FlyBase Allele Report: Dmel\VAChT[GD3054]

General Information

Symbol

Dmel\VAChT^GD3054

Species

D. melanogaster

Name

FlyBase ID

FBal0208955

Feature type

allele

Associated gene

Dmel\VAChT

Associated Insertion(s)

Carried in Construct

P{GD3054}

Also Known As

UAS-VAChT-RNAi

Key Links

Genomic Maps

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Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - RNAi

(Dickson et al., 2007.7.18)

in vitro construct - regulatory fusion

(Dickson et al., 2007.7.18)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{GD3054}

Cytology

Nature of the lesion

Statement

Reference

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

VAChT

Associated Sequence Features

dsRNA-GD3054

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight, with Scer\GAL4^elav.PLu

(Dietzl et al., 2007)

abnormal locomotor behavior, with Scer\GAL4^elav.PLu

(Dietzl et al., 2007)

abnormal locomotor behavior, with Scer\GAL4^Mef2.PR

(Dietzl et al., 2007)

abnormal locomotor behavior | adult stage, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

lethal, with Scer\GAL4^elav.PLu

(Dietzl et al., 2007)

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

tormogen cell, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Expression of VAChT^GD3054 under the control of Scer\GAL4^Tab2-201Y does not induce any eclosion defect.

(Hamid et al., 2019)

Expression of VAChT^GD3054 under the control of Scer\GAL4^dimm-929 does not affect sensitivity to (S,Z,Z)-CH503 (a more potent stereoisomer of the gustatory sex pheromone CH503). As in wild type flies, courtship defects are seen in response to (S,Z,Z)-CH503.

(Shankar et al., 2015)

Adults expressing VAChT^GD3054 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in external sensory organs consisting of empty or multiple sockets in 40-50% of the Scer\GAL4^pnr-MD237 expression domain of the notum.

(Mummery-Widmer et al., 2009)

Expression of VAChT^GD3054 under the control of Scer\GAL4^elav.PLu causes either lethality or locomotory and flight defects, depending on the insertion of the the P{GD3054} transgene.

(Dietzl et al., 2007)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development