FlyBase Gene Report: Dmel\FMRFaR

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\FMRFaR

General Information

Symbol

Dmel\FMRFaR

Species

D. melanogaster

Name

FMRFamide Receptor

Annotation Symbol

CG2114

Feature Type

protein_coding_gene

FlyBase ID

FBgn0035385

Gene Model Status

Stock Availability

15 publicly available

Gene Summary

FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

FR, FMRFa-R, larval-opioid-receptor

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:3,001,716..3,011,860 [+]

Recombination map

3-5

RefSeq locus

NT_037436 REGION:3001716..3011860

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables neuropeptide receptor activity

inferred from physical interaction with FLYBASE:FMRFa; FB:FBgn0000715

(Johnson et al., 2003, Cazzamali and Grimmelikhuijzen, 2002)

enables peptide receptor activity

inferred from direct assay

(Meeusen et al., 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

enables neuropeptide receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000508514

(GO Reference Genome Project, 2011-)

inferred from sequence model

(Hewes and Taghert, 2001)

Biological Process (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in adult locomotory behavior

inferred from mutant phenotype

(Kiss et al., 2013)

involved_in behavioral defense response

inferred from mutant phenotype

(Klose et al., 2010)

involved_in larval locomotory behavior

inferred from mutant phenotype

(Klose et al., 2010)

involved_in neuropeptide signaling pathway

inferred from direct assay

(Johnson et al., 2003, Cazzamali and Grimmelikhuijzen, 2002)

inferred from mutant phenotype

(Ravi et al., 2018)

involved_in positive regulation of cytosolic calcium ion concentration

inferred from direct assay

(Meeusen et al., 2002)

inferred from mutant phenotype

(Ravi et al., 2018)

acts_upstream_of_positive_effect positive regulation of synaptic transmission, dopaminergic

inferred from mutant phenotype

(Ravi et al., 2018)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from sequence model

(Hewes and Taghert, 2001)

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

involved_in neuropeptide signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000508514

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Johnson et al., 2003, Cazzamali and Grimmelikhuijzen, 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR017452

(InterPro Project Members, 2004-)

inferred from sequence model

(Hewes and Taghert, 2001)

non-traceable author statement

(Meeusen et al., 2002)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000508514

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 1 family. (Q9VZW5)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS -: The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).

Protein Function (UniProtKB)

A receptor for the FMRFamide peptides (PubMed:12218185, PubMed:12438685). Reacts with high affinity to FMRFamide and intrinsic FMRFamide-related peptides (PubMed:12218185, PubMed:12438685). By stimulating intracellular calcium signaling through the inositol 1,4,5-trisphosphate receptor, Itpr, in dopaminergic neurons, may be involved in the maintenance of neuronal excitability and in the regulation of flight bout duration (PubMed:30110323).

(UniProt, Q9VZW5)

Gene Model and Products

Number of Transcripts

3

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\FMRFaR for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VZW5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0072980

3638

549

FBtr0332085

3638

549

FBtr0340706

3912

549

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0072850

61.8

549

9.07

FBpp0304395

61.8

549

9.07

FBpp0309525

61.8

549

9.07

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

549 aa isoforms: FMRFaR-PA, FMRFaR-PB, FMRFaR-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FMRFaR using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FMRFaR_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.00

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

RNA-seq

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

ventral midline of embryo

(Fontana and Crews, 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Johnson et al., 2003, Cazzamali and Grimmelikhuijzen, 2002)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\FMRFaR in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\FMRFaR

View exonic expression by tissue for Dmel\FMRFaR

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38357/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035385

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035385

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035385

Flygut - An atlas of the Drosophila adult midgut

FBgn0035385

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of FMRFaR

Transgenic constructs containing regulatory region of FMRFaR

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

FMRFaR^GD638

viable, with Scer\GAL4^Act5C.PU

FMRFaR^NIG.2114R

viable, with Scer\GAL4^Mef2.PR

FMRFaR^GD638

viable, with Scer\GAL4^pnr-MD237

FMRFaR^GD638

viable, with Scer\GAL4^tin.CΔ4

FMRFaR^GD638

Sterility

Allele

fertile, with Scer\GAL4^Act5C.PU

FMRFaR^NIG.2114R

Other Phenotypes

Allele

decreased rate of movement | adult stage, with Scer\GAL4^elav.PU

FMRFaR^JF01879

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (107)

