FlyBase Gene Report: Dmel\SPR

General Information

Symbol

Dmel\SPR

Species

D. melanogaster

Name

Sex peptide receptor

Annotation Symbol

CG16752

Feature Type

protein_coding_gene

FlyBase ID

FBgn0029768

Gene Model Status

Current

Stock Availability

124 publicly available

Gene Summary

Receptor for two functionally unrelated ligands; SP (A70A) for controlling reproductive behaviors and MIP for controlling sleep behavior (PubMed:18066048, PubMed:20308537, PubMed:20458515, PubMed:24089336, PubMed:25333796). MIP-SPR pathway functions as a sleep homeostat which perceives the need for sleep and stabilizes it by providing a slow-acting inhibitory input to the fly arousal system that involve the pigment dispersing factor (pdf) neurons (PubMed:25333796). SP-SPR is one of the multiple SP pathways that induce female post-mating behavioral responses (PMR) such as the suppression of mating receptivity and initiation of egg laying (PubMed:18066048, PubMed:24089336). The PMR switch is achieved by mediating the synaptic output of neurons such as those expressing fruitless (fru), double sex (dsx) and pickpocket (ppk) (PubMed:18066048, PubMed:24089336). (UniProt, Q8SWR3)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

4F11-5A1

Sequence location

X:5,446,656..5,494,012 [+]

Recombination map

1-11

RefSeq locus

NC_004354 REGION:5446656..5494012

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables G protein-coupled peptide receptor activity

inferred from physical interaction with FLYBASE:SP; FB:FBgn0003034

(Yapici et al., 2008)

inferred from physical interaction with FLYBASE:SP; FB:FBgn0003034,FLYBASE:Mip; FB:FBgn0036713,FLYBASE:Dup99B; FB:FBgn0250832

(Kim et al., 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables G protein-coupled peptide receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN002931424

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR019427

(InterPro Project Members, 2004-)

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from direct assay

(Kim et al., 2010, Yapici et al., 2008)

involved_in negative regulation of female receptivity, post-mating

inferred from mutant phenotype

(Yapici et al., 2008)

involved_in regulation of egg-laying behavior

inferred from mutant phenotype

(Haussmann et al., 2013, Yapici et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN002931424

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Yapici et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR017452

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002931424

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 1 family. (Q8SWR3)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS -: The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).

Protein Function (UniProtKB)

(UniProt, Q8SWR3)

Summary (Interactive Fly)

G-protein coupled receptor - required in Fruitless plus neurons for post-mating switch in female reproductive behaviour - acts in a small subset of internal sensory neurons that innervate the female uterus and oviduct - these neurons project to regions of the central nervous system that have been implicated in the control of reproductive behaviors

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SPR for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8SWR3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.55

Double stop-codon suppression (UAG, UAA) postulated; FBrf0243886.

Gene model reviewed during 6.32

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

SPR-RA

FBtr0070778

NM_131997

3093

435

SPR-RB

FBtr0339781

NM_001297964

3357

435

SPR-RC

FBtr0344824

NM_001297963

2804

435

SPR-RD

FBtr0479797

NM_001382034

3093

512

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

SPR-PA

FBpp0070744

50.3

435

7.37

FBpp0308828

50.3

435

7.37

FBpp0311140

50.3

435

7.37

FBpp0428130

58.7

512

7.91

QJC18359

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

435 aa isoforms: SPR-PA, SPR-PB, SPR-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SPR using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

SPR_1
SPR_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.95

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

neuron | subset of lateral oviduct

(Yang et al., 2009)

neuron | subset of uterus

(Yang et al., 2009)

Additional Descriptive Data

SPR protein is detected in 8 neurons on the female lateral oviduct and uterus. These neurons co-express ScerGAL4^fru.P1.D.

(Yang et al., 2009)

SPR protein is detected in the spermathecum and lower oviduct. In adult females, staining is observed in the brain and ventral nerve cord, particularly in the subesophageal ganglion, cervical ganglion, and in many nerve roots.

(Yapici et al., 2008)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Yapici et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SPR in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\SPR

View exonic expression by tissue for Dmel\SPR

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029768

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31463/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029768

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029768

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029768

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16752

Flygut - An atlas of the Drosophila adult midgut

FBgn0029768

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of SPR

Transgenic constructs containing regulatory region of SPR

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)Exel6234

(Yapici et al., 2008, Ryder, 2004.4.26)

Inferred from location ( 12 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

SPR^GD3237

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

SPR^GD3236

Sterility

Allele

female semi-sterile, with Scer\GAL4^elav.PLu

SPR^GD3236

Other Phenotypes

Allele

abnormal behavior | female, with Scer\GAL4^elav.PLu

abnormal behavior | female, with Scer\GAL4^fru.P1.D

SPR^GD3236

abnormal copulation | female limited | chemical conditional, with Scer\GAL4^ppk.PG

