mAChR, mAcR-60C, DM1, Acr60C, muscarinic Acetylcholine Receptor 60C
Gene model reviewed during 5.52
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mAChR-A using the Feature Mapper tool.
Transcripts are 80 times more prevalent in female head than body and also more prevalent in male head than body. Transcripts are detected at all stages tested but are most prevalent in 3-day male and female pupae and in adults and are more abundant in males than females.
GBrowse - Visual display of RNA-Seq signalsView Dmel\mAChR-A in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
FlyBase curator comment: Renamed from 'mAcR-60C' to 'mAcR' as there is a single mAcR gene in the D. melanogaster genome (so there's no need for the '60C' suffix) and to better reflect preferred usage in the literature.
Immunostaining demonstrates that mAcR-60C has a discrete localisation pattern in the brain including staining in regions associated with the processing of sensory information and certain neurosecretory cells.
The pharmacological properties of the mAcR-60C protein, as measured after expression in monkey COS-7 cells and Xenopus oocytes, is similar to that of the mammalian M1 and M3 subtypes.
The structural gene encoding a Drosophila homologue of vertebrate muscarinic acetylcholine receptor (mAChR). When expressed in Y1 adrenal cells it is physiologically active as measured by agonist- dependent stimulation of phosphatidylinositol metabolism.