FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term monoatomic cation channel activity ID (Ontology) GO:0005261 (Gene Ontology)
Definition Enables the energy-independent facilitated diffusion of a monoatomic cation through a transmembrane aqueous pore or channel.[ ISBN:0815340729 ]
Also Known As "cation diffusion facilitator activity"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       2
Genes (FBgn)  GO_MOLECULAR_FUNCTION      21
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 monoatomic cation channel activity (all annotations which use CV term, excluding "NOT" statements)       3     21
     contributes_to | monoatomic cation channel activity       --       1
     enables | monoatomic cation channel activity       --      20
Spanning Tree (Parents/Children)
Only view relationship: 
monoatomic ion transmembrane transporter activity
 |__monoatomic ion channel activity_______________________
 |__monoatomic cation transmembrane transporter activity__|
channel activity                                          |
 |__monoatomic ion channel activity_______________________|
                                                          monoatomic cation channel activity  228 rec.
                                                           |__calcium channel activity 70 rec.
                                                           |   |__ligand-gated calcium channel activity(+) 20 rec.
                                                           |   |__store-operated calcium channel activity 7 rec.
                                                           |   |__stretch-activated, monoatomic cation-selective, calcium channel activity 2 rec.
                                                           |   |__voltage-gated calcium channel activity(+) 10 rec.
                                                           |__ligand-gated monoatomic cation channel activity 95 rec.
                                                           |   |__acetylcholine-gated monoatomic cation-selective channel activity 12 rec.
                                                           |   |__calcium-activated cation channel activity(+) 10 rec.
                                                           |   |__chloride-activated potassium channel activity
                                                           |   |__extracellularly ATP-gated monoatomic cation channel activity
                                                           |   |__glycine betaine-activated nonselective monoatomic cation channel activity
                                                           |   |__glycine-gated cation channel activity
                                                           |   |__intracellular sodium-activated potassium channel activity 2 rec.
                                                           |   |__intracellularly cyclic nucleotide-activated monoatomic cation channel activity(+) 7 rec.
                                                           |   |__intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity 1 rec.
                                                           |   |__inward rectifier potassium channel activity(+) 5 rec.
                                                           |   |__ligand-gated calcium channel activity(+) 20 rec.
                                                           |   |__ligand-gated sodium channel activity(+) 41 rec.
                                                           |   |__mitochondrial ATP-gated potassium channel activity
                                                           |   |__serotonin-gated monoatomic cation channel activity
                                                           |__mechanosensitive monoatomic cation channel activity 14 rec.
                                                           |   |__mechanosensitive potassium channel activity
                                                           |   |__mechanosensitive voltage-gated sodium channel activity
                                                           |   |__stretch-activated, monoatomic cation-selective, calcium channel activity 2 rec.
                                                           |__osmolarity-sensing monoatomic cation channel activity
                                                           |__potassium channel activity 46 rec.
                                                           |   |__calcium-activated potassium channel activity(+) 6 rec.
                                                           |   |__chloride-activated potassium channel activity
                                                           |   |__G-protein gated potassium channel activity
                                                           |   |__intracellular sodium-activated potassium channel activity 2 rec.
                                                           |   |__kainate selective glutamate receptor activity 9 rec.
                                                           |   |__mechanosensitive potassium channel activity
                                                           |   |__mitochondrial ATP-gated potassium channel activity
                                                           |   |__potassium ion leak channel activity 11 rec.
                                                           |   |__voltage-gated potassium channel activity(+) 27 rec.
                                                           |__proton channel activity 33 rec.
                                                           |   |__proton-transporting ATP synthase activity, rotational mechanism 29 rec.
                                                           |   |__voltage-gated proton channel activity
                                                           |__sodium channel activity 50 rec.
                                                           |   |__bile acid-gated sodium channel activity
                                                           |   |__ligand-gated sodium channel activity(+) 41 rec.
                                                           |   |__voltage-gated sodium channel activity(+) 5 rec.
                                                           |__temperature-gated cation channel activity 1 rec.
                                                           |__voltage-gated monoatomic cation channel activity 41 rec.
                                                               |__voltage-gated calcium channel activity(+) 10 rec.
                                                               |__voltage-gated potassium channel activity(+) 27 rec.
                                                               |__voltage-gated proton channel activity
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Is a monoatomic ion channel activity
monoatomic cation transmembrane transporter activity
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Synonyms
  • "cation channel activity" BROAD
    "cation diffusion facilitator activity" EXACT
    "non-selective cation channel activity" NARROW
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-1168376 "STIM1 oligomerizes"
Reactome:R-HSA-1296043 "Activation of HCN channels"
Reactome:R-HSA-169683 "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol"
Reactome:R-HSA-2089943 "TRPC1 translocates calcium from the extracellular region to the cytosol"
Reactome:R-HSA-426223 "Cation influx mediated by TRPC3/6/7"
Reactome:R-HSA-4420052 "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT"
Reactome:R-HSA-9706720 "SARS-CoV-1 E transports Ca2+"
Reactome:R-HSA-9712190 "cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol"
Reactome:R-HSA-9754616 "SARS-CoV-2 E pentamer transports Ca2+"
Reactome:R-HSA-9837835 "SH pentamer transports K+"