FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\GABA-B-R2
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General Information
Symbol
Dmel\GABA-B-R2
Species
D. melanogaster
Name
metabotropic GABA-B receptor subtype 2
Annotation Symbol
CG6706
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027575
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Summary
G-protein coupled receptor - expressed by pheromone-sensing olfactory receptor neurons which as a consequence exhibit strong presynaptic inhibition - mediates inter-glomerular inhibition - responsible for decreased intracellular calcium of clock neurons blocking their calcium cycling (Interactive Fly, GABA-B-R2 )
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

GABABR2, GABAB-R2, GABABR2, GBR, GABAB-R2

Key Links
Genomic Location
Cytogenetic map
93F9-93F9
Sequence location
Recombination map
3-73
RefSeq locus
NT_033777 REGION:21770333..21775840
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables G protein-coupled GABA receptor activity
inferred from direct assay
(Mezler et al., 2001)
enables protein heterodimerization activity
inferred from physical interaction with FLYBASE:GABA-B-R1; FB:FBgn0260446
(Mezler et al., 2001)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables G protein-coupled GABA receptor activity
inferred from electronic annotation with InterPro:IPR002455
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000054983
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
enables G protein-coupled receptor activity
inferred from electronic annotation with InterPro:IPR017978, InterPro:IPR017979
(InterPro Project Members, 2004-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
inferred from direct assay
(Mezler et al., 2001)
involved_in cellular response to mechanical stimulus
inferred from mutant phenotype
(Muthukumar et al., 2014)
involved_in gamma-aminobutyric acid signaling pathway
inferred from direct assay
(Mezler et al., 2001)
involved_in negative regulation of insulin secretion
inferred from mutant phenotype
(Enell et al., 2010)
involved_in negative regulation of synaptic vesicle fusion to presynaptic active zone membrane
inferred from direct assay
(Root et al., 2008)
involved_in olfactory behavior
inferred from direct assay
(Root et al., 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in G protein-coupled receptor signaling pathway
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
inferred from electronic annotation with InterPro:IPR002455, InterPro:IPR017978, InterPro:IPR017979
(InterPro Project Members, 2004-)
involved_in gamma-aminobutyric acid signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000054983
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
part_of G protein-coupled receptor heterodimeric complex
inferred from physical interaction with FLYBASE:GABA-B-R1; FB:FBgn0260446
(Mezler et al., 2001)
located_in plasma membrane
inferred from direct assay
(Mezler et al., 2001)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of G protein-coupled receptor heterodimeric complex
inferred from biological aspect of ancestor with PANTHER:PTN000828857
(GO Reference Genome Project, 2011-)
located_in membrane
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
inferred from electronic annotation with InterPro:IPR002455, InterPro:IPR017978, InterPro:IPR017979
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
GABA(B) RECEPTORS -
Metabotropic GABA(B) receptors are Class C GPCRs. They function as obligate heterodimers, binding the inhibitory neurotransmitter GABA (γ-aminobutyric acid). (Adapted from FBrf0134605).
Summary (Interactive Fly)

G-protein coupled receptor - expressed by pheromone-sensing olfactory receptor neurons which as a consequence exhibit strong presynaptic inhibition - mediates inter-glomerular inhibition - responsible for decreased intracellular calcium of clock neurons blocking their calcium cycling

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\GABA-B-R2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4LHR4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
GABA-B-R2-RA
FBtr0084167
NM_169968
3973
1220
GABA-B-R2-RB
FBtr0084168
NM_079714
3976
1221
GABA-B-R2-RC
FBtr0339154
NM_001300527
3985
1224
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
GABA-B-R2-PA
FBpp0083565
138.0
1220
8.86
Q8IN24
NP_732658
AAN13882
GABA-B-R2-PB
FBpp0083566
138.1
1221
8.81
Q9Y133
NP_524438
AAF55916
GABA-B-R2-PC
FBpp0308298
138.5
1224
8.92
A0A0B4LHR4
NP_001287456
AHN57455
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GABA-B-R2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.70

