FlyBase Allele Report: Zzzz\CGG[90.UAS.EGFP]

in vitro construct

Nature of the Allele

Transgenic product class

trinucleotide_repeat_expansion

(Jin et al., 2003)

Mutagen

in vitro construct

(Jin et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-CGG90-EGFP}

Cytology

Description

UASt regulatory sequences are fused upstream of the EGFP version of Avic\GFP. A fragment containing 90 Zzzz\CGG repeats has been inserted between the transcriptional and translational start sites of Avic\GFP. The repeat fragment is derived from the 5'UTR of a Hsap\FMR1 gene containing premutation-length repeats, and consists of the sequence (CGG)[[9]]AGG(CGG)[[9]]AGG(CGG)[[70]].

(Jin et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Zzzz\CGG

Tagged with

EGFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of fragile X-associated tremor/ataxia syndrome

CEA

(Bhat et al., 2021, Malik et al., 2021, Kong et al., 2019, Linsalata et al., 2019, Weber et al., 2016, Oh et al., 2015, Galloway et al., 2014, Tan et al., 2012, Sofola et al., 2007, Sofola et al., 2007)

CEC

(Jin et al., 2007)

model of fragile X syndrome

CEA

(Zhang et al., 2018, Todd et al., 2013)

model of neurodegenerative disease

CEA

(Green et al., 2022, Peng et al., 2021, He et al., 2014, Todd et al., 2013, Qurashi et al., 2012, Tan et al., 2012, Todd et al., 2010, Jin et al., 2003)

model of primary ovarian insufficiency

CEA

(Trevino et al., 2021)

model of C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

CEA

(Glineburg et al., 2024)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CCG^90.UAS.EGFP

(Sofola et al., 2007)

model of fragile X-associated tremor/ataxia syndrome

is ameliorated by Zzzz\CCG^90.UAS.EGFP

(Sofola et al., 2007)

is ameliorated by Hsap\TARDBP^UAS.cLa

(Galloway et al., 2014)

is exacerbated by TBPH^GD6943

(Galloway et al., 2014)

is ameliorated by Hsap\CELF1^UAS.cdHa

(Sofola et al., 2007)

is ameliorated by Hsap\HNRNPA2B1^UAS.cSa

(Sofola et al., 2007)

is ameliorated by Hrb87F^UAS.cSa

(Sofola et al., 2007)

is ameliorated by Hrb98DE^UAS.cSa

(Sofola et al., 2007)

is exacerbated by Prosβ6^1.B.UAS

(Oh et al., 2015)

is exacerbated by Prosβ2^1.UAS

(Oh et al., 2015)

is ameliorated by Hsc70-4^UAS.cEa

(Oh et al., 2015)

is ameliorated by Pur-α^UAS.Tag:FLAG

(Jin et al., 2007)

is exacerbated by Rhau^EY09315

(Linsalata et al., 2019)

is exacerbated by RpS25^GD10582

(Linsalata et al., 2019)

is exacerbated by RpS25^KK107958

(Linsalata et al., 2019)

is ameliorated by SF2^HM05199

(Malik et al., 2021, Linsalata et al., 2019)

is ameliorated by SF2^HMS00358

(Malik et al., 2021, Linsalata et al., 2019)

is ameliorated by bel⁵

(Linsalata et al., 2019)

is ameliorated by bel⁶

(Linsalata et al., 2019)

is ameliorated by bel^GD1324

(Linsalata et al., 2019)

is ameliorated by bel^GL00057

(Linsalata et al., 2019)

is ameliorated by bel^GL00205

(Linsalata et al., 2019)

is ameliorated by bel^JF02884

(Linsalata et al., 2019)

is ameliorated by bel^L4740

(Linsalata et al., 2019)

is exacerbated by eIF4B^GD7103

(Linsalata et al., 2019)

is ameliorated by bel^S074407

(Linsalata et al., 2019)

is ameliorated by bel^cap-1

(Linsalata et al., 2019)

is ameliorated by bgcn^GD10012

(Linsalata et al., 2019)

is ameliorated by eIF4H1^KK108805

(Linsalata et al., 2019)

is ameliorated by eIF4H2^KK103972

(Linsalata et al., 2019)

is ameliorated by bgcn^KK106752

(Malik et al., 2021, Linsalata et al., 2019)

is ameliorated by eIF1^EY02210

(Linsalata et al., 2019)

is ameliorated by eIF1^GLC01849

(Linsalata et al., 2019)

is ameliorated by eIF1^HMC04556

(Linsalata et al., 2019)

is exacerbated by eIF1^HMC04556

(Linsalata et al., 2019)

is exacerbated by eIF1^KK109232

(Linsalata et al., 2019)

is exacerbated by eIF1A⁶⁴⁵

(Linsalata et al., 2019)

is exacerbated by eIF1A^GD10618

(Linsalata et al., 2019)

is exacerbated by eIF1A^JF01698

(Linsalata et al., 2019)

is exacerbated by eIF1A^JF02475

(Linsalata et al., 2019)

is exacerbated by eIF1A^KK108681

(Linsalata et al., 2019)

is exacerbated by eIF2α^815-29

(Linsalata et al., 2019)

is exacerbated by eIF2α^GD1430

(Linsalata et al., 2019)

is exacerbated by eIF2α^KK100282

(Linsalata et al., 2019)

