FlyBase Gene Report: Dmel\Dop2R

General Information

Symbol

Dmel\Dop2R

Species

D. melanogaster

Name

Dopamine 2-like receptor

Annotation Symbol

CG33517

Feature Type

protein_coding_gene

FlyBase ID

FBgn0053517

Gene Model Status

Current

Stock Availability

129 publicly available

Gene Summary

Dopamine 2-like receptor (Dop2R) encodes a G protein-coupled receptor that is activated by dopamine. Postulated Dop2R-mediated functions include regulation of: aggression, cardiac function, feeding, levels of juvenile hormone and 20-hydroxyecdysone, lifespan, locomotor activity, nocturnal activity, olfactory associative learning, response to stress, sleep and sucrose acceptance. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

D2R, DD2R

Key Links

Genomic Location

Cytogenetic map

19A4-19A6

Sequence location

X:20,004,680..20,062,706 [-]

Recombination map

1-64

RefSeq locus

NC_004354 REGION:20004680..20062706

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables dopamine neurotransmitter receptor activity, coupled via Gi/Go

inferred from direct assay

(Hearn et al., 2002)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables dopamine neurotransmitter receptor activity, coupled via Gi/Go

inferred from biological aspect of ancestor with PANTHER:PTN000664816

(GO Reference Genome Project, 2011-)

enables G protein-coupled amine receptor activity

inferred from sequence or structural similarity with FLYBASE:5-HT7; FB:FBgn0004573

(Brody and Cravchik, 2000)

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from biological aspect of ancestor with PANTHER:PTN002798190

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in anesthesia-resistant memory

inferred from mutant phenotype

(Scholz-Kornehl and Schwärzel, 2016)

involved_in G protein-coupled dopamine receptor signaling pathway

inferred from direct assay

(Hearn et al., 2002)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from sequence or structural similarity with FLYBASE:5-HT7; FB:FBgn0004573

(Brody and Cravchik, 2000)

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence or structural similarity with FLYBASE:5-HT7; FB:FBgn0004573

(Brody and Cravchik, 2000)

non-traceable author statement

(Hearn et al., 2002)

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR017452

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002798190

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

DOPAMINE RECEPTORS

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 1 family. (Q8IS44)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

DOPAMINE RECEPTORS -: Dopamine GPCRs are Class A GPCRs. Dopamine is a neurotransmitter involved in a variety of behavioural and physiological functions such as memory, arousal and mating behaviour. (Adapted from PMID:17088868 and FBrf0219823).

Protein Function (UniProtKB)

Receptor for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

(UniProt, Q8IS44)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dop2R for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8IS44)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dop2R-RB

FBtr0070034

NM_001014759

4359

466

Dop2R-RF

FBtr0343167

NM_001014757

5461

760

Dop2R-RG

FBtr0343168

NM_001298548

5756

897

Dop2R-RH

FBtr0343169

NM_001014758

5896

905

Dop2R-RI

FBtr0343170

NM_001014760

5893

904

Dop2R-RJ

FBtr0343171

NM_001031909

5596

805

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Dop2R-PB

FBpp0099563

51.0

466

9.59

NP_001014759

AAF45375

Dop2R-PF

FBpp0309861

80.2

760

4.76

NP_001014757

AAX52463

Dop2R-PG

FBpp0309862

94.2

897

5.03

FBpp0309863

95.1

905

5.03

FBpp0309864

95.0

904

5.03

NP_001014760

AAX52462

Dop2R-PJ

FBpp0309865

85.2

805

5.06

Q4ABK5

NP_001027080

AAZ52487

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q8IS44

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dop2R using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dop2R_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.72

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult ventral nerve cord | restricted

(Draper et al., 2007)

adult deutocerebrum | restricted

(Draper et al., 2007)

adult fat body

Comment: assayed in females

(Gruntenko et al., 2012)

adult corpus allatum

Comment: assayed in females

(Gruntenko et al., 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Expression of Dop2R protein is more pronounced in the fat bodies of newly eclosed female flies than in sexually mature (6 days old) flies; while the opposite is observed in the corpus allatum of newly eclosed vs. mature female flies, where higher levels are observed in older flies.

