FlyBase Gene Report: Dmel\Hrb98DE

(Fisher et al., 2012)

embryonic stage 7 -- 8

dorsal head epidermis primordium

(Fisher et al., 2012)

embryonic stage 9 -- 10

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

Comment: 0-20 hr AEL

(Haynes et al., 1990)

organism

(Haynes et al., 1990)

pupal stage

(Haynes et al., 1990)

oogenesis & adult stage | female

ovary

(Haynes et al., 1990)

pcr

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

Comment: 12-20 hr AEL

(Haynes et al., 1990)

pupal stage

organism

(Haynes et al., 1990)

oogenesis & adult stage | female

ovary

(Haynes et al., 1990)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

ovary

(Pisa et al., 2009)

third instar larval stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from high throughput direct assay

(Lye et al., 2014)

inferred from direct assay

(Ji and Tulin, 2012)

located_in polytene chromosome puff

inferred from direct assay

(Ji and Tulin, 2009)

part_of ribonucleoprotein complex

inferred from direct assay

(Matunis et al., 1992)

inferred from physical interaction with FLYBASE:sqd; FB:FBgn0263396

(Matunis et al., 1992)

Expression Deduced from Reporters

Reporter: Mi{PT-GFSTF.1}Hrb98DE^{MI10594-GFSTF.1}

Stage

Tissue/Position (including subcellular localization)

Reference

larval brain

(Nagarkar-Jaiswal et al., 2015)

Reporter: P{PTT-GC}Hrb98DE^ZCL0588

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis & adult stage | female

• nucleus

(Cooley et al., 2003.5)

• nucleus

(Cooley et al., 2003.5)

Reporter: PBac{602.P.SVS-1}Hrb98DE^CPTI000165

Stage

Tissue/Position (including subcellular localization)

Reference

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

oogenesis

(Lowe et al., 2014)

(Lowe et al., 2014)

spermatogenesis

primary spermatocyte

(Lowe et al., 2014)

Y chromosome loop

(Lowe et al., 2014)

Reporter: PBac{602.P.SVS-1}Hrb98DE^CPTI000205

Stage

Tissue/Position (including subcellular localization)

Reference

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

oogenesis

(Lowe et al., 2014)

(Lowe et al., 2014)

spermatogenesis

primary spermatocyte

(Lowe et al., 2014)

Y chromosome loop

(Lowe et al., 2014)

Reporter: PBac{768.FSVS-0}Hrb98DE^CPTI003669

Stage

Tissue/Position (including subcellular localization)

Reference

adult brain cell body rind

Comment: punctate expression in adult brain cortex

(Knowles-Barley, 2011.8.24)

adult gnathal ganglion

(Knowles-Barley, 2011.8.24)

adult brain

Comment: low expression throughout adult brain

(Knowles-Barley, 2011.8.24)

oogenesis

(Lowe et al., 2014)

View Dmel\Hrb98DE in JBrowse

(Lowe et al., 2014)

spermatogenesis

primary spermatocyte

(Lowe et al., 2014)

Y chromosome loop

(Lowe et al., 2014)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Hrb98DE

View exonic expression by tissue for Dmel\Hrb98DE

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0001215

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43385/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0001215

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0001215

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0001215

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9983

Flygut - An atlas of the Drosophila adult midgut

FBgn0001215

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 15 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hrb98DE

Transgenic constructs containing regulatory region of Hrb98DE

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6209

(Ji and Tulin, 2012, Ji and Tulin, 2009)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Scer\GAL4^Act5C.PI

Hrb98DE^GD14939

lethal, with Scer\GAL4^αTub84B.PL

Hrb98DE^GD14939

lethal | female limited, with Scer\GAL4^dome-PG14

Hrb98DE^HMS00342

partially lethal - majority die, with Scer\GAL4^VGlut1-OK371

partially lethal - majority die (with Df(3R)Exel6209)

Hrb98DE^d05172

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Hrb98DE^GD14939

viable, with Scer\GAL4^elav.PLu

Hrb98DE^GS12795

viable, with Scer\GAL4^pnr-MD237

Hrb98DE^GD14939

viable, with Scer\GAL4^tin.CΔ4

Hrb98DE^GD14939

Sterility

Allele

female semi-sterile, with Scer\GAL4^VP16.otu

Hrb98DE^HMS00342

female semi-sterile (with Df(3R)Exel6209)

