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FB2026_02
,
released June 18, 2026
dTrpA1, dANKTM1, TrpA, Transient receptor potential A1, DmTRPA1
heat-activated TRP family cation channel that is essential for thermotaxis - controls thermotaxis at innocuous temperatures, as well as thermal and chemical nociception in response to noxious heat and chemical exposure
Please see the JBrowse view of Dmel\TrpA1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Initial two exons previously annotated as final exons of one alternative transcript of CG5747 mfr. Species conservation data supporst the current gene structures.
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Gene model reviewed during 6.32
None of the polypeptides share 100% sequence identity.
Homotetramer.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TrpA1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
TrpA1 immunoreactivity was observed across most of the anterior midgut and in two lateral domains across middle midgut boundaries facing the anterior or posterior midgut. TrpA1-expressing cells were closely associated with immunoreactivity of the enteroendocrine cell nuclear marker, pros, but not with those of intestinal stem cell and enteroblast markers.
TrpA1 protein expression was observed in the mouthparts in neurons innervating sensilla numbers 8 and 9 of the labral sense organ.
TrpA1 is expressed in two uncharacterised groups of cells in the adult brain: the lateral cells (LC) and ventral cells (VC).
JBrowse - Visual display of RNA-Seq signals
View Dmel\TrpA1 in JBrowse3-27
3-21.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
TrpA1 functions in temperature control of circadian rhythm in pacemaker neurons.
The isoform referred to as TRPA1(B) in FBrf0222493 is called "TRPA1-A" in FBrf0217493. The isoform referred to as TRPA1(A) in FBrf0222493 is similar to that called "TRPA1-D" in FBrf0217493, except that "TRPA1(A)" has an additional N-terminal amino acids.
The TRPA1(B) isoform encodes a non-selective cation channel that can be activated by heat, voltage and chemicals.
The "TRPA1(B)" isoform is activated by noxious chemicals when expressed in Xenopus oocytes and expression of this isoform can restore an avoidance response to noxious chemicals in TrpA1 mutant flies. However, the expression of this isoform inside the head should minimise its exposure to environmental irritants, and thus in wild-type flies its primary function may be as a warmth sensor.
The "TRPA1(A)" isoform is much less thermosensitive than TRPA1(B) when expressed in Xenopus oocytes and does not confer thermal sensitivity on neurons when expressed in them. Expression of this isoform can restore an avoidance response to noxious chemicals in TrpA1 mutant flies.
S2R+ cells expressing the "TRP1-A" isoform show heat-induced Ca[2+] responses.
S2R+ cells expressing the "TRPA1-B" isoform lack Ca[2+] responses to temperature in the 20-42[o]C range, but show Ca[2+] responses to an irritant chemical.
The "TRPA1-C" isoform rescues thermal nociception phenotypes when expressed in TrpA1 mutant nociceptors. S2R+ cells expressing this isoform do not show a meaningful response to temperatures in the range of 15-42[o]C, which suggests that "TRPA1-C" is not acting directly as a noxious heat sensor. S2R+ cells expressing this isoform do show Ca[2+] responses to an irritant chemical.
S2R+ cells expressing the "TRPA1-D" isoform show Ca[2+] responses significantly above the baseline beginning at a temperature of 34[o]C.
TrpA1 is required for thermal nociception in both larvae and adult flies.
TrpA1 is essential for class IV dendritic arborization neuron light responses.
TrpA1 is required cell autonomously for light transduction in class IV dendritic arborization neurons.
TrpA1 functions as a molecular sensor of warmth.
TrpA1 is required for normal thermotactic behaviour.
Larvae injected with dsRNA against TrpA1 show abnormal thermotactic behaviour, while their chemotactic response to n-octyl acetate and response to being touched with a hot (55oC) probe is normal.
The threshold for response of the "TRPA1(B)" isoform is 24-29[o]C.
Source for identity of: TrpA1 Anktm1
