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Citation
Trcek, T., Lehmann, R. (2019). Germ granules in Drosophila.  Traffic 20(9): 650--660.
FlyBase ID
FBrf0243238
Publication Type
Review
Abstract

Germ granules are hallmarks of all germ cells. Early ultrastructural studies in Drosophila first described these membraneless granules in the oocyte and early embryo as filled with amorphous to fibrillar material mixed with RNA. Genetic studies identified key protein components and specific mRNAs that regulate germ cell-specific functions. More recently these ultrastructural studies have been complemented by biophysical analysis describing germ granules as phase-transitioned condensates. In this review, we provide an overview that connects the composition of germ granules with their function in controlling germ cell specification, formation and migration, and illuminate these mysterious condensates as the gatekeepers of the next generation.

PubMed ID
PubMed Central ID
PMC6771631 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Traffic
    Title
    Traffic
    Publication Year
    2000-
    ISBN/ISSN
    1398-9219
    Data From Reference