is exacerbated by eIF3b^EY14430

(Linsalata et al., 2019)

is ameliorated by eIF4B^GD7103

(Linsalata et al., 2019)

is ameliorated by CG4306^HMC06152

(Kong et al., 2019)

is exacerbated by CG8353^HMS03373

(Kong et al., 2019)

is exacerbated by ChAT^HMC05021

(Kong et al., 2019)

is exacerbated by Pect^HMJ30278

(Kong et al., 2019)

is exacerbated by Ppat-Dpck^HMC04615

(Kong et al., 2019)

is exacerbated by Sk2^HMS03001

(Kong et al., 2019)

is exacerbated by ras^JF01445

(Kong et al., 2019)

is exacerbated by schlank^JF02502

(Kong et al., 2019)

is ameliorated by Pur-α^RI.RII.UAS

(Weber et al., 2016)

is ameliorated by Pur-α^UAS.cWa

(Weber et al., 2016)

is exacerbated by lncRNA:flam^BG02658

(Tan et al., 2012)

is exacerbated by lncRNA:flam^KG00476

(Tan et al., 2012)

is ameliorated by Drep2^ex13

(Bhat et al., 2021)

is ameliorated by bsk¹

(Bhat et al., 2021)

is ameliorated by SC35^EY07391

(Malik et al., 2021)

is ameliorated by SC35^HMC06150

(Malik et al., 2021)

is exacerbated by SF2^UAS.Tag:HA

(Malik et al., 2021)

is ameliorated by SRPK^HMS04491

(Malik et al., 2021)

is ameliorated by SRPK^HMS04507

(Malik et al., 2021)

is ameliorated by B52^HMS01661

(Malik et al., 2021)

is exacerbated by Syp^HMC04412

(Malik et al., 2021)

is exacerbated by Cbp80^KK100796

(Malik et al., 2021)

is exacerbated by Syp^MI11035

(Malik et al., 2021)

is exacerbated by Hel25E^HMS00076

(Malik et al., 2021)

is exacerbated by Hel25E^k11511

(Malik et al., 2021)

is ameliorated by eIF3g1^GLC01430

(Malik et al., 2021)

is exacerbated by Pabp2^HMS00553

(Malik et al., 2021)

is ameliorated by RpLP0^JF01335

(Malik et al., 2021)

is exacerbated by glo^HMS00079

(Malik et al., 2021)

model of neurodegenerative disease

is ameliorated by Hsc70-4^UAS.cEa

(Jin et al., 2003)

is exacerbated by Hsc70-4^K71S.UAS

(Jin et al., 2003)

is ameliorated by GIIIspla2^EP1516

(Qurashi et al., 2012)

is ameliorated by GIIIspla2^GD17243

(Qurashi et al., 2012)

is ameliorated by HDAC3^{UAS.Tag:V5,Tag:polyHis}

(Todd et al., 2010)

is exacerbated by HDAC6^RNAi.UAS

(Todd et al., 2010)

is ameliorated by HDAC6^{UAS.Tag:V5,Tag:polyHis}

(Todd et al., 2010)

is ameliorated by HDAC11^{UAS.Tag:V5,Tag:polyHis}

(Todd et al., 2010)

is exacerbated by HDAC11^RNAi.UAS

(Todd et al., 2010)

is exacerbated by vimar^k16722

(Tan et al., 2012)

is exacerbated by Drep2^KG02396

(Tan et al., 2012)

is ameliorated by Avic\GFP^{EGFP.Scer\UAS.P\T.mir-276aSP}

(Tan et al., 2012)

is exacerbated by mir-277^UAS.cTa

(Tan et al., 2012)

is ameliorated by Drep2^d00223

(Tan et al., 2012)

is ameliorated by DENR^GD17852

(Green et al., 2022)

is ameliorated by DENR^KK109336

(Green et al., 2022)

is exacerbated by Hrb87F^JF01757

(He et al., 2014)

is exacerbated by Hrb98DE^JF01249

(He et al., 2014)

is exacerbated by Hsap\FUS^UAS.Tag:HA

(He et al., 2014)

is ameliorated by Hsap\HNRNPA2B1^UAS.Tag:MYC

(He et al., 2014)

is exacerbated by Hsap\TARDBP^{Δ321-366.UAS.Tag:HA}

(He et al., 2014)

is ameliorated by Hsap\TARDBP^{FFLL.UAS.Tag:HA}

(He et al., 2014)

is exacerbated by Hsap\TARDBP^{G294A.UAs.Tag:MYC}

(He et al., 2014)

is exacerbated by Hsap\TARDBP^{M337V.UAS.Tag:MYC}

(He et al., 2014)

is exacerbated by Hsap\TARDBP^{NLSmut.UAS.Tag:MYC}

(He et al., 2014)

is ameliorated by Hsap\TARDBP^UAS.Tag:MYC

(He et al., 2014)

is ameliorated by Hsap\TARDBP^{UAS.cHa.Tag:HA}

(He et al., 2014)

model of primary ovarian insufficiency

is ameliorated by Pdha1^HMC04032

(Trevino et al., 2021)

is ameliorated by Sumo^HMS01540

(Trevino et al., 2021)

is ameliorated by dbe^HMS04474

(Trevino et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 2 )

Expression of Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} in the eye is used to model neurodegeneration associated with fragile X-associated tremor/ataxia syndrome.