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 14 -- 17
larval central nervous system
(Mezler et al., 2001)
larval gnathal ganglion
(Mezler et al., 2001)
larval brain
(Mezler et al., 2001)
larval ventral nerve cord
(Mezler et al., 2001)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
centrifugal neuron C2
(Kolodziejczyk et al., 2008)
centrifugal neuron C3
(Kolodziejczyk et al., 2008)
lamina tangential neuron
(Kolodziejczyk et al., 2008)
medulla
(Kolodziejczyk et al., 2008)
lobula plate
(Kolodziejczyk et al., 2008)
lobula
(Kolodziejczyk et al., 2008)
lamina
(Kolodziejczyk et al., 2008)
antenna | restricted
(Root et al., 2008)
maxillary palp | restricted
(Root et al., 2008)
adult insulin secreting cell of pars intercerebralis | subset
(Enell et al., 2010)
adult pars intercerebralis
(Enell et al., 2010)
adult brain | restricted
(Enell et al., 2010)
adult antennal lobe | restricted
(Root et al., 2008)
ellipsoid body outer central domain | restricted
(Kahsai et al., 2012)
ellipsoid body outer posterior domain | restricted
(Kahsai et al., 2012)
protocerebral bridge | restricted
(Kahsai et al., 2012)
bulb | restricted
(Kahsai et al., 2012)
fan-shaped body
(Kahsai et al., 2012)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

GABA-B-R2 protein is strongly expressed in the ellipsoid body ring between the innervation regions of R3 and R4d ring neurons. Weak expression is observed in the R3 ring. GABA-B-R2 protein is detected in the fan-shaped body and in the bulb (lateral triangle).

(Kahsai et al., 2012)

GABA-B-R2 protein is expressed in the insulin producing cells (IPC), a subset of the dorsomedial neurosecretory cells of the pars intercerebralis and in other cells ventral to the IPC cells. IPC cells labeled by the expression of ScerGAL4GABA-B-R2.PR are also labeled by the expression of ScerGAL4Ilp2.PW.

