FlyBase Gene Report: Dmel\CCKLR-17D3

General Information

Symbol

Dmel\CCKLR-17D3

Species

D. melanogaster

Name

Cholecystokinin-like receptor at 17D3

Annotation Symbol

CG32540

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030954

Gene Model Status

Current

Stock Availability

33 publicly available

Gene Summary

Cholecystokinin-like receptor at 17D3 (CCKLR-17D3) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Dsk. It acts through the cAMP-PKA-CREB pathway and it is needed for the growth of neuromuscular junctions. It regulates food ingestion, satiety, hyperactivity, aggression and escape-related locomotion. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

DSK-R1, CCK-like receptor at 17D3

Key Links

Genomic Location

Cytogenetic map

17D3-17D4

Sequence location

X:18,764,483..18,774,027 [-]

Recombination map

1-60

RefSeq locus

NC_004354 REGION:18764483..18774027

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables G protein-coupled receptor activity

inferred from sequence or structural similarity

(Radford et al., 2002, Brody and Cravchik, 2000)

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

enables gastrin receptor activity

inferred from electronic annotation with InterPro:IPR000314

(InterPro Project Members, 2004-)

enables neuropeptide receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001201778

(GO Reference Genome Project, 2011-)

inferred from sequence model

(Hewes and Taghert, 2001)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in adult locomotory behavior

inferred from mutant phenotype

(Kiss et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR000314, InterPro:IPR009126

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from sequence model

(Hewes and Taghert, 2001)

involved_in neuropeptide signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001201778

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence model

(Hewes and Taghert, 2001)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR000314, InterPro:IPR009126, InterPro:IPR017452

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001201778

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS -: The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CCKLR-17D3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7M3J6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

RNAseq data also supports the deletion of CCKLR-17D3-RA; the transcript model supported by cDNAs fails to correspond to either exon junctions or RPKM values.

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CCKLR-17D3-RB

FBtr0113003

NM_001103553

2230

584

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CCKLR-17D3-PB

FBpp0111916

62.2

584

8.09

Q7M3J6

NP_001097023

AAF48879

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7M3J6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CCKLR-17D3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CCKLR-17D3_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.09

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CCKLR-17D3 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CCKLR-17D3

View exonic expression by tissue for Dmel\CCKLR-17D3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32864/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030954

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030954

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030954

Flygut - An atlas of the Drosophila adult midgut

FBgn0030954

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CCKLR-17D3

Transgenic constructs containing regulatory region of CCKLR-17D3

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)Exel7464

(Ryder, 2004.4.26)

Inferred from location ( 20 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^nub.PU

CCKLR-17D3^GD731

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Act5C.PU

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

CCKLR-17D3^GD3431

Other Phenotypes

Allele

abnormal behavior | adult stage

CCKLR-17D3^KK110484

abnormal copulation, with Scer\GAL4^{CCKLR-17D3-2A-GAL4}

CCKLR-17D3^JF02968

abnormal copulation, with Scer\GAL4^elav.PU

CCKLR-17D3^JF02968

abnormal copulation | recessive

CCKLR-17D3^attP

abnormal copulation | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

CCKLR-17D3^JF02968

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CCKLR-17D3^GD731

abnormal pain response | larval stage

visible | adult stage, with Scer\GAL4^nub.PU

CCKLR-17D3^GD731

Phenotype manifest in

Allele

larval Goro neuron

CCKLR-17D3^Δ1

wing | absent, with Scer\GAL4^nub.PU

CCKLR-17D3^GD731

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (111)

Hsap\CCKAR

11 of 14

Yes

10 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\AVPR1B

1 of 14

Yes

Hsap\AVPR2

1 of 14

Hsap\BDKRB1

1 of 14

Yes

Hsap\BRS3

1 of 14

Hsap\CCR1

1 of 14

Yes

Hsap\CCR8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CXCR2

1 of 14

Yes

Hsap\CXCR4

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\GPR183

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\OR1M1

1 of 14

Yes

Hsap\OR14L1P

1 of 14

Yes

Hsap\OXTR

1 of 14

Yes

Hsap\P2RY8

1 of 14

Yes

Hsap\PRLHR

1 of 14

Hsap\PROKR1

1 of 14

Yes

Hsap\PROKR2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (54)

Rnor\Cckar

11 of 14

Yes

Rnor\Cckbr

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Avpr1b

1 of 14

Yes

Rnor\Brs3

1 of 14

Rnor\Ccr1

1 of 14

Yes

Rnor\Ccr2

1 of 14

Yes

Rnor\Ccr3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Prokr2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (51)

Mmus\Cckbr

11 of 14

Yes

Mmus\Cckar

10 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Avpr1b

1 of 14

Yes

Mmus\Brs3

1 of 14

Mmus\Ccr1

1 of 14

Yes

Mmus\Ccr2

1 of 14

Yes

Mmus\Ccr3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (90)

Xtro\cckar

6 of 13

Yes

Xtro\cckbr

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\avpr2

1 of 13

Yes

Xtro\brs3

1 of 13

Xtro\ccr3

1 of 13

Yes

Xtro\ccr6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\hrh4.b2

1 of 13

Xtro\hrh4.d1

1 of 13

Yes

Xtro\hrh4.g3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100495677

1 of 13

Yes

Xtro\LOC100498398

1 of 13

Yes

Xtro\LOC101733812

1 of 13

Yes

Xtro\LOC101733830

1 of 13

Yes

Xtro\LOC101734771

1 of 13

Xtro\LOC105946838

1 of 13

Xtro\LOC116411706

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xtro\opnpl [provisonal]

