FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
SPR, SP
FlyBase ID
FBig0000112192
Interaction Network
Interactions Browser links
SPR network
SP network
Reported Interactions
FBrf0202765-1.PBD
Reference
Yapici et al., 2008
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
SPR 

SPR

unspecified role
SPR 

SPR

unspecified role
SPR 

SPR

unspecified role
SP 

SP

unspecified role
SP 

SP

unspecified role
SP 

SP

unspecified role
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in CHO cell system; ligand peptide synthesized in vitro; receptor produced from transfected construct.

(Yapici et al., 2008)

Interaction inferred from the ability of SP to activate a reporter in a heterologous system expressing SPR.

(Yapici et al., 2008)
FBrf0210504-2.PH
Reference
Kim et al., 2010
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
SPR 

SPR

unspecified role
SPR 

SPR

unspecified role
SPR 

SPR

unspecified role
SP 

SP

unspecified role
SP 
SP 
SP 

SP

unspecified role
SP 

SP

unspecified role
SP 
SP 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
SP 
interaction domain
sufficient binding region
aa 40-55

coordinates relative to SP-PA, DKWCRLNLGPAWGGRC

SP 
interaction domain
mutation disrupting interaction
aa 42,51

coordinates relative to SP-PA, DKACRLNLGPAAGGRC

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in CHO cell system; ligand peptide synthesized in vitro; receptor produced from transfected construct.

(Kim et al., 2010)

Interaction inferred based on SP\'s ability to induce increase in [Ca2+] through SPR in a heterologous system.

(Kim et al., 2010)
FBrf0247343-1.PBD
Reference
Lee et al., 2020
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
SPR 

SPR

unspecified role
SPR 
SPR 
SPR 

SPR

unspecified role
SPR 
SPR 
SPR 

SPR

unspecified role
SP 

SP

unspecified role
SP 

SP

unspecified role
SP 

SP

unspecified role
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
SPR 
interaction domain
necessary binding region
aa 224-340

coordinates relative to SPR-PA

SPR 
interaction domain residue 238
mutation decreasing interaction
aa 238

P238L, coordinates relative to SPR-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction inferred from the ability of ligand peptide to induce a phenotype in a heterologous system expressing the receptor.

(Lee et al., 2020)

Interaction in CHO cell system; ligand peptide produced commercially; receptor produced from transfected construct.

(Lee et al., 2020)
External Crossreferences and Linkouts ( 0 )
References (3)