(Enell et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of G protein-coupled receptor heterodimeric complex
inferred from physical interaction with FLYBASE:GABA-B-R1; FB:FBgn0260446
(Mezler et al., 2001)
located_in plasma membrane
inferred from direct assay
(Mezler et al., 2001)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\GABA-B-R2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of GABA-B-R2
Transgenic constructs containing regulatory region of GABA-B-R2
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel6187
(Ryder, 2004.4.26)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal chemosensory behavior | third instar larval stage, with Scer\GAL4Orco.PU
abnormal chemosensory behavior | third instar larval stage | calorie restriction conditional, with Scer\GAL4Or47a.PU
abnormal circadian rhythm, with Scer\GAL4P0.5.Pdf
abnormal copulation | male, with Hsim\VP16AD-VGlut1-OK371, Scer\GAL4dsx-GAL4-DBD
abnormal courtship behavior, with Scer\GAL4Orco.2.642.Hsim\VP22
abnormal feeding behavior | third instar larval stage, with Scer\GAL4Or47a.PU
abnormal neurophysiology, with Scer\GAL4Or47b.PC
abnormal neurophysiology, with Scer\GAL4Orco.2.642.Hsim\VP22
abnormal touch perception | adult stage, with Scer\GAL4GMR41E11
increased size | adult stage, with Scer\GAL4nub.PU
short lived, with Scer\GAL4GABA-B-R2.PR
short lived | nutrition conditional, with Scer\GAL4ey-OK107
short lived | nutrition conditional, with Scer\GAL4Ilp2.PW
short lived | nutrition conditional, with Scer\GAL4Ilp3.PB
visible | adult stage, with Scer\GAL4nub.PU
Phenotype manifest in
Allele
wing, with Scer\GAL4nub.PU
wing vein | ectopic, with Scer\GAL4nub.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (25)
Hsap\GABBR2
13 of 14
Yes
Yes
Hsap\GPR156
4 of 14
No
Yes
Hsap\GABBR1
3 of 14
No
No
Hsap\CASR
1 of 14
No
No
Hsap\GPR158
1 of 14
No
No
Hsap\GPR179
1 of 14
No
No
Hsap\GPRC6A
1 of 14
No
Yes
Hsap\GRIN1
1 of 14
No
No
Hsap\GRM1
1 of 14
No
No
1  
Hsap\GRM2
1 of 14
No
No
Hsap\GRM3
1 of 14
No
No
Hsap\GRM4
1 of 14
No
No
1  
Hsap\GRM5
1 of 14
No
No
Hsap\GRM6
1 of 14
No
No
Hsap\GRM7
1 of 14
No
No
Hsap\GRM8
1 of 14
No
No
Hsap\GUCY2C
1 of 14
No
No
Hsap\GUCY2D
1 of 14
No
No
Hsap\GUCY2F
1 of 14
No
No
Hsap\NPR1
1 of 14
No
No
Hsap\NPR2
1 of 14
No
No
Hsap\NPR3
1 of 14
No
No
Hsap\TAS1R1
1 of 14
No
Yes
Hsap\TAS1R2
1 of 14
No
Yes
Hsap\TAS1R3
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (42)
Rnor\Gabbr2
13 of 14
Yes
Yes
Rnor\Gpr156
4 of 14
No
Yes
Rnor\Gabbr1
3 of 14
No
No
Rnor\Gpr158
1 of 14
No
No
Rnor\Gpr179
1 of 14
No
No
Rnor\Grin1
1 of 14
No
No
Rnor\Grm1
1 of 14
No
No
Rnor\Grm2
1 of 14
No
No
Rnor\Grm3
1 of 14
No
No
Rnor\Grm4
1 of 14
No
No
Rnor\Grm5
1 of 14
No
No
Rnor\Grm6
1 of 14
No
No
Rnor\Grm7
1 of 14
No
No
Rnor\Grm8
1 of 14
No
No
Rnor\Gucy2c
1 of 14
No
No
Rnor\Gucy2d