SPR^GD3236

abnormal copulation | female limited | conditional, with Scer\GAL4^5-136

SPR^GD3236

abnormal copulation | female limited | conditional, with Scer\GAL4^elav.PLu

SPR^GD3236

abnormal copulation | female limited | conditional, with Scer\GAL4^NP2024

SPR^GD3236

abnormal copulation | female limited | conditional, with Scer\GAL4^ppk.PG

SPR^GD3236

abnormal copulation | female limited | conditional, with Scer\GAL4^UH3-50

SPR^GD3236

abnormal copulation | female limited | conditional, with Scer\GAL4^UH11-2

SPR^GD3236

abnormal copulation | female limited | conditional, with Scer\GAL4^UH14-15

SPR^GD3236

abnormal copulation | female limited | conditional, with Scer\GAL4^UH21-49

SPR^GD3236

abnormal courtship behavior | female, with Scer\GAL4^elav.PLu

abnormal courtship behavior | female, with Scer\GAL4^fru.P1.D

SPR^GD3236

abnormal flight, with Scer\GAL4^Mef2.PR

SPR^GD3237

abnormal mating behavior | female, with Scer\GAL4^dsx.KI

SPR^GD3236

abnormal mating behavior | female, with Scer\GAL4^fru.P1.D

SPR^GD3236

abnormal mating behavior | female, with Scer\GAL4^ppk.PG

SPR^GD3236

abnormal size | adult stage | mated female, with Scer\GAL4^Tub.PU

SPR^KK103356

decreased fecundity | female limited, with Scer\GAL4^5-136

SPR^GD3236

decreased fecundity | female limited, with Scer\GAL4^elav.PLu

SPR^GD3236

decreased fecundity | female limited, with Scer\GAL4^NP2024

SPR^GD3236

decreased fecundity | female limited, with Scer\GAL4^ppk.PG

SPR^GD3236

decreased fecundity | female limited, with Scer\GAL4^UH3-50

SPR^GD3236

decreased fecundity | female limited, with Scer\GAL4^UH11-2

SPR^GD3236

decreased fecundity | female limited, with Scer\GAL4^UH14-15

SPR^GD3236

decreased fecundity | female limited, with Scer\GAL4^UH21-49

SPR^GD3236

some die during pupal stage, with Scer\GAL4^pnr-MD237

SPR^GD3237

Phenotype manifest in

Allele

adult midgut | mated female, with Scer\GAL4^Tub.PU

SPR^KK103356

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (9)

Hsap\GPR142

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (6)

Rnor\Gpr139

2 of 14

Yes

Rnor\Gpr142

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (7)

Mmus\Gpr142

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (9)

Xtro\brd1

1 of 13

Yes

Xtro\gpr142

1 of 13

Yes

Xtro\LOC407755

1 of 13

Yes

Xtro\LOC100489056

1 of 13

Yes

Xtro\opn1lw

1 of 13

Yes

Xtro\opn1sw

1 of 13

Yes

Xtro\opn4

1 of 13

Yes

Xtro\XB5817984

1 of 13

Yes

Xtro\XB5957215

1 of 13

Yes

Danio rerio (Zebrafish) (22)

Drer\gpr142

3 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\sprr-1

11 of 14

Yes

Cele\sprr-2

7 of 14

Yes

Cele\sprr-3

4 of 14

Yes

Cele\dmsr-8

2 of 14

Cele\K01A6.6

2 of 14

Yes

Cele\T02D1.4

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (12)

Agam\GPRNNA16

8 of 12

Yes

Agam\AgaP_AGAP012426

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:SPR. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (12)

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Rh2

1 of 13

Rh3

1 of 13

Rh4

1 of 13

Rh6

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

SPR - Mip

phenotype-based detection assay, inferred by author

(Lee et al., 2020, Kim et al., 2010)

SPR - SP

phenotype-based detection assay, inferred by author

(Lee et al., 2020, Kim et al., 2010, Yapici et al., 2008)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0029768

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_stop_codon_read_through

(FlyBase Genome Annotators, 2020, FlyBase Genome Annotators, 2019-)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-11

Cytogenetic map

4F11-5A1

Sequence location

X:5,446,656..5,494,012 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

4F11-5A1

Limits computationally determined from genome sequence between P{EP}CG3249^EP1400 and P{EP}Tre1^EP496

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-11

(FlyBase, 2016)

1-13.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (124)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Korea

10711

P{EP}SPR^G887

11993

P{VT057292-GAL4}attP2

12249

P{VT057295-GAL4}attP2

12541

P{VT057282-GAL4}attP2

13578

P{VT057286-GAL4}attP2

13579

P{VT057293-GAL4}attP2

VDRC

v330048

P{VSH330048}attP40

v106804

P{KK103356}VIE-260B

v200311

P{VT057278-GAL4}attP2

v200916

P{VT057280-GAL4}attP2

v203225

P{VT057283-GAL4}attP2

v200828

P{VT057294-GAL4}attP2

More stocks available...

