TDP-43, dTDP-43, dTDP
RNA-binding protein - regulation of synaptic efficacy and motor control - regulation of Futsch activity at the neuromuscular junction - regulation of the robustness of neuronal specification through microRNA-9a - a model for Amyotrophic lateral sclerosis (ALS), often referred to as Lou Gehrig's Disease
Please see the JBrowse view of Dmel\TBPH for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.
3.166, 1.916, 1.638 (longest cDNA)
531, 332 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TBPH using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
TBPH transcripts are expressed at high levels in embryonic and pupal stages.
TBPH protein is expressed in the nuclei of neurons, glia, and muscle cells throughout development, including in muscle cells of wandering third instar larvae, and in both neurons and glial cells of the adult brain. TBPH protein can be detected in the perinuclear region of post-mitotic neurons of the adult ellipsoid body.
TBPH is highly expressed in neuronal tissues in developmental stages and in adults.
JBrowse - Visual display of RNA-Seq signals
View Dmel\TBPH in JBrowse
2-105
2-109.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: TBPH CG10327