1 of 14
No
No
Rnor\Gucy2e
1 of 14
No
No
Rnor\Gucy2f
1 of 14
No
No
Rnor\Gucy2g
1 of 14
No
No
Rnor\Npr1
1 of 14
No
No
1  
Rnor\Npr2
1 of 14
No
No
Rnor\Npr3
1 of 14
No
No
Rnor\Tas1r1
1 of 14
No
Yes
Rnor\Tas1r2
1 of 14
No
Yes
Rnor\Vom2r1
1 of 14
No
Yes
Rnor\Vom2r4
1 of 14
No
Yes
Rnor\Vom2r5
1 of 14
No
Yes
Rnor\Vom2r6
1 of 14
No
Yes
Rnor\Vom2r10
1 of 14
No
Yes
Rnor\Vom2r11
1 of 14
No
Yes
Rnor\Vom2r18
1 of 14
No
Yes
Rnor\Vom2r37
1 of 14
No
Yes
Rnor\Vom2r44
1 of 14
No
Yes
Rnor\Vom2r47
1 of 14
No
Yes
Rnor\Vom2r53
1 of 14
No
Yes
Rnor\Vom2r54
1 of 14
No
Yes
Rnor\Vom2r67
1 of 14
No
Yes
Rnor\Vom2r68
1 of 14
No
Yes
Rnor\Vom2r70
1 of 14
No
Yes
Rnor\Vom2r79
1 of 14
No
Yes
Rnor\Vom2r80
1 of 14
No
Yes
Rnor\Vom2r-ps27
1 of 14
No
Yes
Mus musculus (laboratory mouse) (61)
Mmus\Gabbr2
12 of 14
Yes
Yes
Mmus\Gpr156
4 of 14
No
Yes
Mmus\Gabbr1
3 of 14
No
No
Mmus\Gm14496
1 of 14
No
Yes
Mmus\Gpr158
1 of 14
No
No
Mmus\Gpr179
1 of 14
No
No
Mmus\Grin1
1 of 14
No
No
Mmus\Grm1
1 of 14
No
No
Mmus\Grm2
1 of 14
No
No
Mmus\Grm3
1 of 14
No
No
Mmus\Grm4
1 of 14
No
No
Mmus\Grm5
1 of 14
No
No
Mmus\Grm6
1 of 14
No
No
Mmus\Grm7
1 of 14
No
No
Mmus\Grm8
1 of 14
No
No
Mmus\Gucy2c
1 of 14
No
No
Mmus\Gucy2d
1 of 14
No
No
Mmus\Gucy2e
1 of 14
No
No
Mmus\Gucy2f
1 of 14
No
No
Mmus\Gucy2g
1 of 14
No
No
Mmus\Npr1
1 of 14
No
No
Mmus\Npr2
1 of 14
No
No
Mmus\Npr3
1 of 14
No
No
Mmus\Tas1r2
1 of 14
No
Yes
Mmus\Vmn2r2
1 of 14
No
Yes
Mmus\Vmn2r4
1 of 14
No
Yes
Mmus\Vmn2r5
1 of 14
No
Yes
Mmus\Vmn2r6
1 of 14
No
Yes
Mmus\Vmn2r7
1 of 14
No
Yes
Mmus\Vmn2r9
1 of 14
No
Yes
Mmus\Vmn2r10
1 of 14
No
Yes
Mmus\Vmn2r11
1 of 14
No
Yes
Mmus\Vmn2r14
1 of 14
No
Yes
Mmus\Vmn2r15
1 of 14
No
Yes
Mmus\Vmn2r61
1 of 14
No
Yes
Mmus\Vmn2r80
1 of 14
No
Yes
Mmus\Vmn2r81
1 of 14
No
Yes
Mmus\Vmn2r82
1 of 14
No
Yes
Mmus\Vmn2r84
1 of 14
No
Yes
Mmus\Vmn2r85
1 of 14
No
Yes
Mmus\Vmn2r86
1 of 14
No
Yes
Mmus\Vmn2r87
1 of 14
No
Yes
Mmus\Vmn2r90
1 of 14
No
Yes
Mmus\Vmn2r91
1 of 14
No
Yes
Mmus\Vmn2r92
1 of 14
No
Yes
Mmus\Vmn2r93
1 of 14
No
Yes
Mmus\Vmn2r94
1 of 14
No
Yes
Mmus\Vmn2r95
1 of 14
No
Yes
Mmus\Vmn2r96
1 of 14
No
Yes
Mmus\Vmn2r100
1 of 14
No
Yes
Mmus\Vmn2r101
1 of 14
No
Yes
Mmus\Vmn2r102
1 of 14
No
Yes
Mmus\Vmn2r104
1 of 14
No
Yes
Mmus\Vmn2r107
1 of 14
No
Yes
Mmus\Vmn2r112
1 of 14
No
Yes
Mmus\Vmn2r113
1 of 14
No
Yes
Mmus\Vmn2r115
1 of 14
No
Yes
Mmus\Vmn2r116
1 of 14
No
Yes
Mmus\Vmn2r117
1 of 14
No
Yes
Mmus\Vmn2r129
1 of 14
No
Yes
Mmus\Vmn2r130
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (33)
Xtro\gabbr2
10 of 13
Yes
Yes
Xtro\gabbr1
2 of 13
No
No
Xtro\gpr156
2 of 13
No
Yes
Xtro\c11orf49
1 of 13
No
Yes
Xtro\frs2
1 of 13
No
No
Xtro\gigyf1
1 of 13
No
No
Xtro\gng2
1 of 13
No
No
Xtro\gpr179
1 of 13
No
No
Xtro\grm1
1 of 13
No
No
Xtro\grm2
1 of 13
No
No
Xtro\grm5
1 of 13
No
No
Xtro\grm7
1 of 13
No
No
Xtro\gucy2d
1 of 13
No
No
