FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term calcium channel activity ID (Ontology) GO:0005262 (Gene Ontology)
Definition Enables the energy-independent facilitated diffusion of a calcium ion through a transmembrane aqueous pore or channel.[ ISBN:0815340729 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 calcium channel activity (all annotations which use CV term, excluding "NOT" statements)
     contributes_to | calcium channel activity       --
     enables | calcium channel activity       --
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monoatomic ion channel activity
 |__monoatomic cation channel activity________________
monoatomic cation transmembrane transporter activity  |
 |__monoatomic cation channel activity________________|
metal ion transmembrane transporter activity          |
 |__calcium ion transmembrane transporter activity____|
                                                      calcium channel activity  70 rec.
                                                       |__ligand-gated calcium channel activity 19 rec.
                                                       |   |__glutamate-gated calcium ion channel activity 7 rec.
                                                       |   |__intracellularly gated calcium channel activity(+) 7 rec.
                                                       |   |__pH-gated calcium channel activity 1 rec.
                                                       |__store-operated calcium channel activity 7 rec.
                                                       |__stretch-activated, monoatomic cation-selective, calcium channel activity 1 rec.
                                                       |__voltage-gated calcium channel activity 10 rec.
                                                           |__high voltage-gated calcium channel activity 3 rec.
                                                           |__intermediate voltage-gated calcium channel activity
                                                           |__light-activated voltage-gated calcium channel activity
                                                           |__low voltage-gated calcium channel activity 2 rec.
                                                           |__voltage-gated calcium channel activity involved in cardiac muscle cell action potential(+)
                                                           |__voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
                                                           |__voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels(+)
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Is a monoatomic cation channel activity
calcium ion transmembrane transporter activity
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Reactome:R-HSA-139854 "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol"
Reactome:R-HSA-139855 "P2X1-mediated entry of Ca++ from plasma"
Reactome:R-HSA-210420 "Ca2+ influx through voltage gated Ca2+ channels"
Reactome:R-HSA-3295579 "TRPs transport extracellular Ca2+ to cytosol"
Reactome:R-HSA-8949145 "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space"
Reactome:R-HSA-8949178 "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix"
Reactome:R-HSA-9663785 "CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol"
Reactome:R-HSA-9858800 "TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol"