FlyBase Allele Report: Scer\GAL4[NP6510]

Drives expression in non-dopaminergic neurons in the fan-shaped body, including the adult lateral fan-shaped body tangential-protocerebrum neuron ExFl1; and in a subset of 15 dopaminergic PAM neurons that innervate beta- and beta'-lobes of the adult mushroom body.

(FlyBase Curators, 2017)

ScerGAL4^NP6510 drives expression in a subset of 15 dopaminergic PAM neurons that innervate beta- and beta'-lobes of the adult mushroom body. Projections are observed both to the ipsilateral and the contralateral side. Neurons innervating the beta'-lobe show extensive dendritic arborization. Two to three labelled neurons innervating the fan-shaped body are non-dopaminergic. GRASP experiments show that ScerGAL4^NP6510 expression is presynaptic in Kenyon cells of the mushroom body medial lobes.

(Riemensperger et al., 2013)

The number of neurons detected by ScerGAL4^NP6510 varied between hemispheres of the same brain.

(Cheng et al., 2013)

ScerGAL4^NP6510 drives expression in a subset of dopaminergic PAM neurons that innervate the mushroom body beta' lobe segment 2, beta lobe segment 1 and alpha lobe segment 1.

(Aso et al., 2012)

Approximately 7 fan-shaped F1 somata are labelled with ScerGAL4^NP6510. Neurites from these cells converge into a bundle that runs dorsally and the posteriorly into the fan-shaped body.

(Li et al., 2009)

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

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Modifiers Based on Experimental Evidence ( 0 )

Disease

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Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal adult locomotory behavior | progressive, with Spyo\Cas9^UAS.uM, mbt^HD_CFD00807

(Pütz et al., 2021)

abnormal locomotor behavior | adult stage, with Hsap\SNCA^A30P.UAS

(Riemensperger et al., 2013)

abnormal locomotor behavior | adult stage, with Hsap\SNCA^UAS.cFa

(Riemensperger et al., 2013)

abnormal locomotor behavior | adult stage, with ple^JF01813

(Riemensperger et al., 2013)

abnormal locomotor behavior | adult stage | heat sensitive, with shi^1.UAS

(Sun et al., 2018)

abnormal locomotor behavior | adult stage | heat sensitive, with TrpA1^UAS.(B).cKa

(Sun et al., 2018)

abnormal locomotor behavior | adult stage | progressive | heat sensitive, with TrpA1^UAS.(B).cKa

(Riemensperger et al., 2013)

abnormal neuroanatomy | adult stage | progressive, with Hsap\SNCA^A30P.UAS

(Riemensperger et al., 2013)

decreased rate of adult locomotory behavior, with Aprt^KK108921

(Petitgas et al., 2024)

lethal, with Hsap\KCNJ2^UAS.EGFP

(Hong et al., 2008)

Phenotype Manifest In

adult dopaminergic PAM neuron | progressive, with Hsap\SNCA^A30P.UAS

(Riemensperger et al., 2013)

Detailed Description

Statement

Reference

Inhibition (using shi^1.UAS at 32[o]C) of Scer\GAL4^NP6510 cells in adults results in a small, but significant, increase in startle-induced climbing behavior, compared to controls.

Thermogenetic activation (using TrpA1^UAS.(B).cKa at 32[o]C) of Scer\GAL4^NP6510 cells in adults results in a small, but significant, decrease in startle-induced climbing behavior, compared to controls.

(Sun et al., 2018)

Thermogenetic activation (using TrpA1^UAS.(B).cKa at 30[o]C) of Scer\GAL4^NP6510 cells in adults, in combination with a paired odor, does not significantly affect 2-min olfactory memory, compared to controls.

(Aso et al., 2010)

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Xenogenetic Interactions