Genomic Clones (36)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (13)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE15519

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0029768

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0029768

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

SPR encodes the receptor for Acp70A protein.

(Yapici et al., 2008)

SPR is required in the subset of neurons that also express the fru gene for normal post-mating responses in females.

(Yapici et al., 2008)

Females lacking SPR fail to respond to Acp70A and continue to show virgin behaviours even after mating.

(Yapici et al., 2008)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG16752 CG12731

(FlyBase Genome Annotators, 2002-2003)

Additional comments

FlyBase curator comment: Correspondence with author Yapici revealed that 'SPR' = 'CG16752'.

(Yapici et al., 2008)

Annotations CG16752 and CG12731 merged as CG16752 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: SPR CG16752

(Yapici et al., 2008)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG12731

(Luschnig, 2003.12.17, Solano et al., 2003)

CG16752

(Mao et al., 2024, Kondo et al., 2020, Meadows, 2017.1.11, Bendena et al., 2012, Kim and Marqués, 2010, Nässel and Winther, 2010, Poels et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Prokupek et al., 2009, Holloway et al., 2008, Yapici et al., 2008, Metpally and Sowdhamini, 2005)

DrmSPR

(Kim et al., 2016)

SP-R

(Taghert, 2022)

SPR

(Nässel, 2025, Corthals et al., 2023, Deshpande et al., 2022, Majane et al., 2022, Schlichting et al., 2022, White and Wolfner, 2022, Goodwin and Hobert, 2021, Hoshino and Niwa, 2021, Kannangara et al., 2021, Liu et al., 2021, McLaughlin et al., 2021, White et al., 2021, FlyBase Genome Annotators, 2020, Kondo et al., 2020, Lee et al., 2020, FlyBase Genome Annotators, 2019-, Meltzer et al., 2019, Morimoto et al., 2019, Rao and Deng, 2019.10.23, Scheunemann et al., 2019, Yoshinari et al., 2019, Aranha and Vasconcelos, 2018, Gene Disruption Project members, 2018-, Jékely et al., 2018, Tian and Wang, 2018, Jang et al., 2017, Kurz et al., 2017, Smith et al., 2017, Bontonou et al., 2015, Kim et al., 2015, Kohl et al., 2015, Tsuda et al., 2015, Bussell et al., 2014, Feng et al., 2014, Findlay et al., 2014, Jung et al., 2014, Vernes, 2014, Haussmann et al., 2013, Pavlou and Goodwin, 2013, Caers et al., 2012, Chintapalli et al., 2012, Chow et al., 2010, Kim et al., 2010, Poels et al., 2010, Ribeiro and Dickson, 2010, Sokolowski, 2010, Häsemeyer et al., 2009, Prokupek et al., 2009, Yang et al., 2009, Yapici et al., 2008, Yapici et al., 2008)

Spr

(Keegan and Hughes, 2021)

sex peptide receptor

(Peng et al., 2024)

spr

(Garbe et al., 2016, Min et al., 2016)

Name Synonyms

CG16752

SP receptor

(Sokolowski, 2010)

Sex Peptide Receptor

(Majane et al., 2022)

Sex peptide Receptor

(Billeter and Wolfner, 2018)

Sex peptide receptor

(Shafer, 2025, Yu et al., 2016, Itskov and Ribeiro, 2013, Caers et al., 2012)

sex peptide receptor

(Pavlou and Goodwin, 2013, Bendena et al., 2012, Schnakenberg et al., 2012, Kim et al., 2010, Ribeiro and Dickson, 2010, Häsemeyer et al., 2009, Yapici et al., 2008, Yapici et al., 2008)

Secondary FlyBase IDs

FBgn0029767

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31463

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8SWR3

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q8SWR3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A6H2EEN9

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8SWR3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029768

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31463/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029768

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029768

FlyMine - An integrated database for Drosophila genomics

FBgn0029768

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG16752

MARRVEL_MODEL - MARRVEL (model organism gene)

31463

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0029768

DroID - A comprehensive database of gene and protein interactions.

FBgn0029768

DRSC - Results frm RNAi screens

FBgn0029768

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

SPR_1
SPR_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029768

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0029768

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16752

Flygut - An atlas of the Drosophila adult midgut

FBgn0029768

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002917

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (134)

The following external sites may use different assemblies or annotations than FlyBase.

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