The longer time it takes for third instar larvae expressing TBPHGD6943 under the control of Scer\GAL4Toll-6-D42 to roll over in a turning assay compared to wild-type controls is lengthened further by co-expression of Fmr1GD1288 RNAi.
Expression of TBPHGD6943 under the control of Scer\GAL4elav.PU enhances the climbing defects, shortened life span and neuropil degeneration seen in TBPHΔ23/+ flies expressing Hrb98DEJF01249 under the control of Scer\GAL4elav.PU.
Expression of Syx1AScer\UAS.cBa significantly suppresses the climbing defects seen in adult hypomorphic TBPH mutants (generated by expressing TBPHGD6943 in adult flies under the control of Scer\GAL4tub.PU and Scer\GAL80ts.αTub84B, in a TBPHΔ23/+ background).
Expression of TBPHGD6943 in the developing eye dominantly suppresses the eye degeneration phenotype found upon expression of TER94R152H.Scer\UAS.R (with both transgenes driven by Scer\GAL4GMR.PF). This is concurrent with a significant reduction in the blinded phenotypic severity score.
The co-expression of TBPHGD6943 enhances the severity of the eye defects resulting from the expression of Zzzz\UGGAAW.Scer\UAS under the control of Scer\GAL4GMR.PS (i.e. reduced size, loss of pigmentation, defective morphology and ommatidial abnormalities); the severe eye defects resulting from this co-expression are fully or partially suppressed by the additional co-expression of Hsap\FUSScer\UAS.cIa or Hsap\HNRNPA2B1Scer\UAS.cKa, respectively.
The co-expression of TBPHGD6943 and Zzzz\UGGAAS.Scer\UAS under the control of Scer\GAL4GMR.PS leads to lethality, which is rescued by the additional co-expression of either Hsap\FUSScer\UAS.cIa or Hsap\HNRNPA2B1Scer\UAS.cKa; the rescued adults exhibit significantly less severe eye phenotypes, as compared to adults only expressing Zzzz\UGGAAS.Scer\UAS under the control of Scer\GAL4GMR.PS.
Co-expression of TBPHGD6943 with Hsap\TARDBPScer\UAS.T:Ivir\haemagglutinin,T:Disc\RFP under the control of Scer\GAL4VGlut-OK371 results in improved larval movement compared to the Hsap\TARDBPScer\UAS.T:Ivir\haemagglutinin,T:Disc\RFP-expressing parental line.