(Gruntenko et al., 2012)

In the dorsal aspect of the larval VNC, D2R is expressed in a series of 11 paired neurons, one in each of the three thoracic segments and 8 abdominal segments, and are often in close proximity to dopaminergic cells. In the ventral aspect of the ventral nerve cord, one pair of D2R positive cells are found in each of the larval thoracic segments. In adults, D2R is expressed in three pairs of dorsal neurons within each thoracic segment of the ventral ganglion, and in a U-shaped cluster of cells in the abdominal neuromere.

(Draper et al., 2007)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Dop2R in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dop2R

View exonic expression by tissue for Dmel\Dop2R

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0053517

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33007/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0053517

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0053517

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0053517

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0053517

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Dop2R

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 18 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dop2R

Transgenic constructs containing regulatory region of Dop2R

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene partially disrupted in

Df(1)Dop2R^Δ1

(Scholz-Kornehl and Schwärzel, 2016)

Df(1)Dop2R^Δ2

(Scholz-Kornehl and Schwärzel, 2016)

Inferred from location ( 13 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dop2R^GD732

viable, with Scer\GAL4^Mef2.PR

Dop2R^GD732

viable, with Scer\GAL4^pnr-MD237

Dop2R^GD732

viable, with Scer\GAL4^tin.CΔ4

Dop2R^GD732

Other Phenotypes

Allele

abnormal feeding behavior, with Scer\GAL4^elav-C155

Dop2R^JF02025

abnormal feeding behavior, with Scer\GAL4^l.Trhn.PK

Dop2R^JF02025

abnormal locomotor behavior, with Scer\GAL4^Act5C.PI

Dop2R^RNAi.UAS.cDa

abnormal locomotor behavior, with Scer\GAL4^elav-C155

Dop2R^RNAi.UAS.cDa

abnormal memory | adult stage

abnormal memory | adult stage, with Scer\GAL4^17d

Dop2R^RNAi.UAS.cDa

abnormal memory | adult stage, with Scer\GAL4^elav.PU

Dop2R^RNAi.UAS.cDa

abnormal memory | adult stage, with Scer\GAL4^GH146

abnormal memory | adult stage, with Scer\GAL4^GH298

Dop2R^RNAi.UAS.cDa

abnormal memory | adult stage, with Scer\GAL4^Mef2.247

Dop2R^RNAi.UAS.cDa

abnormal memory | adult stage, with Scer\GAL4^NP1131

Dop2R^RNAi.UAS.cDa

abnormal memory | adult stage, with Scer\GAL4^NP1227

Dop2R^RNAi.UAS.cDa

abnormal memory | adult stage, with Scer\GAL4^NP2426

Dop2R^RNAi.UAS.cDa

abnormal memory | adult stage, with Scer\GAL4^NP2631

abnormal memory | adult stage, with Scer\GAL4^ple.PF

Dop2R^RNAi.UAS.cDa

abnormal memory | adult stage (with Df(1)BSC587)

abnormal memory | adult stage (with Dop2R^Δ1)

Dop2R^Δ2

abnormal memory | adult stage (with Dop2R^Δ2)

Dop2R^Δ1

abnormal sleep | adult stage

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (156)

