FlyBase Gene Report: Dmel\TrissinR

General Information

Symbol

Dmel\TrissinR

Species

D. melanogaster

Name

Trissin receptor

Annotation Symbol

CG34381

Feature Type

protein_coding_gene

FlyBase ID

FBgn0085410

Gene Model Status

Current

Stock Availability

36 publicly available

Gene Summary

G-protein coupled receptor which is activated by the Trissin peptide in vitro, leading to increased intracellular calcium ion levels. (UniProt, Q9VML9)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

25F5-26A1

Sequence location

2L:5,824,004..5,856,767 [+]

Recombination map

2-18

RefSeq locus

NT_033779 REGION:5824004..5856767

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables G protein-coupled peptide receptor activity

inferred from physical interaction with FLYBASE:Trissin; FB:FBgn0038343

(Ida et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables G protein-coupled peptide receptor activity

inferred from sequence or structural similarity with FLYBASE:TkR99D; FB:FBgn0004622

(Brody and Cravchik, 2000)

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000662653

(GO Reference Genome Project, 2011-)

enables neuropeptide receptor activity

inferred from sequence model

(Hewes and Taghert, 2001)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from direct assay

(Ida et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cellular response to hormone stimulus

inferred from biological aspect of ancestor with PANTHER:PTN001202348

(GO Reference Genome Project, 2011-)

involved_in G protein-coupled receptor signaling pathway

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

inferred from sequence model

(Hewes and Taghert, 2001)

inferred from sequence or structural similarity with FLYBASE:TkR99D; FB:FBgn0004622

(Brody and Cravchik, 2000)

inferred from biological aspect of ancestor with PANTHER:PTN000662653

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Ida et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence model

(Hewes and Taghert, 2001)

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR017452

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with FLYBASE:TkR99D; FB:FBgn0004622

(Brody and Cravchik, 2000)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000662653

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 1 family. (Q9VML9)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS -: The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).

Protein Function (UniProtKB)

G-protein coupled receptor which is activated by the Trissin peptide in vitro, leading to increased intracellular calcium ion levels.

(UniProt, Q9VML9)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\TrissinR for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VML9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

TrissinR-RB

FBtr0112619

NM_001103622

2826

669

TrissinR-RC

FBtr0330221

NM_135118

2811

664

TrissinR-RD

FBtr0330222

NM_001273179

3637

659

TrissinR-RE

FBtr0342612

NM_001298712

3601

664

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

TrissinR-PB

FBpp0111531

74.5

669

9.37

FBpp0303254

73.9

664

9.44

FBpp0303255

73.4

659

9.52

FBpp0309550

73.9

664

9.44

R4GRV6

NP_001285641

AHN54156

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

664 aa isoforms: TrissinR-PC, TrissinR-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TrissinR using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

TrissinR_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.01

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Ida et al., 2011)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\TrissinR in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\TrissinR

View exonic expression by tissue for Dmel\TrissinR

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33812/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085410

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085410

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085410

Flygut - An atlas of the Drosophila adult midgut

FBgn0085410

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of TrissinR

Transgenic constructs containing regulatory region of TrissinR

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)Exel6014

(Ryder, 2004.4.26)

Df(2L)rau^Δ

(Sieglitz et al., 2013)

Inferred from location ( 13 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

TrissinR^MI05488

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Other Phenotypes

Allele

abnormal locomotor rhythm | adult stage

TrissinR^attP

abnormal locomotor rhythm | adult stage, with Scer\GAL4^Clk.-856

TrissinR^KK107157

abnormal locomotor rhythm | adult stage, with Scer\GAL4^GMR73B06

TrissinR^KK107157

abnormal sleep | adult stage, with Hsap\RELA^AD.R11B03, Scer\GAL4^DBD.R77H08, Spyo\Cas9^UAS.P2

TrissinR^{UAS.gRNAx3.pCFD6}

abnormal sleep | adult stage, with Hsap\RELA^AD.R11B03, Scer\GAL4^DBD.VT002670

TrissinR^GL01058

abnormal sleep | adult stage, with Hsap\RELA^AD.R11B03, Scer\GAL4^DBD.VT002670, Spyo\Cas9^UAS.P2

TrissinR^{UAS.gRNAx3.pCFD6}

decreased rate of movement | adult stage

TrissinR^attP

decreased sleep | adult stage, with Hsap\RELA^AD.R11B03, Scer\GAL4^DBD.R77H08, Spyo\Cas9^UAS.P2

