CCKLR, CCK-like receptor at 17D1, DSK-R2, CCKLR17D1
G-protein coupled receptor - along with drosulfakinin, its predicted ligand, a strong positive growth regulator of the larval neuromuscular junction
Please see the JBrowse view of Dmel\CCKLR-17D1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.53
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CCKLR-17D1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\CCKLR-17D1 in JBrowse1-60
1-59.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Sulfated Dsk isoforms 1 and 2 activate the CCKLR-17D1 receptor in a cell culture assay. Dsk/CCKLR-17D1 signaling appears to promote larval body wall muscle contraction and is necessary for mediating locomotor behaviour in the stress-induced escape response.
Source for merge of: CCKLR-17D1 anon-WO0170980.62 anon-WO0170980.61
Annotation CG6857 split into CG42301 (which corresponds to CCKLR-17D1) and CG42302 in release 5.9 of the genome annotation.
Source for merge of CCKLR-17D1 anon-WO0170980.62 anon-WO0170980.61 was sequence comparison ( date:051113 ).
Source for identity of: CCKLR-17D1 CG6857