Hsap\DRD2

8 of 14

Yes

Hsap\DRD3

7 of 14

Yes

Hsap\DRD4

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\AVPR1B

1 of 14

Yes

Hsap\BDKRB1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CCR2

1 of 14

Yes

Hsap\CCR8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CXCR1

1 of 14

Yes

Hsap\CXCR4

1 of 14

Yes

Hsap\CXCR5

1 of 14

Yes

Hsap\CYSLTR1

1 of 14

Yes

Hsap\DRD1

1 of 14

Hsap\DRD5

1 of 14

Hsap\EDNRA

1 of 14

Yes

Hsap\EDNRB

1 of 14

Yes

Hsap\F2RL2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\GPR12

1 of 14

Yes

Hsap\GPR17

1 of 14

Hsap\GPR19

1 of 14

Yes

Hsap\GPR21

1 of 14

Hsap\GPR25

1 of 14

Hsap\GPR27

1 of 14

Yes

Hsap\GPR34

1 of 14

Yes

Hsap\GPR39

1 of 14

Hsap\GPR45

1 of 14

Yes

Hsap\GPR50

1 of 14

Hsap\GPR52

1 of 14

Hsap\GPR61

1 of 14

Yes

Hsap\GPR63

1 of 14

Yes

Hsap\GPR83

1 of 14

Hsap\GPR84

1 of 14

Hsap\GPR85

1 of 14

Yes

Hsap\GPR88

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\GPR173

1 of 14

Yes

Hsap\GPR174

1 of 14

Yes

Hsap\GPR176

1 of 14

Yes

Hsap\GPR183

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\OR14I1

1 of 14

Yes

Hsap\P2RY1

1 of 14

Yes

Hsap\PROKR1

1 of 14

Yes

Hsap\PROKR2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (93)

Rnor\Drd2

9 of 14

Yes

Rnor\Drd3

7 of 14

Yes

Rnor\Drd4

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Gpr39

1 of 14

Rnor\Gpr84

1 of 14

Rnor\Gpr85

1 of 14

Yes

Rnor\Gpr88

1 of 14

Yes

Rnor\Gpr101

1 of 14

Yes

Rnor\Gpr139

1 of 14

Rnor\Gpr161

1 of 14

Yes

Rnor\Gpr173

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (102)

Mmus\Drd2

9 of 14

Yes

Mmus\Drd3

7 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Drd5

1 of 14

Mmus\Ednrb

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Gpr21

1 of 14

Mmus\Gpr27

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Gpr88

1 of 14

Yes

Mmus\Gpr101

1 of 14

Yes

Mmus\Gpr139

1 of 14

Mmus\Gpr161

1 of 14

Yes

Mmus\Gpr173

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Pgr15l

1 of 14

Mmus\Prlhr

1 of 14

Mmus\Prokr2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Tbxa2r

1 of 14

Mmus\Trhr2

1 of 14

Mmus\Trhr

1 of 14

Xenopus tropicalis (Western clawed frog) (120)

Xtro\drd2

4 of 13

Yes

Xtro\hkdc1

4 of 13

Yes

Xtro\drd4

3 of 13

Yes

Xtro\ackr4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\avpr2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\f2rl3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\gpr6

1 of 13

Yes

Xtro\gpr27

1 of 13

Yes

Xtro\gpr65

1 of 13

Yes

Xtro\gpr78

1 of 13

Yes

Xtro\gpr83

1 of 13

Xtro\gpr85

1 of 13

Yes

Xtro\gpr142

1 of 13

Xtro\gpr161

1 of 13

Yes

Xtro\gpr173

1 of 13

Yes

Xtro\gpr174

1 of 13

Yes

Xtro\gpr176

1 of 13

Yes

Xtro\hrh4.b2

1 of 13

Xtro\hrh4.d1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100496229

1 of 13

Yes

Xtro\LOC100498398

1 of 13

Yes

Xtro\LOC101732366

1 of 13

Xtro\LOC101733812

1 of 13

Yes

Xtro\LOC101734771

1 of 13

Xtro\LOC105946838

1 of 13

Xtro\LOC116411706

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\opn5

1 of 13

Xtro\opn8

1 of 13

Xtro\opnpl [provisonal]

1 of 13

Xtro\oprk1

1 of 13

Xtro\p2ry4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\qrfpr

1 of 13

Yes

Xtro\rho

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\tmtops

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (159)