TrissinR^{UAS.gRNAx3.pCFD6}

decreased sleep | adult stage, with Hsap\RELA^AD.R11B03, Scer\GAL4^DBD.VT002670

TrissinR^GL01058

decreased sleep | adult stage, with Hsap\RELA^AD.R11B03, Scer\GAL4^DBD.VT002670, Spyo\Cas9^UAS.P2

TrissinR^{UAS.gRNAx3.pCFD6}

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (133)

Hsap\GALR1

2 of 14

Yes

Hsap\GALR2

2 of 14

Yes

Hsap\GALR3

2 of 14

Yes

Hsap\GHSR

2 of 14

Yes

Hsap\KISS1R

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\AVPR1B

1 of 14

Yes

Hsap\AVPR2

1 of 14

Hsap\BDKRB1

1 of 14

Yes

Hsap\BRS3

1 of 14

Hsap\C5AR1

1 of 14

Yes

Hsap\CCKAR

1 of 14

Hsap\CCKBR

1 of 14

Hsap\CCR1

1 of 14

Yes

Hsap\CCR2

1 of 14

Yes

Hsap\CCR9

1 of 14

Yes

Hsap\CCRL2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CYSLTR2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\F2R

1 of 14

Yes

Hsap\F2RL1

1 of 14

Yes

Hsap\GNRHR2

1 of 14

Hsap\GNRHR

1 of 14

Hsap\GPBAR1

1 of 14

Yes

Hsap\GPER1

1 of 14

Yes

Hsap\GPR3

1 of 14

Yes

Hsap\GPR19

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\GPR176

1 of 14

Yes

Hsap\GPR182

1 of 14

Yes

Hsap\GPR183

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\OR1L1

1 of 14

Yes

Hsap\OR1M1

1 of 14

Yes

Hsap\OR4D2

1 of 14

Yes

Hsap\OR4K1

1 of 14

Yes

Hsap\OR4K5

1 of 14

Yes

Hsap\OR4L1

1 of 14

Yes

Hsap\OR14I1

1 of 14

Yes

Hsap\OXTR

1 of 14

Yes

Hsap\P2RY1

1 of 14

Yes

Hsap\PROKR1

1 of 14

Yes

Hsap\PROKR2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (87)

Rnor\Galr1

2 of 14

Yes

Rnor\Galr2

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Ccr8

1 of 14

Yes

Rnor\Ccr9

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Cysltr2

1 of 14

Yes

Rnor\Galr3

1 of 14

Rnor\Ghsr

1 of 14

Rnor\Gpbar1

1 of 14

Yes

Rnor\Gpr3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Gpr176

1 of 14

Yes

Rnor\Gpr182

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Olr1405

1 of 14

Yes

Rnor\Olr1627

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Prokr2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Taar5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (87)

Mmus\Galr2

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Ccr6

1 of 14

Yes

Mmus\Ccr8

1 of 14

Yes

Mmus\Ccr9

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Cysltr1

1 of 14

Yes

Mmus\Fpr-rs6

1 of 14

Yes

Mmus\Fpr-rs7

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Gpr15

1 of 14

Yes

Mmus\Gpr84

1 of 14

Mmus\Gpr139

1 of 14

Mmus\Gpr161

1 of 14

Yes

Mmus\Gpr176

1 of 14

Yes

Mmus\Gpr182

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Olfr1028

1 of 14

Yes

Mmus\Olfr1029

1 of 14

Yes

Mmus\Olfr1232

1 of 14

Yes

Mmus\Olfr1377

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Prokr2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (107)

