FlyBase Gene Report: Dmel\nan

General Information

Symbol

Dmel\nan

Species

D. melanogaster

Name

nanchung

Annotation Symbol

CG5842

Feature Type

protein_coding_gene

FlyBase ID

FBgn0036414

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

nanchung (nan) encodes a member of the transient Receptor Potential (TRP) channel family. It is involved in the response to different stimuli such as startle, humidity or sound. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

TRPV

Key Links

Genomic Location

Cytogenetic map

70D3-70D3

Sequence location

3L:14,186,249..14,189,648 [-]

Recombination map

3-42

RefSeq locus

NT_037436 REGION:14186249..14189648

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (28 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

contributes_to calcium channel activity

inferred from physical interaction with FLYBASE:iav; FB:FBgn0086693

(Kandasamy et al., 2022)

inferred from physical interaction with FLYBASE:wtrw; FB:FBgn0260005

(Kandasamy et al., 2022)

enables mechanosensitive monoatomic cation channel activity

inferred from direct assay

(Li et al., 2021)

enables mechanosensitive monoatomic ion channel activity

inferred from mutant phenotype

(Zhang et al., 2020)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables calcium channel activity

inferred from sequence or structural similarity

(Littleton and Ganetzky, 2000)

enables monoatomic cation channel activity

inferred from sequence or structural similarity with FLYBASE:pyx; FB:FBgn0035113

(Gene Ontology Curators, 2002-)

enables monoatomic ion channel activity

inferred from electronic annotation with InterPro:IPR005821, InterPro:IPR024862

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000061616

(GO Reference Genome Project, 2011-)

Biological Process (19 terms)

Terms Based on Experimental Evidence (14 terms)

CV Term

Evidence

References

acts_upstream_of adult walking behavior

inferred from mutant phenotype

(Akitake et al., 2015)

involved_in calcium ion transmembrane transport

inferred from direct assay

(Kandasamy et al., 2022)

involved_in detection of mechanical stimulus involved in sensory perception of sound

inferred from genetic interaction with FLYBASE:iav; FB:FBgn0086693

(Li et al., 2021)

involved_in detection of mechanical stimulus involved in sensory perception of touch

inferred from mutant phenotype

(Zhang et al., 2020, Jeong et al., 2016)

involved_in detection of mechanical stimulus involved in sensory perception

inferred from mutant phenotype

(Zhang et al., 2020)

inferred from mutant phenotype

(Kamikouchi et al., 2009)

acts_upstream_of mechanosensory behavior

inferred from mutant phenotype

(Zhang et al., 2020)

involved_in monoatomic ion transmembrane transport

inferred from mutant phenotype

(Zhang et al., 2020)

involved_in negative gravitaxis

inferred from mutant phenotype

(Sun et al., 2009)

involved_in neuromuscular process controlling posture

inferred from mutant phenotype

(Akitake et al., 2015)

involved_in regulation of mechanosensory behavior

inferred from mutant phenotype

(Zhang et al., 2020)

involved_in response to auditory stimulus

inferred from direct assay

(Zhang et al., 2013)

involved_in response to humidity

inferred from mutant phenotype

(Liu et al., 2007)

involved_in sensory perception of sound

inferred from mutant phenotype

(Sun et al., 2009, Gopfert et al., 2006, Kim et al., 2003)

involved_in startle response

inferred from mutant phenotype

(Zhang et al., 2013)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in calcium ion import across plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000061616

(GO Reference Genome Project, 2011-)

involved_in calcium ion transport

inferred from sequence or structural similarity

(Littleton and Ganetzky, 2000)

involved_in monoatomic cation transport

inferred from sequence or structural similarity with FLYBASE:pyx; FB:FBgn0035113

(Gene Ontology Curators, 2002-)

involved_in monoatomic ion transport

inferred from electronic annotation with InterPro:IPR005821, InterPro:IPR024862

(InterPro Project Members, 2004-)

involved_in transmembrane transport

inferred from electronic annotation with InterPro:IPR005821

(InterPro Project Members, 2004-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

part_of calcium channel complex

inferred from direct assay

(Kandasamy et al., 2022)

part_of cation channel complex

inferred from direct assay

(Li et al., 2021)

is_active_in plasma membrane

inferred from direct assay

(Li et al., 2021)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of cation channel complex