Drer\drd2a

8 of 14

Yes

Drer\drd2b

8 of 14

Yes

Drer\drd2l

7 of 14

Yes

Drer\drd3

7 of 14

Yes

Drer\drd4-rs

6 of 14

Yes

Drer\drd4a

3 of 14

Yes

Drer\drd4b

3 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\bdkrb1

1 of 14

Yes

Drer\cckar

1 of 14

Drer\cckbra

1 of 14

Drer\ccr2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\gpr27

1 of 14

Yes

Drer\gpr34b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\gpr139

1 of 14

Drer\gpr142

1 of 14

Drer\gpr161b

1 of 14

Yes

Drer\gpr173

1 of 14

Yes

Drer\gpr176

1 of 14

Yes

Drer\hcrtr2

1 of 14

Drer\hrh2a

1 of 14

Drer\hrh3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC101886918

1 of 14

Yes

Drer\LOC108179103

1 of 14

Drer\lpar6a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\prokr1b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:ch211-207g17.3

1 of 14

Yes

Drer\si:dkey-247m21.3

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (265)

Cele\dop-3

11 of 14

Yes

Cele\dop-2

5 of 14

Yes

Cele\ador-1

1 of 14

Cele\aexr-2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\daf-37

1 of 14

Cele\daf-38

1 of 14

Cele\dcar-1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\F40A3.7

1 of 14

Yes

Cele\F57C9.6

1 of 14

Yes

Cele\F59B2.13

1 of 14

Yes

Cele\fbxa-199

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\K03H6.5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\srsx-2

