FlyBase Gene Report: Dmel\TyrRII

General Information

Symbol

Dmel\TyrRII

Species

D. melanogaster

Name

Tyramine receptor II

Annotation Symbol

CG16766

Feature Type

protein_coding_gene

FlyBase ID

FBgn0038541

Gene Model Status

Current

Stock Availability

39 publicly available

Gene Summary

Tyramine receptor II (TyrRII) encodes a Tyramine 3 class receptor. When heterologously expressed it shows a high affinity for both tyramine and phenylethylamine, and a lower affinity for a range of other related biogenic amines, in both the inhibition of adenylyl cyclase activity and in the release of calcium from internal stores. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

TyRII, TAR3

Key Links

Genomic Location

Cytogenetic map

90C2-90C2

Sequence location

3R:17,736,611..17,747,470 [+]

Recombination map

3-61

RefSeq locus

NT_033777 REGION:17736611..17747470

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables G protein-coupled amine receptor activity

inferred from direct assay

(Bayliss et al., 2013)

enables tyramine receptor activity

inferred from mutant phenotype

(Zhang and Blumenthal, 2017)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables G protein-coupled amine receptor activity

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN002798190

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

inferred from direct assay

(Bayliss et al., 2013)

involved_in cellular response to amine stimulus

inferred from direct assay

(Bayliss et al., 2013)

involved_in tyramine signaling pathway

inferred from direct assay

(Bayliss et al., 2013)

inferred from mutant phenotype

(Zhang and Blumenthal, 2017)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating adrenergic receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001205212

(GO Reference Genome Project, 2011-)

involved_in G protein-coupled receptor signaling pathway

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

involved_in positive regulation of MAPK cascade

inferred from biological aspect of ancestor with PANTHER:PTN001205212

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Bayliss et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR017452

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002798190

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

TYRAMINE RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

TYRAMINE RECEPTORS -: Tyramine receptors belong to the Class A GPCR family. In mammalian systems, tyramine is a member of the trace amines, but in insects octopamine and tyramine are thought to be the main neurotransmitters. (Adapted from PMID:17088868, FBrf0214056 and FBrf0190865).

Summary (Interactive Fly)

GPCRs that arose by gene duplication - neuromodulation - adult brain - regulates courtship activity - TyrR is expressed in heart muscles - TyrRII is expressed in oenocytes

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\TyrRII for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VEG2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.54

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

TyrRII-RA

FBtr0083512

NM_142394

2514

586

TyrRII-RB

FBtr0332173

NM_001275753

2313

586

TyrRII-RC

FBtr0332174

NM_001275754

2812

586

TyrRII-RD

FBtr0344630

NM_001300451

4089

586

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

TyrRII-PA

FBpp0082936

64.9

586

9.22

FBpp0304482

64.9

586

9.22

FBpp0304483

64.9

586

9.22

FBpp0310947

64.9

586

9.22

Q9VEG2

NP_001287380

AHN57379

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

586 aa isoforms: TyrRII-PA, TyrRII-PB, TyrRII-PC, TyrRII-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VEG2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TyrRII using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

TyrRII_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.97

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval brain

(El-Kholy et al., 2015)

embryonic/larval hindgut

(El-Kholy et al., 2015)

embryonic/larval tracheal section

(El-Kholy et al., 2015)

embryonic/larval Malpighian tubule

(El-Kholy et al., 2015)

adult stage

adult brain

(El-Kholy et al., 2015)

adult muscle system

(El-Kholy et al., 2015)

adult hindgut

(El-Kholy et al., 2015)

adult tracheal section

(El-Kholy et al., 2015)

female reproductive system

(El-Kholy et al., 2015)

male reproductive system

(El-Kholy et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Bayliss et al., 2013)

Expression Deduced from Reporters

Reporter: P{TyrRII-GAL4.E}

Stage

Tissue/Position (including subcellular localization)

Reference

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\TyrRII in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\TyrRII

View exonic expression by tissue for Dmel\TyrRII

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42135/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038541

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038541

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038541

Flygut - An atlas of the Drosophila adult midgut

FBgn0038541

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of TyrRII

Transgenic constructs containing regulatory region of TyrRII

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)Exel6177

(Ryder, 2004.4.26)