(Sofola et al., 2007)

The Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} allele models pre-mutation alleles of Fragile X syndrome carriers.

(Jin et al., 2003)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior, with Scer\GAL4^elav.PU

(Galloway et al., 2014)

abnormal neuroanatomy, with Scer\GAL4^GMR.PU

(Galloway et al., 2014)

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.PF

(Tan et al., 2012, Sofola et al., 2007)

lethal, with Scer\GAL4^elav-C155

(Jin et al., 2003)

lethal | dominant, with Scer\GAL4^elav.PU

(Qurashi et al., 2012)

lethal - all die before end of larval stage, with Scer\GAL4^Act5C.PI

(Jin et al., 2003)

majority die during embryonic stage | dominant, with Scer\GAL4^elav.PU

(Qurashi et al., 2012)

short lived | RU486 conditional, with Scer\GAL4^{αTub84B.Switch.PK}

(Singh et al., 2021, Todd et al., 2010)

some die during larval stage, with Scer\GAL4^Act5C.PI

(Jin et al., 2003)

visible, with Scer\GAL4^GMR.PF

(Jin et al., 2003)

visible, with Scer\GAL4^GMR.PU

(Zhang et al., 2016, Sofola et al., 2007)

visible | adult stage, with Scer\GAL4^elav.PU

(Jiao et al., 2021)

visible | adult stage, with Scer\GAL4^GMR.long

(Oh et al., 2015)

visible | adult stage, with Scer\GAL4^GMR.PF

(Singh et al., 2021, Tan et al., 2012, Sofola et al., 2007)

visible | adult stage, with Scer\GAL4^GMR.PU

(Kong et al., 2019, Wong et al., 2014, Qurashi et al., 2012, Tan et al., 2012, Qurashi et al., 2011)

visible | heat sensitive, with Scer\GAL4^GMR.PF

(Todd et al., 2010)

wild-type, with Scer\GAL4^dpp.blk1

(Jin et al., 2003)

Phenotype Manifest In

eye

(Oh et al., 2015)

eye, with Scer\GAL4^elav.PU

(Jiao et al., 2021)

eye, with Scer\GAL4^GMR.PF

(Singh et al., 2021, Tan et al., 2012, Sofola et al., 2007, Jin et al., 2003)

eye, with Scer\GAL4^GMR.PU

(Kong et al., 2019, Chawla et al., 2016, Zhang et al., 2016, Galloway et al., 2014, Qurashi et al., 2012, Qurashi et al., 2011, Jin et al., 2007, Sofola et al., 2007)

eye | adult stage, with Scer\GAL4^GMR.PU

(Wong et al., 2014, Tan et al., 2012)

eye | heat sensitive, with Scer\GAL4^GMR.PF

(Todd et al., 2010)

eye photoreceptor cell, with Scer\GAL4^GMR.PU

(Sofola et al., 2007)

interommatidial bristle | adult stage, with Scer\GAL4^GMR.PU

(Qurashi et al., 2011)

interommatidial bristle | heat sensitive, with Scer\GAL4^GMR.PF

(Todd et al., 2010)

ommatidium, with Scer\GAL4^GMR.PF

(Singh et al., 2021, Tan et al., 2012, Sofola et al., 2007, Jin et al., 2003)

ommatidium | adult stage, with Scer\GAL4^GMR.PU

(Qurashi et al., 2011)

ommatidium | heat sensitive, with Scer\GAL4^GMR.PF

(Todd et al., 2010)

pigment cell, with Scer\GAL4^GMR.PF

(Jin et al., 2003)

retina, with Scer\GAL4^GMR.PU

(Chawla et al., 2016)

Detailed Description

Statement

Reference

The expression of Zzzz\CGG^90.UAS.EGFP under the control of Scer\GAL4^GMR.long induces eye necrosis.

(Jiao et al., 2021)

Individuals expressing Zzzz\CGG^90.UAS.EGFP under the control of Scer\GAL4^GMR.PF exhibit a rough eye phenotype, with ommatidial fusion.

The expression of Zzzz\CGG^90.UAS.EGFP during adulthood only, under the Scer\GAL4^{αTub84B.Switch.PK} and induced by RU486, leads to short adult lifespan.

(Singh et al., 2021)

Expressing Zzzz\CGG^90.UAS.EGFP under the control of Scer\GAL4^GMR.PU induces a rough eye phenotype, with some depigmentation.

(Kong et al., 2019)

Constant expression of Zzzz\CGG^90.UAS.EGFP under the control of Scer\GAL4^GMR.PU, or only during the developmental stages by the additional control of Gal80[ts], induces retinal degeneration.

(Chawla et al., 2016)

Expression of Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.PU results in eye neurodegeneration.

(Zhang et al., 2016)

Expression of Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.long leads to moderate rough eye phenotype in adult flies maintained at 28[o]C.

(Oh et al., 2015)

Expression of Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} in the developing eye, under the control of Scer\GAL4^GMR.PU, disrupts eye morphology, resulting in ommatidial loss and necrosis.

(Galloway et al., 2014)

Expression of Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.PU results in a rough eye phenotype.

(Wong et al., 2014, Qurashi et al., 2012, Sofola et al., 2007)

Expression of Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.PU results in neurodegenerative rough eye phenotype.