Hrb98DE^d05172

fertile

Hrb98DE^ZCL0588

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

Hrb98DE^GD14939

abnormal cell adhesion | oogenesis, with Scer\GAL4^slbo.2.6

Hrb98DE^HMS00342

abnormal cell migration | oogenesis, with Scer\GAL4^slbo.2.6

Hrb98DE^HMS00342

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

Hrb98DE^JF01249

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Hrb98DE^GD14939

abnormal planar polarity, with Scer\GAL4^pnr-MD237

Hrb98DE^GD14939

flightless, with Scer\GAL4^Mef2.PR

Hrb98DE^GD14939

majority die during pharate adult stage, with Scer\GAL4^VGlut1-OK371

short lived, with Scer\GAL4^elav.PU

Hrb98DE^JF01249

some die during larval stage (with Df(3R)Exel6209)

Hrb98DE^d05172

visible, with Scer\GAL4^Mhc.PW

visible, with Scer\GAL4^nub-AC-62

Hrb98DE^HMS00342

visible, with Scer\GAL4^pnr-MD237

Hrb98DE^GD14939

Phenotype manifest in

Allele

border follicle cell, with Scer\GAL4^slbo.2.6

Hrb98DE^HMS00342

chaeta | increased number, with Scer\GAL4^pnr-MD237

Hrb98DE^GD14939

egg chamber | anterior (with Df(3R)Exel6209)

Hrb98DE^d05172

egg chamber | lateral (with Df(3R)Exel6209)

Hrb98DE^d05172

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

Hrb98DE^HMS00342

female germline stem cell (with Df(3R)Exel6209)

Hrb98DE^d05172

indirect flight muscle cell, with Scer\GAL4^Mhc.PW

Hrb98DE^{D302V.UAS.Tag:FLAG}

indirect flight muscle cell | progressive, with Scer\GAL4^Mhc.PW

Hrb98DE^{D302V.UAS.Tag:FLAG}

mesonotum, with Scer\GAL4^pnr-MD237

Hrb98DE^GD14939

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

Hrb98DE^HMS00342

myofibril, with Scer\GAL4^Mef2.PR

Hrb98DE^GD14939

oocyte (with Df(3R)Exel6209)

Hrb98DE^d05172

sarcomere, with Scer\GAL4^Mef2.PR

Hrb98DE^GD14939

trichogen cell, with Scer\GAL4^pnr-MD237

Hrb98DE^GD14939

wing, with Scer\GAL4^Mhc.PW

wing, with Scer\GAL4^nub-AC-62

Hrb98DE^HMS00342

Z disc, with Scer\GAL4^Mef2.PR

Hrb98DE^GD14939

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (72)

Hsap\HNRNPA1L2

11 of 14

Yes

Hsap\HNRNPA1

10 of 14

Yes

Hsap\HNRNPA2B1

10 of 14

Yes

Hsap\HNRNPA3

9 of 14

Yes

Hsap\HNRNPA1P48

8 of 14

Yes

Hsap\HNRNPA0

3 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\RBMY1B

1 of 14

Hsap\RBMY1D

1 of 14

Hsap\RBMY1E

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

144

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (35)

Rnor\Hnrnpa1

11 of 14

Yes

Rnor\Hnrnpa2b1

10 of 14

Yes

Rnor\Hnrnpa3

9 of 14

Yes

Rnor\LOC100911361

8 of 14

Yes

Rnor\LOC681410

3 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Rbm31y

1 of 14

Rnor\Rbm34

1 of 14

Rnor\Rbm38

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (37)

Mmus\Hnrnpa1

11 of 14

Yes

Mmus\Hnrnpa2b1

10 of 14

Yes

Mmus\Hnrnpa3

9 of 14

Yes

Mmus\Gm17190

6 of 14

Yes

Mmus\Hnrnpa0

3 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Gm21379

1 of 14

Mmus\Hnrnpa1l2-ps2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (38)

Xtro\hnrnpa3

9 of 13

Yes

Xtro\hnrnpa1

8 of 13

Yes

Xtro\hnrnpa2b1

6 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (43)

