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Reference
Citation
Shimell, M., Pan, X., Martin, F.A., Ghosh, A.C., Leopold, P., O'Connor, M.B., Romero, N.M. (2018). Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing.  Development 145(6): dev159699.
FlyBase ID
FBrf0238358
Publication Type
Research paper
Abstract

Adult size and fitness are controlled by a combination of genetics and environmental cues. In Drosophila, growth is confined to the larval phase and final body size is impacted by the duration of this phase, which is under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting and metamorphosis. Here, we test this by examining the consequences of null mutations in the P tth gene for Drosophila development. Loss of P tth causes several developmental defects, including a delay in developmental timing, increase in critical weight, loss of coordination between body and imaginal disc growth, and reduced adult survival in suboptimal environmental conditions such as nutritional deprivation or high population density. These defects are caused by a decrease in ecdysone production associated with altered transcription of ecdysone biosynthetic genes. Therefore, the PTTH signal contributes to coordination between environmental cues and the developmental program to ensure individual fitness and survival.

PubMed ID
PubMed Central ID
PMC5897599 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location data for the Ptth[Delta] deletion.
Romero, 2019.3.26, Location data for the Ptth[Delta] deletion. [FBrf0241945]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference