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Citation
Scaplen, K.M., Petruccelli, E. (2021). Receptors and Channels Associated with Alcohol Use: Contributions from Drosophila.  Neurosci Insights 16(): 26331055211007441.
FlyBase ID
FBrf0248772
Publication Type
Review
Abstract

Alcohol Use Disorder (AUD) is a debilitating disorder that manifests as problematic patterns of alcohol use. At the core of AUD's behavioral manifestations are the profound structural, physiological, cellular, and molecular effects of alcohol on the brain. While the field has made considerable progress in understanding the neuromolecular targets of alcohol we still lack a comprehensive understanding of alcohol's actions and effective treatment strategies. Drosophila melanogaster is a powerful model for investigating the neuromolecular targets of alcohol because flies model many of the core behavioral elements of AUD and offer a rich genetic toolkit to precisely reveal the in vivo molecular actions of alcohol. In this review, we focus on receptors and channels that are often targeted by alcohol within the brain. We discuss the general roles of these proteins, their role in alcohol-associated behaviors across species, and propose ways in which Drosophila models can help advance the field.

PubMed ID
PubMed Central ID
PMC8020223 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neurosci Insights
    Title
    Neuroscience insights
    ISBN/ISSN
    2633-1055
    Data From Reference