Gene partially disrupted in

Df(3R)TAR3Δ29

(Zhang and Blumenthal, 2017)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

TyrRII^GD690

viable, with Scer\GAL4^tin.CΔ4

TyrRII^GD690

Other Phenotypes

Allele

abnormal sleep | adult stage

TyrRII^KOGal4

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (132)

Hsap\ADRA1A

2 of 14

Yes

Hsap\ADRA1B

2 of 14

Yes

Hsap\ADRA1D

2 of 14

Yes

Hsap\DRD2

2 of 14

Yes

Hsap\DRD3

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CCR2

1 of 14

Yes

Hsap\CCR4

1 of 14

Yes

Hsap\CCRL2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CXCR5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\GPR4

1 of 14

Yes

Hsap\GPR19

1 of 14

Yes

Hsap\GPR21

1 of 14

Hsap\GPR26

1 of 14

Yes

Hsap\GPR45

1 of 14

Yes

Hsap\GPR50

1 of 14

Hsap\GPR52

1 of 14

Hsap\GPR63

1 of 14

Yes

Hsap\GPR78

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\GPR183

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\OR1M1

1 of 14

Yes

Hsap\OR4D2

1 of 14

Yes

Hsap\OR4K5

1 of 14

Yes

Hsap\OR4L1

1 of 14

Yes

Hsap\OR14I1

1 of 14

Yes

Hsap\P2RY1

1 of 14

Yes

Hsap\PROKR1

1 of 14

Yes

Hsap\PROKR2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (66)

Rnor\Adra1a

2 of 14

Yes

Rnor\Adra1b

2 of 14

Yes

Rnor\Adra1d

2 of 14

Yes

Rnor\Drd2

2 of 14

Yes

Rnor\Drd3

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Ccr4

1 of 14

Yes

Rnor\Ccr8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Gpr83

1 of 14

Rnor\Gpr84

1 of 14

Rnor\Gpr161

1 of 14

Yes

Rnor\Gpr183

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (71)

Mmus\Adra1a

2 of 14

Yes

Mmus\Adra1b

2 of 14

Yes

Mmus\Adra1d

2 of 14

Yes

Mmus\Drd3

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Ccr8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Drd5

1 of 14

Mmus\Galr2

1 of 14

Mmus\Gpr26

1 of 14

Yes

Mmus\Gpr50

1 of 14

Mmus\Gpr84

1 of 14

Mmus\Gpr161

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Tbxa2r

1 of 14

Mmus\Trhr

1 of 14

Xenopus tropicalis (Western clawed frog) (104)

Xtro\adra1a

2 of 13

Yes

Xtro\ackr4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\avpr2

1 of 13

Yes

Xtro\brs3

1 of 13

Xtro\cbwd1.1

1 of 13

Xtro\ccr3

1 of 13

Yes

Xtro\ccr9

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\gpr65

1 of 13

Yes

Xtro\gpr78

1 of 13

Yes

Xtro\gpr83

1 of 13

Xtro\gpr148

1 of 13

Xtro\gpr161

1 of 13

Yes

Xtro\gpr173

1 of 13

Yes

Xtro\gpr174

1 of 13

Yes

Xtro\hrh4.b2

1 of 13

Xtro\hrh4.d1

1 of 13

Yes

Xtro\hrh4.g3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100498398

1 of 13

Yes

Xtro\LOC101733812

1 of 13

Yes

Xtro\LOC101734771

1 of 13

Xtro\LOC105946838

1 of 13

Xtro\LOC116411706

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\opn5

1 of 13

Xtro\opn8

1 of 13

Xtro\opnpl [provisonal]

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\qrfpr

1 of 13

Yes

Xtro\rho

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\tmtops

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (112)

Drer\adra1ab

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\gpr61l

1 of 14

Yes

Drer\gpr78a

1 of 14

Yes

Drer\gpr78b

1 of 14

Yes

Drer\gpr84

1 of 14

Drer\gpr161b

1 of 14

Yes

Drer\hcrtr2

1 of 14

Drer\hrh2a

1 of 14

Drer\hrh3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:ch211-213o11.11

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\trhr2

1 of 14

Drer\trhrb

1 of 14

Drer\zgc:162592

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (47)