1 of 13

Xtro\oprk1

1 of 13

Xtro\prlhr

1 of 13

Xtro\qrfprl2.2

1 of 13

Yes

Xtro\qrfpr

1 of 13

Yes

Xtro\rho

1 of 13

Yes

Xtro\rrh

1 of 13

Xtro\shisal2b

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\tmtops

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (97)

Drer\cckar

11 of 14

Yes

Drer\cckbra

11 of 14

Yes

Drer\LOC100331465

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\prlhr2a

1 of 14

Drer\prlhr2b

1 of 14

Drer\qrfpra

1 of 14

Yes

Drer\qrfprb

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:ch73-160i9.2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\tmtops3b

1 of 14

Drer\tmtopsa

1 of 14

Drer\tmtopsb

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (66)

Cele\ckr-1

11 of 14

Yes

Cele\ckr-2

9 of 14

Yes

Cele\B0563.6

1 of 14

Cele\C24B5.1

1 of 14

Cele\C34B4.3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\F59B2.13

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\R13H7.2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\srw-53

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (56)

Agam\GPRCCK1

9 of 12

Yes

8 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CCKLR-17D3. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (51)

12 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Lkr

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Rh2

1 of 13

Rh3

1 of 13

Rh6

1 of 13

Rh7

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

anxiety modulator(s), CCK-like receptors

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CCKAR; cholecystokinin A receptor

11 of 14

118444

CCKBR; cholecystokinin B receptor

10 of 14

118445

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

TrpA1

suppressible

CCKLR-17D3

(Wang et al., 2022)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0030954

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-60

Cytogenetic map

17D3-17D4

Sequence location

X:18,764,483..18,774,027 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

17D3-17D4

Limits computationally determined from genome sequence between P{EP}EP443^EP443&P{EP}Bx^EP1383 and P{EP}Pk17E^EP438

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-60

(FlyBase, 2016)

1-59.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (33)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

49056

w¹¹¹⁸; P{GMR24A06-GAL4}attP2

49066

w¹¹¹⁸; P{GMR24B06-GAL4}attP2

49117

w¹¹¹⁸; P{GMR25C03-GAL4}attP2

54640

w¹¹¹⁸; P{GMR24B06-lexA}attP40

Korea

12010

P{VT063954-GAL4}attP2

12824

P{VT063956-GAL4}attP2

15339

P{VT063959-GAL4}attP2

17337

P{VT063959-lexA::GADfl}attP2

6881R-1

v102039

v1815

v9154

w¹¹¹⁸; P{GD3431}v9154/TM3

More stocks available...

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (3)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030954

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030954

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CCKLR-17D3 anon-WO0170980.64 anon-WO0170980.65

(FlyBase, 1996-)

Source for merge of: CCKLR-17D3 CG6881

(McBride, 2001.3.16)

Additional comments

Annotations CG6881, CG6894 merged as CG32540 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CCKLR-17D3 anon-WO0170980.64 anon-WO0170980.65 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: CCKLR-17D3 CG6894

(McBride, 2001.3.16)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

17D3

(Guo et al., 2021)

CCKLR-17D3-R

(Taghert, 2022)

CCKLR-D3

(Walker et al., 2013)

CCKLR17D3

(Song et al., 2025)

CG32540

(Mao et al., 2024, Kondo et al., 2020, Kiss et al., 2013, Keleman et al., 2009.8.5, Perkins et al., 2009, Metpally and Sowdhamini, 2005)

CG6861

(Vanden Broeck, 2001)

CG6881

(Hauser et al., 2006, Hauser et al., 2006, Kubiak et al., 2002, Hewes and Taghert, 2001, Hewes and Taghert, 2001.7.31)

CG6894

(Kubiak et al., 2002, Hewes and Taghert, 2001, Vanden Broeck, 2001)

DSK-R1

(Nichols et al., 2022, Bass et al., 2014, Kubiak et al., 2002)

DskR-1

(Kiss et al., 2013)

SK-R

(Rasmussen et al., 2015)

anon-WO0131005.21

anon-WO0170980.64

anon-WO0170980.65

Name Synonyms

CCK-like receptor at 17D3

(Saad and Hipfner, 2021, McBride, 2001.3.16)

Cholecystokinin-like receptor at 17D3

DSK-receptor2

(Veenstra et al., 2008)

Sulfakinin receptor

(Caers et al., 2012)

Secondary FlyBase IDs

FBgn0030953
FBgn0044361
FBgn0046518
FBgn0046519
FBgn0052540

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 34 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32864

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7M3J6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q7M3J6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7M3J6

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32864/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030954

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030954

FlyMine - An integrated database for Drosophila genomics

FBgn0030954

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32540

MARRVEL_MODEL - MARRVEL (model organism gene)

32864

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030954

DroID - A comprehensive database of gene and protein interactions.

FBgn0030954

DRSC - Results frm RNAi screens

FBgn0030954

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CCKLR-17D3_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030954

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030954

Flygut - An atlas of the Drosophila adult midgut

FBgn0030954

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

References (87)

The following external sites may use different assemblies or annotations than FlyBase.

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