FB2026_02 , released June 18, 2026
Allele: Scer\GAL4DBD.R37E10
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General Information
Symbol
Scer\GAL4DBD.R37E10
Species
S. cerevisiae
Name
FlyBase ID
FBal0303997
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{R37E10-GAL4.DBD}
Also Known As
R37E10-ZpGdbd
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Tuthill et al., 2013)
Progenitor genotype
Carried in construct
P{R37E10-GAL4.DBD}
Cytology
Description

The R37E10 enhancer fragment is fused upstream of the Drosophila synthetic core promoter (DSCP) followed by the GAL4(DBD)::Zip- hemidriver (component of the 'Split GAL4' system, contains the GAL4 DNA-binding domain). A Hsp70 transcriptional terminator is present.

(Tuthill et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
GMR37E10
Encoded product / tool
GAL4(DBD)::Zip-
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      dopaminergic PAM neuron 11

      Comment: when combined with P{R58E02-p65.AD} (combination referred to as 'MB299B')

      (Ichinose et al., 2015, Yamagata et al., 2015, Aso et al., 2014)
      lamina monopolar neuron L5

      Comment: when combined with P{R64B07-p65.AD}

      when combined with P{R64H10-p65.AD} (combination referred to as 'SS55445')

      (Riddiford et al., 2018, Strother et al., 2018, Tuthill et al., 2013)
      dopaminergic PAM neuron 10 | faint

      Comment: when combined with P{R58E02-p65.AD} (combination referred to as 'MB299B')

      (Aso et al., 2014)
      dopaminergic PAM neuron 4 | faint

      Comment: when combined with P{R58E02-p65.AD} (combination referred to as 'MB299B')

      (Aso et al., 2014)
      lamina monopolar neuron L5 | subset

      Comment: when combined with P{R64B07-p65.AD} (combination referred to as 'L5b-Gal4')

      (Yuan et al., 2021)
      Additional Information
      Statement
      Reference
       
      Marker for
      lamina monopolar neuron L5
      (Tuthill et al., 2013)
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using shi1.UAS at 32[o]C) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R37E10 and Hsap\RELAAD.R58E02 in adults during, or immediately after, training, but not during, or immediately before, testing, significantly impairs long-term appetitive olfactory memory, compared to controls; inhibition does not affect short-term memory.

      (Ichinose et al., 2015)

      Thermogenetic activation (using TrpA1UAS.(B).cKa at 30[o]C) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R37E10 and Hsap\RELAAD.R58E02 in adults, in combination with a paired odor, results in a significant increase in long-term associative attractive olfactory memory, compared to controls.

      Inhibition (using shits1.IVS.p10.20xUAS at 33[o]C) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R37E10 and Hsap\RELAAD.R58E02 in adults during training significantly reduces long-term, but not short-term, associative appetitive (sugar) olfactory memory, compared to controls.

      (Yamagata et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Split-GAL4 transgene, constructed as described in FBrf0212052.

      (Tuthill et al., 2013)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Scer\GAL4DBD.R37E10.T:Zzzz\Zip-
      Scer\GAL4DBD.R37E10
      Name Synonyms
      Secondary FlyBase IDs
        References (19)