

1 of 14

Yes

Hsap\ZNF274

1 of 14

Hsap\ZNF337

1 of 14

Hsap\ZNF366

1 of 14

Yes

Hsap\ZNF432

1 of 14

Hsap\ZNF444

1 of 14

Yes

Hsap\ZNF446

1 of 14

Yes

Hsap\ZNF496

1 of 14

Yes

Hsap\ZNF518B

1 of 14

Yes

Hsap\ZNF572

1 of 14

Hsap\ZNF576

1 of 14

Hsap\ZNF641

1 of 14

Yes

Hsap\ZNF653

1 of 14

Yes

Hsap\ZNF692

1 of 14

Hsap\ZNF710

1 of 14

Hsap\ZNF770

1 of 14

Yes

Hsap\ZNF852

1 of 14

Hsap\ZSCAN5A

1 of 14

Yes

Hsap\ZSCAN5B

1 of 14

Yes

Hsap\ZSCAN5C

1 of 14

Hsap\ZSCAN10

1 of 14

Hsap\ZSCAN18

1 of 14

Yes

Hsap\ZSCAN29

1 of 14

Hsap\ZSCAN32

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (31)

Rnor\Ikzf5

4 of 14

Yes

Rnor\RGD1564807

4 of 14

Yes

Rnor\Rest

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Plag1

1 of 14

Yes

Rnor\Plagl1

1 of 14

Yes

Rnor\Plagl2

1 of 14

Rnor\Rbak

1 of 14

Rnor\Scand1

1 of 14

Yes

Rnor\Zfp18

1 of 14

Yes

Rnor\Zfp26

1 of 14

Rnor\Zfp110

1 of 14

Yes

Rnor\Zfp131

1 of 14

Rnor\Zfp174

1 of 14

Yes

Rnor\Zfp202

1 of 14

Yes

Rnor\Zfp236

1 of 14

Yes

Rnor\Zfp335

1 of 14

Rnor\Zfp366

1 of 14

Yes

Rnor\Zfp444

1 of 14

Yes

Rnor\Zfp496

1 of 14

Yes

Rnor\Zfp518a

1 of 14

Yes

Rnor\Zfp518b

1 of 14

Yes

Rnor\Zfp641

1 of 14

Yes

Rnor\Zfp770

1 of 14

Yes

Rnor\Zfp819

1 of 14

Rnor\Zkscan2

1 of 14

Rnor\Zscan5b

1 of 14

Yes

Mus musculus (laboratory mouse) (34)

Mmus\Ikzf5

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Plag1

1 of 14

Yes

Mmus\Plagl1

1 of 14

Yes

Mmus\Plagl2

1 of 14

Yes

Mmus\Rbak

1 of 14

Mmus\Rest

1 of 14

Yes

Mmus\Scand1

1 of 14

Yes

Mmus\Zfp26

1 of 14

Mmus\Zfp110

1 of 14

Yes

Mmus\Zfp131

1 of 14

Mmus\Zfp174

1 of 14

Mmus\Zfp202

1 of 14

Yes

Mmus\Zfp229

1 of 14

Mmus\Zfp251

1 of 14

Yes

Mmus\Zfp335

1 of 14

Mmus\Zfp366

1 of 14

Yes

Mmus\Zfp369

1 of 14

Yes

Mmus\Zfp444

1 of 14

Yes

Mmus\Zfp446

1 of 14

Yes

Mmus\Zfp518a

1 of 14

Yes

Mmus\Zfp518b

1 of 14

Yes

Mmus\Zfp641

1 of 14

Yes

Mmus\Zfp770

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zscan5b

1 of 14

Yes

Mmus\Zscan18

1 of 14

Yes

Mmus\Zscan29

1 of 14

Xenopus tropicalis (Western clawed frog) (16)

