FlyBase Allele Report: Dmel\Hrb98DE[UAS.cSa]

General Information

Symbol

Dmel\Hrb98DE^UAS.cSa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Sofola

FlyBase ID

FBal0279776

Feature type

allele

Associated gene

Dmel\Hrb98DE

Associated Insertion(s)

Carried in Construct

P{UAS-Hrb98DE.S}

Key Links

Transgenic product class

cDNA

(Sofola et al., 2007)

wild_type

(Sofola et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Sofola et al., 2007)

wild_type

(Sofola et al., 2007)

Mutagen

in vitro construct

(Sofola et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-Hrb98DE.S}

Cytology

Description

UASt regulatory sequences drive expression of a full length Hrb98DE cDNA.

(Sofola et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hrb98DE

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Sofola et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Hrb98DE^Scer\UAS.cSa suppresses neurodegeneration in the Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} eye expression model of fragile X-associated tremor/ataxia syndrome.

(Sofola et al., 2007)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hrb98DE^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of visible | adult stage phenotype of Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Hrb98DE^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Sofola et al., 2007)

Hrb98DE^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Sofola et al., 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hrb98DE^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PF

(Sofola et al., 2007)

Hrb98DE^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Sofola et al., 2007)

Hrb98DE^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of ommatidium phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Sofola et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hrb98DE^Scer\UAS.cSa suppresses the rough eye phenotype seen when Hsap\CELF1^{Scer\UAS.cdHa} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of Hrb98DE^Scer\UAS.cSa suppresses the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

(Sofola et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hrb98DE^Scer\UAS.cSa

Hrb98DE^UAS.cSa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Sofola

Secondary FlyBase IDs

References (1)

Report Sections

Open Close