Xtro\galr1

2 of 13

Yes

Xtro\galr2

2 of 13

Yes

Xtro\galr3

2 of 13

Yes

Xtro\kiss1r

2 of 13

Yes

Xtro\kissr1b

2 of 13

Yes

Xtro\kissr2

2 of 13

Yes

Xtro\ackr4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\avpr2

1 of 13

Yes

Xtro\bdkrb2

1 of 13

Xtro\brs3

1 of 13

Xtro\ccr3

1 of 13

Yes

Xtro\ccr6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\f2rl1

1 of 13

Yes

Xtro\f2rl3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\gpr27

1 of 13

Yes

Xtro\gpr68

1 of 13

Yes

Xtro\gpr83

1 of 13

Xtro\gpr142

1 of 13

Xtro\gpr161

1 of 13

Yes

Xtro\gpr173

1 of 13

Yes

Xtro\gpr174

1 of 13

Yes

Xtro\gpr176

1 of 13

Yes

Xtro\hrh4.b2

1 of 13

Xtro\hrh4.d1

1 of 13

Yes

Xtro\hrh4.g3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100498398

1 of 13

Yes

Xtro\LOC101732366

1 of 13

Xtro\LOC101733812

1 of 13

Yes

Xtro\LOC101733830

1 of 13

Yes

Xtro\LOC105946838

1 of 13

Xtro\LOC116406441

1 of 13

Xtro\LOC116411706

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\p2ry2

1 of 13

Xtro\prlhr

1 of 13

Xtro\qrfprl2.2

1 of 13

Yes

Xtro\qrfpr

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\XB5962511

1 of 13

Danio rerio (Zebrafish) (150)

Drer\galr1b

2 of 14

Yes

Drer\galr2b

2 of 14

Yes

Drer\kiss1rb

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\aplnr2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ccr9a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\cysltr3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\gpr61l

1 of 14

Yes

Drer\gpr139

1 of 14

Drer\gpr142

1 of 14

Drer\gpr161b

1 of 14

Yes

Drer\gpr176

1 of 14

Yes

Drer\gpr183a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ltb4r2a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\prlhr2a

1 of 14

Drer\prlhr2b

1 of 14

Drer\qrfprb

1 of 14

Yes

Drer\rxfp3

1 of 14

Drer\si:ch211-207g17.3

1 of 14

Yes

Drer\si:ch211-238p8.31

1 of 14

Drer\si:dkey-6n21.13

1 of 14

Drer\si:dkey-42l23.2

1 of 14

Drer\si:dkey-63b1.1

1 of 14

Yes

Drer\si:dkey-247m21.3

1 of 14

Drer\si:zfos-169g10.2

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (153)

Cele\npr-21

9 of 14

Yes

Cele\npr-20

8 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\C54D10.5

1 of 14

Yes

Cele\ckr-1

1 of 14

Cele\ckr-2

1 of 14

Cele\D1014.2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\egl-6

1 of 14

Cele\F16C3.1

1 of 14

Cele\F20A1.2

1 of 14

Yes

Cele\F52D10.4

1 of 14

Cele\F56A11.4

1 of 14

Yes

Cele\F57A8.4

1 of 14

Yes

Cele\F59B2.13

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\R13H7.2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\srw-4

1 of 14

Yes

Cele\srw-26

1 of 14

Yes

Cele\srw-29

1 of 14

Yes

Cele\srw-31

1 of 14

Yes

Cele\srw-32

1 of 14

Yes

Cele\srw-33

1 of 14

Yes

Cele\srw-41

1 of 14

Yes

Cele\srw-42

1 of 14

Yes

Cele\srw-44

1 of 14

Yes

Cele\srw-51

1 of 14

Yes

Cele\srw-53

1 of 14

Yes

Cele\srw-56

1 of 14

Yes

Cele\srw-57

1 of 14

Yes

Cele\srw-59

1 of 14

Yes

Cele\srw-60

1 of 14

Yes

Cele\srw-67

1 of 14

Yes

Cele\srw-69

1 of 14

Yes

Cele\srw-90

1 of 14

Yes

Cele\srw-99

1 of 14

Yes

Cele\srw-112

1 of 14

Yes

Cele\srw-115

1 of 14

Yes

Cele\srw-117

1 of 14

Yes

Cele\srw-118

1 of 14

Yes

Cele\srw-119

1 of 14

Yes

Cele\srw-121

1 of 14

Yes

Cele\srw-122

1 of 14

Yes

Cele\srw-123

1 of 14

Yes

Cele\srw-124

1 of 14

Yes

Cele\srw-133

1 of 14

Yes

Cele\srw-136

1 of 14

Yes

Cele\srw-137

1 of 14

Yes

Cele\srw-138

1 of 14

Yes

Cele\srw-141

1 of 14

Yes

Cele\srw-142

1 of 14

Yes

Cele\srw-143

1 of 14

Yes

Cele\T10E10.3

1 of 14

Cele\T11F9.1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\Y40C5A.4

1 of 14

Yes

Cele\Y41D4B.24

1 of 14

Yes

Cele\Y70D2A.1

1 of 14

Cele\ZK1307.7

1 of 14

Yes

Cele\zzz-1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (59)

Agam\GPRNPR2

10 of 12

Yes

Agam\AgaP_AGAP008703

7 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:TrissinR. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (56)

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Lkr

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Rh2

1 of 13

Rh3

1 of 13

Rh6

1 of 13

Rh7

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

TrissinR - Trissin

ion exchange chromatography, molecular sieving, Identification by mass spectrometry, inferred by author

(Ida et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59979

DroID - A comprehensive database of gene and protein interactions.

