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Citation
Yamagata, N., Ichinose, T., Aso, Y., Pla├žais, P.Y., Friedrich, A.B., Sima, R.J., Preat, T., Rubin, G.M., Tanimoto, H. (2015). Distinct dopamine neurons mediate reward signals for short- and long-term memories.  Proc. Natl. Acad. Sci. U.S.A. 112(2): 578--583.
FlyBase ID
FBrf0227330
Publication Type
Research paper
Abstract

Drosophila melanogaster can acquire a stable appetitive olfactory memory when the presentation of a sugar reward and an odor are paired. However, the neuronal mechanisms by which a single training induces long-term memory are poorly understood. Here we show that two distinct subsets of dopamine neurons in the fly brain signal reward for short-term (STM) and long-term memories (LTM). One subset induces memory that decays within several hours, whereas the other induces memory that gradually develops after training. They convey reward signals to spatially segregated synaptic domains of the mushroom body (MB), a potential site for convergence. Furthermore, we identified a single type of dopamine neuron that conveys the reward signal to restricted subdomains of the mushroom body lobes and induces long-term memory. Constant appetitive memory retention after a single training session thus comprises two memory components triggered by distinct dopamine neurons.

PubMed ID
PubMed Central ID
PMC4299218 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Alleles (36)
    Genes (7)
    Insertions (1)
    Transgenic Constructs (36)
    Transcripts (30)