inferred from sequence or structural similarity with FLYBASE:pyx; FB:FBgn0035113

(Gene Ontology Curators, 2002-)

located_in membrane

inferred from electronic annotation with InterPro:IPR005821, InterPro:IPR024862

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000061616

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

TRANSIENT RECEPTOR POTENTIAL ION CHANNELS

MECHANOSENSITIVE TRANSIENT RECEPTOR POTENTIAL ION CHANNELS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

TRANSIENT RECEPTOR POTENTIAL ION CHANNELS -: The Transient Receptor Potential (TRP) channel family are cation channels conserved from invertebrates to humans. TRP channels respond to diverse stimuli and are involved in a number of environmental sensory pathways. (Adapted from FBrf0220930 and FBrf0225477).
MECHANOSENSITIVE TRANSIENT RECEPTOR POTENTIAL ION CHANNELS -: The Transient Receptor Potential (TRP) ion channels are cation channels. Some members of the TRP family have been shown to be gated by mechanical stimulation (Adapted from FBrf0248531.)

Summary (Interactive Fly)

calcium channel, TRP family - partners with the channel Inactive in hearing transduction - in labellar mechanosensory neurons involved in preference for soft food - Nan-expressing neurons under recurved bristles along the wing margin are essential sensory components for defensive behavior - insecticides serve as specific agonists of Nan-Iav complexes that, by promoting cellular calcium influx, silence the stretch receptor cells

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\nan for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PI57)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

nan-RA

FBtr0089524

NM_140439

2847

833

nan-RB

FBtr0321258

NM_001274904

2850

834

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

nan-PA

FBpp0088509

96.2

833

5.26

FBpp0302810

96.3

834

5.20

M9PI57

NP_001261833

AGB94526

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nan using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

nan_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

chordotonal organ

(Kim et al., 2003)

adult stage

third segment of antenna | restricted

(Liu et al., 2007)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of calcium channel complex

inferred from direct assay

(Kandasamy et al., 2022)

part_of cation channel complex

inferred from direct assay

(Li et al., 2021)

is_active_in plasma membrane

inferred from direct assay

(Li et al., 2021)

Expression Deduced from Reporters

Reporter: P{nan-GAL4.K}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

chordotonal neuron

• cell projection

Comment: late stage 16

(Kim et al., 2003)

vch neuron

Comment: late stage 16

(Kim et al., 2003)

larval abdominal lch5 neuron

Comment: late stage 16

(Kim et al., 2003)

larval prothoracic lch3 neuron

Comment: late stage 16

(Kim et al., 2003)

larval stage

chordotonal neuron | subset

(Kwon et al., 2010)

pupal stage

Johnston organ

(Lee et al., 2010)

Johnston organ neuron

(Lee et al., 2010)

adult stage

adult antennal lobe local neuron

(Chou et al., 2010)

Johnston organ neuron

Comment: expression in ciliary outer segment

(Kamikouchi et al., 2009, Kim et al., 2003)

sound activated Johnston organ neuron

(Kamikouchi et al., 2009)

gravity sensitive Johnston organ neuron

(Kamikouchi et al., 2009)

zone A Johnston organ neuron

(Kamikouchi et al., 2009)

zone B Johnston organ neuron

(Yamada et al., 2018, Kamikouchi et al., 2009)

zone C Johnston organ neuron

(Kamikouchi et al., 2009)

zone E Johnston organ neuron

(Kamikouchi et al., 2009)

chordotonal organ | subset

(Yorozu et al., 2009)

chordotonal organ

(Sehadova et al., 2009)

labial sensillum | subset

(Sehadova et al., 2009)

external sensory organ | subset

(Sehadova et al., 2009)

external sensory organ of labellum | subset

(Sehadova et al., 2009)

external sensory organ of maxillary palp | subset

(Sehadova et al., 2009)

external sensory organ of first segment of antenna | subset

(Sehadova et al., 2009)

wing sensillum | subset

(Sehadova et al., 2009)

wing sensillum of wing margin | subset | ventral

(Sehadova et al., 2009)

wing sensillum of wing vein L1

(Sehadova et al., 2009)

wing sensillum of wing vein L2

(Sehadova et al., 2009)

wing sensillum of wing vein L3

(Sehadova et al., 2009)

wing sensillum of wing vein L4

(Sehadova et al., 2009)

wing sensillum of wing vein L5

(Sehadova et al., 2009)

haltere sensillum | subset

(Sehadova et al., 2009)

haltere sensillum of capitellum | subset

(Sehadova et al., 2009)

leg sensillum | subset

(Sehadova et al., 2009)

leg sensillum of femur | distal | restricted

(Sehadova et al., 2009)

leg sensillum of tibia | proximal | restricted

(Sehadova et al., 2009)

adult brain | restricted

(Sehadova et al., 2009)

adult olfactory receptor neuron | subset

(Chou et al., 2010)