(Tan et al., 2012)

7 day-old flies expressing Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} under the control of Scer\GAL4^GMR.PF have disorganised, fused ommatidia.

(Tan et al., 2012)

Flies expressing Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.PU display eye degeneration phenotype (rough eye with disorganized ommatidial lattice and interommatidial bristles).

(Qurashi et al., 2011)

Expression of Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} in the fly eye under the control of Scer\GAL4^GMR.PF leads to a dose- and temperature-dependent rough-eye phenotype characterised by loss of pigmentation, ommatidial disorganization and abnormal eye bristle patterning.

There are very few deaths in flies transgenic for Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} and Scer\GAL4^{αTub84B.Switch.PK} in the absence of RU-486. When exposed to RU-486. however, these flies begin to die 3-4 days post drug, with 95% of flies dead by day 7. Treatment with the broad spectrum histone acetyltransferase (HAT) inhibitor drug Garcinol leads to dose-dependent increase in survival.

Flies expressing the Scer\GAL4^{αTub84B.Switch.PK} driver alone show no significant alterations in lifespan after exposure to RU-486.

(Todd et al., 2010)

7 day old eyes of Scer\GAL4^GMR.PU Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} flies contain Pur-α- and 'Hsp70'-positive inclusions.

Scer\GAL4^GMR.PU-mediated expression of Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} causes eye neurodegeneration.

(Jin et al., 2007)

Flies expressing Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} under the control of Scer\GAL4^GMR.PF have disorganised, fused ommatidia.

(Sofola et al., 2007)

Strong expression of Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.PF results in rough eyes, loss of pigmentation, and severe cell death. Moderate expression Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.PF results in a mild rough eye phenotype with holes in tangential sections of the eye. This phenotype strengthens with age.

Strong expression of Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^Act5C.PI results in late larval lethality, while moderate expression results in male lethality and reduced viability in females.

(Jin et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by kra[+]/kra^j9B6

(Singh et al., 2021)

Scer\GAL4^{αTub84B.Switch.PK}, Zzzz\CGG^90.UAS.EGFP has short lived | male limited | RU486 conditional phenotype, enhanceable by kra^JF02556/Scer\GAL4^{αTub84B.Switch.PK}

(Singh et al., 2021)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by schlank^JF02502/Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by Sk2^HMS03001/Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by ras^JF01445/Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by CG8353^HMS03373, Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by ChAT^HMC05021, Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by Pect^HMJ30278, Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by Ppat-Dpck^HMC04615, Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.long, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by Prosβ6^1.B.UAS, Scer\GAL4^GMR.long

(Oh et al., 2015)

Scer\GAL4^GMR.long, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by Prosβ2^1.UAS, Scer\GAL4^GMR.long

(Oh et al., 2015)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy phenotype, enhanceable by TBPH^GD6943/Scer\GAL4^GMR.PU

(Galloway et al., 2014)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by lncRNA:flam^BG02658/flam[+]

(Tan et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by lncRNA:flam^KG00476/flam[+]

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by mir-277^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, enhanceable by mir-277^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by Drep-2[+]/Drep2^KG02396

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, enhanceable by Drep-2[+]/Drep2^KG02396

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by vimar^k16722/vimar[+]

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, enhanceable by vimar^k16722/vimar[+]

(Tan et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by hts[+]/hts⁰¹¹⁰³

(Qurashi et al., 2011)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, enhanceable by Rm62[+]/Rm62⁰¹⁰⁸⁶

(Qurashi et al., 2011)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | heat sensitive phenotype, enhanceable by HDAC6^RNAi.UAS, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | heat sensitive phenotype, enhanceable by HDAC11^RNAi.UAS, Scer\GAL4^GMR.PF

(Todd et al., 2010)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.long, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, non-enhanceable by Atg6^RNAi.UAS, Scer\GAL4^GMR.long

(Oh et al., 2015)

Scer\GAL4^GMR.long, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, non-enhanceable by Atg12^RNAi.UAS, Scer\GAL4^GMR.long

(Oh et al., 2015)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, non-enhanceable by mir-ban^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by mir-ban^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, non-enhanceable by mir-1^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by mir-1^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, non-enhanceable by mir-let7^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by mir-let7^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, non-enhanceable by ban[+]/mir-ban¹²

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by ban[+]/mir-ban¹²

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, non-enhanceable by ban[+]/mir-ban²⁰

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by ban[+]/mir-ban²⁰

(Tan et al., 2012)

HDAC6^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | heat sensitive phenotype, non-enhanceable by Atg12^RNAi.UAS, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Suppressed by

Statement

Reference

Scer\GAL4^{αTub84B.Switch.PK}, Zzzz\CGG^90.UAS.EGFP has short lived | RU486 conditional phenotype, suppressible by kra^UAS.Tag:FLAG/Scer\GAL4^{αTub84B.Switch.PK}

(Singh et al., 2021)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, suppressible by kra^UAS.Tag:FLAG/Scer\GAL4^GMR.PF

(Singh et al., 2021)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, suppressible by CG4306^HMC06152, Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^elav.PU, Zzzz\CGG^90.UAS.EGFP has abnormal locomotor behavior phenotype, suppressible by Hsap\TARDBP^UAS.cLa, Scer\GAL4^elav.PU

(Galloway et al., 2014)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy phenotype, suppressible by Hsap\TARDBP^UAS.cLa, Scer\GAL4^GMR.PU