Xtro\ikzf5

4 of 13

Yes

Xtro\asb8

1 of 13

Xtro\ctgfl

1 of 13

Xtro\eea1

1 of 13

Yes

Xtro\gli2

1 of 13

Xtro\ikzf2

1 of 13

Yes

Xtro\impa2

1 of 13

Xtro\LOC496795

1 of 13

Xtro\rest

1 of 13

Yes

Xtro\smco1

1 of 13

Yes

Xtro\XB1010452

1 of 13

Xtro\XB5795368

1 of 13

Xtro\XB5959486

1 of 13

Yes

Xtro\znf148

1 of 13

Yes

Xtro\znf653

1 of 13

Xtro\zxdc

1 of 13

Yes

Danio rerio (Zebrafish) (13)

Drer\ikzf5

3 of 14

Yes

Drer\rest

2 of 14

Yes

Drer\e4f1

1 of 14

Yes

Drer\ikzf2

1 of 14

Drer\LOC100333012

1 of 14

Drer\LOC110437819

1 of 14

Yes

Drer\plag1

1 of 14

Yes

Drer\plagl2

1 of 14

Yes

Drer\plagx

1 of 14

Yes

Drer\si:ch211-214e3.5

1 of 14

Yes

Drer\znf131

1 of 14

Yes

Drer\znf236

1 of 14

Yes

Drer\znf977

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\hbl-1

5 of 14

Yes

Cele\sdz-12

2 of 14

Cele\F26F4.8

1 of 14

Cele\ztf-16

1 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP010777

10 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\ADR1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\prz1

1 of 12

Yes

Spom\sfc2

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:hb. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (20)

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

erm

1 of 13

ham

1 of 13

ich

1 of 13

MESR4

1 of 13

MTF-1

1 of 13

ovo

1 of 13

Saft

1 of 13

zld

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

REST; RE1 silencing transcription factor

model of gingival fibromatosis 5

IEA

(FlyBase, 2019-)

model of autosomal dominant nonsyndromic deafness 27

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

hb^KK106631

exacerbates atypical teratoid rhabdoid tumor

modeled by Snr1^KK101602

(Tegeder et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

IKZF5; IKAROS family zinc finger 5

4 of 14

606238

THROMBOCYTOPENIA 7; THC7

REST; RE1 silencing transcription factor

3 of 14

600571

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

hb - brat

electrophoretic mobility shift assay, autoradiography, molecular sieving, static light scattering, anti tag coimmunoprecipitation, quantitative reverse transcription pcr, microscale thermophoresis, predetermined participant, nucleic acid uv cross-linking assay, Identification by mass spectrometry

(Malik et al., 2020, Malik et al., 2019, Loedige et al., 2014)

hb - nanos

nucleic acid uv cross-linking assay, autoradiography, rna three hybrid, anti tag coimmunoprecipitation, quantitative reverse transcription pcr, x-ray crystallography

(Malik et al., 2019, Weidmann et al., 2016, Edwards et al., 2001, Sonoda and Wharton, 1999)

protein-protein

Physical Interaction

Assay

References

hb - Adf1

pull down, tag visualisation

(Cheng et al., 2013)

hb - Ubx

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

hb - abd-A

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

hb - cindr

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

hb - sina

two hybrid

(Hu et al., 2017.6.13)

hb - sinah

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Janody et al., 2000)

nanos|hb

suppressible

(Simpson-Brose et al., 1994)

enhanceable

bnl

(Wolf and Schuh, 2000)

suppressible

cas

(Tran et al., 2010)

enhanceable

dan

(Kohwi et al., 2013)

enhanceable

ftz

(Bender et al., 1987)

suppressible

(Wu et al., 2001)

enhanceable

Lam

(Kohwi et al., 2013)

hb|nanos

suppressible

mxc

(Saget et al., 1998)

enhanceable

nanos

(Deshpande et al., 2005)

suppressible

pdm2

(Tran et al., 2010)

hb|nanos

suppressible

pho

(Saget et al., 1998)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

hb|tsl

(Schulz and Tautz, 1994)

suppressible

(Wimmer et al., 2000)