GABAergic local interneuron of the adult antennal lobe | subset

Comment: 3 of 5 labeled neurons

(Chou et al., 2010)

chordotonal neuron of femoral chordotonal organ

• cell projection

(Kim et al., 2003)

hygrosensory system

(Liu et al., 2007)

antennal segment 3 sense organ

(Liu et al., 2007)

Reporter: P{nan-GFP.557}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

chordotonal organ precursor cell

(Newton et al., 2012)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\nan in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\nan

View exonic expression by tissue for Dmel\nan

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39571/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036414

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036414

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036414

Flygut - An atlas of the Drosophila adult midgut

FBgn0036414

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of nan

Transgenic constructs containing regulatory region of nan

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6120

(Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

nan^KK103594

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

nan^GD2456

viable, with Scer\GAL4^Mef2.PR

nan^GD2456

viable, with Scer\GAL4^pnr-MD237

nan^GD2456

viable, with Scer\GAL4^tin.CΔ4

nan^GD2456

viable (with nan^36a)

nan^dy5

viable (with nan^dy5)

nan^36a

Other Phenotypes

Allele

abnormal auditory perception

abnormal behavior

abnormal courtship behavior | recessive

nan^unspecified

abnormal feeding behavior | adult stage

abnormal feeding behavior | adult stage, with Scer\GAL4^nan.PK

abnormal feeding behavior | adult stage, with Scer\GAL4^nSyb.PU

abnormal feeding behavior | adult stage, with Scer\GAL4^VT011155

abnormal locomotor behavior | adult stage

nan^36a

abnormal locomotor behavior | larval stage

nan^36a

abnormal neurophysiology

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

nan^GD2456

abnormal touch perception | adult stage

abnormal touch response | larval stage

uncoordinated

uncoordinated (with nan^36a)

nan^dy5

uncoordinated (with nan^dy5)

nan^36a

uncoordinated | adult stage

nan^36a

Phenotype manifest in

Allele

Johnston organ neuron

nan^36a

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (20)

Hsap\TRPV5

11 of 14

Yes

Hsap\TRPV6

11 of 14

Yes

Hsap\TRPV1

8 of 14

Yes

Hsap\TRPV2

7 of 14

Yes

Hsap\TRPV3

7 of 14

Yes

Hsap\TRPV4

7 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\Trpv5

11 of 14

Yes

Rnor\Trpv6

11 of 14

Yes

Rnor\Trpv4

8 of 14

Yes

Rnor\Trpv1

7 of 14

Yes

Rnor\Trpv2

7 of 14

Yes

Rnor\Trpv3

7 of 14

Yes

Rnor\Ank2

1 of 14

Rnor\Ank3

1 of 14

Rnor\Ankk1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Asb15

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (20)

Mmus\Trpv5

11 of 14

Yes

Mmus\Trpv6

11 of 14

Yes

Mmus\Trpv1

7 of 14

Yes

Mmus\Trpv2

7 of 14

Yes

Mmus\Trpv3

7 of 14

Yes

Mmus\Trpv4

7 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (32)

Xtro\LOC101734375

8 of 13

Yes

Xtro\cat1

7 of 13

Yes

Xtro\LOC105947301

6 of 13

Yes

Xtro\trpv2

6 of 13

Yes

Xtro\trpv4

6 of 13

Yes

Xtro\trpv6

6 of 13

Yes

Xtro\LOC116412277

5 of 13

Yes

Xtro\trpv3

3 of 13

Yes

Xtro\trpv4l.1

3 of 13

Yes

Xtro\trpv4l.4

3 of 13

Yes

Xtro\commd9

2 of 13

Yes

Xtro\trpv1

2 of 13

Yes

Xtro\ankdd1a

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\lgals4.1

1 of 13

Xtro\LOC100492165

1 of 13

Yes

Xtro\LOC100494817

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\trpv4l.3

1 of 13

Yes

Xtro\trpv5

1 of 13

Yes

Danio rerio (Zebrafish) (29)

