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Citation
Zhang, S.X., Rogulja, D., Crickmore, M.A. (2019). Recurrent Circuitry Sustains Drosophila Courtship Drive While Priming Itself for Satiety.  Curr. Biol. 29(19): 3216--3228.e9.
FlyBase ID
FBrf0243713
Publication Type
Research paper
Abstract

Motivations intensify over hours or days, promoting goals that are achieved in minutes or hours, causing satiety that persists for hours or days. Here we develop Drosophila courtship as a system to study these long-timescale motivational dynamics. We identify two neuronal populations engaged in a recurrent excitation loop, the output of which elevates a dopamine signal that increases the propensity to court. Electrical activity within the recurrent loop accrues with abstinence and, through the activity-dependent transcription factor CREB2, drives the production of activity-suppressing potassium channels. Loop activity is decremented by each mating to reduce subsequent courtship drive, and the inhibitory loop environment established by CREB2 during high motivation slows the reaccumulation of activity for days. Computational modeling reproduces these behavioral and physiological dynamics, generating predictions that we validate experimentally and illustrating a causal link between the motivation that drives behavior and the satiety that endures after goal achievement.

PubMed ID
PubMed Central ID
PMC6783369 (PMC) (EuropePMC)
Related Publication(s)
Note

Neuroscience: Tantalized Flies Are Primed for Satiety.
Ahmed and Murthy, 2019, Curr. Biol. 29(21): R1146--RR1148 [FBrf0243941]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference
    Alleles (64)
    Genes (27)
    Natural transposons (1)
    Insertions (16)
    Experimental Tools (8)
    Transgenic Constructs (57)
    Transcripts (6)