FBgn0085410

MIST (protein-protein) - An integrated Molecular Interaction Database

33812

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

G alpha (q) signalling events

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-18

Cytogenetic map

25F5-26A1

Sequence location

2L:5,824,004..5,856,767 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

25F5-26A1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-18

(FlyBase, 2016)

2-19.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (36)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

48778

w¹¹¹⁸; P{GMR17F11-GAL4}attP2

48780

w¹¹¹⁸; P{GMR17G01-GAL4}attP2

48783

w¹¹¹⁸; P{GMR17G06-GAL4}attP2

48800

w¹¹¹⁸; P{GMR18B06-GAL4}attP2

48805

w¹¹¹⁸; P{GMR18C06-GAL4}attP2

48823

w¹¹¹⁸; P{GMR18G01-GAL4}attP2

89588

w¹¹¹⁸; P{R18G01-p65.AD}JK22C

52531

w¹¹¹⁸; P{GMR18G01-lexA}attP40

Korea

12570

P{VT002963-GAL4}attP2

17310

P{VT002963-lexA::GADfl}attP40

VDRC

v107943

P{KK107157}VIE-260B

v7886

w¹¹¹⁸; P{GD927}v7886

More stocks available...

Genomic Clones (29)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (6)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

IP12396

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0085410

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0085410

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG14004 CG31645

(FlyBase Genome Annotators, 2007)

Source for merge of: CG31645 anon-WO0170980.172 anon-WO0170980.173

(FlyBase, 1996-)

Source for merge of: CG14002 CG14003

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG14004 and CG31645 merged as CG34381 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Annotations CG14002 and CG14003 merged as CG31645 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG31645 anon-WO0170980.172 anon-WO0170980.173 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: TrissinR CG34381

(Ida et al., 2011)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG14002

CG14003

(Hauser et al., 2006, Hauser et al., 2006, Radford et al., 2002, Hewes and Taghert, 2001, Hewes and Taghert, 2001.7.31)

CG14004

CG31645

CG34381

(Mao et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Ashwal-Fluss et al., 2014, Cardoso et al., 2012, Cherbas et al., 2011, Ida et al., 2011, Jungreis, 2011.11.18, Keleman et al., 2009.8.5, Perkins et al., 2009, FlyBase Genome Annotators, 2007)

Trissin-R

(Taghert, 2022)

TrissinR

(Jiang et al., 2025, Sekiguchi et al., 2024, Corthals et al., 2023, Deshpande et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Schlichting et al., 2022, Liu et al., 2021, McLaughlin et al., 2021, Pang et al., 2021, Rao and Deng, 2019.10.23, Gene Disruption Project members, 2015-, Caers et al., 2012, Ni et al., 2011.7.19)

anon-WO0170980.172

anon-WO0170980.173

Name Synonyms

CG14004

CG31645

Trissin receptor

(Faisal et al., 2014, Caers et al., 2012)

trissin receptor

(Ida et al., 2011)

Secondary FlyBase IDs

FBgn0046569
FBgn0031744
FBgn0031743
FBgn0046570
FBgn0031742
FBgn0051645

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33812

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VML9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VML9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VML9

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33812/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085410

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085410

FlyMine - An integrated database for Drosophila genomics

FBgn0085410

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34381

MARRVEL_MODEL - MARRVEL (model organism gene)

33812

Linkouts

BioGRID - A database of protein and genetic interactions.

59979

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0085410

DroID - A comprehensive database of gene and protein interactions.

FBgn0085410

DRSC - Results frm RNAi screens

FBgn0085410

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

TrissinR_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085410

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0085410

Flygut - An atlas of the Drosophila adult midgut

FBgn0085410

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014731

MIST (protein-protein) - An integrated Molecular Interaction Database

33812

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

G alpha (q) signalling events

References (62)

The following external sites may use different assemblies or annotations than FlyBase.

-1.01

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