Drer\hnrnpa1b

11 of 14

Yes

Drer\hnrnpa1a

10 of 14

Yes

Drer\hnrnpa3

9 of 14

Yes

Drer\hnrnpa0l

5 of 14

Yes

Drer\hnrnpa0a

3 of 14

Yes

Drer\hnrnpa0b

3 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (34)

Cele\hrpa-1

10 of 14

Yes

Cele\hrpa-2

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (36)

Agam\AgaP_AGAP002374

10 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP013440

1 of 12

Agam\NCBP2_ANOGA

1 of 12

Arabidopsis thaliana (thale-cress) (108)

Atha\AT3G13224

3 of 13

Yes

Atha\AT5G40490

3 of 13

Yes

Atha\AT1G01080

2 of 13

Yes

Atha\AT1G17640

2 of 13

Atha\AT1G60000

2 of 13

Atha\AT2G22100

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Atha\AT3G07810

2 of 13

Atha\AT3G15010

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Atha\NUC-L2

2 of 13

Yes

Atha\PHIP1

2 of 13

Yes

Atha\RBP31

2 of 13

Atha\UBA1A

2 of 13

Yes

Atha\UBA2A

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT3G46020

1 of 13

Yes

Atha\AT4G09040

1 of 13

Atha\AT4G13860

1 of 13

Yes

Atha\AT4G36960

1 of 13

Atha\AT5G03495

1 of 13

Yes

Atha\AT5G06210

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G46840

1 of 13

Atha\AT5G47620

1 of 13

Atha\AT5G51730

1 of 13

Yes

Atha\AT5G53680

1 of 13

Atha\AT5G53700

1 of 13

Yes

Atha\AT5G53720

1 of 13

Atha\AT5G54580

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\GR-RBP5

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\UBP1B

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (9)

Scer\HRP1

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Scer\NSR1

1 of 13

Yes

Scer\PAB1

1 of 13

Scer\PUB1

1 of 13

Scer\SGN1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\SPBC660.15

3 of 12

Yes

Spom\gar2

2 of 12

Yes

Spom\nop12

1 of 12

Spom\pab2

1 of 12

Spom\rnp24

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Hrb98DE. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (40)

12 of 13

9 of 13

4 of 13

3 of 13

3 of 13

sqd

3 of 13

Caper

2 of 13

CG34354

2 of 13

msi

2 of 13

SLIRP1

2 of 13

SLIRP2

2 of 13

Sxl

2 of 13

Syp

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

hfp

1 of 13

lark

1 of 13

LS2

1 of 13

maca

1 of 13

orb2

1 of 13

orb

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Spx

1 of 13

ssx

1 of 13

HNRNPA1; heterogeneous nuclear ribonucleoprotein A1

1 of 13

trv

1 of 13

U2af50

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Hrb98DE^JF01249

model of neurodegenerative disease

CEA

(Romano et al., 2014)

Hrb98DE^{D302V.UAS.Tag:FLAG}

model of inclusion body myopathy with Paget disease of bone and frontotemporal dementia

CEC

(Li et al., 2016)

Potential Models Based on Orthology ( 4 )

Human Ortholog

Disease

Evidence

References

model of inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3

IEA

(FlyBase, 2019-)

model of amyotrophic lateral sclerosis type 20

IEA

(FlyBase, 2019-)

model of distal myopathy 3

IEA

(FlyBase, 2019-)

HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1

model of inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

Hrb98DE^UAS.cSa

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Sofola et al., 2007)

Hrb98DE^JF01249

exacerbates neurodegenerative disease

modeled by TBPH^GD6943, TBPH^Δ23

(Romano et al., 2014)

modeled by Zzzz\CGG^90.UAS.EGFP

(He et al., 2014)

ameliorates neurodegenerative disease

modeled by TBPH^UAS.Tag:FLAG

(Appocher et al., 2017)

Hrb98DE^GD14939

DOES NOT ameliorate spinocerebellar ataxia 31

modeled by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^W.UAS, Hsap\TARDBP^UAS.cIb

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^S.UAS, Hsap\TARDBP^UAS.cIb

(Ishiguro et al., 2017)

