FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Scer\GAL4NP5272
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General Information
Symbol
Scer\GAL4NP5272
Species
S. cerevisiae
Name
FlyBase ID
FBal0245078
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
P{GawB}NP5272
Carried in Construct
Also Known As
NP5272-gal4, NP5272
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}NP5272
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        distribution deduced from reporter (Gal4 UAS)
        Stage
        Tissue/Position (including subcellular localization)
        Reference
        adult stage
        dopaminergic PAM neuron 3
        (Flybrain Neuron Database et al., 2018.6.28, Shuai et al., 2015, Aso et al., 2012, Tanaka et al., 2008)
        mushroom body beta lobe slice 2
        (Shuai et al., 2015, Tanaka et al., 2008)
        mushroom body beta lobe posterior layer
        (Tanaka et al., 2008)
        mushroom body beta lobe surface layer
        (Tanaka et al., 2008)
        adult dopaminergic PAM neuron | subset
        (Aso et al., 2012)
        adult brain | restricted
        (Shuai et al., 2015)
        mushroom body extrinsic neuron
        (Shuai et al., 2015)
        mushroom body beta' lobe slice 2
        (Shuai et al., 2015)
        Additional Information
        Statement
        Reference

        ScerGAL4NP5272 drives expression in mushroom body extrinsic neurons, including mushroom body medial lobe arborizing neuron 3, that innervate mushroom body beta lobe slice 2 and mushroom body beta' lobe slice 2.

        (Shuai et al., 2015)

        ScerGAL4NP5272 drives expression in three dopaminergic PAM neurons (MB-M3 neurons).

        (Aso et al., 2012)
         
        Marker for
        dopaminergic PAM neuron 3
        (Tanaka et al., 2008)
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Inhibition (using shi1.UAS at 32[o]C) of Scer\GAL4NP5272 cells in adults does not affect startle-induced climbing behavior, compared to controls.

        Thermogenetic activation (using TrpA1UAS.(B).cKa at 32[o]C) of Scer\GAL4NP5272 cells in adults does not affect startle-induced climbing behavior, compared to controls.

        (Sun et al., 2018)

        Inhibition (using Hsap\KCNJ2UAS.EGFP) of Scer\GAL4NP5272 neurons, in combination with a Gal80[ts] transgene to restrict expression to 1 day prior to training and testing, does not affect 3 hour aversive olfactory memory, compared to controls.

        (Shuai et al., 2015)

        Inhibition (using shi1.UAS at 33[o]C) of Scer\GAL4NP5272 cells in adults during training and testing or training alone, but not only after training, significantly reduces 30-min aversive, but not appetitive, olfactory memory, compared to controls; inhibition during training significantly reduces 2-hour total, but not anaesthesia-resistant, memory, but has little effect on immediate or 9-hour memory; inhibition does not affect naive shock avoidance, compared to controls.

        Thermogenetic activation (using TrpA1UAS.(B).cKa at 30[o]C) of Scer\GAL4NP5272 cells in adults, in combination with a paired odor, results in a significant increase in 2-min, but not 2-hour, aversive olfactory memory, compared to controls; this increase is no longer seen when activation is restricted to a smaller subset of Scer\GAL4NP5272 cells using Scer\GAL80ple.PK.

        (Aso et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Scer\GAL4NP5272
        Name Synonyms
        Secondary FlyBase IDs
          References (13)