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General Information
Symbol
Dmel\TBPHQ367X
Species
D. melanogaster
Name
FlyBase ID
FBal0314153
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dTDP-43Q367X
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    Nucleotide change:

    C23860174T

    Reported nucleotide change:

    G?A

    Amino acid change:

    Q367term | TBPH-PB; Q367term | TBPH-PC; Q367term | TBPH-PD; Q367term | TBPH-PE; Q367term | TBPH-PF

    Reported amino acid change:

    Q367term

    Comment:

    The nucleotide substitution was reported with respect to the non-coding strand.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Nucleotide substitution: G?A.

    Amino acid replacement: Q367term.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    TBPHQ367X/TBPHQ367X mutant adults (with higher penetrance in females than males) have an increase in supernumerary large sensory bristles on the mesothoracic tergum, most often on the scutellum, but some show supernumerary bristles at the anterior postalar or dorsocentral bristle positions; there are also some flies that show supernumerary sensory bristles on the anterior wing margin, and some embryos show additional sensory neurons in the abdominal dorsal cluster.

    TBPHQ367X/+ mutant adults exhibit supernumerary bristles on the mesothoracic tergum at low penetrance, usually scutellar bristles.

    A subset of TBPHQ367X/TBPHΔ142 mutant adults (with higher penetrance in females than males) display supernumerary anterior postalar bristles (most common phenotype when reared at 18[o]C or 25[o]C), supernumerary scutellar bristles (most common phenotype when reared at 30[o]C) or, in a small fraction of cases, supernumerary dorsocentral bristles. supernumerary bristles in mutants are accompanied by supernumerary sensory neurons. In general, supernumerary bristles are observed more frequently when flies are grown at 18[o]C than when reared at 25[o]C or 30[o]C.

    There is a significant decrease in dendritic branching in the ddaE and ddaF neurons of homozygous third instar larvae.

    Expression of TBPHGD6943 under the control of Scer\GAL4221 in a TBPHQ367X/+ background results in a significant decrease in dendritic branching in the ddaE and ddaF neurons of third instar larvae.

    Homozygous single cell ddaE mutant clones show a significant reduction in the number of dendritic ends compared to controls.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference

    TBPHQ367X has visible | adult stage phenotype, enhanceable by mir-9aJ22/mir-9a[+]

    TBPHQ367X has visible | adult stage phenotype, enhanceable by mir-9aE39/mir-9a[+]

    Suppressed by
    Statement
    Reference
    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    TBPHQ367X has scutellar bristle | supernumerary phenotype, enhanceable by mir-9aJ22/mir-9a[+]

    TBPHQ367X has scutellar bristle | supernumerary phenotype, enhanceable by mir-9aE39/mir-9a[+]

    Suppressed by
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    mir-9aE39/+ or mir-9aJ22/+ significantly enhances the supernumerary scutellar bristle phenotype of TBPHQ367X/+ flies.

    Expression of mir-9aScer\UAS.cLa under the control of Scer\GAL4vg.PU partially rescues the supernumerary scutellar bristle phenotype of TBPHQ367X/TBPHQ367X mutants.

    The presence of the sensE58/+ mutation partially rescues the supernumerary bristle phenotype of TBPHQ367X/TBPHQ367X mutants.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments

    Expression of TBPHScer\UAS.cLu under the control of Scer\GAL4vg.PU rescues the supernumerary anterior postalar bristle phenotype of TBPHQ367X/TBPHΔ142 mutants.

    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (4)