ScerGAL4VT030604 drives expression in adult alpha'/beta' Kenyon cell, and in a subset of gnathal neurons.
Drives expression in alpha'/beta' Kenyon cells in the adult mushroom body.
Inhibition (using Hsap\KCNJ2UAS.EGFP) of Scer\GAL4VT030604 cells, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, reduces the number of lipid droplets, but does not affect food intake or climbing rate, compared to controls.
Thermogenetic activation (using TrpA1UAS.(B).cKa at 30[o]C) of Scer\GAL4VT030604 cells in adults increases the number of lipid droplets and significantly increases food intake, but does not affect climbing rate, compared to controls.
Inhibition (using shits1.IVS.p10.20xUAS at 32[o]C) of Scer\GAL4VT030604 cells in adults during consolidation alone, or acquisition and consolidation, but not acquisition or retrieval alone, significantly reduces 24-hour associative olfactory water-reward memory, compared to controls; inhibition has no effect on water preference, compared to controls.
Inhibition (using shi1.UAS at 31[o]C) of Scer\GAL4VT030604 cells in adults during testing only significantly reduces 3-hour aversive olfactory anaesthesia-resistant memory (ARM), compared to controls; ARM is further reduced when Scer\GAL4c739 and Scer\GAL4VT030604 cells are simultaneously inhibited during testing; neither of these combinations affect odor or shock avoidance, compared to controls.
Scer\GAL4VT030604/Octβ2RKK109808 is an enhancer of abnormal memory | adult stage phenotype of rsh1
shi1.UAS/Scer\GAL4VT030604 is an enhancer | heat sensitive of abnormal memory | adult stage phenotype of rsh1
Inhibition (using shi1.UAS at 31[o]C) of Scer\GAL4VT030604 cells during testing only significantly enhances the reduction in 3-hour aversive olfactory anaesthesia-resistant memory (ARM) seen in rad1 mutant adults.