1 of 14

Yes

Cele\srsx-5

1 of 14

Yes

Cele\srsx-6

1 of 14

Yes

Cele\srsx-8

1 of 14

Yes

Cele\srsx-10

1 of 14

Yes

Cele\srsx-12

1 of 14

Yes

Cele\srsx-14

1 of 14

Yes

Cele\srsx-15

1 of 14

Yes

Cele\srsx-16

1 of 14

Yes

Cele\srsx-21

1 of 14

Yes

Cele\srsx-22

1 of 14

Yes

Cele\srsx-24

1 of 14

Yes

Cele\srsx-25

1 of 14

Yes

Cele\srsx-26

1 of 14

Yes

Cele\srsx-27

1 of 14

Yes

Cele\srsx-28

1 of 14

Yes

Cele\srsx-29

1 of 14

Yes

Cele\srsx-30

1 of 14

Yes

Cele\srsx-31

1 of 14

Yes

Cele\srsx-32

1 of 14

Yes

Cele\srsx-33

1 of 14

Yes

Cele\srsx-35

1 of 14

Yes

Cele\srsx-36

1 of 14

Yes

Cele\srsx-37

1 of 14

Yes

Cele\srsx-38

1 of 14

Yes

Cele\srsx-39

1 of 14

Yes

Cele\srsx-40

1 of 14

Yes

Cele\srw-3

1 of 14

Yes

Cele\srw-4

1 of 14

Yes

Cele\srw-17

1 of 14

Yes

Cele\srw-26

1 of 14

Yes

Cele\srw-29

1 of 14

Yes

Cele\srw-33

1 of 14

Yes

Cele\srw-34

1 of 14

Yes

Cele\srw-41

1 of 14

Yes

Cele\srw-42

1 of 14

Yes

Cele\srw-43

1 of 14

Yes

Cele\srw-44

1 of 14

Yes

Cele\srw-51

1 of 14

Yes

Cele\srw-53

1 of 14

Yes

Cele\srw-54

1 of 14

Yes

Cele\srw-56

1 of 14

Yes

Cele\srw-57

1 of 14

Yes

Cele\srw-59

1 of 14

Yes

Cele\srw-60

1 of 14

Yes

Cele\srw-61

1 of 14

Yes

Cele\srw-63

1 of 14

Yes

Cele\srw-67

1 of 14

Yes

Cele\srw-68

1 of 14

Yes

Cele\srw-69

1 of 14

Yes

Cele\srw-73

1 of 14

Yes

Cele\srw-84

1 of 14

Yes

Cele\srw-88

1 of 14

Yes

Cele\srw-89

1 of 14

Yes

Cele\srw-90

1 of 14

Yes

Cele\srw-94

1 of 14

Yes

Cele\srw-95

1 of 14

Yes

Cele\srw-98

1 of 14

Yes

Cele\srw-99

1 of 14

Yes

Cele\srw-100

1 of 14

Yes

Cele\srw-103

1 of 14

Yes

Cele\srw-111

1 of 14

Yes

Cele\srw-112

1 of 14

Yes

Cele\srw-115

1 of 14

Yes

Cele\srw-121

1 of 14

Yes

Cele\srw-124

1 of 14

Yes

Cele\srw-127

1 of 14

Yes

Cele\srw-130

1 of 14

Yes

Cele\srw-133

1 of 14

Yes

Cele\srw-134

1 of 14

Yes

Cele\srw-136

1 of 14

Yes

Cele\srw-137

1 of 14

Yes

Cele\srw-138

1 of 14

Yes

Cele\srw-139

1 of 14

Yes

Cele\srw-140

1 of 14

Yes

Cele\srw-142

1 of 14

Yes

Cele\srw-143

1 of 14

Yes

Cele\srx-12

1 of 14

Yes

Cele\srx-13

1 of 14

Yes

Cele\srx-16

1 of 14

Yes

Cele\srx-17

1 of 14

Yes

Cele\srx-18

1 of 14

Yes

Cele\srx-19

1 of 14

Yes

Cele\srx-20

1 of 14

Yes

Cele\srx-21

1 of 14

Yes

Cele\srx-22

1 of 14

Yes

Cele\srx-23

1 of 14

Yes

Cele\srx-24

1 of 14

Yes

Cele\srx-26

1 of 14

Yes

Cele\srx-28

1 of 14

Yes

Cele\srx-29

1 of 14

Yes

Cele\srx-31

1 of 14

Yes

Cele\srx-32

1 of 14

Yes

Cele\srx-33

1 of 14

Yes

Cele\srx-34

1 of 14

Yes

Cele\srx-36

1 of 14

Yes

Cele\srx-38

1 of 14

Yes

Cele\srx-39

1 of 14

Yes

Cele\srx-41

1 of 14

Yes

Cele\srx-42

1 of 14

Yes

Cele\srx-43

1 of 14

Yes

Cele\srx-44

1 of 14

Yes

Cele\srx-45

1 of 14

Yes

Cele\srx-46

1 of 14

Yes

Cele\srx-47

1 of 14

Yes

Cele\srx-48

1 of 14

Yes

Cele\srx-50

1 of 14

Yes

Cele\srx-51

1 of 14

Yes

Cele\srx-54

1 of 14

Yes

Cele\srx-56

1 of 14

Yes

Cele\srx-58

1 of 14

Yes

Cele\srx-59

1 of 14

Yes

Cele\srx-60

1 of 14

Yes

Cele\srx-62

1 of 14

Yes

Cele\srx-63

1 of 14

Yes

Cele\srx-64

1 of 14

Yes

Cele\srx-65

1 of 14

Yes

Cele\srx-66

1 of 14

Yes

Cele\srx-67

1 of 14

Yes

Cele\srx-68

1 of 14

Yes

Cele\srx-73

1 of 14

Yes

Cele\srx-74

1 of 14

Yes

Cele\srx-76

1 of 14

Yes

Cele\srx-77

1 of 14

Yes

Cele\srx-78

1 of 14

Yes

Cele\srx-80

1 of 14

Yes

Cele\srx-82

1 of 14

Yes

Cele\srx-84

1 of 14

Yes

Cele\srx-85

1 of 14

Yes

Cele\srx-86

1 of 14

Yes

Cele\srx-87

1 of 14

Yes

Cele\srx-88

1 of 14

Yes

Cele\srx-90

1 of 14

Yes

Cele\srx-92

1 of 14

Yes

Cele\srx-93

1 of 14

Yes

Cele\srx-96

1 of 14

Yes

Cele\srx-98

1 of 14

Yes

Cele\srx-105

1 of 14

Yes

Cele\srx-114

1 of 14

Yes

Cele\srx-117

1 of 14

Yes

Cele\srx-118

1 of 14

Yes

Cele\srx-119

1 of 14

Yes

Cele\srx-125

1 of 14

Yes

Cele\srx-128

1 of 14

Yes

Cele\srx-129

1 of 14

Yes

Cele\srx-130

1 of 14

Yes

Cele\srx-131

1 of 14

Yes

Cele\srx-134

1 of 14

Yes

Cele\srx-135

1 of 14

Yes

Cele\srx-137

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (69)