(Galloway et al., 2014)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, suppressible by GIIIspla2^EP1516/GIIIspla2[+]

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, suppressible by GIIIspla2^GD17243, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, suppressible by P{UAS-gypsy.RNAi}, Scer\GAL4^GMR.PU

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, suppressible | partially by mir-277^{sponge.UASp.EGFP}/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, suppressible | partially by mir-277^{sponge.UASp.EGFP}/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, suppressible by Drep2^d00223, Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, suppressible by Drep2^d00223, Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, suppressible by Rm62^EP3607, Scer\GAL4^GMR.PU

(Qurashi et al., 2011)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^GMR.PU

(Qurashi et al., 2011)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | heat sensitive phenotype, suppressible by HDAC11^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | heat sensitive phenotype, suppressible by HDAC3^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | heat sensitive phenotype, suppressible by HDAC6^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, suppressible by Zzzz\CCG^90.UAS.EGFP/Scer\GAL4^GMR.PU

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, suppressible by Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, suppressible by Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, suppressible by Hrb98DE^UAS.cSa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, suppressible by Hrb98DE^UAS.cSa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, suppressible by Hrb87F^UAS.cSa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, suppressible by Hrb87F^UAS.cSa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, suppressible by Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, suppressible by Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, non-suppressible by Scer\GAL4^GMR.long/Top2^GL00338

(Jiao et al., 2021)

Scer\GAL4^elav.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, non-suppressible by Top2^JF01300/Scer\GAL4^GMR.long

(Jiao et al., 2021)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by SK^BG01378

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by SK^d11567

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by sPLA2^GD5739/Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by CG14507^GD13420, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by GXIVsPLA2^G16441

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by GXIVsPLA2^f00744

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by GXIVsPLA2^GD3593, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by rsh^GD8769/Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by GIIIspla2^EP325

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by GIIIspla2^GD1217, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by CG3009^GD3534, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by JMJD7^GD6875, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by JMJD7^KG04150, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by iPLA2-VIA^EY05103/Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by iPLA2-VIA^KK101305/Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by Dhrs4^KG07864

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by Dhrs4^GD7058, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by sni^KG00373

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by sni^EY20992

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by CG10602^f04195

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by CG10602^GD7033, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by Gtpx^G7172

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by GstD8^GD17241, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by CG1492^GD3329, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible phenotype, non-suppressible by Ggt-1^d02194

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, non-suppressible by P{UAS-copia.RNAi}, Scer\GAL4^GMR.PU

(Tan et al., 2012)

Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has visible | adult stage phenotype, non-suppressible by Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Suppressor of

Statement

Reference

Zzzz\CGG^90.UAS.EGFP/Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\CCG^90.UAS.EGFP

(Sofola et al., 2007)

Other

Statement

Reference

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP, kra^JF02556 has lethal phenotype

(Singh et al., 2021)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP, kra[+]/kra^j9B6 has increased cell death | adult stage phenotype

(Singh et al., 2021)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP, kra^GL00690 has lethal phenotype

(Singh et al., 2021)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP, schlank^JF02502 has increased cell death phenotype

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Sk2^HMS03001, Zzzz\CGG^90.UAS.EGFP has increased cell death phenotype

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP, ras^JF01445 has increased cell death phenotype

(Kong et al., 2019)

CG8353^HMS03373, Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has increased cell death phenotype

(Kong et al., 2019)

ChAT^HMC05021, Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has increased cell death phenotype

(Kong et al., 2019)

Pect^HMJ30278, Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has increased cell death phenotype

(Kong et al., 2019)

Ppat-Dpck^HMC04615, Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has increased cell death phenotype

(Kong et al., 2019)

AGO2⁴¹⁴, Scer\GAL4^GMR.PU, Zzzz\CCG^90.UAS.EGFP, Zzzz\CGG^90.UAS.EGFP has lethal | pupal stage phenotype

(Sofola et al., 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by kra[+]/kra^j9B6

(Singh et al., 2021)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, enhanceable by kra[+]/kra^j9B6

(Singh et al., 2021)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by schlank^JF02502/Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by Sk2^HMS03001/Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by ras^JF01445/Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by CG8353^HMS03373, Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by ChAT^HMC05021, Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by Pect^HMJ30278, Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by Ppat-Dpck^HMC04615, Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by mir-100^sponge.UAS/Scer\GAL4^GMR.PU

(Chawla et al., 2016)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has retina phenotype, enhanceable by mir-100^sponge.UAS/Scer\GAL4^GMR.PU

(Chawla et al., 2016)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by mir-125^sponge.UAS/Scer\GAL4^GMR.PU

(Chawla et al., 2016)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has retina phenotype, enhanceable by mir-125^sponge.UAS/Scer\GAL4^GMR.PU

(Chawla et al., 2016)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by mir-let7^sponge.UAS/Scer\GAL4^GMR.PU

(Chawla et al., 2016)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has retina phenotype, enhanceable by mir-let7^sponge.UAS/Scer\GAL4^GMR.PU

(Chawla et al., 2016)

Scer\GAL4^GMR.long, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by Prosβ6^1.B.UAS, Scer\GAL4^GMR.long

(Oh et al., 2015)

Scer\GAL4^GMR.long, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by Prosβ2^1.UAS, Scer\GAL4^GMR.long