Xtro\LOC100488863
1 of 13
No
Yes
Xtro\LOC100490505
1 of 13
No
Yes
Xtro\LOC100491800
1 of 13
No
Yes
Xtro\LOC100494461
1 of 13
No
Yes
Xtro\LOC100496766
1 of 13
No
Yes
Xtro\LOC100496848
1 of 13
No
Yes
Xtro\LOC100498444
1 of 13
No
Yes
Xtro\LOC101733546
1 of 13
No
Yes
Xtro\LOC101734131
1 of 13
No
Yes
Xtro\LOC105946413
1 of 13
No
No
Xtro\LOC108646252
1 of 13
No
Yes
Xtro\LOC108648105
1 of 13
No
Yes
Xtro\LOC116409579
1 of 13
No
Yes
Xtro\npr3
1 of 13
No
No
Xtro\rtp3
1 of 13
No
Yes
Xtro\stam2
1 of 13
No
No
Xtro\steap2
1 of 13
No
No
Xtro\vn2r1p
1 of 13
No
Yes
Xtro\XB991396
1 of 13
No
Yes
Xtro\XB5919979
1 of 13
No
No
Danio rerio (Zebrafish) (60)
Drer\gabbr2
13 of 14
Yes
Yes
Drer\gpr156
4 of 14
No
Yes
Drer\gabbr1a
3 of 14
No
No
Drer\gabbr1b
3 of 14
No
No
Drer\gc2
1 of 14
No
No
Drer\gpr158a
1 of 14
No
No
Drer\gpr158b
1 of 14
No
No
Drer\gpr179
1 of 14
No
No
Drer\grm1a
1 of 14
No
No
Drer\grm1b
1 of 14
No
No
Drer\grm2a
1 of 14
No
No
Drer\grm2b
1 of 14
No
No
Drer\grm3
1 of 14
No
No
Drer\grm4
1 of 14
No
No
Drer\grm5a
1 of 14
No
No
Drer\grm5b
1 of 14
No
No
Drer\grm6a
1 of 14
No
No
Drer\grm6b
1 of 14
No
No
Drer\grm8a
1 of 14
No
No
Drer\grm8b
1 of 14
No
No
Drer\gucy2ca
1 of 14
No
No
Drer\gucy2cb
1 of 14
No
No
Drer\gucy2d
1 of 14
No
No
Drer\gucy2f
1 of 14
No
No
Drer\gucy2g
1 of 14
No
No
Drer\LOC560647
1 of 14
No
No
Drer\LOC793043
1 of 14
No
Yes
Drer\LOC100007225
1 of 14
No
Yes
Drer\LOC100331190
1 of 14
No
No
Drer\npr1a
1 of 14
No
No
Drer\npr1b
1 of 14
No
No
Drer\npr2
1 of 14
No
No
Drer\npr3
1 of 14
No
No
Drer\olfcd1
1 of 14
No
Yes
Drer\olfcd2
1 of 14
No
Yes
Drer\olfcd3
1 of 14
No
Yes
Drer\olfce2
1 of 14
No
Yes
Drer\olfcg1
1 of 14
No
Yes
Drer\olfcg2
1 of 14
No
Yes
Drer\olfcg3
1 of 14
No
Yes
Drer\olfcg4
1 of 14
No
Yes
Drer\olfcg5
1 of 14
No
Yes
Drer\olfcg6
1 of 14
No
Yes
Drer\olfcg7
1 of 14
No
Yes
Drer\olfcg8
1 of 14
No
Yes
Drer\olfcg9
1 of 14
No
Yes
Drer\olfcg12
1 of 14
No
Yes
Drer\olfch1
1 of 14
No
Yes
Drer\olfcj1
1 of 14
No
Yes
Drer\olfck1
1 of 14
No
Yes
Drer\olfck2
1 of 14
No
Yes
Drer\olfcn1
1 of 14
No
Yes
Drer\olfcq12
1 of 14
No
Yes
Drer\olfcu1
1 of 14
No
Yes
Drer\olfcv1
1 of 14
No
Yes
Drer\olfcv2
1 of 14
No
Yes
Drer\olfcv3
1 of 14
No
Yes
Drer\olfcw1
1 of 14
No
Yes
Drer\si:dkey-37g12.1
1 of 14
No
No
Drer\tas1r1
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (34)
Cele\gbb-2
13 of 14
Yes
Yes
Cele\gbb-1
2 of 14
No
No
Cele\daf-11
1 of 14
No
No
Cele\F35H10.10
1 of 14
No
No
Cele\F39B2.8
1 of 14
No
No
Cele\gcy-1
1 of 14
No
No
Cele\gcy-2
1 of 14
No
No
Cele\gcy-3
1 of 14
No
No
Cele\gcy-4
1 of 14
No
No
Cele\gcy-5
1 of 14
No
No
Cele\gcy-6
1 of 14
No
No
Cele\gcy-7
1 of 14
No
No
Cele\gcy-8
1 of 14
No
No
Cele\gcy-9
1 of 14
No
No
Cele\gcy-11
1 of 14
No
No
Cele\gcy-12
1 of 14
No
No
Cele\gcy-13
1 of 14
No
No
Cele\gcy-14
1 of 14
No
No
Cele\gcy-15
1 of 14
No
No
Cele\gcy-17
