FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hrb98DED302V.UAS.Tag:FLAG
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General Information
Symbol
Dmel\Hrb98DED302V.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0319287
Feature type
allele
Associated gene
Dmel\Hrb98DE
Associated Insertion(s)
Carried in Construct
P{UAS-Flag-Hrb98DE.D302V}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Li et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Li et al., 2016)
Mutagen
in vitro construct
(Li et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-Flag-Hrb98DE.D302V}
Cytology
Description

UASt regulatory sequences drive expression of a mutated Hrb98DE LD38464 cDNA (contains the amino acid replacement D302V, which is associated with disease in the human ortholog Hsap\HNRNPA2B1) which is tagged with Tag:FLAG.

(Li et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hrb98DE
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:28,603,211..28,603,211 [+]
Nucleotide change:

A28603211T

Amino acid change:

D305V | Hrb98DE-PA; D306V | Hrb98DE-PB; D306V | Hrb98DE-PC; D302V | Hrb98DE-PD; D301V | Hrb98DE-PE; D302V | Hrb98DE-PF

Reported amino acid change:

D302V

Comment:

Analogous mutation in human HNRNPA2B1 implicated in inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2; mutation carried on in vitro construct; site of nucleotide substitution in fly gene and specific disease association inferred by FlyBase curator.

(Li et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Li et al., 2016)

      Analogous mutation in two paralogous human genes (HNRNPA2B1 and HNRNPA1) implicated in sub-types of IBMPFD.

      HNRNPA2B1:p.Asp302Val
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      HNRNPA2B1:p.As290Val
      Associated human disease model(s)
      External database links
      ClinVar: 65454
      Comments concerning this variant
      HNRNPA1:p.Asp314Val
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      HNRNPA1:p.Asp262Val
      Associated human disease model(s)
      External database links
      ClinVar: 65451
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hrb98DED302V.Scer\UAS.T:Zzzz\FLAG driven by Scer\GAL4Mhc.PW leads to abnormal wing postures (up or down compared to wild type) and age-related accumulation of cytoplasmic aggregates in indirect flight muscle. Expression in the eye driven by Scer\GAL4GMR.PU does not lead to abnormal eye phenotypes. Expression driven by Scer\GAL4VGlut-OK371 does not significantly affect locomotion in third instar larvae or lead to cytoplasmic aggregates in indirect flight muscle, but results in late pupal lethality (almost 100% of flies die when trying to leave the pupal case).

      (Li et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of mrjScer\UAS.WT.T:Zzzz\FLAG significantly suppresses (and presence of Df(2R)BSC434 significantly enhances) cytoplasmic aggregation in indirect flight muscle seen in flies with expression of Hrb98DED302V.Scer\UAS.T:Zzzz\FLAG driven by Scer\GAL4Mhc.PW; co-expression of mrjScer\UAS.WT.T:Zzzz\FLAG also partially suppresses abnormal wing posture in Scer\GAL4Mhc.PW>Hrb98DED302V.Scer\UAS.T:Zzzz\FLAG flies.

      (Li et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hrb98DED302V.Scer\UAS.T:Zzzz\FLAG
      Hrb98DED302V.UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)