2 of 14

Yes

No

2 of 14

Yes

No

1 of 14

No

No

2

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

5

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

8

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

3

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (74)

3 of 14

Yes

No

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Mus musculus (laboratory mouse) (88)

2 of 14

Yes

No

2 of 14

Yes

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Xenopus tropicalis (Western clawed frog) (84)

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

Xtro\LOC100488258

1 of 13

Yes

No

Xtro\LOC100488533

1 of 13

Yes

Yes

Xtro\LOC100489056

1 of 13

Yes

No

Xtro\LOC100490372

1 of 13

Yes

No

Xtro\LOC100491715

1 of 13

Yes

No

Xtro\LOC100491797

1 of 13

Yes

No

Xtro\LOC100491885

1 of 13

Yes

No

Xtro\LOC100496229

1 of 13

Yes

Yes

Xtro\LOC100498402

1 of 13

Yes

Yes

Xtro\LOC101733812

1 of 13

Yes

Yes

Xtro\LOC101734771

1 of 13

Yes

No

Xtro\LOC116406441

1 of 13

Yes

No

Xtro\LOC116411706

1 of 13

Yes

Yes

Xtro\LOC116412268

1 of 13

Yes

No

Xtro\LOC116412424

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

Xtro\opnpl [provisonal]

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

Yes

Danio rerio (Zebrafish) (157)

3 of 14

Yes

No

3 of 14

Yes

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Drer\LOC100331465

1 of 14

No

No

Drer\LOC100536357

1 of 14

No

No

Drer\LOC101884544

1 of 14

No

No

Drer\LOC108179083

1 of 14

No

No

Drer\LOC108179223

1 of 14

No

No

Drer\LOC108191508

1 of 14

No

No

Drer\LOC110438872

1 of 14

No

Yes

Drer\LOC110438873

1 of 14

No

No

Drer\LOC110440076

1 of 14

No

No

Drer\LOC110440145

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

Drer\si:ch73-160i9.1

1 of 14

No

Yes

Drer\si:ch73-160i9.2

1 of 14

No

Yes

Drer\si:ch211-207g17.3

1 of 14

No

Yes

Drer\si:ch211-238p8.24

1 of 14

No

Yes

Drer\si:ch211-238p8.35

1 of 14

No

No

Drer\si:dkey-6n21.13

1 of 14

No

No

Drer\si:dkey-63b1.1

1 of 14

No

Yes

Drer\si:dkey-148a17.6

1 of 14

No

Yes

Drer\si:zfos-169g10.2

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Caenorhabditis elegans (Nematode, roundworm) (256)

9 of 14

Yes

Yes

9 of 14

Yes

Yes

9 of 14

Yes

Yes

9 of 14

Yes

Yes

6 of 14

No

Yes

6 of 14

No

Yes

6 of 14

No

Yes

5 of 14

No

Yes

4 of 14

No

Yes

4 of 14

No

Yes

4 of 14

No

Yes

4 of 14

No

Yes

3 of 14

No

Yes

3 of 14

No

Yes

3 of 14

No

Yes

3 of 14

No

Yes

3 of 14

No

Yes

3 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

Yes

2 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

Cele\Y37E11AL.1

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

Anopheles gambiae (African malaria mosquito) (37)

12 of 12

Yes

Yes

Agam\AgaP_AGAP004122

1 of 12

No

No

Agam\AgaP_AGAP005229

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:FMRFaR. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (36)

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

phenotype-based detection assay, fluorescence microscopy, inferred by author

(Johnson et al., 2003)

phenotype-based detection assay, fluorescence microscopy, inferred by author

(Johnson et al., 2003)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0035385