1 of 14
No
No
Cele\gcy-18
1 of 14
No
No
Cele\gcy-19
1 of 14
No
No
Cele\gcy-20
1 of 14
No
No
Cele\gcy-21
1 of 14
No
No
Cele\gcy-22
1 of 14
No
No
Cele\gcy-23
1 of 14
No
No
Cele\gcy-25
1 of 14
No
No
Cele\gcy-27
1 of 14
No
No
Cele\gcy-28
1 of 14
No
No
Cele\gcy-29
1 of 14
No
No
Cele\mgl-1
1 of 14
No
No
Cele\mgl-2
1 of 14
No
No
Cele\mgl-3
1 of 14
No
No
Cele\odr-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (15)
Agam\GPRGBB2
12 of 12
Yes
Yes
Agam\GPRGBB3
4 of 12
No
No
Agam\GPRGBB1
3 of 12
No
No
Agam\AgaP_AGAP009158
2 of 12
No
Yes
Agam\AgaP_AGAP002233
1 of 12
No
No
Agam\AgaP_AGAP003283
1 of 12
No
No
Agam\AgaP_AGAP003284
1 of 12
No
No
Agam\AgaP_AGAP008691
1 of 12
No
No
Agam\AgaP_AGAP008848
1 of 12
No
No
Agam\AgaP_AGAP012161
1 of 12
No
No
Agam\AgaP_AGAP012163
1 of 12
No
No
Agam\GPRMGL1
1 of 12
No
No
Agam\GPRMGL2
1 of 12
No
No
Agam\GPRMGL3
1 of 12
No
No
Agam\GPRMGL5
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (17)
Atha\GLR3.4
2 of 13
Yes
No
Atha\GLR3.5
2 of 13
Yes
No
Atha\GLR5
2 of 13
Yes
No
Atha\GLR1.3
1 of 13
No
No
Atha\GLR2.1
1 of 13
No
No
Atha\GLR2.2
1 of 13
No
No
Atha\GLR2.3
1 of 13
No
No
Atha\GLR2.4
1 of 13
No
No
Atha\GLR2.5
1 of 13
No
No
Atha\GLR2.6
1 of 13
No
No
Atha\GLR2.7
1 of 13
No
No
Atha\GLR2.8
1 of 13
No
No
Atha\GLR2.9
1 of 13
No
No
Atha\GLR2
1 of 13
No
No
Atha\GLR3.3
1 of 13
No
No
Atha\GLR3.6
1 of 13
No
No
Atha\GLUR2
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:GABA-B-R2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (17)
GABA-B-R1
6 of 13
GABA-B-R3
6 of 13
mGluR
2 of 13
CG3216
1 of 13
CG14877
1 of 13
CG31183
1 of 13
CG31760
1 of 13
CG42637
1 of 13
CG43795
1 of 13
EHR
1 of 13
Gucy2d
1 of 13
Gyc32E
1 of 13
Gyc76C
1 of 13
KaiR1D
1 of 13
mtt
1 of 13
Nmdar1
1 of 13
smog
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 2 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
GABBR2; gamma-aminobutyric acid type B receptor subunit 2
13 of 14
607340
GPR156; G protein-coupled receptor 156
4 of 14
610464
    GABBR1; gamma-aminobutyric acid type B receptor subunit 1
    3 of 14
    603540
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      GABA-B-R2 - GABA-B-R1
      nuclear magnetic resonance
      (Zhang et al., 2020)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      eas
      suppressible
      GABA-B-R2
      (Muthukumar et al., 2014)
      Lrp4
      suppressible
      GABA-B-R2
      (Mosca et al., 2017)
      Myc
      suppressible
      GABA-B-R2
      (Li et al., 2020)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-73
      Cytogenetic map
      93F9-93F9
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      93F9-93F9
      Limits computationally determined from genome sequence between P{PZ}InR05545 and P{PZ}tsl00617
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-73

