FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Ecol\lexAGMR18C11
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General Information
Symbol
Ecol\lexAGMR18C11
Species
E. coli
Name
FlyBase ID
FBal0289006
Feature type
allele
Associated gene
Ecol\lexA
Associated Insertion(s)
Carried in Construct
P{GMR18C11-lexA}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Pfeiffer et al., 2013.10.9)
Progenitor genotype
Carried in construct
P{GMR18C11-lexA}
Cytology
Description

A 2145 base pair fragment from the flanking non-coding or intronic region of Dr is fused upstream of a Drosophila core synthetic promoter (DSCP) followed by sequence encoding a lexA::p65 driver. The driver sequence has been optimized for Drosophila codon usage. An Hsp70 transcriptional terminator is present.

(Pfeiffer et al., 2013.10.9)
Allele components
Component
Use(s)
Regulatory region(s)
GMR18C11
Encoded product / tool
lexA::p65
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      antennal grooming descending neuron 1
      (Hampel et al., 2015)
      antennal grooming descending neuron 2
      (Hampel et al., 2015)
      antennal grooming descending neuron 3
      (Hampel et al., 2015)
      adult brain | restricted
      (Hampel et al., 2015)
      adult ventral nerve cord | restricted
      (Hampel et al., 2015)
      Additional Information
      Statement
      Reference

      EcollexAGMR18C11 expressing antennal grooming descending neurons 1-3 projections are in close proximity to projections from antennal grooming brain interneuron 1 expressing the split-GAL4 combination, ScerGAL4DBD.R34C03 and HsapRELAAD.R11B11.

      (Hampel et al., 2015)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Thermogenetic activation (using TrpA113xlexAop.JFRC26 at 30-31[o]C) of Ecol\lexAGMR18C11 neurons results in a significant increase of antennal grooming behavior compared to control flies.

      (Hampel et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Although alleles from the Janelia Farm lexA driver collection incorporate the same enhancer fragments used to create the Janelia Farm GAL4 driver alleles (GMR_Brain_exp_1), significant differences are frequently observed in the expression pattern of a given enhancer fragment inserted in the P{CaryP}attP40 or other docking site compared to the same fragment inserted in the P{CaryP}attP2 docking site. Generally the Ecol\lexA patterns are subsets of the Scer\GAL4 patterns.

      (Pfeiffer et al., 2013.10.9)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ecol\lexAGMR18C11
      Name Synonyms
      Secondary FlyBase IDs
        References (2)