Drer\trpv6

10 of 14

Yes

Drer\trpv4

9 of 14

Yes

Drer\trpv1

8 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\ocr-4

13 of 14

Yes

Cele\ocr-3

10 of 14

Yes

Cele\ocr-2

9 of 14

Yes

Cele\ocr-1

8 of 14

Yes

5 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP012241

12 of 12

Yes

5 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (6)

Atha\AT1G07710

1 of 13

Yes

Atha\AT1G10340

1 of 13

Yes

Atha\AT2G24600

1 of 13

Yes

Atha\AT5G54710

1 of 13

Yes

Atha\ITN1

1 of 13

Yes

Atha\KEG

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\AKR1

1 of 13

Yes

Scer\AVO2

1 of 13

Yes

Scer\YVC1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:nan. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

iav

10 of 13

nompC

1 of 13

pyx

1 of 13

TrpA1

1 of 13

wtrw

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 10 )

Human Ortholog

Disease

Evidence

References

TRPV4; transient receptor potential cation channel subfamily V member 4

model of parastremmatic dwarfism

IEA

(FlyBase, 2019-)

model of Charcot-Marie-Tooth disease axonal type 2C

IEA

(FlyBase, 2019-)

model of scapuloperoneal spinal muscular atrophy

IEA

(FlyBase, 2019-)

model of metatropic dysplasia

IEA

(FlyBase, 2019-)

model of spondylometaphyseal dysplasia Kozlowski type

IEA

(FlyBase, 2019-)

model of spondyloepiphyseal dysplasia Maroteaux type

IEA

(FlyBase, 2019-)

model of brachyolmia

IEA

(FlyBase, 2019-)

model of autosomal dominant distal hereditary motor neuronopathy 8

IEA

(FlyBase, 2019-)

TRPV3; transient receptor potential cation channel subfamily V member 3

model of autosomal dominant mutilating palmoplantar keratoderma with periorificial keratotic plaques

IEA

(FlyBase, 2019-)

model of focal nonepidermolytic palmoplantar keratoderma 2

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TRPV5; transient receptor potential cation channel subfamily V member 5

11 of 14

606679

TRPV6; transient receptor potential cation channel subfamily V member 6

11 of 14

606680

HYPERPARATHYROIDISM, TRANSIENT NEONATAL; HRPTTN

TRPV1; transient receptor potential cation channel subfamily V member 1

8 of 14

602076

TRPV2; transient receptor potential cation channel subfamily V member 2

7 of 14

606676

TRPV3; transient receptor potential cation channel subfamily V member 3

7 of 14

607066

TRPV4; transient receptor potential cation channel subfamily V member 4

7 of 14

TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY V, MEMBER 4; TRPV4

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

nan - iav

anti tag coimmunoprecipitation, anti tag western blot, fluorescent resonance energy transfer, fluorescence microscopy

(Nesterov et al., 2015)

nan - wtrw

anti tag coimmunoprecipitation, anti tag western blot

(Kandasamy et al., 2022)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

nan

suppressible

Dnah3

(Karak et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0036414

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

TRP channels

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-42

Cytogenetic map

70D3-70D3

Sequence location

3L:14,186,249..14,189,648 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

70D3-70D3

Limits computationally determined from genome sequence between P{PZ}l(3)70Da⁰²⁴⁰²&P{PZ}btl⁰⁰²⁰⁸ and P{PZ}Mpcp⁰⁰⁵⁶⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-42

(FlyBase, 2016)

3-35.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

24903

w^*; P{nan-GAL4.K}2

31295

y¹ v¹; P{TRiP.JF01240}attP2

31674

y¹ v¹; P{TRiP.JF01467}attP2

53312

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03541}attP2

600030

y¹ w^*; TI{CRIMIC.TG4.0}nan^{CR70966-TG4.0}/TM3, Sb¹ Ser¹

VDRC

v100090

P{KK103594}VIE-260B

v5261

w¹¹¹⁸; P{GD2456}v5261

Genomic Clones (26)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0036414

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0036414

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

nan is involved in detecting dry air.

(Liu et al., 2007)

Larvae simultaneously injected with dsRNAs against iav and nan show normal thermotactic behaviour.

(Rosenzweig et al., 2005)

nan is required for hearing.

(Kim et al., 2003)

Mutants are deaf.

(Kim, 2003.2.11)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: nan CG5842

(Kim, 2003.2.11)

Nomenclature comments

Etymology

'nanchung' is Korean for deafness.

(Kim, 2003.2.11)

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG5842

(Yamaguchi and Takashima, 2018, Kanamori et al., 2013, Tsubouchi et al., 2012, Ni et al., 2010.12.1, Hazelett et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2008, Roos et al., 2005)

CT18317

(Littleton and Ganetzky, 2000)

DmNan

(Matsuura et al., 2009)

Iav

(Li et al., 2018)

NAN

(Zhang et al., 2013, Montell, 2005)

Nanchung

(Paschapur et al., 2025)

OCR

(Kim et al., 2003)

TRPV

(Montell, 2021, Kamikouchi et al., 2009, Caterina and Montell, 2005)

nan

(Komarov et al., 2025, Meng et al., 2025, Gowda et al., 2024, Luedke et al., 2024, Sang and Lee, 2024, Kandasamy et al., 2022, Liu et al., 2022, Tian et al., 2022, Li and Montell, 2021, Li et al., 2021, Crava et al., 2020, Jacobs and Sehgal, 2020, Jiang et al., 2020, Keder et al., 2020, Kitani-Morii and Noto, 2020, Kwon et al., 2020, Ma and Freeman, 2020, Wang et al., 2020, Zhang et al., 2020, Zhang et al., 2020, He et al., 2019, Huang et al., 2019, Rimal and Lee, 2019, Trcek and Lehmann, 2019, Zhou et al., 2019, Gene Disruption Project members, 2018-, Yan et al., 2018, Zanini et al., 2018, Bussmann and Storkebaum, 2017, Versteven et al., 2017, Enjin et al., 2016, Knecht et al., 2016, Peng et al., 2016, Akitake et al., 2015, Karak et al., 2015, Nesterov et al., 2015, Scholz et al., 2015, Menuz et al., 2014, Wong et al., 2014, Aleksic et al., 2013, Matsuo and Kamikouchi, 2013, Zhang et al., 2013, Lu et al., 2012, Newton et al., 2012, Senthilan et al., 2012, Tsubouchi et al., 2012, Cachero et al., 2011, Nadrowski et al., 2011, Kim et al., 2010, Kwon et al., 2010, Kwon et al., 2010, Kamikouchi et al., 2009, Sun et al., 2009, Yorozu et al., 2009, Horner and Wolfner, 2008, Kwon et al., 2008, Lee et al., 2008, Liu et al., 2007, Lumpkin and Caterina, 2007, Gopfert et al., 2006, Montell, 2005, Tobin and Bargmann, 2004)

Name Synonyms

NANCHUNG

(Zhang et al., 2013)

Nanchung

(Dhar et al., 2022, Yapici, 2020, Ishikawa and Kamikouchi, 2016, Fowler and Montell, 2013, Padinjat and Andrews, 2004, Tobin and Bargmann, 2004)

nanchung

(Himmel and Cox, 2020, Yamaguchi and Takashima, 2018, Jourjine, 2017, Nesterov et al., 2015, Ramdya et al., 2015, Matsuo and Kamikouchi, 2013, Tsubouchi et al., 2012, Cachero et al., 2011, Sénatore et al., 2010, Kamikouchi et al., 2009, Sun et al., 2009, Yorozu et al., 2009, Horner and Wolfner, 2008, Liu et al., 2007, Lumpkin and Caterina, 2007, Boekhoff-Falk, 2005, Montell, 2005, Kim, 2003.2.11, Kim et al., 2003)

transient receptor potential vanilloid

(Kamikouchi et al., 2009)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 34 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39571

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AY262004

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PI57

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PI57

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39571/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036414

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036414

FlyMine - An integrated database for Drosophila genomics

FBgn0036414

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5842

MARRVEL_MODEL - MARRVEL (model organism gene)

39571

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0036414

DroID - A comprehensive database of gene and protein interactions.

FBgn0036414

DRSC - Results frm RNAi screens

FBgn0036414

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

nan_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036414

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0036414

Flygut - An atlas of the Drosophila adult midgut

FBgn0036414

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0036414

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013928

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

TRP channels

References (155)

The following external sites may use different assemblies or annotations than FlyBase.

NA

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