(Oh et al., 2015)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by TBPH^GD6943/Scer\GAL4^GMR.PU

(Galloway et al., 2014)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye | adult stage phenotype, enhanceable by lncRNA:flam^BG02658/flam[+]

(Tan et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye | adult stage phenotype, enhanceable by lncRNA:flam^KG00476/flam[+]

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by mir-277^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, enhanceable by mir-277^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by Drep-2[+]/Drep2^KG02396

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, enhanceable by Drep-2[+]/Drep2^KG02396

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by vimar^k16722/vimar[+]

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, enhanceable by vimar^k16722/vimar[+]

(Tan et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by hts[+]/hts⁰¹¹⁰³

(Qurashi et al., 2011)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has ommatidium | adult stage phenotype, enhanceable by hts[+]/hts⁰¹¹⁰³

(Qurashi et al., 2011)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has interommatidial bristle | adult stage phenotype, enhanceable by hts[+]/hts⁰¹¹⁰³

(Qurashi et al., 2011)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by Rm62[+]/Rm62⁰¹⁰⁸⁶

(Qurashi et al., 2011)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has ommatidium | adult stage phenotype, enhanceable by Rm62[+]/Rm62⁰¹⁰⁸⁶

(Qurashi et al., 2011)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has interommatidial bristle | adult stage phenotype, enhanceable by Rm62[+]/Rm62⁰¹⁰⁸⁶

(Qurashi et al., 2011)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye | heat sensitive phenotype, enhanceable by HDAC6^RNAi.UAS, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium | heat sensitive phenotype, enhanceable by HDAC6^RNAi.UAS, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has interommatidial bristle | heat sensitive phenotype, enhanceable by HDAC6^RNAi.UAS, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye | heat sensitive phenotype, enhanceable by HDAC11^RNAi.UAS, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium | heat sensitive phenotype, enhanceable by HDAC11^RNAi.UAS, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has interommatidial bristle | heat sensitive phenotype, enhanceable by HDAC11^RNAi.UAS, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, enhanceable by Hsc70-4^UAS.cEa, Scer\GAL4^GMR.PF

(Jin et al., 2003)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PF

(Jin et al., 2003)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has pigment cell phenotype, enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PF

(Jin et al., 2003)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.long, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-enhanceable by Atg6^RNAi.UAS, Scer\GAL4^GMR.long

(Oh et al., 2015)

Scer\GAL4^GMR.long, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-enhanceable by Atg12^RNAi.UAS, Scer\GAL4^GMR.long

(Oh et al., 2015)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-enhanceable by mir-ban^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, non-enhanceable by mir-ban^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-enhanceable by mir-1^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, non-enhanceable by mir-1^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-enhanceable by mir-let7^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, non-enhanceable by mir-let7^UAS.cTa/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-enhanceable by ban[+]/mir-ban¹²

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, non-enhanceable by ban[+]/mir-ban¹²

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-enhanceable by ban[+]/mir-ban²⁰

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, non-enhanceable by ban[+]/mir-ban²⁰

(Tan et al., 2012)

HDAC6^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye | heat sensitive phenotype, non-enhanceable by Atg12^RNAi.UAS, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by kra^UAS.Tag:FLAG/Scer\GAL4^GMR.PF

(Singh et al., 2021)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, suppressible by kra^UAS.Tag:FLAG/Scer\GAL4^GMR.PF

(Singh et al., 2021)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by CG4306^HMC06152, Scer\GAL4^GMR.PU

(Kong et al., 2019)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by GIIIspla2^EP1516/GIIIspla2[+]

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by GIIIspla2^GD17243, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye | adult stage phenotype, suppressible by P{UAS-gypsy.RNAi}, Scer\GAL4^GMR.PU

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible | partially by mir-277^{sponge.UASp.EGFP}/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, suppressible | partially by mir-277^{sponge.UASp.EGFP}/Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by Drep2^d00223, Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, suppressible by Drep2^d00223, Scer\GAL4^GMR.PF

(Tan et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by Rm62^EP3607, Scer\GAL4^GMR.PU

(Qurashi et al., 2011)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has ommatidium | adult stage phenotype, suppressible by Rm62^EP3607, Scer\GAL4^GMR.PU

(Qurashi et al., 2011)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has interommatidial bristle | adult stage phenotype, suppressible by Rm62^EP3607, Scer\GAL4^GMR.PU

(Qurashi et al., 2011)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^GMR.PU

(Qurashi et al., 2011)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has ommatidium | adult stage phenotype, suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^GMR.PU

(Qurashi et al., 2011)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has interommatidial bristle | adult stage phenotype, suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^GMR.PU

(Qurashi et al., 2011)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye | heat sensitive phenotype, suppressible by HDAC11^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium | heat sensitive phenotype, suppressible by HDAC11^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has interommatidial bristle | heat sensitive phenotype, suppressible by HDAC11^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye | heat sensitive phenotype, suppressible by HDAC3^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium | heat sensitive phenotype, suppressible by HDAC3^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has interommatidial bristle | heat sensitive phenotype, suppressible by HDAC3^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye | heat sensitive phenotype, suppressible by HDAC6^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium | heat sensitive phenotype, suppressible by HDAC6^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has interommatidial bristle | heat sensitive phenotype, suppressible by HDAC6^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^GMR.PF