Hrb98DE^{D302V.UAS.Tag:FLAG}

model of inclusion body myopathy with Paget disease of bone and frontotemporal dementia

is ameliorated by mrj^{UAS.WT.Tag:FLAG}

(Li et al., 2016)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HNRNPA1L2; heterogeneous nuclear ribonucleoprotein A1 like 2

11 of 14

HNRNPA1; heterogeneous nuclear ribonucleoprotein A1

10 of 14

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1; HNRNPA1

HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1

10 of 14

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A2/B1; HNRNPA2B1

inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2

HNRNPA3; heterogeneous nuclear ribonucleoprotein A3

9 of 14

605372

HNRNPA1L3; heterogeneous nuclear ribonucleoprotein A1 like 3

8 of 14

HNRNPA0; heterogeneous nuclear ribonucleoprotein A0

3 of 14

609409

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hrb98DE - CG9106

two hybrid

(Hu et al., 2017.6.13)

Hrb98DE - Hrb27C

pull down, autoradiography

(Horan et al., 2015)

Hrb98DE - Hrb87F

experimental knowledge based

(Guruharsha et al., 2011)

Hrb98DE - InR

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Hrb98DE - Mettl14

anti tag coimmunoprecipitation, anti tag western blot

(Tang et al., 2021)

Hrb98DE - Nca

two hybrid

(Hu et al., 2017.6.13)

Hrb98DE - PGRP-LB

experimental knowledge based

(Guruharsha et al., 2011)

Hrb98DE - Parp1

anti tag coimmunoprecipitation, western blot

(Ji and Tulin, 2009)

Hrb98DE - Pi3K21B

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Hrb98DE - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Hrb98DE - Su(var)205

anti tag coimmunoprecipitation, western blot

(Tan et al., 2012)

Hrb98DE - TBPH

far western blotting, Identification by mass spectrometry

(Romano et al., 2014)

Hrb98DE - foxo

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Hrb98DE - gig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Hrb98DE - glo

experimental knowledge based

(Guruharsha et al., 2011)

Hrb98DE - kel

proximity-dependent biotin identification, Identification by mass spectrometry

(Mannix et al., 2019)

Hrb98DE - mrj

anti tag coimmunoprecipitation, anti tag western blot

(Li et al., 2016)

Hrb98DE - sqd

anti bait coimmunoprecipitation, molecular weight estimation by autoradiography, molecular weight estimation by staining

(Amero et al., 1993, Matunis et al., 1992)

RNA-protein

Physical Interaction

Assay

References

Hrb98DE - Dscam1

anti bait coimmunoprecipitation, nucleotide sequence identification

(Olson et al., 2007)

Hrb98DE - how

anti bait coimmunoprecipitation, reverse transcription pcr

(Ji and Tulin, 2016)

Hrb98DE - lncRNA:Hsrω

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Ji and Tulin, 2009)

Hrb98DE - nanos

anti tag coimmunoprecipitation, nucleic acid uv cross-linking assay, tag visualisation, anti bait coimmunoprecipitation, reverse transcription pcr

(Ji and Tulin, 2016)

Hrb98DE - pelo

anti bait coimmunoprecipitation, reverse transcription pcr

(Ji and Tulin, 2016)

Hrb98DE - pros

pull down, Identification by mass spectrometry

(Borah et al., 2009)

Hrb98DE - pum

anti bait coimmunoprecipitation, reverse transcription pcr

(Ji and Tulin, 2016)

Hrb98DE - shg

nucleic acid uv cross-linking assay, tag visualisation, anti bait coimmunoprecipitation, quantitative reverse transcription pcr, reverse transcription pcr, electrophoretic mobility shift assay

(Ji and Tulin, 2016, Ji and Tulin, 2012)

Hrb98DE - shu

anti bait coimmunoprecipitation, reverse transcription pcr

(Ji and Tulin, 2016)

RNA-RNA

Physical Interaction

Assay

References

Hrb98DE - mir-1

luminiscence technology

(King et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Li et al., 2016)

enhanceable

(Ji and Tulin, 2012)

Parg|Hrb98DE

suppressible

shg

(Ji and Tulin, 2012)

suppressible

shg

(Ji and Tulin, 2012)

enhanceable

(Romano et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Romano et al., 2014)

suppressible