Cele\ser-5

2 of 14

Yes

Cele\tyra-3

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (63)

Agam\GPRNNA4

6 of 12

Yes

Agam\AgaP_AGAP013324

4 of 12

Agam\GPROAR2

4 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:TyrRII. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (54)

8 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Lkr

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Rh2

1 of 13

Rh3

1 of 13

Rh4

1 of 13

Rh5

1 of 13

Rh6

1 of 13

Rh7

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0038541

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-61

Cytogenetic map

90C2-90C2

Sequence location

3R:17,736,611..17,747,470 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

90C2-90C2

Limits computationally determined from genome sequence between P{PZ}l(3)07882⁰⁷⁸⁸² and P{EP}cpo^EP3679

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-61

(FlyBase, 2016)

3-60.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (39)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

86150

w^*; P{UAS-TyrRII.D}2

38863

w¹¹¹⁸; P{GMR53B06-GAL4}attP2

53497

w¹¹¹⁸; P{GMR52E06-lexA}attP40

72923

w¹¹¹⁸; P{VT043284-p65.AD}attP40

FlyORF

F003141

M{UAS-TyrRII.ORF.3xHA.GW}ZH-86Fb

Korea

15236

P{VT043285-GAL4}attP2

16295

P{GMR52E06-lexA}attP18

16278

P{GMR52E06-lexA}su(Hw)attP8

VDRC

v110525

P{KK110990}VIE-260B

v201277

P{VT043284-GAL4}attP2

v51387

w¹¹¹⁸ P{GD690}v51387

v318784

PBac{fTRG01174.sfGFP-TVPTBF}VK00002

More stocks available...

Genomic Clones (31)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP13425

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0038541

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0038541

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG16766 anon-WO0170980.124 anon-WO0170980.125

(FlyBase, 1996-)

Additional comments

Source for merge of CG16766 anon-WO0170980.124 anon-WO0170980.125 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG16766

(Mao et al., 2024, Kondo et al., 2020, Park et al., 2018, Zhang and Blumenthal, 2017, Jayakumar et al., 2016, Bayliss et al., 2013, Keleman et al., 2009.8.5, Perkins et al., 2009, Hauser et al., 2006, Cazzamali et al., 2005, Metpally and Sowdhamini, 2005)

DmCG16766

(Roeder et al., 2003)

TAR3

(Rosikon et al., 2023, Li et al., 2017, Zhang and Blumenthal, 2017)

TyRII

(Palermo et al., 2023, Schlichting et al., 2022, Liu et al., 2021)

TyrR2

(Wu et al., 2025)

TyrR3

(Roeder, 2020)

TyrRII

(Agard et al., 2024, Blum et al., 2021, Deng, 2020.1.10, Deng and Rao, 2020.1.8, Kondo et al., 2020, Deng et al., 2019, Meltzer et al., 2019, Rao and Deng, 2019.10.23, Park et al., 2018, Damrau et al., 2017, Sarov et al., 2016, Deady and Sun, 2015, Gene Disruption Project members, 2015-, Faisal et al., 2014, Vernes, 2014, Japanese National Institute of Genetics, 2012.5.21)

TyrRIII

(El-Kholy et al., 2015)

anon-WO0170980.124

anon-WO0170980.125

tyrRII

(Ma and Freeman, 2020, Zhang and Blumenthal, 2017)

Name Synonyms

CG16766

Tyramine receptor II

tyramine receptor

(Selcho and Pauls, 2019)

Secondary FlyBase IDs

FBgn0046605
FBgn0046606

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42135

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VEG2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VEG2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VEG2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42135/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038541

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038541

FlyMine - An integrated database for Drosophila genomics

FBgn0038541

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG16766

MARRVEL_MODEL - MARRVEL (model organism gene)

42135

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0038541

DroID - A comprehensive database of gene and protein interactions.

FBgn0038541

DRSC - Results frm RNAi screens

FBgn0038541

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

TyrRII_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038541

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0038541

Flygut - An atlas of the Drosophila adult midgut

FBgn0038541

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0038541

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034301

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (65)

The following external sites may use different assemblies or annotations than FlyBase.

-0.97

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