(Todd et al., 2010)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by Pur-α^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Jin et al., 2007)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by Zzzz\CCG^90.UAS.EGFP/Scer\GAL4^GMR.PU

(Sofola et al., 2007)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye photoreceptor cell phenotype, suppressible by Zzzz\CCG^90.UAS.EGFP/Scer\GAL4^GMR.PU

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, suppressible by Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by Hrb98DE^UAS.cSa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, suppressible by Hrb98DE^UAS.cSa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by Hrb87F^UAS.cSa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, suppressible by Hrb87F^UAS.cSa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, suppressible by Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^GMR.PF

(Jin et al., 2003)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has pigment cell phenotype, suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^GMR.PF

(Jin et al., 2003)

Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^GMR.PF

(Jin et al., 2003)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by Scer\GAL4^GMR.long/Top2^GL00338

(Jiao et al., 2021)

Scer\GAL4^elav.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by Top2^JF01300/Scer\GAL4^GMR.long

(Jiao et al., 2021)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by GXIVsPLA2^GD3593, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by rsh^GD8769/Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by GIIIspla2^EP325

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by GIIIspla2^GD1217, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by CG3009^GD3534, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by JMJD7^GD6875, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by JMJD7^KG04150

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by iPLA2-VIA^EY05103

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by iPLA2-VIA^KK101305/Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by Dhrs4^KG07864

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by Dhrs4^GD7058, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by sni^KG00373

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by sni^EY20992

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by CG10602^f04195

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by CG10602^GD7033, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by Gtpx^G7172

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by GstD8^GD17241, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by CG1492^GD3329, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by Ggt-1^d02194

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by SK^BG01378

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by SK^d11567

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by sPLA2^GD5739/Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by CG14507^GD13420, Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by GXIVsPLA2^G16441

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by GXIVsPLA2^f00744

(Qurashi et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP has eye | adult stage phenotype, non-suppressible by P{UAS-copia.RNAi}, Scer\GAL4^GMR.PU

(Tan et al., 2012)

Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has eye phenotype, non-suppressible by Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Hsap\HNRNPA2B1^UAS.cSa, Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP has ommatidium phenotype, non-suppressible by Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Suppressor of

Statement

Reference

Zzzz\CGG^90.UAS.EGFP/Scer\GAL4^GMR.PU is a suppressor of eye photoreceptor cell phenotype of Scer\GAL4^GMR.PU, Zzzz\CCG^90.UAS.EGFP

(Sofola et al., 2007)

Zzzz\CGG^90.UAS.EGFP/Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CCG^90.UAS.EGFP

(Sofola et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The retinal degeneration induced by the expression of Zzzz\CGG^90.UAS.EGFP under the control of Scer\GAL4^GMR.PU is enhanced by the co-expression of mir-let7^sponge.UAS, mir-125^sponge.UAS or mir-100^sponge.UAS; If expression is limited to the developmental stages (using Gal8[ts] for the temporal control of expression), there is phenotypic enhancement by the co-expression of mir-let7^sponge.UAS, but not mir-125^sponge.UAS.

(Chawla et al., 2016)

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype induced by the expression of Zzzz\CGG^90.UAS.EGFP under the control of Scer\GAL4^GMR.PF is enhanced by kra^j9B6, even leading to some necrosis.

(Singh et al., 2021)

The eye defects induced by the expression of Zzzz\CGG^90.UAS.EGFP under the control of Scer\GAL4^GMR.PU (rough eye and depigmentation) are enhanced by the co-expression of either schlank^JF02502, Sk2^HMS03001 or ras^JF01445, even leading to necrotic patches.

(Kong et al., 2019)

The eye degeneration phenotype observed in adult flies expressing Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.long (and maintained at 28[o]C) is significantly enhanced by co-expression of either Prosβ6^1.B.Scer\UAS or Prosβ2^1.Scer\UAS (the latter of which on its own also induces rough eye phenotype), the eye degeneration is most severe when two copies of the Prosβ2^1.Scer\UAS transgene are used. The Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP}-induced eye phenotype is not modified by co-expression of either Atg6^{dsRNA.Scer\UAS} or Atg12^{dsRNA.Scer\UAS}.

(Oh et al., 2015)

Co-expression of Hsap\TARDBP^UAS.cLa suppresses the neurodegeneration seen in flies expressing Zzzz\CGG^90.UAS.EGFP under the control of Scer\GAL4^GMR.PU. The locomotion defects seen in flies expressing Zzzz\CGG^90.UAS.EGFP neuronally is also suppressed in these flies.

Knockdown of TBPH, through expression of TBPH^GD6943, enhances the eye phenotype seen in flies expressing Zzzz\CGG^90.UAS.EGFP under the control of Scer\GAL4^GMR.PU.

(Galloway et al., 2014)

One copy of GIIIspla2^EP1516 partially suppresses the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of GIIIspla2^GD17243 partially suppresses the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of SK^BG01378 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of SK^d11567 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of sPLA2^GD5739 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of CG14507^GD13420 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of GXIVsPLA2^G16441 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of GXIVsPLA2^f00744 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of GXIVsPLA2^GD3593 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of rad^GD8769 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of GIIIspla2^EP325 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of GIIIspla2^GD1217 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of CG3009^GD3534 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of CG10133^GD6875 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of CG10133^KG04150 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of iPLA2-VIA^EY05103 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of iPLA2-VIA^KK101305 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of CG10672^KG07864 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of CG10672^GD7058 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of sni^KG00373 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of sni^EY20992 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of CG10602^f04195 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of CG10602^GD7033 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of PHGPx^G7172 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of GstD8^GD17241 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of CG1492^GD3329 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of Ggt-1^d02194 does not suppress the rough eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PU.