Agam\GPRDOP3

9 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Dop2R. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (67)

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Lkr

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Pgr

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Rh2

1 of 13

Rh3

1 of 13

Rh4

1 of 13

Rh5

1 of 13

Rh6

1 of 13

Rh7

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Dop2R^GD732

model of alcohol use disorder

CEA

(Petruccelli et al., 2018)

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

DRD3; dopamine receptor D3

model of schizophrenia

IEA

(FlyBase, 2019-)

model of essential tremor 1

IEA

(FlyBase, 2019-)

HTR2A; 5-hydroxytryptamine receptor 2A

model of schizophrenia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Dop2R^GD732

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DRD2; dopamine receptor D2

8 of 14

126450

DRD3; dopamine receptor D3

7 of 14

126451

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Dop2R

suppressible

Gad1

(Zhou et al., 2019)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59301

DroID - A comprehensive database of gene and protein interactions.

FBgn0053517

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-64

Cytogenetic map

19A4-19A6

Sequence location

X:20,004,680..20,062,706 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

19A4-19A6

Limits computationally determined from genome sequence between P{EP}amn^EP1639&P{EP}amn^EP367 and P{EP}CG1702^EP1525;

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-64

(FlyBase, 2016)

1-63.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (129)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Korea

12012

P{VT064568-GAL4}attP2

12013

P{VT064569-GAL4}attP2

12014

P{VT064583-GAL4}attP2

12286

P{VT064563-GAL4}attP2

12287

P{VT064567-GAL4}attP2

12560

P{VT064564-GAL4}attP2

13877

P{VT064562-GAL4}attP2

13878

P{VT064566-GAL4}attP2

15537

P{GMR72C10-GAL4}attP2

17573

P{VT064569-lexA}JK22C

NIG-Fly

17004R-2

P{NIG.17004R}2

17004R-3

P{NIG.17004R}3

More stocks available...

Genomic Clones (39)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (10)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE06088

Other clones

MIP20105

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0053517

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0053517

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Zhou et al., 2019, Draper et al., 2007)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Dop2R is required for support of consolidated anesthesia-resistant memory.

(Scholz-Kornehl and Schwärzel, 2016)

Pharmacologic assessment of D2R reveals that among the biogenic amines, dopamine is the most potent agonist. Stimulation of D2R with dopamine triggers pertussis toxin sensitive Gi/o mediated signaling. The D2 selective agonist, bromocriptine, stimulates D2R with a nanomolar EC50.

(Hearn et al., 2002)

Pharmacologic assessment of the D2R reveals that among the endogenous biogenic amines, dopamine is the most potent agonist. Stimulation of D2R with dopamine triggers pertussis toxin sensitive Gi/o mediated signaling. The D2 selective agonist, bromocriptine stimulates the D2R with nanomolar EC50.

(Ren et al., 2002)

Relationship to Other Genes

Source for database merge of

Source for merge of: D2R CG9569

(Hearn et al., 2002)

Source for merge of: D2R anon-WO0170980.130 anon-WO0170980.131 anon-WO0170980.31 anon-WO0170980.32

(FlyBase, 1996-)

Additional comments

Annotations CG9569 and CG17004 merged as CG33517 (which corresponds to D2R) in release 4.1 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Source for identity of DD2R CG17004 was sequence comparison ( date:021108 ).