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3L

Recombination map

3-5

Cytogenetic map

Sequence location

3L:3,001,716..3,011,860 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

63A3-63A3

Limits computationally determined from genome sequence between P{PZ}Spn⁰⁶⁹¹¹ and P{PZ}l(3)06803⁰⁶⁸⁰³

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-5

(FlyBase, 2016)

3-6.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

602872

39345

w¹¹¹⁸; P{GMR65C08-GAL4}attP2

39407

w¹¹¹⁸; P{GMR67C02-GAL4}attP2

600780

w¹¹¹⁸; P{R65C08-p65.AD}JK22C

84502

w^*; TI{TI}FMRFaR^attP

601435

w¹¹¹⁸; P{R65C08-GAL4.DBD}attP2

24212

w¹¹¹⁸; Mi{ET1}FMRFaR^MB04659

25858

y¹ v¹; P{TRiP.JF01879}attP2

2114R-1

2114R-2

v330070

P{VSH330070}attP40

v9594

w¹¹¹⁸; P{GD638}v9594

More stocks available...

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0035385

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0035385

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Source for identity of larval-opioid-receptor CG2114 was sequence comparison ( date:020313 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: larval-opioid-receptor CG2114

(FlyBase, 1996-)

Source for identity of: FMRFaR FR

(FlyBase, 2009-)

Nomenclature comments

Renamed from 'FR/Fmrf Receptor' to 'FMRFaR/FMRFamide Receptor' to introduce consistency in the nomenclature between this gene and 'FMRFa' and provide more informative symbol.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG2114

(Mao et al., 2024, Meadows, 2017.1.11, Jayakumar et al., 2016, Yu et al., 2016, Kiss et al., 2013, Bendena et al., 2012, Collin et al., 2011, Hamanaka et al., 2010, Nässel and Winther, 2010, Perkins et al., 2009.1.15, Johnson et al., 2008, Yapici et al., 2008, Hauser et al., 2006, Hauser et al., 2006, Johnson et al., 2003, Cazzamali and Grimmelikhuijzen, 2002, Hewes and Taghert, 2001, Hewes and Taghert, 2001.7.31, Brody and Cravchik, 2000)

Dm FMRFa-R

(Collin et al., 2011)

DmFR

(Qi et al., 2017)

DrmFMRFa-R

(Meeusen et al., 2002)

FMRFa-R

(Taghert, 2022, Rasmussen et al., 2015, Bass et al., 2014, Hauser et al., 2006)

FMRFaR

(Miyamoto et al., 2024, Bossen et al., 2023, Corthals et al., 2023, Song et al., 2023, Deshpande et al., 2022, Schlichting et al., 2022, Liu et al., 2021, Hajji et al., 2019, Rao and Deng, 2019.10.23, Ravi et al., 2018, Fontana and Crews, 2012, Meeusen, 2002.5.30)

FMRFaR2

(Nässel, 2025)

FR

(Milakovic et al., 2014, Kiss et al., 2013, Bendena et al., 2012, Caers et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Luo et al., 2011, Klose et al., 2010, Johnson et al., 2008, Yapici et al., 2008)

Fmrf R

(Qi et al., 2021)

Name Synonyms

FMRFa receptor

(Ormerod et al., 2022)

FMRFa-receptor

(Veenstra et al., 2008)

FMRFamide Receptor

FMRFamide receptor

(Yu et al., 2016, Caers et al., 2012)

Fmrf Receptor

Fmrf receptor

(Milakovic et al., 2014)

dFMRFa receptor

(Hamanaka et al., 2010)

larval-opioid-receptor

(Cazzamali, 2001.2.20)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 36 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38357

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VZW5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VZW5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9PBK3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VZW5

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38357/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035385

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035385

FlyMine - An integrated database for Drosophila genomics

FBgn0035385

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2114

MARRVEL_MODEL - MARRVEL (model organism gene)

38357

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0035385

DroID - A comprehensive database of gene and protein interactions.

FBgn0035385

DRSC - Results frm RNAi screens

FBgn0035385

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FMRFaR_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035385

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0035385

Flygut - An atlas of the Drosophila adult midgut

FBgn0035385

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001381

References (79)