(Qurashi et al., 2012)

The neurodegenerative rough eye phenotype characteristic for adult flies expressing Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.PU is exacerbated further by combination with a single copy of either flam^BG02658 or flam^KG00476 (both of which are permissive for the gypsy retrotransposon expression); the phenotype can be partially suppressed by co-expression of P{UAS-gypsy.dsRNA} but not P{UAS-copia.dsRNA}.

(Tan et al., 2012)

Expression of mir-277^Scer\UAS.cTa enhances the eye phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF. Enhanced disorganised, fused ommatidia are seen compared with expression of Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} alone.

Expression of ban^Scer\UAS.cTa has no effect on the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of mir-1^Scer\UAS.cTa has no effect on the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of let-7^Scer\UAS.cTa has no effect on the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

One copy of ban¹² has no effect on the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

One copy of ban²⁰ has no effect on the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of Avic\GFP^{EGFP.Scer\UAS.P\T.mir-276aSP} partially suppresses the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

One copy of Drep-2^KG02396 enhances the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of Drep-2^d00223 partially suppresses the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

One copy of vimar^k16722 enhances the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of mir-277^Scer\UAS.cTa enhances the eye phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PF. Enhanced disorganised, fused ommatidia are seen compared with expression of Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} alone.

Expression of ban^Scer\UAS.cTa has no effect on the fused ommatidia phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of mir-1^Scer\UAS.cTa has no effect on the fused ommatidia phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of let-7^Scer\UAS.cTa has no effect on the fused ommatidia phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PF.

One copy of ban¹² has no effect on the fused ommatidia phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PF.

One copy of ban²⁰ has no effect on the fused ommatidia phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of mir-277^{sponge.Scer\UAS.P\T.T:Avic\GFP-EGFP} partially suppresses the fused ommatidia phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PF.

One copy of Drep2^KG02396 enhances the fused ommatidia phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of Drep2^d00223 partially suppresses the fused ommatidia phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PF.

One copy of vimar^k16722 enhances the fused ommatidia phenotype seen when Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^GMR.PF.

(Tan et al., 2012)

The eye degeneration phenotype (rough eye with disorganized ommatidial lattice and interommatidial bristles) characteristic for flies expressing Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.PU is significantly worsened by combination with a single copy of either hts⁰¹¹⁰³ or Rm62⁰¹⁰⁸⁶ and partially rescued by co-expression of Rm62^EP3607 or Hsc70-4^Scer\UAS.cEa.

(Qurashi et al., 2011)

Co-expression of HdacX^{dsRNA.Scer\UAS} exacerbates the Scer\GAL4^GMR.PF>Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP}-induced rough-eye phenotype.

Overexpression of HdacX^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} suppresses the rough-eye phenotype resulting from the expression of Scer\GAL4^GMR.PF>Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP}.

Overexpression of Hdac3^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} suppresses the rough-eye phenotype resulting from the expression of Scer\GAL4^GMR.PF>Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP}.

Co-expression of Atg12^{dsRNA.Scer\UAS} has no effect on suppression of the Scer\GAL4^GMR.PF>Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} phenotype by HDAC6^{Scer\UAS.T:SV5\V5,T:Zzzz\His6}.

Co-expression of HDAC6^{dsRNA.Scer\UAS} enhances the Scer\GAL4^GMR.PF>Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP}-induced rough-eye phenotype.

Overexpression of HDAC6^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} suppresses the rough-eye phenotype resulting from the expression of Scer\GAL4^GMR.PF>Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP}.

(Todd et al., 2010)

Co-expression of both Zzzz\CCG^{90.Scer\UAS.T:Avic\GFP-EGFP} and Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.PU suppresses the disorganised external eye phenotype and photoreceptor cell degeneration which is seen when either construct is expressed singly under the control of Scer\GAL4^GMR.PU. This mutual suppression by Zzzz\CCG^{90.Scer\UAS.T:Avic\GFP-EGFP} and Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} does not occur if they are co-expressed under the control of Scer\GAL4^GMR.PU in a AGO2⁴¹⁴ homozygous background - in this case, the flies show pupal lethality and have a more severe eye phenotype than that seen when either construct is expressed singly.

(Sofola et al., 2007)

Expression of Hsap\CELF1^{Scer\UAS.cdHa} suppresses the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of Hrb98DE^Scer\UAS.cSa suppresses the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of Hrb87F^Scer\UAS.cSa suppresses the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of Hsap\HNRNPA2B1^Scer\UAS.cSa suppresses the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

Co-expression of Hsap\CELF1^{Scer\UAS.cdHa} does not prevent Hsap\HNRNPA2B1^Scer\UAS.cSa from suppressing the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

(Sofola et al., 2007)

Complementation and Rescue Data

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Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Avic\GFP^{Fmr1.CGG90.E.Scer\UAS}

Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP}

Zzzz\CGG^90.UAS.EGFP

Name Synonyms

Secondary FlyBase IDs

FBal0280528
FBal0157337

References (33)

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