(FlyBase, 1996-)

Source for merge of D2R anon-WO0170980.130 anon-WO0170980.131 anon-WO0170980.31 anon-WO0170980.32 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: DD2R CG17004

(FlyBase, 1996-)

Source for identity of: Dop2R D2R

(FlyBase, 2009-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

CG17004

(Aradska et al., 2015, Hauser et al., 2006, Srivastava et al., 2005, Brody and Cravchik, 2000)

CG33517

(Mao et al., 2024, Kondo et al., 2020, Park et al., 2018, Scholz-Kornehl and Schwärzel, 2016, Meadows, 2014.12.12, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Perkins et al., 2009.1.15)

CG9569

(Srivastava et al., 2005, Bryson-Richardson et al., 2004, Brody and Cravchik, 2000)

DD2R

(Mazzotta et al., 2020, Zhou et al., 2019, Wiemerslage et al., 2016, Qi and Lee, 2014, Alekseyenko et al., 2013, Wiemerslage et al., 2013, Gruntenko et al., 2012, Bogomolova et al., 2011, Karpova et al., 2011, Rauschenbach et al., 2011, Bogomolova et al., 2010, Bogomolova et al., 2010, Chintapalli et al., 2007, Draper et al., 2007, Yuan and Lee, 2007, Hearn, 2002.9.17, Hearn et al., 2002, Ren et al., 2002)

DOP2R

(Noyes and Davis, 2023)

DmDOP3

(Qi et al., 2017)

Dop2R

(Hakim et al., 2025, Jean-François et al., 2025, Shi et al., 2025, Song et al., 2025, Avila et al., 2024, Castells-Nobau et al., 2024, Dai et al., 2024, Ike et al., 2024, Larnerd et al., 2024, Qu et al., 2024, Bossen et al., 2023, Godfrey et al., 2023, Hao et al., 2023, Lyman et al., 2023, Okray et al., 2023, Bourouliti and Skoulakis, 2022, Braco et al., 2022, Kapoor et al., 2022, Philyaw et al., 2022, Qiao et al., 2022, Saitoe et al., 2022, Schlichting et al., 2022, Yoon et al., 2022, Baker et al., 2021, Ceder et al., 2021, El Kholy et al., 2021, Ganguly et al., 2021, Liu et al., 2021, Sareen et al., 2021, Scaplen and Petruccelli, 2021, Xie et al., 2021, Zhang et al., 2021, Jakšić et al., 2020, Kondo et al., 2020, Naz et al., 2020, Petruccelli et al., 2020, Scaplen et al., 2020, Brunet Avalos et al., 2019, Deng et al., 2019, Meltzer et al., 2019, Rao and Deng, 2019.10.23, Shih et al., 2019, Croset et al., 2018, Park et al., 2018, Zhang et al., 2018, Branco et al., 2017, Pimentel et al., 2016, Zhang et al., 2016, Gene Disruption Project members, 2015-, Vernes, 2014, Sepp et al., 2008)

Dop2r

(Li et al., 2023)

DopD2R

(Wang et al., 2025)

anon-WO0170980.130

anon-WO0170980.131

anon-WO0170980.31

anon-WO0170980.32

d2r

(Naganos et al., 2016)

dD2R

(Pavlowsky et al., 2018, Lee et al., 2013)

dop2r

(O'Farrell et al., 2023)

Name Synonyms

D2 autoreceptor

(Privman Champaloux et al., 2021)

D2-like receptor

(Rauschenbach et al., 2011)

D2 receptor

(Neckameyer and Bhatt, 2012)

D2-like receptor

(Srivastava et al., 2005)

Dopamine 2-like Receptor

(Sepp et al., 2008)

Dopamine 2-like receptor

(Hearn, 2002.9.17)

dopamine 2-like receptor

(Draper et al., 2007)

dopamine D2 receptor

(Lee et al., 2013)

Secondary FlyBase IDs

FBgn0031083
FBgn0031084
FBgn0046542
FBgn0046543
FBgn0046600
FBgn0046601
FBgn0062410

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 64 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33007

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8IS44

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q8IS44

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8IS44

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0053517

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33007/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0053517

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0053517

FlyMine - An integrated database for Drosophila genomics

FBgn0053517

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG33517

MARRVEL_MODEL - MARRVEL (model organism gene)

33007

Linkouts

BioGRID - A database of protein and genetic interactions.

59301

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0053517

DroID - A comprehensive database of gene and protein interactions.

FBgn0053517

DRSC - Results frm RNAi screens

FBgn0053517

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dop2R_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0053517

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0053517

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0053517

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0053517

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032795

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (199)

The following external sites may use different assemblies or annotations than FlyBase.

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