FlyBase Allele Report: Dmel\mir-9a[UAS.cLa]

General Information

Symbol

Dmel\mir-9a^UAS.cLa

Species

D. melanogaster

Name

FlyBase ID

FBal0198150

Feature type

allele

Associated gene

Dmel\mir-9a

Associated Insertion(s)

Carried in Construct

P{UAS-mir-9a.L}

Also Known As

UAS-pre-miR-9a, UAS-mir-9a

Key Links

Transgenic product class

wild_type

(Li et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Li et al., 2006)

Mutagen

in vitro construct

(Li et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-mir-9a.L}

Cytology

Description

UASt regulatory sequences drive expression of the wild-type 78bp mir-9a precursor.

(Li et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

mir-9a

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4²²¹

(Xu et al., 2008)

visible, with Scer\GAL4^ap-md544

(Li et al., 2006)

Phenotype Manifest In

abdominal 1 dorsal multidendritic neuron ddaE, with Scer\GAL4²²¹

(Xu et al., 2008)

abdominal 1 dorsal multidendritic neuron ddaF, with Scer\GAL4²²¹

(Xu et al., 2008)

dendrite, with Scer\GAL4²²¹

(Xu et al., 2008)

dendritic arborizing neuron, with Scer\GAL4²²¹

(Xu et al., 2008)

scutellar bristle, with Scer\GAL4^ap-md544

(Li et al., 2006)

sensory mother cell, with Scer\GAL4^ap-md544

(Li et al., 2006)

Detailed Description

Statement

Reference

Ectopic expression of mir-9a^Scer\UAS.cLa in ddaE, ddaF and DA neurons in the dorsal cluster under the control of Scer\GAL4²²¹ significantly increases the number of dendritic ends of both ddaE and ddaF neurons.

(Xu et al., 2008)

Expression of mir-9a^Scer\UAS.cLa under the control of Scer\GAL4^ap-md544 results in a loss of scutellar bristles in adult flies.

Expression of mir-9a^Scer\UAS.cLa under the control of Scer\GAL4^ap-md544 results in the loss of sensory organ precursors in the notum region of the wing disc.

(Li et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

mir-9a^UAS.cLa/Scer\GAL4^vg.PU is a suppressor | partially of visible | adult stage phenotype of TBPH^Q367X

(Li et al., 2013)

mir-9a^UAS.cLa/Scer\GAL4^vg.PU is a suppressor | partially of visible phenotype of Scer\GAL4^vg.PU, sens^UAS.cNa

(Li et al., 2006)

Phenotype Manifest In

Suppressor of

Statement

Reference

mir-9a^UAS.cLa/Scer\GAL4^vg.PU is a suppressor | partially of scutellar bristle | increased number phenotype of TBPH^Q367X

(Li et al., 2013)

mir-9a^UAS.cLa/Scer\GAL4^vg.PU is a suppressor | partially of chaeta | ectopic phenotype of Scer\GAL4^vg.PU, sens^UAS.cNa

(Li et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of mir-9a^Scer\UAS.cLa under the control of Scer\GAL4^vg.PU partially rescues the supernumerary scutellar bristle phenotype of TBPH^Q367X/TBPH^Q367X mutants.

(Li et al., 2013)

Co-expression of mir-9a^Scer\UAS.cLa results in the suppression of the ectopic bristle phenotype caused by expression of sens^Scer\UAS.cNa under the control of Scer\GAL4^vg.PU.

(Li et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^ap-md544/mir-9a^UAS.cLa rescues mir-9a^J22/mir-9a^E39

(Bejarano et al., 2010)

Partially rescues

mir-9a^UAS.cLa/Scer\GAL4^vg.PU partially rescues mir-9a^J22

(Li et al., 2006)

Comments

Expression of mir-9a^Scer\UAS.cLa under the control of Scer\GAL4^ap-md544 completely rescues the continuity of the wing margin in mir-9a^J22/mir-9a^E39 animals. In the developing wing disc, the increased apoptosis seen in the wing pouch in mir-9a^J22/mir-9a^E39 animals is rescued in the dorsal compartment by expression of mir-9a^Scer\UAS.cLa under the control of Scer\GAL4^ap-md544.

(Bejarano et al., 2010)

The posterior wing margin defects seen in mir-9a^J22 flies are are completely rescued by expression of mir-9a^Scer\UAS.cLa under the control of Scer\GAL4^vg.PU, and the anterior margin bristle defects are also largely rescued.

(Li et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

mir-9a^Scer\UAS.cLa

mir-9a^UAS.cLa

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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