FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hangUAS.cSa
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General Information
Symbol
Dmel\hangUAS.cSa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Scholz
FlyBase ID
FBal0179550
Feature type
allele
Associated gene
Dmel\hang
Associated Insertion(s)
Carried in Construct
P{UAS-hang.S}
Also Known As
UAS-hang
Key Links
Transgenic product class
cDNA
(Scholz et al., 2005)
wild_type
(Scholz et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Scholz et al., 2005)
wild_type
(Scholz et al., 2005)
Mutagen
in vitro construct
(Scholz et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-hang.S}
Cytology
Description

UASt regulatory sequences drive expression of the full length GH14331 hang cDNA.

(Scholz et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
hang
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of hangScer\UAS.cSa under the control of Scer\GAL4dnc.RA - together with tub-Gal80[ts] to limit the expression to a short period before the inebriation test - leads to increased sensitivity to ethanol during initial exposure but also increased tolerance upon re-exposition. Expression during development (without tub-Gal80[ts]-mediated temporal control) is lethal.

      (Ruppert et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Pde4.RA/hangUAS.cSa rescues hangAE10

      (Ruppert et al., 2017)

      Scer\GAL4NP6510/hangUAS.cSa rescues hangAE10

      (Ruppert et al., 2017)

      Scer\GAL4Appl.G1a/hangUAS.cSa rescues hangAE10

      (Scholz et al., 2005)
      Comments

      The reduced ability of hangAE10 mutant adults to develop tolerance to ethanol upon re-exposition is rescued by expression of hangScer\UAS.cSa under the control of either Scer\GAL4dnc.RA or Scer\GAL4NP6510 together with tub-Gal80[ts] to limit the expression to a short period before the inebriation test (temporally unrestricted expression of hangScer\UAS.cSa in the mutant background using either of the two drivers is lethal).

      (Ruppert et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      hangScer\UAS.cSa
      hangUAS.cSa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Scholz
      (Scholz et al., 2005)
      Secondary FlyBase IDs
        References (2)