FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Scer\GAL4VP16.natalisin
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General Information
Symbol
Scer\GAL4VP16.natalisin
Species
S. cerevisiae
Name
FlyBase ID
FBal0291516
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{natalisin-GAL4-VP16}
Also Known As
NTL-Gal4
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Jiang et al., 2013)
Progenitor genotype
Carried in construct
P{natalisin-GAL4-VP16}
Cytology
Description

A 2249bp fragment from upstream of natalisin is fused upstream of the Drosophila synthetic core promoter (DSCP) sequence encoding a GAL4::VP16 driver. The entire coding region has been optimised for Drosophila codon usage. An Hsp70 transcriptional terminator is present.

(Jiang et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
natalisin
natalisin_NTL-Gal4
Encoded product / tool
GAL4::VP16
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      interneuron | subset of adult cerebrum
      (Jiang et al., 2013)
      adult subesophageal zone | restricted
      (Jiang et al., 2013)
      anterior ventrolateral protocerebrum | restricted
      (Jiang et al., 2013)
      neuron | subset of adult ventral nerve cord
      (Jiang et al., 2013)
      Additional Information
      Statement
      Reference

      ScerGAL4natalisin.HsimVP16 drives expression in two pairs of interneurons in the adult cerebrum. These were named by the authors according to their location as anterior dorso-lateral interneurons (ADLI) and inferior contralateral interneurons (ICLI). These arborize in the anterior ventrolateral protocerebrum, the anterior adult subesophageal zone and project to the thoracico-abdominal ganglion. In contrast to immunolabeling the reporter is not expressed in neurons of the adult pars intercerebralis.

      (Jiang et al., 2013)
       
      Marker for
      Reflects expression of
      natalisin
      (Jiang et al., 2013)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Pka-C1UAS.Tag:FLAG/Scer\GAL4VP16.natalisin is a non-suppressor of abnormal copulation | recessive | male phenotype of Pka-C3d

      (Cassar et al., 2018)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Scer\GAL4VP16.natalisin
      Scer\GAL4natalisin.Hsim\VP16
      Name Synonyms
      Secondary FlyBase IDs
        References (4)