      (FlyBase, 2016)

      3-75.1

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (18)
      Genomic Clones (17)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (25)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Hamasaka et al., 2005)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: GABA-B-R2 anon-WO0170980.59 anon-WO0170980.58

            (FlyBase, 1996-)
            Additional comments

            Source for identity of GABA-B-R2 BcDNA:GH07312 was sequence comparison ( date:010307 ).

            (FlyBase, 1996-)

            Source for merge of GABA-B-R2 anon-WO0170980.59 anon-WO0170980.58 was sequence comparison ( date:051113 ).

            (FlyBase, 1996-)
            Nomenclature History
            Source for database identify of

            Source for identity of: GABA-B-R2 BcDNA:GH07312

            (FlyBase, 1996-)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (30)
            Reported As
            Symbol Synonym
            :GABA-B-R2
            (Nässel and Wu, 2022)
            BcDNA:GH07312
            CG6706
            (Mao et al., 2024, Kondo et al., 2020, Enell et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Brody and Cravchik, 2000)
            D-GABA-B-R2
            (Khuong et al., 2019)
            D-GABABR2
            (Mezler et al., 2001)
            D-Gaba2
            (Mezler et al., 2001)
            GABA B R2
            (Shankar et al., 2015)
            GABA-BR2
            (Enell et al., 2010)
            GABA-B R2
            (Chaturvedi and Emery, 2024)
            GABA-B-R2
            (Li et al., 2024, Zhu et al., 2024, Bossen et al., 2023, Schlichting et al., 2022, Liu et al., 2021, Romano et al., 2021, Scaplen and Petruccelli, 2021, Wang et al., 2021, Kondo et al., 2020, Li et al., 2020, Nässel and Zandawala, 2020, Takai et al., 2020, Texada et al., 2020, Wilson et al., 2020, Alekseyenko et al., 2019, Hegazi et al., 2019, Meltzer et al., 2019, Rao and Deng, 2019.10.23, Sakakibara et al., 2018, Cheung and Scott, 2017, Crocker et al., 2016, Sarov et al., 2016, Omelyanchuk et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Dahdal et al., 2010, Okada et al., 2009, Hoopfer et al., 2008, Root et al., 2008)
            GABA-BR2
            (Dissel et al., 2015)
            GABA2
            (Landayan et al., 2021)
            GABAB
            (Mallick et al., 2024)
            GABAB-R2
            (Ko et al., 2023, Choi et al., 2017, Suh et al., 2017, Pavlou et al., 2016, Lei et al., 2013, Ren et al., 2012, Hamasaka et al., 2005)
            GABABR2
            (Slankster et al., 2020, Mosca et al., 2017, Jeong et al., 2016, Muthukumar et al., 2014, Yuan et al., 2014, Freifeld et al., 2013, Kahsai et al., 2012, Enell et al., 2010, Kolodziejczyk et al., 2008, Dzitoyeva et al., 2003)
            GABAB(R2)
            (Mazzotta et al., 2020)
            GABAB-R2
            (Bae et al., 2023, Jo et al., 2021)
            GABABR-R2
            (Martelli and Fiala, 2019)
            GABABR2
            (Jafari and Alenius, 2021, Enell et al., 2010, Root et al., 2008)
            GB2
            (Mitri et al., 2004)
            GBR
            (Lei et al., 2013, Nässel et al., 2013, Ren et al., 2012)
            GH07312
            (Vanden Broeck, 2001)
            anon-WO0170980.58
            anon-WO0170980.59
            dGB2
            (Zhang et al., 2020)
            Name Synonyms
            GABAB- 2 receptor
            (Hamasaka et al., 2005)
            GABABreceptor2
            (Enell et al., 2010)
            Metabotropic GABA-B receptor subtype 2
            (Saad and Hipfner, 2021)
            metabotropic GABA-B receptor subtype 2
            (Mezler, 2000.11.2)
            metabotropic GABAB receptor 2
            (Kolodziejczyk et al., 2008)
            Secondary FlyBase IDs
            • FBgn0046522
            • FBgn0046523
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 59 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            PDB - An information portal to biological macromolecular structures
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (114)